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이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
임성철,박상기,도남용,박상학,이승일,송창훈,박종 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1
There are many advantages and disadvantages under the limited bachelor's admission system. To diminish the demerits and to increase the merits of this system, the authors posed questions to the faculties and students of the Department of Medicine. Chosun University College of Medicine and other colleges in Korea. The questionnaire was made according to trends and feelings in this system. We received a lot of information and suggestions as to how to improve the system, in the following paper we discuss and report the prospective aspects of the bachelor's admission system.
하드 디스크 드라이브 회전축계의 유한요소 강제진동 해석
임승철 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-
In this paper, the methods to analyze various forced vibration responses are described with focus on hard disk drive spindle systems based on the finite element model. Among the numerical end results, the forced time response is expected useful for the vibration control of the spindle itself or the position servo control of the magnetic head. On the other hand, the steady state responses such as the frequency response function and the unbalance response are useful for system identification. Furthermore, through a certain coordinate transformation the equations of motion are also derived with respect to the inertial coordinate frame for convenient analyses of certain classes.
회전축계의 진동제어용 ER 유체 댐퍼의 설계 및 반능동 비례제어
임승철,채정재,박상민 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-
This paper is concerned with the design and application of an Electro-Rheological(ER) fluid damper to suppress vibration of rotor systems. The example system at hand is flexible with a slender shaft and a thin disk, being su pported by two ball bearings. In addition, to investigate the system performances also in the high speed range, the driving torque is made to transmit through a speed increasing gear train. Along with the experiments, to predict and compare the ER damper effect, the rotor system is simulated as to its free and forced vibration characteristics. Such simulations are done by means of a finite element analysis code, which includes the mathematical model of the designed ER damper.
임영도,설재훈,한창훈,김승철,박종오,이준탁,방석원 東亞大學校 附設 情報通信硏究所 1998 情報通信硏究所論文誌 Vol.6 No.1
This paper describes an intelligent cruise control system for automobile. With the remarkable numericalincrease of automobiles on the roal, the optimized traffic flow control using the cruise control is one of the very important traffic problems to overcome the limitation of an existing road capacity. Based onthis idea that minimize the fuel cost and teh air pollution, and accept a driver's needs for driving, we have developed an intelligent cruise control system for vehicle. This proposed intelligent fuzzy cruise controller was successfully implemented using the fuzzy algorithm, the i80c196 μ-controller board and the throttle valve actuator. The field test results on an linear road was introduced.
PID-FGS(Fuzzy Gain Scheduling)를 결합한 병렬제어기 설계
김승철,박종오,정영호,설재훈,임영도 東亞大學校 附設 情報通信硏究所 1999 情報通信硏究所論文誌 Vol.7 No.1
본 논문에서는 PID-FGS(Fuzzy Gain Scheduling) 제어기를 사용한 병렬제어기를 구상한다. PID 제어기는 산업현장에서 널리 쓰이는 제어기로서, 지금까지도 널리 사용되고 있다. 그러나 PID 제어기는 적응성이 없기 때문에 초기에 적절한 파라메터의 설정이 중요하다. 그에 반해 FGS는 초기에 많은 오차를 수반하지만, 시뮬레이션 동한 초기오차를 수정한다. 따라서 본 논문에서는 이러한 각 제어기의 장점을 취합하여 병력제어기를 구성하는 것이다. 그리고 본 논문에서 사용한 제어기의 성능을 평가하기 위하여 PID, FGS, PID-FGS 제어기의 각각의 시뮬레이션 결과를 살펴본다.
Ti-6Al-4V 합금의 피로특성-열처리, 온도, 주파수의 영향을 중심으로
김승한,김현철,임병수 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1
The effect of temperature, frequency and microstructure on fatigue crack propagation property of Ti-6Al-4V alloy has been investigated. The temperatures employed were room temperature, 200℃ and 400℃. The frequencies were 20Hz and 8Hz. The microstructures tested were equiaxed and bimodal microstructures. The bimodal microstructure was obtained by heat treatment of aging the quenched specimen for 1 hour at 500℃ which was solutionized in β-field at 971℃. Mechanical properties, fatigue crack growth rates were measured in different test conditions. From the experimental results, following conclusions were obtained. (1) Bimodal microstructure showed superior strength and fatigue crack growth resistance to equiaxed microstructure. (2) In all test conditions, fatigue crack growth rate increased with test temperature. (3) With the frequency decreasing from 20Hz to 8Hz, fatigue crack growth rate increased.