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명기범 梨花女子大學校 醫科大學 醫科學硏究所 1989 EMJ (Ewha medical journal) Vol.12 No.4
Cosmetics that are moderately to strongly comedogenic in the rabbit ear model test have been found to be capable of inducing comedones in human model. In humans the test cosmetics were applied under occlusion for 4 weeks to the scapular region of young adults. The degree of follicular hyperkeratosis was assessed by a noninvasive skin surface biopsy technique, employing a fast-setting cyanoacrylate adhesive to remove the follicular content. The rabbit model was more sensitive than the human. The test materials were applied once every day for 2 weeks onto the ventral surface of ear just external to ear canal. Excised tissue was thus immeresd in water at 60℃ for 2 minutes, yielding a sheet of epidermis with microcomedones attached. The magnitude of follicular hyperkeratosis was assessed under the stereomicroscope. High correlation between assay results of comedogenicity in humans and rabbits was found. So, it was concluded that rabbit ear assay is a simple and rapid method to assess the comedogenicity of cosmetics and other contactants.
H_1 및 H_2 수용체 차단제가 피부 히스타민반응에 미치는 영향
명기범 梨花女子大學校 醫科大學 醫科學硏究所 1987 EMJ (Ewha medical journal) Vol.10 No.2
Histamine-induced cutaneous wheal responses were measured in 24 healthy subjects. The effect of the potent H_1 blocker, hydroxyzine HCI, the H_2 blocker, cimetidine, and the two drugs in combination was determined. The H_1 blocker alone produced a mean wheal suppression of 77%(p<0.005). The H_2 blocker alone produced a mean wheal suppression of 35%(p<0.01). The H_1 plus H_2 blocker produced 79% suppression. But the augmented suppression of H_1 plus H_2 blocker vs H_1 blocker was not statistically significant (p>0.05). The result provide evidence that H_2 receptors are present in the human cutaneous blood vessel, but additional studies must be performed to determine the significance of combined H_1 and H_2 blockade over H_1 blocker alone in suppression of histamine-induced wheal formation.
명기범 梨花女子大學校 醫科大學 醫科學硏究所 1992 EMJ (Ewha medical journal) Vol.15 No.1
The composition of skin surface lipids of scalp was studied by thin-layer chromatography and photodensitometry in 10 normal adult males. The results are as follows: 1) In each of the subjects, the scalp skin surface lipids were composed of cholesterol, free fatty acid. triglyceride, wax ester, steryl ester, squalene and saturated hydrocarbon. 2) The average value of cholesterol was 3.0±0.78%, and free fatty acid 26.9±6.61%, triglyceride 18.4±6.62%. wax ester 24.3±4.58%. steryl ester 3.2±2.64%, squalene 17.1±2.67%, hydrocarbon 6.6±12.54%. 3) Free fatty acid/triglyceride ratio was 1.68±0.76. 4) Epidermal lipid(cholesterol+steryl ester)/sebaceous lipid(wax ester+squalene) ratio was 0.15±0.06. These data show the distinctive feature of scalp skin surface lipids, namely the high sebaceous lipids content and low concentration of epidermal lipids.
명기범 梨花女子大學校 醫科大學 醫科學硏究所 1992 EMJ (Ewha medical journal) Vol.15 No.4
A lipid absorbent tape(Sebutape®)is a new device for measurement of skin surface lipid I have tested the utility of lipid absorbent tape method for the measurement of sebum secretion rates of 20 healthy adult males comparing with conventional hexane extraction technique. The results are as follows : 1) The average amount of total sebum collected using lipid absorbent tape technique and hexane extraction technique were 109.20±43.89㎍/3hrs/㎠ and 113.94±47.l2㎍/3hrs/㎠ respectively. and the correlated well(r=0.93). 2) The 2 techniques were in good accord with reference to their efficacy in collection of free fatty acid(r=0.55). triglyceride(r=0.76). wax and cholesterol esters(r=0.91), and squlaene (r=0.89) from the surface of the skin, but the correlation of cholesterol(r=0.17) was poor. 3) Lipid absorbent tape furnished a good means of visualization of the droplets produced by individual follicles. Above results indicate that the lipid absorbent tape provide a new convenient technique for the measurement of sebum secretion rate and quantitation of components of skin surface lipids.
명기범 梨花女子大學校 醫科大學 醫科學硏究所 1989 EMJ (Ewha medical journal) Vol.12 No.3
A study was made on 1,210 cases of skin tumors which were diagnosed by histopathologic examination during the periods of 14 years and 6 months from January, 1975 to June, 1989 at Department of Dermatology, Ewha Womans University Hospital in Seoul. The results were summerized as follow ; 1) The 1,210 cases of skin tumors consisted of 1,020 cases(84.3%) of benign and 190 cases(15.7%) of malignant tumors, and male to female ratio was 1: 1.4. 2) Male to female ratio for benign tumors was 1:1.6 and for malignant tumors 1.3:1. 3) Among 1,020 cases of benign tumors, 257 cases(25.2%) originated from epidermis, 213 cases(20.9%) from melanocyte, 134 cases(13.1%) from epidermal appendages, 107 cases(10.5%) from fibrous tissue, 86 cases(8.4%) from vessel, 59 cases(5.8%) from nerve, 30 cases(2.9%) from fat tissue, 10 cases(1.0%) from smooth muscle and 126 cases(12.4%) from others. 4) Among 1,020 cases of benign tumors, the most frequent tumor was syringoma(69 cases) which was followed by epidermal cyst(67 cases), epidermal nevus(58 cases). seborrheic keratosis(58 cases), urticaria pigmentosa(52 cases), neurofibromatosis(50 cases). intradermal nevus(42 cases), pyogenic granuloma(39 cases), acquired bilateral nevus of Ota-like macules(37 cases) and others(530 cases) 5) The predilection sites were face(82.6%) in syringoma, head(40.3%) in epidermal cyst, extremities(41.4%) in epidermal nevus, face(60.3%) in seborrheic keratosis, trunk(78.8%) and extremities (73.1%) in urticaria pigmentosa, trunk and extremities(100%) in neurofibromatosis, face(40.5%) in intradermal nevus, extremities(43.6%) in pyogenic granuloma. 6) Among 190 cases of malignant tumors, 57 cases(30.0%) of basal cell carcinoma, 47 cases(24.7%) of squamous cell carcinoma, 17 cases(8.9%) of malignant melanoma, 15 cases(7.9%) of Bowen's disease, 15 cases(8.9%) of Paget's disease, 11 cases(5.8%) of mycosis fungoides, 10 cases(5.3%) of metastatic cancers and 16 cases(8.4%) of others were observed. 7) The average ages of patients with malignancies were 55.6 years in basal cell carcinoma, 56.2 years in squamous cell carcinoma, 54.4 years in malignant melanoma, 58.1 years in Bowen's disease, 58.2 years in Paget's disease, 57.8 years in mycosis fungoides, 53.3 years in metastatic cancers. 8) The predilection sites were face(93.0%) in basal cell carcinoma, head(51.5%) in squamous cell carcinoma, soles(52.9%) in malignant melanoma, tnunk(33.3%) in Bowen's disease, penis(60.0%) in extramammary Paget's disease, trunk and extremities(81.8%) in mycosis fungoides, trunk(60.0%) in metastatic cancers. 9) Among 10 cases of cutaneous metastatic cancers, primary sites were stomach in 4 cases, lung in 1 cases and unknown in 5 cases.