Facile and fast Na-ion intercalation employing amorphous black TiO_2-x/C composite nanofiber anodes

Lee, Na-Won,Jung, Ji-Won,Lee, Jun-Seo,Jang, Hye-Yeon,Kim, Il-Doo,Ryu, Won-Hee Elsevier 2018 ELECTROCHIMICA ACTA Vol.263 No.-

<P><B>Abstract</B></P> <P>Structural and electronic modification of titanium oxide (TiO<SUB>2</SUB>) nanomaterials induced by the co-introduction of fully disordered glass phase and oxygen vacancies can lead to remarkable advances in the electrode performance in emerging energy storage systems. We report on the effective co-creation of fully amorphous nanofibers (NFs) composed of black TiO<SUB>2-x</SUB> and conductive carbons throughout the NF structure, and evaluate the materials as potential anodes in sodium-ion batteries. The black TiO<SUB>2-x</SUB> nanofiber is successfully fabricated by electrospinning a precursor solution followed by a two-step sequential thermal treatment in an air and reducing atmosphere. The NF electrode could deliver approximately two-fold higher 2nd discharge capacity and an excellent kinetic performance even under high rates compared to that delivered by anatase-structured white TiO<SUB>2</SUB> NFs used as reference, because of (i) an inherent free volume in the glass phase corresponding to the enlarged Na<SUP>+</SUP> sites, (ii) increased electrical conductivity (low bandgap) resulting from the presence of Ti<SUP>3+</SUP>, (iii) introduction of conductive carbon agents around the TiO<SUB>2-x</SUB> domain, and (iv) one-dimensional NF feature allowing numerous Na<SUP>+</SUP> reaction sites at the electrochemical interface. We also elucidate the morphological and structural changes in the nanofibers after discharge and charge by <I>ex-situ</I> characterizations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We succeed in co-creating amorphous nanofiber structure composed of black TiO<SUB>2-x</SUB> and conductive carbons. </LI> <LI> Black TiO<SUB>2-x</SUB>/carbon nanofibers are prepared by electrospinning followed by a two-step thermal treatment. </LI> <LI> Black TiO<SUB>2-x</SUB>/carbon nanofiber delivers excellent electrochemical performance compared to those of anatase TiO<SUB>2</SUB> nanofiber. </LI> <LI> The benefits and reaction mechanism of the black TiO<SUB>2-x</SUB>/carbon nanofiber anode in the Na-ion cell operation is elucidated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

De novo Hyponatremia in Patients Undergoing Peritoneal Dialysis: A 12-month Observational Study

( Hyun Hee Lee ),( Soo Jung Choi ),( Heon Nam Lee ),( Sun Young Na ),( Jae Hyun Chang ),( Woo Kyung Chung ),( Se Joong Kim ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.1

Purpose: Hyponatremia occurs infrequently in patients undergoing peritoneal dialysis (PD). Nevertheless, one must understand its pathophysiology, since the therapeutic strategy differs from that of non-PD-related hyponatremia. This study examined the clinical features of hyponatremia in PD and evaluated the factors that may contribute to its development. Methods: We retrospectively enrolled 51 normonatremic PD patients at Gachon University Gil Hospital, South Korea. Using the plasma sodium levels at month 13, the patients were divided into hyponatremia (Na+<135mEq/L) and normonatremia (Na+≥135mEq/L) groups. Then, the clinical variables of these patients were examined, including peritoneal function and adequacy tests, and biochemical parameters. Results: The de novo hyponatremia (n=8) and normonatremia (n=43) groups had no significant differences in baseline characteristics. At month 1, the serum albumin was lower in the hyponatremia group (p=0.022). In the peritoneal equilibration test analysis, the dialysate-to-plasma ratio for creatinine (D/Pcr) measured after 13 months differed significantly between the two groups (p=0.007), while the maximum dip in sodium did not differ. No significant differences were observed in the normalized protein equivalent of nitrogen appearance, Kt/V, or residual renal function. Conclusion: Our data suggest that the development of hyponatremia is associated with a lower initial serum albumin level and increased D/Pcr in patients undergoing PD. Therefore, the serum sodium levels should be monitored more carefully in these patients.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

골반경수술 146예에 대한 임상적 고찰

나준희,김용만,남주현,김영탁,김종혁,목정은 울산대학교 의과대학 1995 울산의대학술지 Vol.4 No.2

Pelviscopic surgery has been reported to have minimal tissue damage and bleeding, and to reduce cost and recovery time for patients undergoing a variety of procedures. The field of gynecologic operations that can be performed by pelviscopic procedures has expanded rapidly. This report is a retrospective review of 146 cases of pelviscopic surgery from January, 1991 to February 1996 to evaluate the efficacy of pelviscopic surgery in gynecologic patients. The results of this review were summarized as follows; 1. The majority of patients was between 21 and 40 years of age(84.2%), mean age was 33.1 years. 2. Preoperative clinical indications were adnexal mass 77 cases(52.7%), ectopic pregnancy 48 cases(33.9%), uterine myoma 9 cases(6.2%), and etc. 3. Types of surgery were salpingectomy 43 cases(29.5%), salpingoophorectomy 41cases(28.1%), LAVH 9 cases(6.2%) and etc. 4. The previous operation history was found in 34 cases(23.3%), and the type of previous operation were Cesarean section 11 cases(32.4%), appendectomy 10 cases(29.4%), and there were 5 cases of previous history of ectopic pregnancy. 5. The mean duration of hospitalization was 5.8 days.

Pseudomonas fluorescens의 Salicylate hydroxylase를 암호하는 유전자의 클로닝

정유선,민경희,이나리 숙명여자대학교 자연과학연구소 1997 자연과학논문집 Vol.- No.8

Pseudomonas fluorescens SME11로 부터 salicylate hydroxylase를 암호하는 nahG 유전자를 클로닝하기 위하여 NAH플라스미드를 주형으로 하여 PCR을 수행하였다. PCR방법으로 얻은 1.6kb DNA절편을 pT7Blue(R)벡터에 삽입시켜 재조합 플라스미드 pNY1을 제조하였으며 이것을 E. coli에 형질전환하였다. 재조합 DNA를 제한효소로 처리하여 EcoRⅤ, KpnⅠ, PvuⅡ, StuⅠ등이 존재함을 확인하였으며, 이것으로 간단한 제한효소지도를 작성하였고 재조합 DNA를 한 방향으로 deletion하여, nahG유전자를 포함한 DNA절편의 염기서열을 결정하였다. 재조합 플라스미드인 pNY1에는 1,305bp크기의 open reading frame이 존재하였으며, salicylate hydroxylase에 해당하는 434개의 아미노산을 암호하였다. 아미노산서열을 비교한 결과, P.putida KF715와 84.1%, P.putida PpG7과 71.4%, P.putida S-1 과 48.7%의 homology를 보였으며, 또한 Sphingmonas sp.와 26.8%의 homology를 보였다. Pseudomonas fluorescens SME11 carrying NAH plasmid was isolated from wastewater. To clone nahG gene encoding salicylate hydroxylase, 1.6kb DNA fragment of PCR product from NAH plasmid was inserted to pT7Blue(R) vertor and resulting recombinant DNA was named pNY1. The transformants, E.coli SMY1, clone containing the recombinant plasmid pNY1 were able to convert salicylate to catechol and produced dark brown color caused by accumulation and auto-oxidation of catechol. Restriction endonuclease mapping of 1.6kb size of the insert of the recombinant plasmid pNY1 was carried out with EcoRⅤ, KpnⅠ, PvuⅡ, StuⅠ. By means of unidirectional ExoⅢ deletion and dideoxynucleotide chain termination, we determined the nucleotide sequence of the DNA fragment containing nahG gene. One open reading frame of 1,305 bp corresponding to 434 amino acids was found in the insert DNA. Deduced amino acid sequences of the nahG gene showed 84.1%, 71.4%, 48.7%, and 26.8% homologies to those from P.putida KF715, P. putida PpG7, P. putida S-1, and Sphingmonas sp., respectively.

흰쥐 뇌줄기에 분포하는 Nitric Oxide Synthase 신경세포에 관한 면역조직화학적 연구

나준희,허영범,박찬,김정혜,유진화,안희경,이원규 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.2

진균 세포벽 형성 저해물질 생성 Streptomyces속 세균의 분리 및 수리동정

서원나,박정희,이지영,김인섭,이계준,배무 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

본 연구의 목적은 진균의 세포벽 합성을 저해하는 항진균 물질생성 방선균을 개발하는 데 있다. 다양한 환경으로부터 채취한 토양 시료로부터 방선균 선택 배지를 이용하여 860여 방선균을 선택적으로 분리하였다. 분리 균주 중 Penicillium cyclopium, Cryptococcus laurentii, Aspergillus flavus에 특이적 항균 활성 물질을 생산하는 균주 EMS4, EMP22, L234를 각각 선별하였다. 화학적 동정과 형태학적 동정을 통해 분리 균주들이 Streptomyces속 세균임을 알 수 있었다. 총 50개의 주군집, 34개의 부군집 형질을 분석하고, 이 실험 결과를 TAXON program에 적용하여 종의 수리동정을 실시하였다. 그 결과 분리균 EMS4는 Streptomyces의 제 61 주군집에 속하는 Streptomyces lavendulae의 한 균주로 동정되었고, EMP22는 제 1B 주군집에 속하는 S. willmorei의 한 균주로 동정되었으며, L234는 제 3 부군집의 S. aburaviensis의 한 균주로 동정되었다. The aim of the present research program wa to identify and develop stains of actinomycetes producing antifungal antibiotics which inhibit cell wall biosynthesis. 860 strains of Actionomycetes were isolated from various soil samples. Three isolates, EMS4, EMP22, and L234 were selected as the strains producing antifungal antibiotics inducing abnormal morphology against Penicillium cyclopium. Cryptococcus laurentii, and Aspergillus flavus, respectively. Taxonomic unit characters of the strains were tested and the data were analyzed numerically using TAXON program. EMS4, EMP22, and L234 were identified to be a member of Streptomyces lavendulae, Streptomyces willmorei, and Streptomyces aburaviensis, respectively.

메치실린 내성 황식 포도상구균(MRSA)에 대한 소독제 및 항생제의 살균력 효능

이희중,나영천,유석근,김동철,김신무 大韓成形外科學會 2002 Archives of Plastic Surgery Vol.29 No.6

메치실린 내성 황색 포도상구균(MRSA)에 대한 소독제 및 항생제의 살균력 효능

이화중,나영천,유석근,김동철,김신무 大韓成形外科學會 2002 Archives of Plastic Surgery Vol.29 No.6

진균 세포벽 형성 저해물질 생성 Streptomyces속 세균의 분리 및 수리동정

서원나,박정희,이지영,김인섭,이계준,배무 이화여자대학교 생명과학연구소 1996 생명과학연구논문집 Vol.7 No.-

본 연구의 목적은 진균의 세포벽 합성을 저해하는 항진균 물질생성 방선균을 개발하는 데 있다. 다양한 환경으로부터 재취한 토양 시료로부터 방선균 선택 배지를 이용하여 860여 방선균을 선택적으로 분리하였다. 분리 균주 중 Penicillum cyclopium, Cryptococcus laurentii, Aspergillus flavus에 특이적 항균 활성 물질을 생산하는 균주 EMS4, EMP22, L234를 각각 선별하였다. 화학적 동정과 형태학적 동정을 통해 분리 균주들이 Streptomyces속 세균임을 알 수 있었다. 총 50개의 주군집, 34개의 부군집 형질을 분석하고, 이 실험 결과를 TAXON program에 적용하여 종의 수리동정을 실시하였다. 그 결과 분리균 EMS4는 Streptomyces의 제 61 주군집에 속하는 Streptomyces lavendulae의 한 균주로 동정되었고, EMP22는 제 1B 주군집에 속하는 S. willmorei의 한 균주로 동정되었으며, L234는 제 3 부군집의 S. aburaviensis의 한 균주로 동정되었다. The aim of the present research program was to identify and develop strains of actinomycetes producing antifungal antibiotics which inhibit cell wall biosynthesis. 860 strains of Actinomycetes were isolated from various soil samples. Three isolates, EMS4, EMP22, and L234 were selected as the strains producing antifungal antibiotics inducing abnormal morphology against Penicillium cyclopium, Cryptococcus laurentii, and Aspergillus flavus, respectively. Taxonomic unit characters of the strains were tested and the data were analyzed numerically using TAXON program. EMS 4,EMP22, and L234 were identified to be a member of Streptomyces lavendulae, Streptomyces willmorei, and Streptomyces aburaviensis, respectively.