정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

마이크로 컴퓨터를 이용한 가속도 측정회로 개발

정태상,황광성 진주산업대학교 1992 論文集 Vol.31 No.-

가속도의 측정은 물체나 기계의 운동하는 부위의 힘, 진동 등을 분석하는데 매우 중요하다. 그러나 가속도는 무게와 같은 형태의 일정한 정적 물리량이 아니어서 측도설정이 어려우므로 동적 물리량의 발생기구가 필요하게 된다. 이러한 가속도 측정 문제들을 해결하기 위하여 가속도 계측 및 측도설정을 위한 가속도 측정회로를 개발하고 가속도 발생기구를 제작하여 실험을 통해 측도설정한 결과 다음과 같은 결론을 얻었다. l. 가속도 전압 변화 회로를 개발하여 실험한 결과 양호한 작동이 이루어 졌다. 2. 가속도 발생기구를 제작하고, 실제접선가속도 측정 및 가속도 전압변화 회로 출력 디지탈값과의 측도설정 시스템을 구성하였으며, 보정프로그램을 개발하였다. 3. 실제접선 가속도 측정을 위해 사용한 전위차계의 각도와 가속도 전압 변환 회로의 A/D변환을 위해 5V의 전압을 걸었을 때 관계 수식은 다음과 같이 나타났고 θ = 0.330483157 × Dig + 0.741133731 상관계수 r=0.99999^**로 나타났으므로 고도의 상관관계가 있음을 알수 있었다. The measurement of acceleration is very important to analyzing the dynamic motion of the moving parts or a machine. a device made of strain gage sensor was developed for acceleration measurement and calibratiom using a personal computer. the normal and tangential reference acceleration was generated from the circular motion of the rotating-lever-type calibrator. An accelerometer was attached to the end of the rotating level so that it undergoes the circular motion with the radius of 1.013 meter. The lever was rotated manually on the horizontal plane to generate the acceleration, so that angular velocity can be varied. The tangential acceleration was used to calibrate and the calibration equation was derived from regression analysis of digital data obtained by a computer. To measure angular acceleration, real time and rotating angle were measured by using an on-board computer clock and a potentiometer attached to the rotation center of the circular motion made by the rotating lever, respectively. The acquired data were treated by non-filtering and digital-filtering method. The correlation filtered were more useful than those from non-filtered data. From the results of the experiment, it was clearly concluded that the developed measuring system could be used to measure acceleration accurately and rapidly, and that the tested calibrator could be used to calibrate any type of accelerometer.

두경부 악성종양 절제술 후 유리피판을 이용한 재건술 40예의 고찰

백정환,손영익,김성민,추광철,하범준,심영목 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7

PID제어를 이용한 Chamber의 냉방제어 시뮬레이션

정태상,황광성,김태규,김유영,정기환 진주산업대학교 산업과학기술연구소 2003 산업과학기술연구소보 Vol.- No.10

A cooling system of chamber is universally appliable with simple ON-OFF control algorithm. It has such disadvantages as having a delay for response time. To solve the above problem, we propose establishing the mathematical model of cooling system for chamber, simulating it with PID control algorithm and evaluating performance tests for control algorithm respectively.

이소매복된 하악 제2소구치의 자가치아이식을 이용한 치험례

정윤주,궁화수,최성철,김광철,박재홍 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

악골내 이소매복된 치아로 인해 유치의 만기잔존, 교합이상과 같은 교정적인 문제가 발생할 경우 그 해결책으로 주기적 관찰, 최소한의 개입, 교정적 견인, 발치, 그리고 환자 자신의 매복치아를 이용하는 자가이식술 등을 들 수 있다. 자가치아이식은 치아를 구강내의 한 위치에서 다른 발치와나 외과적으로 형성된 치조와로 이동시키는 술식으로, 치아가 교정력을 가할 수 없는 위치에 존재하거나 치아 이동에 제한이 있어 통상적인 치료가 불가능할 경우에 발거에 앞서 고려할 수 있는 방법이다. 자가치아이식은 치료기간을 단축시키고, 치근 형성이 완료되지 않은 어린 환자의 경우 이식된 새로운 위치에서 치근 형성이 이루어지며, 새로운 치조골의 형성을 유도할 수 있다. 본 증례는 하악 우측 제2소구치의 매복과 하악 우측 제2유구치의 만기잔존을 주소로 본원에 내원한 11세 여아로, 하악 우측 제2소구치의 매복의 깊이가 깊고, 방향이 교정적 견인에 불리하다는 점, 미성숙 치근 발육 상태와, 만기잔존한 유구치로 인해 공간 상실이 없다는 점 등을 고려하여 자가치아이식을 시행한 뒤, 1년간의 주기적 관찰 결과, 양호한 결과를 얻어 이에 보고하는 바이다. In the case of the impacted teeth, the clinician has to consider development of tooth, site of impaction, eruption path, and cooperation of patient. Treatment options for the management of impacted teeth are separated into four categories: observation, intervention, orthodontic or surgical relocation and extraction. Autotransplantation may be defined as the transplantation of embedded, impacted or erupted teeth, from one site to another in the same individual into extraction site or surgically prepared sockets. Autotransplantation ensures preservation of natural tooth, induction of alveolar bone growth and root development, offers one of the fastest and most economically feasible means in the replacement of young patients' missing teeth. This case presents a malpositioned impacted mandibular premolar of an 11-year-old girl. It was thought that orthodontic traction was difficult because of its unfavorable impacted position. Therefore the tooth was treated by autotransplantation, we can observe good healing pattern during 12 months.

司譯院과 司譯院 譯學書의 變遷 硏究

鄭光,韓相權 德成女子大學校 1985 德成女大論文集 Vol.14 No.-

The scope of this paper centers around the discussion in details of the changes on the Sayon-won and its textbooks in the historical point of view. Sayog-won was the Official Language Institute of Yi-dynasty, which originated from T'ong-mum-gwan, Hano-togam, and Sayog-won in Koryo dynasty. And it did not only administrate the official interpreters who werved the translation of foreign languages but also teach the foreign languages to the students, mainly Chinese, Mongolian, Janpanese, and Jurchen of Manchurian language. Sayog-won was established almost the same time with the foundation of Yi-dynasty. But the officers organization of it had been changed according to the reform of government organization and the changes of international relations or the foreign policy of Yi-dynasty. The examination system for selecting the official interpreters had been changed according to the kinds of foreign language and the number of their interpreters. We considered in this paper the reform of official interpreters' position in Sayon-won, seperatedly from the executive position, the military position, and the attendants position of mission mainly to China. The examination for selecting the official interpseters can be classified three: the national examination, the examination of the Institute, and the periodical test for students at the Institute. We considered their historical changes and the purpose of each examination. The most extensive reform of Sayon-won organization occurred after two wars against Japanese and Manchurian invaders during 17∼18th centuries. The textbooks used in Sayon-won are not only very useful for studies on the history of Korean language but also for studies of pertinent languages. The historical changes of the textbooks can be considered divided three periods. The textbooks in first period had been published since 13th century to the "Kyongguk-taejon", a great code of law in Yi-dynasty, which was published in 1470 A.D. The second period is since "Kyongguk0taejon" to "Sok-taejon", a continued great code of law, which was published in 1744, and third period since "Sok-taejon" to the end of Yi-dynasty. The most of the textbooks used during first period were those edited by foreigners for the purpose of teaching their own languages to the children. But the textbooks used in second period were gpublished in Yi-dynasty and edited by the interpreters in Sayog-won. They were textbooks for teaching coloquial languages in accordance with the respective missions of interpreters. In the third period, Sayon-won revised and reformed all the textbooks used in the second period. We considered the relationship among the textbooks which were used in each period. And we tried to elucidate the main trends of the changes of the textbooks.

유리 전박골피판을 이용한 음경 재건술

정성광,변진석,백봉수,김법완 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2

Reconstruction of the penis is indicated in a traumatic or surgical amputation, congenital penile absence, micropenis, male pseudohermaproditism, or transsexualism. Initially, penile reconstruction has been performed using a local flap, but often failed because of the multiple procedures, fistula or stricture of the urethra, and no sensation of the phallus. Ideally, penile reconstruction should be a one-stage procedure, creating a phallus with both tactile and aerogenous sensibility, water-tight neourethra allowing for voiding while standing, enough bulk with stiffness, and aesthetically acceptable appearance. Since August 1989 we have constructed a penis in 4 patients. We selected the radial forearm flap as a donor site because it offers a reliable artery, veins, nerves, and stiffner. It also offers thin, malleable skin with adequate width and length. We have followed these patients from 5 months to 10 months. All operations were successful except for one fistula formation.

상대농도와 질량농도 측정법에 의한 기중 분진농도의 비교

정광호,성수원,안규동 가톨릭대학산업의학센타 산업의학연구소 1983 韓國의 産業醫學 Vol.22 No.1

This experiment was carried out to investigate the correlation of accuracy among five kinds of instruments which determined an airborne dust at the various locations of same type work. The results obtained were as follows; 1. Digital dust indicator-P type (DDI-P) instrument for determination of relative concentration was found not having significant variations when it was used without corrective coefficient to the quantitative concentration at the places with a few airborne dust in office and laboratory room. 2. Generally, there were the high correlations between determination values resulted by Digital dust indicator(DDI) and Piezobalance(PB). However, the correlation of two instruments to a filter weighing method was insignificant in the same type work. After determining several times (at least 5 times and over), it was desirable to fix the corrective-coefficient. 3. When the size of the particles of airborne dust was large or its concentration was high in suspended airborne dust, the determination values of High volume air sampler-Respirable(HVS(R)) were 2-4 times higher than that of Low volume air sampler-Respirable(LVS(R)). 4. The emyloyment of corrective coefficient for determination values of DDI and PB was not appropriate to HVS(R) comparing with LVS(R) because of the significant changeable differences. In addition, the determination instruments for relative concentration was not appropriate to using by itself at a manufactruing process. There were also problems about sampling time and evaluation when it was determined the total airborne dust with the open face type holder.

급성 심근경색증에 동반된 승모판 폐쇄부전증의 임상적 특징

정상만,조영일,조화상,유광하,송기호,인행환 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-

The early detection and proper management of mitral regurgitation(MR) associated with acute myocardial infarction(MI) is very important to improve the clinical course and outcome of disease. The change of left ventricular shape and regional function, papillary muscle rupture are major determinant of the existence and severity of MR. We performed 2D and M mode echocardiography of 28 patients at the early stage of acute MI to evaluate the existance and degree of MR and its pathogenetic factor. Significant MR occured in 12 (42.9%) patients. In the group of MI with MR, the inferior MI was frequent (7 case) than anterior MI (5 case) comparing to the patient group of MI without MR (inferior MI : 6 case, anterior MI : 10 case) (p<0.01).The left ventricular end diastolic dimension(LVEDD), end systolic dimension (LVESD) and left atrial dimension (LAD) were significantly increased in MI with MR than MI without MR (LVEDD : 57.3 ±8.6 vs 46.4 ±9.2, p<0.05 ; LVESD : 52.9 ±9.2 vs 38.3 ±7.4, p<0.01 ; LAD : 45.4 ±3.8 vs 37.7 ±3.7, p<0.05).However, the ejection fraction was not different between two group two groups. These datas showed that MR was more frequent in inferior MI and the hemodynamic derangement was more serious in acute MI with MR.

유치 외상에 관한 연구

정윤주,김광철,박재홍,최성철 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.3

경희대학교 치과대학병원 소아치과에 2003년 1월 1일부터 2007년 12월 31일까지의 최근 5년간 치아외상을 주소로 내원한 생후 6개월에서 7세 미만(평균 2.8세)의 어린이 758명의 외상 받은 유치 1533개를 대상으로 하였다. 모든 대상자들의 진료기록 및 방사선 사진으로부터 내원한 어린이의 성별, 연령별 발생빈도, 원인, 장소, 외상 후 치료까지의 경과시간, 월별발생률, 발생부위, 치아손상의 개수, 외상의 양상, 초진 시 처치 등을 분석하여 다음과 같은 결과를 얻었다. 1. 유치의 외상은 남아가 여아보다 1.77배 많은 것으로 나타났으며, 남녀 모두 1-2세, 2-3세에 많이 발생하였다(p<0.001). 2. 외상의 주요 원인은 넘어짐, 부딪힘으로 나타났고, 주로 저연령층 어린이에서 두드러지게 나타났다(p<0.05). 외상의 발생장소는 집안, 집밖, 유치원순으로 나타났으며, 특히 기후가 온화한 5월, 9월, 10월에는 집밖의 비율이 높게 나타났다(p<0.001). 3. 외상 후 주로 24시간 이내(77.6%)에 내원하였으며, 월별 치아외상은 겨울을 제외한 3-9월에 고르게 나타났다(p<0.001). 4. 가장 손상을 많이 받은 치아는 상악 유중절치로 나타났으며, 치아손상은 단일치아 또는 두 개의 치아 손상이 주로 나타났다. 5. 치주조직 손상이 치아경조직 손상에 비해 2배정도 많이 발생하였으며, 외상의 양상은 아탈구, 측방탈구, 법랑질파절, 함입, 치근파절 순으로 나타났다. The purpose of this study was to research the traumatized primary teeth and investigate following factors: sex, age, cause, place and time(of the year) of injury, elapsed time, area and type of injury, dental treatment and prognosis. The analysis includes total of 1533 traumatized primary teeth from 758 children aging from 6 months to 6 years(mean age: 2.8) from 2003 to 2007. The result follows : 1. The children of age between 1-2 and 2-3 were involved in the largest number of injuries in both sexes with boy/girl ratio of 1.77:1(p<0.001). 2. Fall and collision were the main causes of traumatic dental injury, especially in younger children(p<0.05). Places of injury occurrence varied: home, outdoors, and kindergarten. Warm climate accounts for frequent outdoor injuries in May, September and October(p<0.001). 3. Most of the children visited dental clinic within 24 hours of the injury(77.6%). From March to September, dental trauma occurrences were distributed evenly, except for Winter period(p<0.001). 4. Upper central incisors were the most commonly affected teeth, and the injuries usually involved 1 tooth or 2 teeth. 5. Periodontal tissue injuries dominated and subluxation was the most common type. Lateral luxation, enamel fracture, intrusion and root fracture followed.