정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

감마선의 질량감쇠계수 측정

정원정,민영기,노태익 東亞大學校 大學院 2000 大學院論文集 Vol.25 No.-

The mass attenuation coefficients of gamma-ray were measured by fitting method through the transmission rate according to sample thickness. The gamma-ray Collimator was fabricated with lead for narrow beam. The standard gamma-ray source, 137Cs(0.662 MeV), 54Mn(0.835 MeV), 60Co(1.173, 1.332MeV) were used, and the sample, Pb, Cu, Sn, Al were used as attenuator. The lead shielded 2˝×2˝NaI(Tl) detector was used by gamma-ray spectrometer.

크레인용 유도전동기의 백터제어 시스템 개발

정태동,장국현,최명규,전태원 울산대학교 1996 공학연구논문집 Vol.27 No.1

지금까지 크레인의 Hoist및 Trolley 구동용으로 직류전동기를 사용하여 왔으나, 현재 벡터제어 유도전동기로 점차 대치되고 있다. 따라서 본 여눅에서는 이 크레인 구동용을로 적합한 유도전동기의 벡터제어 시스템을 제안한다. 유도전동기의 간접 벡터제어러우프및 전류제어 기법을 제시하고, 또한 정확하고 신속하게 콘테이너의 속도 및 위치를 제어하기 �∏�여러 제어기법을 기술하고 실제 실험을 통하여 그 효과를 확인하였다. The dc motor speed control systems have been used to drive the hoist and trolley of container crane, and however because of inherent demerits of dc motor, recently the vector controlled induction drive systems have replaced the dc motor speed drive systems as crane drive. In this paper the vector control system of induction is suggested, which is proper for the crane drive. The indirect vector control loop and current control method are suggested, and several control strategies are proposed in order to control accurately and fastly the velocity and position of container. Through experminets, the good performance of proposed system is verified.

농촌인의 체격 및 체력 실태에 관한 연구

정성태,장창현,전태원 師範大學 體育硏究所 1993 서울大學校 體育硏究所論集 Vol.14 No.2

The purpose of this study was to investigate the physique and physical fitness of the rural area adults. To accomplish this purpose 202 adults were drawn from 4 different rural areas such as Chungnam, Junbook, Kyoungbook, and Chungbook, and their physique and physical fitness were measured. The data from these people were compared with those of 114 Seoul residents. The findings of this study were as followings; physique 1. The heights of rural area adults were shorter than those of urban area adults by about 4cm, and their heights tended to reduce by 2cm every 10 year as they got older. 2. The weights of rural area male adults were lighter that those of their urban counterparts by about 6kg ; rural area female adults were also lighter than their urban counterparts by 10kg. 3. The sizes of waist girths of both the rural area adults and urban area adults tended to increase after their 40s. physical fitness 1. There was no significant difference of grip strengh between rural and urban area male adults; rural area female adults exhibited stronger grip strengh than their urban area counterparts by about 4kg. 2. There was no significant difference of sit-up performance between rural and urban area male adults; rural area female adults showed weaker sit-up performance than their urban counterparts. 3. There was no significant difference of trunk bending performance between rural and urban area male adults; rural area female adults showed more flexible trunk bending performance than their urban counterparts.

상수도관의 노후도에 대한 환경영향인자의 상관성 분석

정원식,이현동,김이태,유명진 대한상하수도학회 2003 상하수도학회지 Vol.17 No.2

This study is performed to evaluate the correlation of environmental factors for drinking water pipe deterioration using statistical analysis such as multiple regression, cluster analysis, discriminant analysis, and the adequacy and dependability of grouping factors used to deterioration prediction model. Results of this study are presented that high correlation related to pipe deterioration is showed not laying year of pipe but characteristic of surrounding area and analysis of chemical components. Therefore, major influence factors of pipe deterioration for types of cast iron pipe are product quality of pipe, environmental factors using pipe deterioration evaluation model is classified to 4 types such as group related to pipe body and to hydraulic & water quality, and to characteristics of surrounding area, and to trouble & discontent of customer. And the very high adequacy of group classification is represented that the applied grouping items in this study are agree to previous studies.

운동생리학 연구의 역사와 과제

정성태,전태원 한국체육사학회 2000 체육사학회지 Vol.6 No.-

The reviews of the developmental history and issues of exercise Physiology have reached to following four suggestions. 1. For the development of exercise physiology, it is necessary to secure specialilst and research facilities and appratus. 2. It is necessary to establish research structures for an educational-industrial complex. 3. The creative academic atmosphere is need to be raised to develop our own unique exercise physiology and exercise science through development of new theories and basic science. 4. It is necessary to joint study with adjacent science for communication of exorcise physiology or exercise science in terms of domestic aspects. It is necessary to change our communication channels from America to Japan or other Europerian nations.

태권도 품새 수련이 아동의 심박수, 심근산소소비량, 에너지 대사에 미치는 영향

정성태,전태원,박익렬,정덕조,우재홍,이광희,이동기,강현주 서울대학교 체육연구소 2000 서울大學校 體育硏究所論集 Vol.21 No.1

The Taegeuk Poomse 1 through 8 of Taekwondo are based upon eight major branches of philosophical theories. The propose of this study was to investigate the nfluence of Taekwondo poomse trainning on heart rate, MVO2, energy metabolism in primary school students. Subjects for this study were eight male the fifth∼sixth grades students who participated in exercise program consist of Taekwondo poomse trainning in dojang which is located in Shinlim-2dong, Kwanak-Gu, Seoul(12.7± 0.5years, 150.8 ±4.6cm, 45.1 ± 9.4kg, 24.9 ± 9trainning length). The results of thet this study are as follows: 1) The average of heart rate was Taegeuk Poomse 1 through 8 of Taekwondo 90.57± 4.gbeats/min in rest and 139.7 ± 17.5beats/min in exercise. The minimum heart rate was 89.0±2.8, peak heart rate was 167.1 ±6.4 in exercise. It was ranged from 42% to 80% 2) of the max heart rate and ranged 42 to 65%HRmax. Taegeuk 1 Jang was differenced with others Jangs significantly(p<0.05), 2) The time of the Taegeuk 1 through 8 Jang of Taekwondo was 5minutes 12seconds. Heart rate was ranged from 90.6 ± 7.85beats/min to 171.8 ±8.Ibeats/min and increased linearly. 3) The average of the MVO2 was 11.1 ±0.78mmHg · bpm-3 in rest and 19.1 ± 1.2mmHg ㆍbpm-3 in exercise. MVO2 was ranged from 10.5mmHg · bpm-3 to 20.3mmHg · bpm-3. There were not difference between Taegeuk Poomses(p<0.05). 4) The energy metabolism was as follows: Mean VO2 Respiratory exchange ratio, energy consumption were 0.51(V02L/min),0.71(RQ),2.32Ckca1/min) in rest respectively. but In exercise Mean VO2 Respiratory exchange ratio, energy consumption were 0.89 ± 0.18( V 02L/min), 0.79±0.08(RQ), 4.26±0.51(kcal/min) respectively . The difference was only between Taegeuk 1 Jang and Taegeuk 3 Jang(p<0.05). This study showed that the Taekwondo Poomse trainning was proper exercise for fitness, body composition and weight control in normal, abnormal(obese) children because the Taekwondo trainning are dynamic and exciting sport.

標識鳥에 依한 韓國産 철새集團의 季節的 分布와 그의 生産(Ⅱ)

元炳旿,禹漢貞,具太會,尹茂夫 慶熙大學校 1969 論文集 Vol.6 No.-

Seasonal distribution and ecology of migrant bird populations were studies by mist-netting and banding primarily in the area of Kyunggi-do, Korea during 1967―1968. 1. From 1 January 1967 to 31 December 1968, a total of 57,087 birds of 105 species were banded in Korea. 527 (237 returns) recoveries have been reported in Korea(outside of baning sites) and 26 recoveries of 7 species from abroad. 2. Through a nationwide preliminary survey on the colonial breeding sites of Ardei dae, 14 breeding colonies were found, and, as a result counted 6340 birds of 5 species and 1580 nestling banded. (See Table 3,4 and Fig. 1). 3. Band returns of the House Swallow banded the previous year obtained within Kyunggi-do, showed that the percentage of returns was 5.66% of 1694 adults and 0.66% of 8600 nestlings. Although the returns are invitably lower than the actual number banded, some tendency as to age is indicated, (Table 12). 4. Based on 208 recoveries at nesting and at roosting sites, the distance beween the two was within a radius of 25㎞. (see Fig. 2 and Table 14). 5. An analysis of age composition and ratio sex of some migrants, and their body wieghts.

국내 최초 보툴리누스 중독증 발생 1예

정경태,강도현,유천권,최종현,성원근 대한임상미샐물학회 2003 Annals of clinical microbiology Vol.6 No.2

인천경제자유구역 물류용지 규모산정 및 역할에 관한 연구 : 영종지구 공항물류단지를 중심으로 Incheon Free Economic Zone

정태원,박영태 한국물류학회 2006 물류학회지 Vol.16 No.1