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뿌리 스트레스를 유발하는 agar농도에 따른 Kalanchoe pinnata의 체세포 배 형성 변화
박종범,김동균,김진석 한국식물생명공학회 2017 JOURNAL OF PLANT BIOTECHNOLOGY Vol.44 No.3
Development of modern agricultural machinery and accompanying agricultural development cause soil compaction and reduce growth by stressing roots. Kalanchoe pinnata was used to investigate the impact of stress on rooting and changes in plant growth and reproduction. K. pinnata forms somatic embryos capable of asexual reproduction at the edge of leaves. Impact of root pressurization of K. pinnata on somatic embryogenesis and organ differentiation according to external stress factors was investigated by using a high concentration of agar and this phenomenon was studied histologically. Agar concentration in culture media ranged from 0.5%-1.5% to induce a compression effect on roots. The stem and leaf of K. pinnata were subjected to a microtechnique process to study changes in tissue. In vivo, K. pinnata produced 2nd and 3rd plantlets at edges of leaves from lack of water and excessive lighting conditions. In in vitro culture studies, the lower the concentration of agar, the higher the population and the higher the biomass, but plantlet did not occur in leaf bends. Conversely, as concentration of agar increased, increase in the number of individuals was low. Plantlet development occurred only in agar 1.5% medium. The difference in agar concentration was a stressor in the root of K. pinnata, and thus the pattern of asexual reproduction changed from the division method in root to a plantlet generation in leaf. This suggests root pressurization may act as stress and change in the plant reproduction pattern.
박종범,이상정,이은호,박노철,김용범 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.6
Nuclear power generates a large portion of the energy used today and plays an important role in energydevelopment. To ensure safe nuclear power generation, it is essential to conduct an accurate analysis ofreactor structural integrity. Accordingly, in this study, a methodology for obtaining accurate structuralresponses to the combined seismic and reactor coolant loads existing prior to the shutdown of a nuclearreactor is proposed. By applying the proposed analysis method to the reactor vessel internals, it ispossible to derive the seismic responses considering the influence of the hydraulic loads present duringoperation for the first time. The validity of the proposed methodology is confirmed in this research byusing the finite element method to conduct seismic and hydraulic load analyses of the advancedAPR1400 1400 MWe power reactor, one of the commercial reactors. The structural responses to thecombined applied loads are obtained using displacement-based and stress-based superpositionmethods. The safety of the subject nuclear reactor is then confirmed by analyzing the design marginaccording to the American Society for Mechanical Engineers (ASME) evaluation criteria, demonstratingthe promise of the proposed analysis method.
박종범,박찬주 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.5
Study Design: In vitro cell culture model. Purpose: To investigate the effect of small interfering RNA (siRNA) on Fas expression, apoptosis, and proliferation in serum-deprived rat disc cells. Overview of Literature: Synthetic siRNA can trigger an RNA interference (RNAi) response in mammalian cells and precipitate the inhibition of specific gene expression. However, the potential utility of siRNA technology in downregulation of specific genes associated with disc cell apoptosis remains unclear. Methods: Rat disc cells were isolated and cultured in the presence of either 10% fetal bovine serum (FBS) (normal control) or 0% FBS (serum deprivation to induce apoptosis) for 48 hours. Fas expression, apoptosis, and proliferation were determined. Additionally, siRNA oligonucleotides against Fas (Fas siRNA) were transfected into rat disc cells to suppress Fas expression. Changes in Fas expression were assessed by reverse transcription-polymerase chain reaction and semiquantitatively analyzed using densitometry. The effect of Fas siRNA on apoptosis and proliferation of rat disc cells were also determined. Negative siRNA and transfection agent alone (Mock) were used as controls. Results: Serum deprivation increased apoptosis by 40.3% (p <0.001), decreased proliferation by 45.3% (p <0.001), and upregulated Fas expression. Additionally, Fas siRNA suppressed Fas expression in serum-deprived cultures, with 68.5% reduction at the mRNA level compared to the control cultures (p <0.001). Finally, Fas siRNA‒mediated suppression of Fas expression significantly inhibited apoptosis by 9.3% and increased proliferation by 21% in serum-deprived cultures (p <0.05 for both). Conclusions: The observed dual positive effect of Fas siRNA might be a powerful therapeutic approach for disc degeneration by suppression of harmful gene expression.
박종범 강남대학교 인문과학연구소 2013 인문과학논집 Vol.26 No.-
본 연구는 은평구에서 수립한 도서관발전종합계획을 분석함으로써 은평구에 적합한 공공도서관 운영에 대한 발전 방향을 모색하고, 정보서비스의 질적 제고와 지역사회 주민들에게 봉사하는 공공도서관에 대한 중장기 발전계획을 위한 기초자료 제공과 정책 제언을 하는 것에 목적으로 하였다. 공공도서관 건립이나 작은 도서관 조성 및 지원, 도서관 협력 방안, 사서 인력 확충 계획, 장서 확충 계획, 독서 문화 활성화 계획을 세우긴 하였으나 도서관에 대한 청사진과 도시 차원의 도서관 정책에 대한 포괄적이고 체계적인 계획을 수립하지 못하였으며, 이에 부족한 부분에 대한 수립 방안 및 정책 방안을 제시 하였다. This study is aimed at finding ways of improving public library management appropriate for Eunpyeong-gu by analyzing the comprehensive library improvement plan worked out by Eunpyeong-gu, and to provide basic data and suggest policies for medium- and long-term improvement plans for public libraries that generate qualitative improvement of information service and serve the residents of local communities. The comprehensive library improvement plan by Eunpyeong-gu included plans for establishing a public library or forming and supporting small libraries, cooperation among libraries, supplementing librarian labor force, expanding books, and revitalizing reading culture, but did not include a blueprint of a library nor an inclusive and systematic plan for library policy on a city level. This study, therefore, suggested policy plans and measures to work on these shortcomings.
반도체 공정에서 인 메모리 데이터 그리드를 이용한 고속의 빅데이터 처리 시스템 구현
박종범,이방원,김성중 한국ITS학회 2016 한국ITS학회논문지 Vol.15 No.5
최근 하드웨어와 소프웨어의 발전으로 데이터의 처리 용량과 처리 속도도 급속하게 증가하고 있다. 이로 인한 데이터 사용량은 기하급수적으로 증가하고 있으며, 이미 컴퓨터가 처리해야하는 자료는 초당 5천 트랜잭션을 넘었다. 이처럼 빅데이터가 중요한 이유는 실시간 때문이며, 이는 어떠한 상황에서도 모든 데이터를 분석하여 정확한 데이터를 적시에 얻을 수 있기 때문이다. 또한, 빅데이터를 활용한 스마트 공장을 만들면 개발 및 생산비용, 품질관리 비용 감소효과가 있을 것으로 예상하고 많은 연구가 수행되고 있다. 본 논문에서는 많은 데이터들이 발생하는 반도체 공정에서 고속의 빅데이터 처리를 위한 인-메모리 데이터 그리드를 이용한 시스템을 구현하였으며, 실험을 통해 향상된 성능을 입증하였다. 구현한 시스템은 반도체 뿐 만 아니라 빅데이터를 사용하는 모든 부분에서 응용 가능 할 것으로 판단된다. Data processing capacity and speed are rapidly increasing due to the development of hardware and software in recent time. As a result, data usage is geometrically increasing and the amount of data which computers have to process has already exceeded five-thousand transaction per second. That is, the importance of Big Data is due to its ‘real-time’ and this makes it possible to analyze all the data in order to obtain accurate data at right time under any circumstances. Moreover, there are many researches about this as construction of smart factory with the application of Big Data is expected to have reduction in development, production, and quality management cost. In this paper, system using In-Memory Data Grid for high speed processing is implemnted in semiconductor process which numerous data occur and improved performance is proven with experiments. Implemented system is expected to be possible to apply on not only the semiconductor but also any fields using Big Data and further researches will be made for possible application on other fields.
Modal Characteristic Analysis of the APR1400 Nuclear Reactor Internals for Seismic Analysis
박종범,최영인,이상정,박노철,박경수,박영필,박찬일 한국원자력학회 2014 Nuclear Engineering and Technology Vol.46 No.5
Reactor internals are sensitive to dynamic loads such as earthquakes and flow induced vibration. Thus, it is essentialto identify the dynamic characteristics to evaluate the seismic integrity of the structures. However, a full-sized system istoo large to perform modal experiments, making it difficult to extract data on its modal characteristics. In this research,we constructed a finite element model of the APR1400 reactor internals to identify their modal characteristics. Thecommercial reactor was selected to reflect the actual boundary conditions. Our FE model was constructed based onscale-similarity analysis and fluid–structure interaction investigations using a fabricated scaled-down model.