Oxalate와 Enrofloxacin투여한 랫트신장에 대한 병리조직학적관찰

오원석,이차수,오규실,정원일,정재용,정다히,정규식 한국임상수의학회 2003 한국임상수의학회지 Vol.20 No.4

To investigate the renal effects of enrofloxacin administration on rats induced with dehydration or hyperoxaluria, male rats were treated with enrofloxacin of 50 mg to 500 mg/kg b.w.. The microscopical observations of kidney and urine sediment were carried out in the experimental groups. The result obtained were as follows; The male rats deprived of water for 72 hours and administered with enrofloxacin. As enrofloxacin administration dose was increased, clinical signs such as loss of appetite, depression, weakness, and loss of urine output became more severe. In the histopathological findings, there were hyperemia and hemorrhage in renal cortex, vacuolation and necrosis of renal tubular epithelia, proteinous casts within renal tubules. The male rats were orally administered with sodium oxalate and injected with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, and weakness became more severe. In the histopathological findings, there are hemorrhage of glomeruli and cortical hyperemia, vacuolation and necrosis of tubular epithelia, proteinous casts in renal tubules. In the microscopical findings of urine sediment, there are calcium oxalate crystal (diamond-like type) and magnesium ammonium phosphate crystals (rhomboid). The male rats were intraperitoneally injected with sodium oxalate and administered with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, weakness were more severe. In the histopathological findings, there were hyperemia and hemorrhage in both glomeruli and renal cortex. Severe necrosis of renal tubular epithelia, bluish materials within renal tubules were also found. In the microscopical findings of urine sediment, there were many calcium oxalate crystals. The present results suggest that enrofloxacin has some injurious effects in rats having dehydration or hyperoxaluria, and clinically, we should consider these renal injury effects when we use enrofloxacin in patients accompanied renal disease, dehydration and hyperoxaluria conditions.

Implementation of UPT Service in WIN-Based Mobile Communication Networks

Yun Won Chung(정윤원),Min Young Chung(정민영),Dan Keun Sung(성단근),In Jeong Kim(김인정),Jung Keun Shin(신정근),Sung Kim(김성) 한국통신학회 1999 한국통신학회 학술대회 및 강연회 Vol.1999 No.4

홈쇼핑 기업과 소비재 중소기업의 해외 동반진출에 관한 사례연구

정소원(So Won Jeong),양희순(Heesoon Yang),정재은(Jae Eun Chung) 한국경영학회 2017 한국경영학회 통합학술발표논문집 Vol.2017 No.08

우리나라의 지속적인 경제발전과 경쟁력을 확보하기 위해서는 대기업과 중소기업의 간의 균형 잡힌 발전이 필요하다. 이에 대중소기업간 상생 및 해외 동반진출에 대한 관심이 높으며, 정부에서도 여러 가지 지원정책을 늘리고 있다. 이에 본 연구에서는 국내 홈쇼핑 기업과 소비재 중소기업의 해외 동반진출에 관한 인터뷰를 통해 홈쇼핑의 특수성을 고려한 효율적인 유통대기업과 중소기업의 해외 동반진출 확대 방안을 모색하고자 한다. 이를 위해 해외 동반진출을 하고 있는 3개의 홈쇼핑 기업을 대상을 인터뷰를 실시하였으며, 결과는 다음과 같다. 홈쇼핑 기업은 소비재 중소기업의 해외 판로 개척에 도움이 되며, 자원과 역량이 부족한 중소기업에게 경영 및 마케팅 역량을 활용할 수 있게 해준다. 홈쇼핑 기업이 소비재 중소기업을 지원하기 위해 영상을 제작하거나 언어를 번역해주기도 하며, 무역 통관과 관련된 서류를 지원해주기도 한다. 또한 시장개척단을 구성하여 해외시장 정보 제공 등의 지원을 한다. 그렇지만 아직까지는 홈쇼핑 기업에게 해외 동반진출이 주는 실질적인 혜택이 미미하기 때문에 장기적으로 서로 win-win할 수 있는 전략이 필요하다. 이를 위해 해외 동반진출을 독려할 수 있도록 실질적인 혜택을 제공해야 하며, 궁극적으로 CSV 개념을 실천할 수 있도록 해야 한다. There must be a balanced development of both conglomerates and small and mid-sized companies in order to secure constant economic growth and competitive edge of South Korea. Accordingly, high expectations are being placed on win-win growth and joint overseas expansion of conglomerates and small and mid-sized companies. This study seeks efficient ways to promote joint overseas expansion of major retailers and small and mid-sized companies considering the distinctiveness of home shopping by conducting interviews about joint overseas expansion of home shopping companies and small and mid-sized consumer goods companies in South Korea. Home shopping companies contribute to opening up overseas markets for small and mid-sized consumer goods companies, and allows them to make use of business and marketing competencies that they lack. Home shopping companies also produce visual materials or provide language translations, and help draw up documents for customs clearance in trading. They also form market development teams and provide information about the overseas markets. However, since the actual benefits from joint overseas expansion are minor for home shopping companies, there is a need for a strategy for win-win growth of both parties in the long run. To this end, it is necessary to provide substantial benefits to encourage joint overseas expansion and ultimately implement the concept of creating shared value (CSV).

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

강력한 생전분 분해효소의 개발과 특성

정만재,허원녕,정재현,谷口肇 한국산업미생물학회 1990 한국미생물·생명공학회지 Vol.18 No.3

생전분 분해력이 강력한 glucoamylase를 생산하는 균주로서 Asp. usamii IAM 2185를 선정하였다. 밀기울배지에서의 효소생산의 최적 initial pH는 6.0∼8.0, 최적 배양온도는 25∼30℃, 최적 배양시간은 72시간이고, 밀기울배지에 ammonium nitrate와 albumin의 첨가는 효소의 생산을 약간 증가시켰다. 황산암모늄분획, CM-cellulose와 DEAE-cellulose column chromatography에 의하여 효소를 정제하였고, 정제효소의 specific activity는 34.3U/㎎ protein, 수율은 10.3%이었다. 정제효소는 polyacrylamide disc gel electrophoresis에 의하여 single band를 나타내었고, SDS-polyacrylamide disc gel electrophoresis에 의하여 추정된 분자량은 67,000이었다. 정제효소의 등전점은 pH3.7, 최적 온도는 60℃, 최적 pH는 3.0, pH 안정범위는 1.0∼11.0, 50℃ 이하에서 안정하였으며, Ca^2+은 효소의 내열성을 크게 증가시켰다. 정제효소는 raw corn starch, raw rice starch, raw yam starch, raw arrow root starch, raw sweet potato starch, raw glutinous rice starch에 대하여 높은 분해율을 나타내었다. Asp. usamii IAM 2185 was selected as a strain producing the powerful raw starch digesting glucoamylase. The optimum initial pH, the optimum temperature and the optimum cultural time for the enzyme production on wheat bran medium were pH 6∼8, 25∼30℃ and 72 hrs, respectively. The addition of ammonium nitrate and albumin on wheat bran medium, respectively, increase slightly the enzyme production. The enzyme was purified by ammonium sulfate fractionation, CM-cellulose and DEAE-cellulose column chromatography. The specific activity of the purified enzyme was 34.3 U/㎎ protein and the yield of enzyme activity was 10.3%. The purified enzyme showed a single band on polyacrylamide disc gel electrophoresis and its molecular weight was estimated to be 67,000 by SDS polyacrylamide disc gel electrophoresis. The isoelectric point for the purified enzyme was pH 3.7. The optimum temperature and optimum pH were 60℃ and pH 3.0 and the purified enzyme was stable in the pH range of 1.0-11.0. The purified enzyme was stable below 50℃ and its thermostability was greatly increased by the addition of Ca^2+. The purified enzyme showed a high hydrolysis rate on various raw starches such as corn, rice, yam, arrow root, sweet potato and glutinous rice.

^(155,156)Gd 동의원소의 keV 영역 중성자 포획단면적 측정

정원정,황정훈,김현,노태익 東亞大學校 2004 東亞論叢 Vol.41 No.-

The Neutron Capture Cross-Section of ^(155,156)Gd were measured in a neutron energy region from 15 to 85 keV using the 3MV Pelletron accelerator of Tokyo Institute of Technology. Pulsed neutrons were produced from the ^(7Li)(p,n)^(7)Be reaction. The incident neutron spectrum on a capture sample was measured by means of a TOF method with a ^(6)Li-glass detector. The capture γ-ray were detected with a large anti-Compton NaI(TI) spectrometer. A pulse-height weighting technique was applied to measured capture γ-ray pulse-height spectra to derive capture yields. The capture cross sections were obtained by using the standard capture cross-section of ^(197)Au. The present results are corrected for isotope impurities of sample because the samples contain various isotope Godolinium. The present results are compared with the previous measurements and the evaluated data of ENDF/B-VI.

여자 고등학교 검도지도자의 리더쉽 유형이 선수들의 만족도와 선호도에 미치는 영향

원충희,정권호 公州大學校 스포츠科學硏究所 2005 스포츠科學硏究所論文集 Vol.17 No.-

This study is for finding the difference of satisfaction and preference of Kumdo (Japanese fencing) players about their coaches who have various teaching styles. The results came from the data that representative Kumdo players of ever province who took part in the National Athletic Games answered. 1) The difference of teaching style based on coaches' characteristic First, there are significant differences between the most favorite teaching style and the least one according to their coaches' age groups. Second, there are more or less differences among players of 17. 18. 19 years old about their most favorite teaching style, but not among players of 20. Third, there are differences of the most favorite teaching style according to their coaches' career groups. Fourth, there are differences of the most favorite teaching style according to their coaches' academic background - only when their coaches have bachelor's degree of higher one. Fifth, there are differences of the most favorite teaching style according to their coaches' career as players. Sixth, there are differences of the most favorite teaching style according to the records of their coaches' winning prizes. 2) The difference of teaching style based on players' characteristic First, there is no difference between the most favorite teaching style and the least one according to the players' career groups. Second, there is no difference between the most favorite teaching style and the least one according to the records of players' winning prizes. 3) The difference of satisfaction and preference of players about their coaches' teaching style Kumdo players don't show any statistically significant difference of satisfaction and preference about their coaches' training activity styles, but they show difference about acceptant, authoritative, social assistance, and compensational activity styles.

Prednisolone 에 의한 장티푸스 抗菌治療의 지연

鄭喜泳,鄭圭源,金在亨,徐廷和,宋貞燮 대한감염학회 1976 감염 Vol.8 No.1

For the purpose of shortening of febrile period of typhoid fever, prednisolone was administered with bacteriocidal antibiotics though corticosteroid had not been used routinely for its possible side effects on typhoid fever. The authors suspected beneficial effects of corticosteroid because the action of bacteriocidal antibiotics was different from the action of bacteriostatic effects of chloramphenicol which was used in the last 30 years. The result was quite different from expectation and the febrile period of the patients was prolonged in all of the cases as shown in figures. Corticosteroid must not be used in typhoid fever so far as it is possible because delay of antibiotic effect than other known side effect. The possible mechanism of the longer intracellular parasitism of Salmonella typhi due to corticosteroid for the prolongation of fever was discussed.

위암환자 전산화단층촬영시 경구조영제로서 물의 유용성에 관한 연구 : Usefulness of Water as an Oral Contrast Agent

정경원,김충현,박청희 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

Computed tomography is valuable for direct visualization of changes of gastric wall and staging of gastric tumor. Gastric distension is essential for the evaluation of gastric wall. Computed tomography of the gastric wall after sequential ingestion of normal saline to 1000cc, followed by rapid intravenous injection of contrast medium, was performed in 36 patients with known gastric tumors. Three patients were excluded due to incomplete gastric distenstion and the lesion was not detected. Thirtythree patient was analysed preoperatively; the changes of wall were analysed in all patients and CT staging is compared with that of 19 cases who underwent surgery. The results were as follows: 1. All cases are adenocarcinomas. 2. Thickening of gastric wall is detected in all cases and the ulceration within the thickened wall is detected only in five cases among the 25 cases of Borrmann type Ⅱ and Ⅲ. 3. Absence or presence of perigastric fat infiltration is correctly diagnosed in 15 cases among the 19 cases who underwent surgery 4. Lymph node metastasis, is correctly diagnosed in nine cases among the 19 cases 5. Pancreatic metastasis is correctly diagnosed in all cases who General acceptance and tolerance of water as a gastric contrast medium was good in all patients, and water made excellent negative contrast with gastric wall, and there was no side effects.

동진강 유역의 농업활동에 의한 수질변화와 실측부하량

원찬희,정팔진,김민정,현미희,박정훈,송재환 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

The entire duration of the research work was from December-2000 to July-2002. Site measurement were conducted during various season, in a dry season(December), in rainfall, in seed-sowing time and also collecting data from the rural public organizations related to water management was done and examined during the mid of research work. Generally, the Dong Jin River watershed contains small three Creeks, KoBu, DongJin(including JeongEup and ChilBo, WonPyong). It was further divided into 32 sub-watersheds which comprises of further 5, 18, 9 watersheds in the creeks respectively. Inflow loading to the river was calculated from measurement of general water quality and quantity and these field surveys were made thrice times in agricultural drainage channels, where fertilizers and pesticides leaching from the surface have an direct effect for the deterioration of the several creek and river. Estimation of contaminant loading has been done by using unit loading based on the notification No. 1999 - 143 of the Ministry of Environment. Most of estimated loading data reported during the research work were slightly higher when compared with the notification of the Ministry but they do not have any significant effect. It was assumed that sub-watersheds have considerable field survey loading data, which were affected due to non-point source pollution load as compared to point source. For investigation of surface rainfall ranging from .50㎜ during non-farming or .10 rainfall on the period of farming, BOD loadings in the field during farming showed slightly higher levels in comparison with discharge loadings, T-N also showed the similar trend as discussed earlier.