腸疾患 診療時 留意点

경난호 藥業新聞社 1976 醫藥情報 Vol.1976 No.10

인슐린비의존형 당뇨병 환자에서 혈청 항 cardiolipin 항체 측정의 의의

경난호,성연아,김희진,홍영선 대한당뇨병학회 1997 Diabetes and Metabolism Journal Vol.21 No.1

인슐린비의존형 당뇨병 환자에서 체중변화에 따른 치료 및 합병증 발생 양상에 관한 관찰

경난호,성연아,김희진,홍영선 대한당뇨병학회 1997 Diabetes and Metabolism Journal Vol.21 No.1

당뇨병환자에서 QT간격 연장의 의의

경난호 梨花女子大學校 韓國生活科學硏究院 1992 韓國生活科學硏究院 論叢 Vol.50 No.-

A long QT interval in diabetic patients is attributed to autonomic neuropathy and is thought to predispose to arrhythmias and sudden death. Measurement of the QTc interval in resting electrocardiography in patients with diabetes mellitus may be a simple method for assessment of alterations in cardiac autonomic innervation. Author studied the value of resting corrected QT interval by Bazzatt's formula (QTc) as a marker of cardiac autonomic neuropathy(CAN) in patients with DM and relationship between a long QTc interval and arrhythmia. Sixty patients with DM(52 with NIDDM, and 8 with IDDM) underwent cardiac autonomic function tests(resting heart rate, heart rate response to standing, deep breathing and Valsalva maneuver and blood pressure response to standing) and had ambulatory electrocardiographic monitoring for 24 hours. The results were as follows, 1) The QTc interval of diabetic patients was significantly prolonged than that of control subjects(p<0.05). 2) Thirty-six diabetic patients had a long QTc interval(>435 msec), and of the patients with long QTc interval, 30(83.3%) had one or more abnormal CAN score compared with 7(29.2%) of those with normal QTc interval. 3) The direct linear relationship between QTc interval and extent of cardiac autonomic neuropathy represented by cardiac autonomic function score was found(r=0,53, p<0.05). 4) Diabetic patients with long QTc interval had significantly longer duration of DM than those with normal QTc interval(p<0.05). 5) Ambulatory electrocardiographic monitoring revealed no significant ventricular arrhythmia in diabetic patients with or without long QTc interval. In conclusion, The QTc interval was an additional non-invasive diagnostic tool in the assessment of CAN in diabetic patients, and these data did not demonstrate a potential arrhythmogenic effect of long QT interval.

제2형 당뇨병의 최신지견

경난호 梨花女子大學校 醫科大學 醫科學硏究所 1983 EMJ (Ewha medical journal) Vol.6 No.4

Unsteady-state 의 ergometer 작업을 할 때의 심박수와 산소섭취량의 변동

박정일,경난호 가톨릭대학산업의학센타 산업의학연구소 1975 韓國의 産業醫學 Vol.14 No.4

8 healthy male subjects aged 22-26 years were performed to ride bicycle ergometer with workload of 125,150 and 175 watts just by the time which the final working heart rate was reached to 130,140,150, and 160(beats, min). We tried to evaluate the effects of work intensity & duration on the oxygen uptake at end of work and recovery phase of heart rate when the final working heart rate was same regardless to workload and duration. The results obtained were as follows; 1. At the ergometer work on which the final heart rate was 130 and 140(beats/min),the heavier the workload, the oxygen uptake at end of work was decreased gradually. But in the case of ergometer work on which the final working heart rate was 150 and 160(beats/min), there was no changes in oxygen uptake at end of work. 2. There were no differences in recovery time regardless to workload and duration when the final working heart rate was same. 3. P?? of ergometer work was increased gradually according to the final heart rate, but not to workload and work duration.

여성에서 성 호르몬결합 글로불린 및 dehydroepiandrosterone sulfate와 심혈관 질환 위험인자간의 상관관계

경난호,성연아,홍영선,오지영,최혜영 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.2

Background: Cardiovascular disease is the major cause of morbidity and mortality. It is well known that androgen and sex hormone-binding globulin(SHBG) in women were associated with risk factors for cardiovascular disease such as obesity, central fat accumulation and atherogenic lipid profile. High resolution B-mode ultrasonography can visualize directly both luminal and vessel wall characteristics, and ultrasonic measurement of carotid intima-medial thickness(IMT) can be used to investigate the atherosclerosis of coronary, cerebral and peripheral arteries. The aim of this study was to evaluate the relationship between the serum dehydroepiandrosterone sulfate(DHEA-S) and SHBG, and body fat distribution pattern, cardiovascular risk factor and carotid atherosclerosis in women. Methods: Blood pressure, fasting serum glucose, insulin, lipid profile, SHBG and DHEA-S were measured. Body fat distribution pattern was assessed by waist to hip ratio, waist to thigh ratio and subscapular to triceps skin fold thickness ratio, faf mass measured by bioelectric impedance analyzer, subcutaneous fat area, visceral fat area, and visceral to subcutaneous fat area ratio(VSR) at the level of umbilicus using the computed tomography. The IMT of the carotid artery was measured by high resolution B mode ultrasound as a marker of atherosclerosis. Results: 1) There was no significant difference of age-adjusted values of carotid IMT among subjects with NGT(0.426+-0.09mm), IGT(0.46+-10.09mm) and NIDDM(0.453+-0.11mm). 2) In postrnenopausal women, carotid IMT was greater(0.484+-0.11mm, p=0.05) than premenopausal women(0.426+-0.08mm), but it was not significant after age adjustment. Serum SHBG and DHEA-S levels in postmenopausal women were significantly lower(p$lt;0.05) than premenopausal women, but they were not significant after age adjustment. 3) Carotid IMT was significantly correlated with age(r=0.37, p$lt;0.01), fasting serum glucose (r=0.32, p$lt;0.01), total cholesterol(r= 0.25, p$lt;0.05), LDL-cholesterol(r=0.26, p$lt;0.05), visceral fat area(r=0.35, p$lt;0.01) and VSR(r=0.31, p$lt;0.05). 4) By the stepwise multiple regression analysis, carotid IMT was positively and significantly associated with age(p$lt;0.01) and serum DHEA-S concentration(p$lt;0.05) in dent of age, body mass index, waist to hip ratio, fasting serum glucose. Conclusion: Carotid IMT was associated with age and serum DHEA-S concentration in women without cardiovascular disease. Therefore, serum DHEA-S may be one of risk factors for cardiovascular disease in women. However, we could not conclude its cause-result relationship because of cross sectional nature of our study, and prospective study will be needed (J Kor Soc Endocrinol 13:205-215, 1998).

糖尿病 患者에서의 血淸脂質代射및 Hemoglobin A_1c에 관한 硏究

경난호,이순남,박이갑 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.3

The authors studied 50 controls(25 male and 25 female) and 79 diabetes mellitus patients(38 male and 41 female) who were admitted to Ewha Womans University Hospital from June, 1983 to May, 1984 to investigate the disorders of lipid metabolism, hemoglobin A_1c and their correlaton. The results were as follows: 1) Age incidence was highest in the 6th decades. 2) Mean fasting blood sugar was 191.9±82.29mg% and postprandial 2hour blood sugar was 278.81±118.19mg% in male diabetes mellitus patients, and 196.48±68.94mg% and 261.16±85.84mg% in female diabetes mellitus patients. After control diabetes mellitus blood sugar levels were decreased significantly. 3) Hemoglobin A_1c levels at fasting and postprandial 2 hour were significantly higher than those of controls. And Hemoglobin A_1c level were progressivly decreased after 3 months' controlling of diabetes mellitus. 4) Pre-β and β-lipoprotein, triglycerides and cholesterol were significantly higher than those of controls but α-lipoprotein was lower than that of controls. After 6 months of diabetic control, pre β-lipoprotein, triglycerides and cholesterol were decreased. 5) Between Hemoglobin A_1c and fasting blodo sugar had positive correlation, an cholesterol and hemoglobin A_1c also had positive correlation, but those were not statistically significant.

관상동맥질환의 임상적 연구

경난호 梨花女子大學校 醫科大學 醫科學硏究所 1982 EMJ (Ewha medical journal) Vol.5 No.4

A clinical observation was done on 144 cases of coronary heart disease admitted to Ewha Womans University Hospital from January, 1973 to December, 1997. The following results have been obtained. 1. The 144 cases were composed with 46.4% of atherosclerotic heart disease, 29.2% of myocardial infarction, 18.8% of coronary insuffiency and 5.6% of angina pectoris. 2. The ration of male to female was 1:1.14. The most patients were in the age group between the 6th and 7th decades(60.4%). 3. The major symptoms of coronary heart disease were precordial pain(54.2%) and dyspnea(45.1%). The pain was radiated in 24.3% 4. The most common preceding disease was hypertension(39.3%) followed by diabetes mellitus(11.5%). 5. There were leukocytosis in 66.6%, increased SGOT in 39.3%, increased LDH in 71.5% and increased cholesterol in 49.5% 6. The common associatd electrocardiographic abnormalities were left ventricular hypertrophy(28%), sinus tachycardia(16.9%), premature ventricular beat(11.6%). first degree AV block (8.4%) and premature atrial beats(6.1%). 7. The ratio of anterior to posterior wall infarction was 4:1. 8. The common findings of chest PA were cardiomegaly(38.5%), Atherosclerotic changes of aorta(15.2%) and pulmonary congestion(2.4%). 9. The mortality rate was 6.2%(10 cases). Among them, myocardial infarcition was 5 cases. atherosclerotic hart disease was 4 cases and coronary insufficiency was 1 case.

Gonadotropin의 분비 조절

경난호 대한내분비학회 1990 Endocrinology and metabolism Vol.5 No.3