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( Hyang Jee ),( Su Hyung Lee ),( Jun Won Park ),( Bo Ram Lee ),( Ki Taek Nam ),( Dae Yong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2013 BMB Reports Vol.46 No.1
Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition, after Cx32 overexpression in the human gastric cancer cell line AGS, cell proliferation, cell cycle analyses, and p21^Cip1 and p27^Kip1 expression levels were examined by bromodeoxyuridine assay, flow cytometry, real-time RT-PCR, and western blotting. Immunohistochemical study noted a strong inverse correlation between Cx32 and Ki67 expression pattern as well as their location. In vitro, overexpression of Cx32 in AGS cells inhibited cell proliferation significantly. G1 arrest, up-regulation of cell cycle-regulatory proteins p21^Cip1 and p27^Kip1 was also found at both mRNA and protein levels. Taken together, Cx32 plays some roles in gastric cancer development by inhibiting gastric cancer cell proliferation through cell cycle arrest and cell cycle regulatory proteins. [BMB Reports 2013; 46(1): 25-30]
비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구
한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2
The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.
서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
댐퍼붙이 거위목바이트를 使用하는 切削系의 動的 安定性에 關한 硏究
李炯植,鄭準基,盧光春 연세대학교 산업기술연구소 1982 논문집 Vol.14 No.2
The effect of the damped goose-neck tool upon the dynamic stability of machine tool was investigated. The dynamic stability of machine tool is directly related to the chatter in the metal cutting process. By the test of the dynamic characteristics for the damped goose-neck tool, theoretical approach of dynamic stability of machine tool is identified. It's results are compared with the results of actual cutting test. And the dynamic stability of machine tool is improved by the higher elasticity and the increase of damping coefficient for the damped goose-neck tool.
Ⅲ-Ⅴ족 반도체의 연구 : GaAs의 합성, 단결성 및 특성 Crystal Growth and Characterization of GaAs
이형재,김영기,신영진,박해용,정양준,최춘태,김병호,김진성 全北大學校 基礎科學硏究所 1982 基礎科學 Vol.5 No.1
Temperature of 618 and 1250℃ at As and Ga sities respectively in the horizontal Bridgman furnace and growht speed of 0.7cm/h were found to be optimal for the production of single crystalline GaAs. Self-seeded and unintentionally doped GaAs crystals showd n-type characteristics with Hall mobillity of ∼0.75㎡/V-sec and carrier density of ∼10^19 m^-3 when the mesurements were made right after the growth. About three month later it was found that the same samples were converted to p-type GaAs. The analysis on the p-type sample showed that impurity scattering is dominant at around room temperature and thus the measured Hall mobility was 0.0065㎡/V-sec at 300K. 7.4±0.6 eV was obtained for acoustic deformation potential in the heavy hole band by fitting the theoretical conductivity and Hall coefficient to the corresponding experimental data. The value is very much higher than the theoretically estimated value, 3.6eV. The carrier density variation with temperature obtained from the present analysis gave 0.38 and 0.17 eV respectively for the activation energies of donor and acceptor.
이상윤,고준빈,명태식,김기길,강형모 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-
The heat transfer mechanism initiating the friction welding is examined and a transient three dimensional heat conduction model for the welding of two dissimilar cylindrical metal bars is investigated. The cylindrical metal bars are made of materials made of A2024 and SM45C. Numerical simulations of heat flow are performed using the finite volume method. Respectively, Commercial FLUENT code is used in the heat flow simulation and maximum temperature and distribution of temperature are calculated. Temperature of friction welded joining face is compared with the temperature distribution measured by experiment and numerical simulation. The maximum temperature of friction welded joining face is lower than melting point of A2024-T6 aluminum alloy using insert metal. The temperature distribution of friction welded joining face with insert metal is more uniform than that of without insert metal
이홍기,전형호,탁태오 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B
In this study, a driver model based on the lead-lag controller for stable maneuver of a highly nonlinear, multi-dimensional, numerically stiff multibody vehicle model according to the various handling test requirements such as steady-state cornering, double lange change, etc. is presented The lead-lag controller is developed with lead and lag compensation. Which use the transfer function with cross-over frequency by frequency response method. The proposed driver model is applied to a vehicle model in steady-state and slalom maneuver to verify its effectiveness and validity. The results show that the proposed path control strategy is excellent both in pursuing the desired course and stability of the vehicle.
국부 마모 부품을 위한 레이저 표면강화 열처리에 관한 연구
이목영,김형준,김기철,김재웅 한국레이저가공학회 2002 학술발표대회 Vol.2002 No.1
두께 10mn 일반기계구조용강재를 사용하여 레이저 종류에 따른 표면경화 열처리특성에 관하여 알아보았다. 경화층의 형성은 레이저의 종류에 크게 영향을 받았는데, 표면경화 열처리를 위해서는 파장이 짧은 Nd-YAG 레이저를 사용하는 것이 유리하였다. 경화층의 최고경도는 700Hv 가량으로 높게 나타났으며, 레이저 표면경화 열처리는 상온에서 사용되는 부품의 내마모성 향상 특히 국부 마모를 겪는 부품에 효과적일 것으로 판단되었다.
이형식,정준기,박태형 연세대학교 산업기술연구소 1983 논문집 Vol.15 No.2
The chatter analysis has been studied by many authors using non-linear. In this study, the stability chart obtained from experimental work with a lathe was qualitatively compared with the result of chatter analysis by non-linear theory. Experimental results verify that the stability of the machining process is affected by the width of cut in the following manner. As the chip width is increased from zero with the rotational speed of the workpiece kept constant, three ranges are distinguished; (a) unconditionally stable range, (b) conditionally stable range, (c) unstable range. In the conditionally stable range the system is stable for small disturbances but unstable when these exceed a certain level. When the chatter occurs, the amplitude initially increases and stabilizes itself at a finite level. This phenomenon agrees well with the analysis of non-linear theory qualitatively.