갑상선 유두상 구조에 Alcian blue, Cytokeratin, AgNOR 및 PCNA 염색의 진단적 의의

한주호,윤기중,문형배 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.1

The papillary structures are occasionally found in the adenomatous goiter, follicular adenoma of the thyroid gland and papillary thyroid carcinoma. These papillary lesions are difficult to differentiate between benign and malignant thyroid diseases by the hematoxylin-eosin stain. This study was aimed to differentiate between benign and malignant papillary structures in the thyroid diseases by the PAS, alcian blue(pH2.5), cytokeratin, nuclear organizer region(AgNOR) and proliferating cell nuclear antigen(PCNA) stains. The tissue sections were taken from 10 cases of papillary lesions in the benign thyroid disease(8 cases of hyperplastic goiter and 2 cases of follicular adenoma) and 13 cases of papillary thyroid carcinoma. The results were as follows. 1. The neutral mucin by the PAS stain was present in the 1 cases of 10 benign papillary lesions(10.0%) and 2 cases of 13 malignant papillary lesions(15.4%). 2. The acid mucin was not stained in the stroma of the all benign papillary lesions, and moderately or strongly stained in the 6 cases of 13 malignant papillary lesions(46.2%) by the alcian blue stain(pH2.5). 3. The cytokeratin was weakly positive in the benign papillary lesions and positive in the 7 cases of 13 malignant papillary lesions(53.8%). 4. The mean number of AgNOR was 1.24±0.31 in the benign papillary lesions and was 1.33±0.05 in the malignant papillary lesion. 5. The percentage of the PCNA positive cells was 1.0±0.4% in the benign papillary lesions and was 12.1±3.0% in the malignant papillary lesions. Above results indicate that the alcian blue(pH2.5), cytokeratin and PCNA stains were helpful methods for differential diagnosis between benign and malignant papillary lesions in the thyroid diseases.

V-groove 박판의 FCAW와 EGW 공정에 따른 변형에 미치는 공정인자 영향

한주호,전재승,박철성,오종인,윤진오,이정수,Han, Juho,Jeon, Jaeseung,Park, Chulsung,Oh, Chongin,Yun, Jinoh,Lee, Jeongsoo 대한용접접합학회 2013 대한용접·접합학회지 Vol.31 No.1

Finite element analysis and welding experiments were performed to evaluate deformation aspect for Flux Cored Arc Welding(FCAW) and Electro Gas Welding(EGW). Numerical researches of FCAW and EGW were performed considering the difference of number of welding pass and welding direction to arc flow. To perform the numerical study of FCAW and EGW, number of welding pass and welding direction to arc flow were considered in the finite element model. FCAW process requires multi pass and its welding direction is vertical to welding torch. On the other hand, EGW process requires single pass and its welding direction is parallel to welding torch. The difference of welding direction and heat input was considered in the finite element analysis. In FCAW process, Goldak's double ellipsoidal heat input model was adopted. In the EGW process, Hemi-spherical power density distribution was adopted. In the results of experiment and finite element analysis, angular deformation of FCAW process is larger than that of EGW process.

오른쪽에 발생한 제4 새열 낭종 1예

한주호,박일석 대한이비인후과학회 2021 대한이비인후과학회지 두경부외과학 Vol.64 No.1

Branchial cleft cyst (BCC) is a relatively common congenital malformation in the neck. However,the fourth BCC is very rare and frequently unknown to clinicians. Failure to appropriatelyrecognize this anomaly may result in misdiagnosis, insufficient treatment, and continuedrecurrence. Even though its rarity, it usually occurs on the left side. Here, we present an unusualcase of fourth branchial cleft cyst that occurred on the right side.

이물질 섭취로 내원한 환자 1,201명에 대한 후향적 고찰

한주호,이준영,이지수,박범정 대한이비인후과학회 부산,울산,경남 지부회 2019 임상이비인후과 Vol.30 No.2

Background and Objectives:Foreign body (FB) ingestion is one of the most commonly encountered otorhino- laryngologic disorders, often requiring urgent decision-making and management. Few studies have comprehen- sively investigated the age distribution and the types and locations of FBs ingested. So in this study, we aimed to describe the clinical characteristics and to search for factors which can help in deciding on proper treatment for patients with FB ingestion. Materials and Methods:The retrospective reviews of the medical records were per- formed for all patients (n=1,201) who visited the outpatient clinic or emergency department of Hallym Univer- sity Sacred Heart Hospital due to suspicion of FB ingestion (with the diagnostic code of ICD-10 : T17-T189) from March 2014 through August 2016. Results:The incidence rate of FB ingestion was 43.9% in children aged 0-14 years, which was much higher than other age groups. At ages 0-4 years, non-food material type FBs were the most common with 29.8% plastics and 17.6% metals. Except ages 0-4 years, fish bone showed the highest frequency in all age group. The most common anatomical site where the FB was found was the tonsil except in the group of patients older than 65 years and under 5 years. Additionally, in food material group, when patients feel continuous discomfort, we did esophagogastroduodenoscopy (EGD) (Ratio : 13.0%). By using EGD, Re- moved ratio was 42.3%. Conclusions:FBs are common in Korean cultures with the highest incidence in chil- dren. The specific characteristics of FB ingestion according to age and the type of FB involved should be consid- ered when managing or performing preventive care for these patients.

비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구

한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.

Backplate의 유무에 따른 맞대기 용접 시험편의 피로강도 평가

한주호,김성민,이우일,강성원,김명현,Han, Ju-Ho,Kim, Seong-Min,Lee, Woo-Il,Kang, Sung-Won,Kim, Myung-Hyun 대한용접접합학회 2009 대한용접·접합학회지 Vol.27 No.1

In this study, a series of fatigue test was performed to evaluate the fatigue strength of butt welded specimens. Effective notch stress through finite element analysis was conducted to analyze the fatigue results. As a results, no significant decrease in fatigue strength was observed when backplates were present. The S-N curve that based on effective notch stress appeared a similar fatigue lift to FAT 225 curve without reference to existence of backplates.

9% 니켈강 용접부 품질확보를 위한 적정 입열조건 시뮬레이션

한주호,이정수,김동규,변지철,정상훈 대한용접·접합학회 2019 대한용접학회 특별강연 및 학술발표대회 개요집 Vol.2019 No.5

자동차 외판 특징선의 시각적 분석을 위한 시편 제작

한주호,정연찬 한국소성가공학회 2014 금형가공 심포지엄 Vol.2014 No.8

비진주종성 만성 중이염의 재수술에 대한 결과 분석

한주호,이지수,홍성광,이효정,김형종 대한이비인후과학회 2021 대한이비인후과학회지 두경부외과학 Vol.64 No.5

Background and Objectives The aim of this study was to investigate the surgical outcomesof revision operation due to recurrence of non-cholesteatomatous chronic otitis media(COM) surgery cases. Subjects and Method From 1989 to 2018, 5197 cases of COM surgery were performed atKangdong and Hallym University Sacred Heart Hospital. Among them, clinical data of 297subjects who had undergone revision tympanoplasty and/or mastoidectomy for recurrent noncholesteatomatousCOM were retrospectively collected from computerized database of middleear surgery (Korean Otological Society program 2005). Each case was categorized by surgicalapproaches into canal wall down mastoidectomy (CWDM), canal wall up mastoidectomy(CWUM), or tympanoplasty only groups. Results Tympanoplasty only was performed in 170 cases, CWDM in 74 cases, and CMUMin 53 cases. Postoperative perforation occurred in 9.4% of total cases, and less frequently inCMDM compared with tympanoplasty only (p=0.023), and CMUM (p=0.049), respectively,whereas no differences between tympanoplasty only and CMUM (p=0.930) were found. Postoperativeinfection rate was 1.0% and did not show any differences among the groups. Postoperativesuccessful hearing was obtained in 66.7% of total cases, and the success rate of tympanoplastyonly was better than that of CMDM (p=0.001), and CMUM (p=0.011). And, that ofCMUM was better than that of CMDM (p=0.011). Conclusion The results showed that postoperative perforation occurred less frequently inCMDM than in tympanoplasty only and in CWUM; successful hearing was achieved morefrequently in tympanoplasty alone than in the other surgical approaches in recurrent non-cholesteatomatousCOM.

전기-유압서어보밸브의 토르크모터개발에 관한 연구

한주호,이진걸 대한기계학회 1983 대한기계학회 춘추학술대회 Vol.- No.-