서울시 마을마당의 이용후 평가

김신원,허준,박율진,Kim, Shin-Won,Heo, Jun,Park, Yool-Jin 한국조경학회 2000 韓國造景學會誌 Vol.27 No.5

The purpose of this study is to provide the basic data for planning and designing Village Parks in Seoul in the future, which result from analyzing post-occupancy evaluation. For conducting this study, 10 Village Parks among 45, built between 1996 and 1997, were selected and analyzed. The results of this study are as follows. The degree of satisfaction of 10 Village Parks in Seoul has been evaluated on a scale of 10, to be a 6.68 average. This result means that the most respondents are satisfied with the existing Village Parks in Seoul. The correlation of the degree of satisfaction with major planning factors for 3 types of Village Parks shows that accessibility is the most important factor. As for future directions of planning and designing Village Parks, many kinds of sitting, leaning and resting place need to be provided. It is also necessary to improve the visual quality of the parks with various spatial elements. The research also shows that various facilities for people's use should be provided in Village Parks.

이면성 및 도플러 심초음파도를 이용하여 진단한 선천성 거대 좌회선지-좌심실 관동맥루

진승원,박준철,이영중,유병현,박현옥,김용주,윤호중,김재형,홍순조,최규보,권종범,원용순,박건 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

S-344 : The Role of Skeletal Muscle Mass in Development of Metabolic Syndrome

( Byung Sam Park ),( Jun Sung Moon ),( Ji Sung Yoon ),( Kyu Chang Won ),( Hyoung Woo Lee ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Introduction: It has been well known that abdominal adiposity is related with insulin resistance and greater risk of metabolic disorder. Skeletal muscle plays central role in insulin mediated glucose disposal of whole body, but we only know a little about the association between skeletal muscle mass and MetS (MetS). The aim of this study is to clarify the clinical role of skeletal muscle mass in developing MetS through using skeletal muscle parameters by body impedance analysis (BIA). Methods: 1,042 healthy adults aged from 20 to 75 years who visited Yeungnam university health promotion center from Jun. 2008 to Jun. 2010 were enrolled. 204 subjects who had prior MetS or chronic disease that can affect to skeletal muscle mass were excluded. After 24 months from baseline, the metabolic parameters were assessed and the development of MetS was diagnosed using modified NCEP-ATP III criteria. From the BIA (Inbody 720), we obtained skeletal muscle mass (SMM, Kg), body fat mass (BFM, Kg), and visceral fat area (VFA, cm2). Then, we had defined as follows; percent of skeletal muscle mass (SMM%, %): SMM (kg)/weight (Kg), skeletal muscle index (SMI, Kg/m2): SMM (Kg)/height (m)2, skeletal muscle to body fat ratio (MFR): SMM (kg)/BFM (Kg) and skeletal muscle to visceral fat ratio (SVR, Kg/cm2): SMM (Kg)/VFA (cm2) Results: Mean follow up periods were 28.7±5.4 months. Among total 838 subjects (46.9±9.9 years, M:F=477:361), 88 (10.5%) were newly diagnosed MetS. 5th quintile of the SMM%, MFR and SVR was associated with decreased risk of development of MetS after adjusting for confounding factors. Conclusion: Decreased skeletal muscle mass may play critical role in development of the MetS and not absolute amount of skeletal muscle mass but relative ratio to body composition may be more important.

심장혈관용 약물코팅풍선카테터의 개발 동향

박정훈 ( Junghun Park ),조원일 ( Won-il Jo ),변대흥 ( Dae-heung Byeon ),강소영 ( So Young Kang ),남충현 ( Choong-hyun Nam ),서경우 ( Kyoung-woo Seo ),박준규 ( Jun-kyu Park ) 한국공업화학회 2022 공업화학 Vol.33 No.5

급격한 고령화 사회로의 진입과 서구화된 식습관에 의해 협심증, 심근경색증, 고혈압 등에 의한 심장질환자의 수가 5년간 10만명 이상 증가했다. 심장질환은 지난 8년간 꾸준히 국내 사망원인 2위를 기록 중이며, 이로 인해 연간 소모되는 의료비는 6조원에 달한다. 증가한 환자와 함께 다양한 치료법이 제시되고 있는 가운데, 현재 보편화 된 관상동맥 중재시술 중 스텐트 삽입술의 단점인 재협착이나 장기간 이중항혈소판제 복용으로 인한 출혈의 위험 증가 등의 문제점을 보완하기 위해 약물코팅풍선카테터가 개발되어 점차 상용화되고 있는데, 국내에선 2010년 ‘SeQuent Please^Ⓡ (비브라운코리아)’라는 제품이 처음 출시되면서 약물코팅풍선카테터를 사용한 시술이 시작되었고, 이후 2012년 보험급여가 적용되면서 그 사용량이 본격적으로 늘어났다. 약물코팅풍선치료는 국내뿐만 아니라 전 세계적으로 사용이 증가하고 있는데, 특히 일본을 포함한 아시아태평양 지역에서 그 사용량이 급격히 증가하고 있다. 현재까지 국산 제품의 수요가 증가하고 있는 상황이며 향후, 동물시험 및 임상시험에서의 성능이 입증된다면 위험성이 높은 스텐트 삽입술에 비해 효과적인 시술이 될 것이라 예상한다. As a result of the rapid entry into an aging society and westernized eating habits, the number of heart disease patients caused by angina pectoris, myocardial infarction, and high blood pressure has increased by more than 100,000 over five years. Heart disease has consistently ranked second in the cause of death in Korea over the past eight years, and medical expenses consumed annually reach 6 trillion won. While various treatments are being proposed for more patients, drug-coated balloon catheters have been developed and gradually commercialized to solve the disadvantages of stent implantation such as restenosis and increased risk of bleeding due to long-term double antiplatelet medication. In Korea, it began to use a drug-coated balloon catheter with the first release of it called “SeQuent Please^Ⓡ (Bibrown Korea)” in 2010. Its demand increased gradually as insurance benefits were applied in 2012. Drug-coated balloon angioplasty is increasing in use not only in Korea but also around the world, especially in the Asia-Pacific region, including Japan. Until now, the demand for domestic products is increasing, and if the efficiency in vivo and clinical trials is proven in the future, it is expected to be an effective procedure compared to high-risk stent implantation.

Clinical usefulness of infrared thermal imaging as a non-invasive screening test for diagnosis of vascular malformations

( Chihyeon Sohng ),( Jun Hong Park ),( Won Kee Lee ),( Jun Young Kim ),( Yong Hyun Jang ),( Weon Ju Lee ),( Seok-jong Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Infrared thermal imaging (ITI), aka thermography, has been used widely in medicine, but been studied rarely its clinical application in vascular malformations (VMs). Objectives: This study investigated validity and usefulness of ITI as a new screening test to differentiate between capillary malformation (CM) and arteriovenous malformation (AVM). Methods: This study included 50 patients with VMs who conducted ITI between 2011 and 2018. They were divided into two groups; CM and AVM, and those with Parkes-Weber syndrome (PWS) were also included in AVM group. Temperature difference (ΔT) between lesional and contralateral non-lesional area was compared using ITI to calculate the maximum ΔT (ΔTmax). The receiver operating characteristic (ROC) curve was then plotted to determine optimal cutoff value of ΔTmax. Results: Of the total 50 patients, 34 were finally diagnosed with CM, and 16 AVM (12 pure AVM, and 4 PWS). AVM group had significantly higher ΔTmax (2.57±1.23°C) than CM group (0.69±0.50°C).The area under the curve of ΔTmax for diagnosis of AVM versus CM was 0.938. The sensitivity and specificity were showed 87.5% and 94.1% (LR+, 14.87; LR-, 0.13) in cutoff value of ΔTmax 1.39°C, and 81.3% and 97.1% (LR+, 27.62; LR-, 0.19) in cutoff value of ΔTmax 1.42°C. Conclusion: The value of ΔTmax measured by ITI was useful to distinguish AVM from CM, so ITI can be employed as a new non-invasive differential screening test for uncertain VMs.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

주의력결핍과잉행동장애와 Alpha-1C-Adrenergic 수용체 유전자와의 연관성에 대한 연구

조수철,김재원,김붕년,황준원,박미라,김순애,조대연,유희정,정운선,손정우,박태원 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1

Objectives : Neurobiological and pharmacological research has suggested that the dysregulation of the central noradrenergic systems might be involved in the pathophysiology of ADHD. The aim of this study was to examine the association of the alpha-1C-adrenergic receptor gene (ADRA1C) with ADHD in Korean subjects. Methods : In a case-control study, we assessed 186 DSM-IV ADHD probands and 150 normal controls. One hundred and eight trios were studied in a family-based association analysis. Psychiatric diagnoses were derived through structured diagnostic interviews. For the clinical evaluation of the ADHD subjects, the Child Behavior Checklist (CBCL), the ADHD Rating Scale-IV (ARS) and the Junior Temperament and Character Inventory (JTCI) were administered. A computerized continuous performance test (CPT) was used to measure the inattention and impulsivity of the ADHD children. Results : There were no significant differences in the genotype or allele frequencies of the ADRA1C PstI polymorphism between the ADHD and control group (p>0.05). The transmission disequilibrium test (TDT) analysis observed no evidence for biased transmission of any of the alleles of the PstI polymorphism. There were no significant differences in the CPT or JTCI profiles between those ADHD subjects with the CC genotype and those with the other (CT+TT) genotypes at the PstI polymorphism. Conclusion : The results of this study do not support the ADRA1C as a major genetic susceptibility factor in ADHD.

Growth Inhibition of Colon Cancer through Inactivation of STAT3 Pathway by IL-10 and IL-1ra Released from Murine Macrophage

Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4

The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway

다도해 해상국립공원 대흑산도의 상록활엽수림 식생구조

조영준 ( Cho Yeong-jun ),김하송 ( Kim Ha-song ),명현호 ( Myeong Hyeon-ho ),박정원 ( Park Jung-won ),오장근 ( Oh Jang-geun ) 한국도서학회 2017 韓國島嶼硏究 Vol.29 No.1

본 연구는 2014년 4월부터 2017년 1월까지 다도해해상국립공원 대흑산도의 상록활엽수림을 중심으로 현지답사를 통하여 식생조사를 실시하였다. 다도해해상국립공원 대흑산도의 상록활엽수림 식생구조 특성을 파악하기 위하여 38개 방형구를 설정하였다. 대흑산도의 상록활엽수림 식생은 임상도(1:5,000)를 바탕으로 각 폴리곤에 따라서 구실잣밤나무군락, 구실잣밤나무-소나무군락, 소나무-구실잣밤나무군락, 구실잣밤나무-곰솔군락, 곰솔-구실잣밤나무군락, 후박나무군락, 붉가시나무군락, 동백나무군락 등으로 구분하였다. 식생학적 정보를 바탕으로 식생단위를 추출하는 방법에 따라 우리나라 상록활엽수림인 구실잣밤나무군락, 후박나무군락, 붉가시나무군락, 동백나무군락 별로 분포지, 서식지 특성, 주요 분포종 등을 비교하였다. 조사된 구실잣밤나무군락은 대흑산도 예리, 사리, 비리, 심리, 소사리 등의 주로 남서사면과 계곡부에 군락을 이루고 있다. 상관형으로는 상록활엽수림이며, 군락구조는 4층 구조로서 높이는 교목층이 12-14m이며 평균 식피율은 교목층 95%, 아교목층 45%, 관목층 51%, 초본층 58%로 나타났다. 한반도에 분포하는 후박나무림의 식생단위는 후박나무-큰천남성군집, 후박나무-섬바디군집, 후박나무-밤일엽군집, 후박나무군락 등이 발표되었으며, 대흑산도에서 후박나무군락은 대흑산도 예리마을, 소사리, 마리 등의 마을주변에서, 붉가시나무군락은 대흑산도 문암산 정상부근과 비리마을 상부지역에서 분포하였다. 동백 나무림의 식생단위는 동백나무전형군집, 동백나무-후박나무군집, 동백나무-곰솔군집, 동백나무-구실잣밤나무군집, 동백나무-까마귀나무군집, 동백나무-모밀잣밤나무군집, 동백나무-붉가시나무군집, 동백나무-참식나무군집, 동백나무-생달나무군집 등이 발표되었으며, 대흑산도에서 동백나무군락은 대흑산도 사리마을, 심리 마을 주변 저지대 및 구릉지을 중심으로 분포하였으나 인간의 간섭으로 인해 교목층의 식생이 교란된 지역이 많았다. 본 조사지역에서 나타난 주요 상록활엽수림 군락들을 중심으로 현존식생도를 제작하였다. 현존식생도에 나타난 주요 상록활엽수림 군락은 구실잣밤나무군락, 구실잣밤나무-소나무군락, 소나무-구실잣밤나무군락, 구실잣밤나무-곰솔군락, 곰솔-구실잣밤나무군락, 후박나무군 락, 붉가시나무군락, 동백나무 등으로 구분하였고, 대흑산도 상록활엽수림 면적은 전체 삼림 면적 중에서 58.01%로 나타났다. 결론적으로 대흑산도의 주요 상록활엽수림은 구실잣밤나무 군락, 후박나무군락, 붉가시나무군락, 동백나무군락 등이며, 향후 이들 군락이 기후변화, 인위 적인 간섭, 자연천이 요인들에 의하여 각 군락의 종 구성 변화가 빠르게 나타날 것으로 생각된다. This research was carried out from April of 2014 to January of 2017 in the evergreen broad-leaved forests around Daehuksan Island in Dadohaehaesang National Park. A total of 38 plots were set up in this study area, and plant communities were divided into 8 communities of Castanopsis cuspidata var. sievoldii community, Castanopsis cuspidata var. sievoldii-Pinus densiflora community, Pinus densiflora-Castanopsis cuspidata var. sievoldii community, Castanopsis cuspidata var. sievoldii-Pinus thunbergii community, Pinus thunbergii-Castanopsis cuspidata var. sievoldii community, Machilus thunbergii community, Quercus acuta community and the Camellia joponica community. Overall, in order to extract vegetation units based on the vegetation ecological information of the evergreen broad-leaved forest in Korea Peninsula, a comparasion study was conducted. The distribution area, habitat characteristic and its main distribution of Castanopsis cuspidata var. sievoldii community, Machilus thunbergii community, Quercus acuta community and the Camellia joponica community were compared for this study. The investigated Castanopsis cuspidata var. sievoldii community is a community identified by the Castanopsis cuspidata var. sievoldii. It forms a community in the southwestern slope and valleys of the Daehuksan Island Yeri, Sari, Simri and Sorasi village. The investigated Machilus thunbergii community is a community identified by Machilus thunbergii. It forms a community in and around towns, mostly in Daehuksan Island Yeri, Sorasi and the Mari village. The investigated Quercus acuta community is a community identified by Quercus acuta, and it forms a community in the top of Mt. Munam and the upper part of Viri village. The investigated Camellia joponica community is a community identified by Camellia joponica, and it was distributed around Daehuksan Island Sari, Simri village, and lowlands and the hilly area. However, there were many areas where tree vegetation was disterbed due to human interference. The actual vegetation map produced by the main evergreen broad-leaved forest communities represented the survey area. The main evergreen broad-leaved forest communities represented in the vegetation map were divided into Castanopsis cuspidata var. sievoldii community, Castanopsis cuspidata var. sievoldii-Pinus densiflora community, Pinus densiflora- Castanopsis cuspidata var. sievoldii community, Castanopsis cuspidata var. sievoldii-Pinus thunbergii community, Pinus thunbergii-Castanopsis cuspidata var. sievoldii community, Machilus thunbergii community, Quercus acuta community and the Camellia joponica community. The area of evergreen broad-leaved forest in Daehuksan Island is 58.0% of the total forest area.

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4