정신장애인 치료에 중요 역할 담당자의 정신질환에 대한 태도조사

김병후,정선욱,강연화,김윤,김창엽,홍진표,한오수,조맹제,김용익 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.5

Objectives : Attitudes of families of mentally ill, health personnels and community leaders to the mentally ill after the development and utilization of the community mental health program and reintegration of the chronically ill patients into society. This study was designed to compare the attitudes toward the mentally ill patient of the persons who have important role in treating the mentally ill and to find the variables influencing the attitudes. Methods : We measured attitudes toward mental illness in psychotic patients' families(N=139), community leaders(N=180) and health personnels(N=324) including mental health personnels before the implementation of community mental health services in Yonchon county and Seodaemun district area. The instrument used to measure attitudes was Opinion about Mental Illness(O. M. I.) scale. Results : 1) Health personnel showed lower Authoritarianism(Factor A) and higher Benevolence(Factor B) scores on the average than community leaders and psychotic patients families. 2) Current residence affect the attitudes in psychotic patients' families, not in community leaders and health personnels. Families in urban area showed lower Authoritarianism(Factor A) and Social Restrictiveness(Factor D) and higher Benevolence(Factor B) scores than in the rural areas. 3) Many patient variables were correlated to the attitudes of families. Duration of illness, number of recurrence, number of admission, age of patient and family burden were positively correlated mainly to Social Restrictiveness(Factor D). 4) Sex and religion of respondents showed no or weak relationship with the factor scores. Conclusions : Education for community leaders and families is required to achieve successful community mental health services. Community support program should be developed for chronic, recurrent and burdensome psychiatric patients in the first place.

고온 접촉식 탐상용 초음파 탐촉자 개발 및 평가

김기복,김병극,이승석,윤남원,윤동진,안윤국 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.1

고온(500℃) 환경에서 접촉식 탐상이 가능한 초음파 탐촉자를 개발하고 평가하였다. 고온용 탐촉자는 Curie 온도가 600 ℃ 이상인 bismuth titanate 계열의 압전세라믹 소자, 텅스텐 분말과 inorganic binder를 혼합한 후면재, 알루미나 튜브, 전면재, 하우징 등으로 구성되었다. 기본 공진주파수가 각각 1.04 및 2.08 ㎒의 2 종류 탐촉자를 제작하였으며 각종 고온용 커플런트의 온도특성을 시험하였다. 개발된 고온용 탐촉자를 이용하여 강재 시편을 대상으로 시편에서의 초음파 반사신호를 측정한 결과 시편의 온도가 증가함에 따라 반사신호의 크기는 감소하였다. 고온에서 반복측정 실험결과 500℃에서 연속적인 접촉식 초음파 탐상이 가능한 것으로 나타났다. Piezoelectric ultrasonic transducers for high temperature contact measurement were developed. These high temperature ultrasonic transducers (HTUT) consisted of bismuth titanate piezoceramic element whose Curie temperature is higher than 600℃, a backing material of the mixture of tungsten powder and inorganic binder, an inner alumina tube, a wear plate and a housing. The operational frequencies of the HTUT were 1.04 and 2.08 ㎒, respectively. Various commercially available couplant for high temperature were evaluated and compared. As a couplant for high temperature ultrasonic testing between HTUT and test specimen, gold epoxy was selected. The peak amplitude of pulse-echo signals from steel test specimen decreased with increasing temperature. The operational temperature of the HTUT reached up to 500℃ at which the continuous contact measurement was possible.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

와동의 형태가 상아질과 복합레진 사이의 미세인장결합강도에 미치는 영향

김예미,박정원,이찬영,송윤정,서덕규,노병덕 大韓齒科保存學會 2008 Restorative Dentistry & Endodontics Vol.33 No.5

이 실험의 목적은 동일한 깊이의 상아질에서 제 6세대의 self-etching system을 사용하여 C-factor가 상아질과 복합레진 사이의 미세인장결합강도에 미치는 영향을 알아보는 것이다. 건전한 대구치 80개를 선정하여 와동의 바닥면적은 각각 16㎟로 동일하게 하고 깊이를 조절하여 C-factor가 각각 0.25, 2, 3, 4인 4개의 군으로 나누었다. 각 군별로 총 20개의 치아를 할당하였으며 접착제와 복합레진의 조합에 따라 다시 4개의 소군에 치아 5개씩을 배정하였다. 상아질 접착제는 AQ Bond Plus또는 Xeno III를 사용하였고, 복합레진은 Fantasista또는 Ceram-X mono를 사용하였다. 제조사의 지시대로 상아질 접착제를 도포한 후 60초간 광중합하였다. 24시간 동안 증류수에 보관 후 단면적이 1.0 x 1.01㎟인 복합레진-상아질 beam을 형성하여 1 mm/min의 속도로 미세 인장결합강도를 측정하였다. One-way ANOVA와 Tukey test, 그리고 Pearson correlation test로 통계처리하여 다음과 같은 결과를 얻었다. l. Xeno III와 Ceram-X mono군에서는 C-factor가 증가할수록 미세인장결합강도가 유의하게 감소했으나 (p < 0.05), 나머지 재료군에서 C-factor군간에 미세인장결합강도의 유의한 차이가 없었다. 2. C-factor 3군에서는 AQ Bond Plus와 Fantasista군이 XenoIII와 Ceram-X mono군에 비해 높은 결합력을 보였으나 (p < 0.05), C-factor 0.25군, 2군, 4군에서 4가지 접착제와 수복 레진의 조합 간에 유의한 차이가 없었다. 3. Fantasista군에서 C-factor와 미세인장결합강도 사이에 일정한 상관관계를 발견할 수 없었고, Ceram-X mono군에서 C-factor가 증가할수록 미세인장결합강도가 감소하는 경향을 보였다 (p < 0.05). 이번 연구의 결과로 상아질의 깊이가 동일하고 6세대의 self-etching system을 사용하여 복합레진을 충전하는 경우와동의 C-factor가 수복물의 미세인장결합강도에 크게 영향을 미치지 않음을 알 수 있었다. This study was conducted to evaluate the influence of the C-factor on the bond strength of a 6th generation self-etching system by measuring the microtensile bond strength of four types of restorations classified by different C-factors with an identical depth of dentin. Eighty human molars were divided into four experimental groups, each of which had a C-factor of 0.25, 2, 3 or 4. Each group was then further divided into four subgroups based on the adhesive and composite resin used. The adhesives used for this study were AQ Bond Plus (Sun Medical, Japan) and Xeno III (DENTSPLY, Germany). And composite resins used were Fantasista (Sun Medical, Japan) and Ceram-X mono (DENTSPLY, Germany). The results were then analyzed using one-way ANOVA, a Tukey's test, and a Pearson's correlation test and were as follows. 1. There was no significant difference among C-factor groups with the exception of groups of Xeno III and Ceram-X mono (p < 0.05). 2. There was no significant difference between any of the adhesives and composite resins in groups with C-factor 0.25, 2 and 4. 3. There was no correlation between the change in C-factor and microtensile bond strength in the Fantasista groups. It was concluded that the C-factor of cavities does not have a significant effect on the microtensile bond strength of the restorations when cavities of the same depth of dentin are restored using composite resin in conjunction with the 6th generation self-etching system.

양·한방 협진병원 이용환자의 상병상태 및 의식조사

윤병준,김영훈 서울보건대학 1996 서울보건대학 부설 병원경영연구소 논문집 Vol.2 No.1

This study was carried out to analyze patents' disease status, their satisfaction with hospital service, the consciousness of co-operative treatment, and the consciousness of doctors on co-operative medical treatment of western and oriental medicine. We investigated 386 patients utilizing three oriental medicine hospitals in co-operation with western medicine hospitals and surveyed 30 doctors in these hospitals. We made use of frequency analysis for general characteristics of the object cases and t -test for distinctions among groups by spss-pc program. The results of this study were as follows. 1. As to general characteristics of the group, 55.2% were female and 44.8% were male. 64% were in the 30-59 age group and 18% were over 60.78% of the patients lived in the city of Seoul. The percent for housewives was 27.7%, professionals were 17.4%, and the unemployed were 17.1%. The percent of those for university graduates was 43.3% and highschool graduates was 33.9%. 36% of the patients had an average family income per month 1.5-2.9million. 2. In regards to disease status for inpatients, 67.5% were in the heart related disease group, and 16.9% in the locomotive organ related disease group. In the case of outpatients, 33.0% in the locomotive organ related disease group. And 18.2% in the heart related disease group. The kind of diseases which received co-operative treatment of western and oriental medicine was cerebrovascular disease or musculoskeletal disease. As the age increases, the number of inpatients for cerebrovascular disease was higher, but the percent of musculoskeletal disease was the highest(47.4%) for the age group between 40~59.

DP-Matching과 HMM을 이용한 온라인 필기 한자 인식

윤병훈,김형태,하진영 강원대학교 정보통신연구소 2007 정보통신논문지 Vol.11 No.-

On-line handwritten Chinese character recognition systems should be fast and yield accurate results in order to be practical systems. DP-matching method for variable length input requires building several allographs (multiple models) per class, which inevitably reduces the recognition speed. HMM is a good alternative, since one HMM per class is usually sufficient to model large variation of data. We proposed a recognition system in which HMM and DP-matching method are combined to improve the recognition speed and recognition accuracy at the same time. The HMM method using structure code features produces recognition candidates, then DP-matching method using chain code features reorders the candidates to get more accurate results. In doing so, we accomplished fast and accurate recognition results for 2,362 Chinese character classes. We also adopted result verification method to discriminate confusable character classes. We got 97.44% recognition accuracy using the proposed method in 113 ms per character in average.

건강행위 실천이 건강상태에 미치는 영향에 관한 연구

윤병준,김영훈 서울保健大學 1995 論文集 Vol.15 No.1

This study was carried out to help an efficient health educational strategy for health promotion. The sample consisted of 5,199 persons aged 20∼59. We select 5 social-demographic variables, 6 health behavior variables, 3 health status conditions and used multiple logistic analysis for the arrangement of results. The analysed results are as follows : 1. The percentage of keeping normal body weight was 60.9% in male and 54.8% in female, for that of physical exercise, male 27.7%, female 13.6%, for that of smoking, male 71.6%, female 5.2%, for that of drinking, male 78.9%, female 24.2%, for that of adequate sleeping, male 72.1%, female 73.2%, for that of regular meals, male 67.6%, female 62.2%. 2. Sex and marital status were significantly associated with normal body weight. Sex, educational level and living standard for physical exercise, Sex, educational level and marital status for smoking, Sex, educational level for drinking, Marital status, living standard for adequate sleeping, Sex and marital status for regular meals were associated respectively(p<0.05). 3. Normal body weight, physical exercise, adequate sleeping were associated with short-term morbidity. Normal body weight, physical exercise, smoking, adequate sleeping were associated with the occurrence of long-term morbidity, and Normal body weight, physical exercise, regular meals were associated with self diagnosed health status(p<0.05).

STI571 (Glivec^(�))에 의하여 빠른 치료 반응을 보인 불응성 Gastrointestinal stromal tumor

윤경원,이제중,김여경,황호인,이병환,조상희,정익주,김형준 全南大醫大 2001 전남의대학술지 Vol.37 No.4

신생아에서 용질배설에 관한 연구

김경범,박재현,최병민,이현희,윤재균 관동대학교 의과학연구소 2000 關東醫大學術誌 Vol.4 No.1

Purpose : Determination of urinary concentration in neonate is mandatory for precise management of fluid and electrolyte requirements. Although measurement of urine specific gravity has been proposed far monitoring fluid requirements, the reliability of specific gravity does not accurately predict urine osmolalities in the neonate period. So specific gravity should be checked by measuring the osmolality. Also the urinary excretion of creatinine has been used for the assessment of hydration state. We present the result of specific gravity, urine osmolality, urine creatinine in a spot urine sample during the first week of life as a reliable reference standard. Methods : Spontaneously-voided urine sample were obtained in 40 full term neonates. Two urine samples were available with a interval of 4 to 7days (A: 1st day, B: 4 - 7days), Urine sample was tested for specific gravity with a strip test. Also urinary osmolality, urinary creatinine, urinary creatinine/osmolality ratio were measured. Results : The mean of specific gravity tested by the strip test was 1.006±0.0040 (A) , 1.005±0.0036 (B). The mean of urine osmolality and creatinine were 177.7 ± 103.0 and 30.9±21.6 (A), 145.7 ±90.3 and 26.4± 17.7 (B). The mean of excretion rate of urine creatinine/osmolality ratio was 18.2 ±8.5 (A), 19.4 ±9.1 (B). There was correlation between urine specific gravity and osmolality in neonate(r=0.833(A), 0.842(B) p<0.001). Urinary creatinine/osmolality levels of the first urine samples were closely correlated with the second samples (r=0.617, p<0.001). Conclusion : Specific gravity of urine was enough to predict the osmolality in neonate. But Specific gravity should be checked by measuring the osmolality of urine. Urine osmolality and creatinine were spread over a wider range and did not used to urinary excretion of solute in neonate. Urinary creatinine/osmolality ratio can be used to standadise the urinary excretion on solute in the first week of life.

투명단열 축열벽 시스템을 적용한 주거용 건물의 냉난방에너지 성능분석

김병수,김재웅,윤종호 대한건축학회 2004 대한건축학회논문집 Vol.20 No.7

In previous study, Overheating/heating performance was carried out through Test-cell measurement used by TI-wall(Transparent Insulation) system and Mass-wall system and the optimum composition of TI-wall system was proposed by simulation analysis in the Korean weather condition. The aim of this study was to analysis the Heating/cooling performance following the optimum composition of TI-wall used in residential building. The process of this study is as follows:1) The ESP-r simulation program was used in energy performance analysis and the reference model of residential building was made up to analysis energy performance on Ti-wall and Mall-wall system. 2) Standard weather file of seoul, Taejon, pusan and Cheju was made that was the format of simulation program(ESP-r). 3) The regional Heating/cooling energy performance was carried pit by suing regional standard weather file of TI-wall and Mass-wall system in residential building and the reduction of Heating/cooling energy with the change of wall size of per system was analyzed. 4) The energy reduction of TI-wall system of foreign country was compared with that of Korean. Consequently, when TI-wall is equipped with South Surface of Residential Building, annual Heating Energy of Building was cut down at the average of 79.1kwh/m²(Seoul:101.7kwh/m², Taejon:59.8kwh/m², pusan:99.5kwh/m², cheju:79.5kwh/m²) or 18% of total heating energy, Cooling energy increased the average of 15.15kWh/m², in the case of using Solar Shading Device and Air ventilation system, the cooling energy is not only increased by Ti-wall at the lever of 97%, the basic cooling energy is but also cut down about 6%.