손, 발바닥 색소성반의 임상적 의의

박장규,성열훈,서기범,이증훈 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

To assess the clinical significance of palm and/or sole pigmented macule, we compared theprev alence rate among 52 patients with internal malignancy(M : F=28 : 24), 59 patients withnonmalign ant (honmalignant) chronic internal disease(M : F=31 : 28) and 147 normal controls(M : F=121 : 26). 1. In normal control group the prevalence rate of palmo-plantar pigmented macule was notrelat ed with age, however, higher in male than in female. 2. The prevalence rate of palmo-plantar pigmented macule in male patient with malignancy was higher than that of male control group. 3. The pigmented macule developed on the palms and soles both in the cases of benign chronic internal disease or malignancy only. The prevalence rate of malignant group was higher than that of benign chronic disease group. Therefore, palmo-plantar pigmented macule occurred more frequently in benign chronic disease and malignant group. Especially, it seemed like marker of malignancy that pigmented macule devoloped on palm and sole both.

제54차 춘계학술대회 : 심포지엄 1: 모발 ; 원형탈모증의 치료

박장규 대한피부과학회 2002 초록집 Vol.40 No.10

206 정상인의 첩포검사에 관한 역학적조사

박장규,성범진,김영호,이증훈 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

206 medical students as being healthy and without a history of contact dermatitis were patch tested with the Hollister-stier standard batteries from February 1989 to March 1991. Men were 184(89.3%) and women were 22(10.7%). Of these, 15(7.3%) reacted to patch test allergens, among whom 8(53.3%) reacted with single substance and total number of sensitizer was 23. The most frequent sensitizers were : mercury chloride ammoniated 9 cases(4.4%), nickel sulfate 4 cases(1.9%), thimerosal 4 cases(1.9%), cinnamic alcohol 2 cases(1.0%), ethylenediamine. Balsam of Peru. benzyl alcohol and epoxy resin 1 case each(0.5%). Most reactors(65%) including all female reactors showed weak reaction(+1). These results gave two informations. One was that popular sensitizers were related with medicaments and metal, and the other was that data of contact sensitization in healthy control should precede those of contact dermatitis for correct evaluation of patch test data of contact dermatitis group.

접촉성 피부염 환자와 정상인의 첩포검사에 관한 연구

박장규,성열훈,성범진 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Numerous studies on epidemiological aspects of contact dermatitis due to various causative antigens have been reported n recent year in Korea. However, degree of sensitization in healthy persons was not reported till now in Korea. We have performed the patch test on patients with contact dermatitis and healthy persons. The study results were as follows; 1. Percent of positive reaction in patients with contact dermatitis was 45.9%. The common allergens of positive reactions were nickel sulfate(21.6%), potassium dichromate (10.8%), neomycin sulfate (8.1%), Balsam of Peru (8.1%), mercuric chloride, ammoniated (5.4%), p-phenylenediamine(5.4%), cinnamic alcohol(5.4%), ethylenediamine dihydrochloride (2.7%), formaldehyde(2.7%), wool wax alcohol(2.7%), thimerosal (2.7%), mercaptobenzothiazole(2.7%), imidazolidinyl urea(2.7%) in order of frequency. 2. Percent of positive reaction in healthy persons was 10.3% and the common allergens were mercuric chloride, ammoniated(5.2%), nickel sulfate(3.1%), cinnamic alcohol(2.1%), ethylenediamine dihydrochloride(1.0%), formaldehyde(1.0%), epoxy resin(1.0%), in order of frequency. We conclude that allergens associated with metals and drugs seem to be the dominant causes of contact dermatitis and healthy persons.

자극성 물질이 첩포시험 결과에 미치는 영향에 대한 연구

박장규,이우재,김경훈,서기범,이증훈 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

We studied the effects of irritants on the positive patch test sites in 6 volunteers. We firstly performed the patch test with 2, 4, 6, 8, 10% sodium lauryl sulfate on the back of 22 volunteers. Allergens (thimerosal, mercury ammonium chloride) were applied in duplicate, and 24 hours later they were removed and sodium lauryl sulfate was applied for a further 24hours to one set of patches. Response of allergen alone were measured at 24 hours, 48 hours, 72 hours, 120hours, 140hours and the degree of inflammation of the other site(allergen + irritant) was graded 30 minutes, 24, 48 and 72 hours later according to International Contact Dermatitis Research Group. The results were as follows 1. Twenty volunteers(90.9%) showed irritation sign on the patch sites with 6% sodium lauryl sulfate. 2. In the results of patch test in 6 cases with positive allergen sites, 5 cases showed the similar results with those of previous patch test (reproducibility = 83 %) 3. When we assessed the patch test results according to ICDRG, the results of patch tests after application with irritants on previous positive allergen slites did not show stronger responses than those of positive allergen alone 4. The results of patch test after application with irritants on previous negative allergen did not show erythema. It seems that the effect irritant application of lower concentration than irritant dose not influence the response to the allergen concentration than to cause erythema, on the response of allergen

피부약에 대한 인식

박장규,노하석,김태원,이증훈 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

Many patients have worried about side effects of drugs which prescribed for skin problems, so this survey was performed to examine the cognition of patients about drugs for skin diseases using questionary. 1. Out of 182 respondents, 67.55 have heard that dermatologic medications were noxious, 49.5% believed it, and 28.65 experienced side effects of drugs for skin diseases. 2. The cognition that dermatologic medications were noxious was related to anti-inflammatory drugs, antibiotics and abuse of corticosteroids. The number of patients who complained of drowsiness and dizziness decreased after development of nonsedative antihistamics. 3. In Korea, many non-specialists, general physicians and pharmaceutists have treated skin diseases. They have prescribed corticosteroids for skin problems without strict principle and education the patients with prevention of side effects of it. So many patients with skin problems gave suffered from peptic ulcer, weight gain and puffy face after being treated for skin problems were noxious. Therefore, doctor should prescribe corticosteroids for skin problems with strict indication and the Ministry of Health and Welfare might estabilish the rule that corticosteroids should not be delievered to the patient without doctor's prescription for keeping peoples mental and physical health.

결절성(結節性) 홍반(紅斑)의 조직소견(組織所見)의 재고찰(再考察)

박장규,이유신 대한피부과학회 1975 대한피부과학회 학술발표대회집 Vol.27 No.2

색소성모반의 임상 및 조직소견에 관한 연구

박장규 충남대학교 의과대학 지역사회의학연구소 1979 충남의대잡지 Vol.6 No.2

Pigmented nevi are the most common skin tumor. However, in spite of this commonness there is much uncertainity regarding the clinical pictures associated with different developing stages of nevi. This paper is an attempt to relate the clinical types with the histological pictures and to find the clinical behaviour of Korean's pigmented nevi. The author had limits to the flat lesion among several forms of pigmented nevi. 1191 randomly selected Korean peoples were studied during 9 months from Jan. to Sept. `79. There were 592 men and 599 women, ranging in age from 2 days to 70 years. The results were summerized as follows: 1. A pigmented nevi on the only one female baby's back was found among 20 new born babys(M:F=1:1), appeared regularly after 2 years old in both sex, increased in number progressively from 6 to 45 in men and from 6 to 30 in female and declined thereafter. 2. There were 22367 pigmented nevi in men and 13.29 in women as average. 3. Predilection site was trunk(35.9%) in men and face(20.7%)in women. 4. In his to pathological study the junctional activity which was to transform to malignant melanoma was found in 80%. However, because of rarity of malignant melanoma, it is concluded that routine excision of pigmented nevi is in feasible and unwarranted.

대상포진의 임상적 연구

박장규,김윤성,구자경 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

The authors analized 78 patients with herpes zoster treated at Department of Dermatology, Chungnam National University Hospital from 1982 to 1985 to find out the epidemiology and clinical course. The results were as follows: 1. The annual prevalence rate of herpes zoster ranged 1.5% to 2.0%(mean 1.8%) and did not increase during 8 years from 1977 to 1984. 2. There was no sexual difference. 3. Herpes zoster was seen most frequently in the 50-59 year age group (24.4%), in July in a year (16.7%) and during summer(34.6%). 4. The dermatomic involvement of herpes zoster was most common on thoracic nerve(48.7%), and others were trigerminal nerve (28.2%), cervical nerve (14.1%), lumbar nerve(6.4%) and sacral nerve(2.6%) in order. 5. The interval of onset of subjective symptoms and vesicle appearance was 3.9 days in average. The mean duration of treatment was 13.8 days. There was a tendency that both interval and duration increased with increasing age. 6. The most common complication of herpes zoster was postherpetic neuralgia (6.4%) and others were keratoconjunctivitis(2.5%), herpes zoster with aberrant vesicles (2.5%) and recurrent herpes zoster (1.3%).

사마귀의 임상적 고찰

박장규 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.2

Warts are the most common viral infection of the skin. Most dermatologists believe that the frequency of warts is increasing. In spite of this commonness and increasing frequency, there is no clear information about warts of koreans. This paper attempts to clarify the epidermiolgical features and behaviour of warts. 1. The sex ration of wart patients was same. 2. The peak age group of wart patients was from 15 years to 24 and within that age there were 48.3% of verruca plana patients, 60.6% of veruca vulgaris patients, and 42.1% of condyloma accuminata patients. 3. Of 112 wart patiens 53.6% had verruca plana, 29.5% verruca vulgaris, and 16.9% condyloma accuminata. 4. Of the wart patients in this series, 60% of verruca plana patients, 37% of verruca vulgaris patients, and 100% of condyloma accuminata patients had the duration of disease less than 1 year at the first visit at out patient department of dermatology. 5. The predilection site of verruca plana is face(90%), verruca vulgaris is the dorsum of hand(69.7%), and condyloma accuminata is sex organ, penis or vagina(42.1%). 6. When the wart patients were compared to the total number and new patients of dermatologic department in each year, the frequency of the wart patients did not increase from 1977 to 1981.