정신분열병 환자들의 自己灣入에 관한 예비 연구

박성봉,김영미,전성일,이기철,김영훈,정영조,이영렬,이정호,최영민 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.6

목 적 : 정 신분열병 환자의 자기만입 정도에 영향을 미치는 인구학적 변인들 및 질병연관 변인들을 규명해 보고자 하였다. 또한. 환자들의 자기만입과 병식 사이의 연관성. 자기만입과 자존심 사이의 연관성을 알아보고자 하였다. 방 법 : 정신과 의사가 병록지와 면담을 통하여 대상 정신분열병 환자들의 인구학적 변인들 및 질병연관 변인들에 관한 자료를 얻고 환자들의 병식 정도를 평가한 후, 환자들로 하여금 자기보고형의 자기만입 척도와 자존심 척도를 시행하게 하였다. 총 111명의 환자가 연구대상으로 선택되었다. 결과: . 1) 여자가 남자보다 유의하게 높은 자기만입 척도 점수를 나타내었다 2) 질병연관 변인들 중 하위집단 사이에 자기만입 척도 점수의 유의한 차이를 보이는 변은 없었다. 3) 자기만입 척도 점수와 병식 점수 사이에 유의한 상관관계가 없었다. 4) 자기만입 척도 점수와 자존심 척도 점수 사이에 유의한 역상관 관계를 보였다. 결 론 : 본 예비 연구의 결과로 보아 정신분열 병 환자의 병식이 부족한 상태에서도 자기만입이 진행될 수 있으며. 자기만입이 심할수록 환자의 자존심이 저하되는 것으로 생각된다. 또한 여자 환자들이 남자 환자들보다 자기만입에 더 취약한 것으로 생각된다. 따라서 정신분열 병 환자의 이해와 치료를 위하여 자기만입에 관한 지속적인 연구가 필요할 것으로 생각된다. objective : This study was conducted to identify demographic variables and illness related variables which may affect the severity of self-engulfment in the patients with schizophrenia. We also studied the relationship between self-engulfment and insight, and the relationship between self-engulfment and self-esteem. Methods : Data on demographic variables and illness related variables for the subjects were gathered from hospital records and clinical interviews by the psychiatrists. Degree of insight for the subjects was assessed through clinical interviews by the psychiatrists. Degree of self-engulfment and self-esteem for the subjects was assessed from the self-engulfment scale and the self-esteem scale respectively. A total of 111 patients with schizophrenia were selected for statistical analysis. Results 1) The females exhibited significantly higher scores than the males on the self-engulfment scale. 2) There was no illness related variable, which exhibited a significant difference among subgroups on the self-engulfment scale. 3) There was no significant correlation between the self-engulfment scores and the insight 4) There was a significantly inverse correlation between the self-engulfment scores and the self-esteem scores. Conclusion : The results of this preliminary study suggest that self-engulfment may develop despite lack of insight and that there was inverse relationship between self-engulfment and self-esteem in the patients with schizophrenia. It also suggests that females are more subject to self-engulfment than males. So, authors suggest that it is valuable to do further studies of self-engulfment in the patients with schizophrenia.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

백서 치아 발거후 잔존 치주인대가 발치와의 치조골 재건에 미치는 영향

조성훈,허익,박준봉,이만섭,권영혁 慶熙大學校 齒科大學 1995 慶熙齒大論文集 Vol.17 No.2

The purpose of this study was to observe the effects of the periodontal ligament on the healing and the formation of alveolar bone in the extraction socket, when this ligament had artificially remained in the socket during the tooth removal. Twenty rats aged 4 weeks were used and devided into the control groups (10) and the experimental groups (10) in this study. The maxillary right and left first molars were extracted in both groups. In the experimental groups the periodontal ligament was remained in the extraction sockets using 0.4% fl-aminopropionitrile, and in the control the periodontal ligament was completely removed by curettage. At 1, 3, 5, 7 and 14 days after the tooth extraction, rats in both groups were serially sacrificed. And the specimens were prepared with HematoxyIin-Eosin stain for the light microscopic evaluation. The results ofthis study were as follows ; 1. On 1 day, the periodontal Iigament was only found in the extraction socket walls of the experimental groups, and there was not the distinguishable difference between the control and the experimental groups. 2. On 3 days, there were more collagen fibers and the appearance of higher cellular density in the experimental groups than in the control. And the cells and collagen of the periodontal ligament were so actively proliferated and synthesized that invaded into the connective tissue of the extraction sockets in the experimental groups. 3. In the experimental groups, the trabecular bone was formed on the basal and lateral bone surface on 5 days. However, there was not the new bone forming appearance in the control groups at this time. 4. On 7 days, the trabecular bone was formed in the control groups. 5. On 14 days, the extraction sockets were almost entirely filled with the bony trabeculae in both groups. But, compared to the control group, the experimental groups showed the prominent differences in the amount & the density of the new bone formed. In conclusion, it was suggested that the residual periodontal ligament tissue in the extraction socket will play a major role as the important cell source in the healing and the new bone formation of the extraction socket.

과일과피로부터 폴리페놀 분리에 따른 생리기능연구

안봉전,이진태,곽재훈,박정미,이진영,박태순,손준호,최청 경산대학교 생명자원개발연구소 2003 생명자원과 산업 Vol.7 No.-

Biological activities and anticarcinogenicity of Korean Pear peel were investigated. Electron donating activity and superoxide dismutase(SOD)-like activity of fraction Ⅱ, Ⅲ were up to 90% and 50-60% at 50ppm, respectively. Inhibitory effects on xanthine oxidase were about 80% at 50ppm, breast adenocarcinoma was about 60% at 2,000 ppm, higher Ⅲ than Ⅱ. Inhibitory effect on prostate adenocarcinoma was about 23% at 500 ppm. In conclusion, Korean Pear peel was expected to use as a functional material.

파손된 치면열구전색제의 수리 방법에 따른 미세누출 비교

강명봉,현홍근,김영재,김정욱,장기택,이상훈,한세현,김종철 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.2

치면열구전색은 수 십년간 교합면 우식의 예방에 가장 효과적인 방법 중 한가지로 알려져 왔다. 하지만 치면열구전색제의 마모와 파절 때문에 치면열구전색제의 재시술 또는 수리를 필요로 하게 되었다. 본 연구의 목적은 파손된 치면열구전색제를 수리할 때 치질과 잔여 전색제의 표면처리 방법에 따른 미세누출 차이를 알아보고자 하는 것이다. 120개의 영구 대구치에 치면열구전색제를 적용하고 인위적인 파손을 만든 뒤 인공타액에 4주 동안 보관하였다. 4주 후 근심 또는 원심의 치면열구전색제가 완전히 파손 양상을 나타내는 치아 60개를 선택하여 각각 15개씩 4개 군으로 나누어 실험에 사용하였다. 각 군을 산부식만 시행한 경우(1군), air-abrasion만 시행한 경우(2군), 산부식 후 결합제를 적용한 경우(3군), air-abrasion 후 결합제를 적용한 경우(4군)로 나눠 각각의 치아를 표면처리한 후 치면열구전색제를 도포하였다. 고온(55℃)과 저온(5℃)에서 각각 30초씩 500회의 열순환을 시행한 뒤 미세누출도를 검사하여 다음과 같은 결과를 얻었다. 1. 치면열구전색제/치면열구전색제 경계면에서 미세누출도는 결합제 사용 유무에 관계없이 air-abrasion을 처리한 2군, 4군에서 산부식을 사용한 1군, 3군보다 낮은 값을 보였고(p<0.05) 1군과 2군, 3군과 4군 사이에는 통계적 유의차가 없었다(p>0.05). 2. 치면열구전색제/치아 경계면에서 미세누출도는 결합제를 사용한 3군, 4군에서 결합제를 사용하지 않은 1군, 2군보다 낮은 값을 보였고(p<0.05) 산부식을 사용한 1, 3군과 air-abrasion을 사용한 2, 4군 사이에는 통계적 유의차가 없었다(p>0.05). 3. SEM 상에서 치면열구전색제를 산부식 처리하였을 때 표면거칠기의 증가가 적었으나 air-abrasion 하였을 경우 표면거칠기가 현저하게 증가하는 것을 관찰하였다. The aim of this study was to investigate whether differences in surface treatment Prior to repair influenced the seal of a resin fissure sealant placed on the occlusal surfaces of permanent molar teeth. One hundred and twenty extracted human molars were selected and a light curing sealant was placed on their occlusal surface following cleaning by prophylaxis and acid etching. The teeth were deliberately damaged, and then stored in artificial saliva for four weeks. Sixty teeth with the desired morphology of sealant failure were randomly divided into four groups where one group was treated with only etching agent, another by only air-abrasion, another by applying an etching agent followed by a bonding agent, and the last by air-abrasion followed by a bonding agent each. After sealant application, the samples were thermocycled and the degree of microleakage was determined. The results were as follows: 1. In the sealant/sealant interface, group 2(0.22), 4(0.23) using air-abrasion showed a significantly lower microleakage score than group 1(0.38), 3(0.35) using an etching agent(p<0.05). There were no statistically significant differences(p>0.05) between groups 1, 2 and groups 3, 4. 2. In the sealant/tooth interface, group 3(0.20), 4(0.20) which used a bonding agent showed a significantly lower microleakage score than group 1(0.35), 2(0.40)(p<0.05). There were no statistically significant differences (p>0.05) between groups 1, 3 and groups 2, 4. 3. In SEM examination, while sealant surfaces treated with etching did not result in highly rough surfaces, those treated with air-abrasion did show rough surfaces.

DSC를 이용한 인듐, 주석, 아연의 열물성 측정 시 승온속도와 분위기의 영향

강종봉,조범래,하영훈 경남대학교 신소재연구소 1999 論文集 Vol.11 No.-

시차주사열량계(DSC)를 이용하여 인듐, 주석, 아연의 융점과 용율열의 차이를 조사하였다. 승온속도는 5, 10, 그리고 20℃/min으로 하였고, 분위기 가스로는 아르곤, 질소, 그리고 건조공기를 사용하였다. 인듐의 경우는 융점은 질소와 공기 분위기에서 5℃/min의 승온속도에서, 용융열은 20℃/min의 승온속도에서 아르곤 분위기에서 문헌 값과 유사하게 나타났다. 주석의 경우는 융점과 용융열이 5℃/min의 승온속도에서 공기 중 분위기에서 문헌값과 유사했다. 아연의 경우는 융점은 5℃/min의 승온속도에서 공기 중 분위기였고, 용융열은 10℃/min에서 아르곤 분위기에서 유사하게 나타났다. 이 실험에서는 승온속도가 증가할수록 융점이 증가하는 것으로 나타났고, 분위기보다는 승온속도에 더 영향을 받는 것으로 나타났다. Indium, Tin, and Zinc were used to investigate the differences of the melting point and heat of fusion by the Differential Scanning Calorimeter (DSC). The heating rates were 5. 10, and 20℃/min, and the purging gases were Ar, N₂. and Air. The best results comparing to reference were obtained at the following conditions: for T_{m} of Indium, 5℃/min heating rate in N2 and Air atmosphere. for AH of Indium, 20℃/min heating rate in Ar: for T_{m} and AH of Tin. 5℃/min heating rate in Air atmosphere: for T_{m}, of Zinc, 5℃/min heating rate in Air atmosphere. for ΔH of Zinc. 10℃/min heating rate in Ar. In this study, as the heating rate increased. the melting point increased all samples. The melting point and heat of fusion were more influenced by the heating rate rather than by purging gas for all samples.

선형유도전자펌프내의 자기유체 유동에 관한 수치적 연구

최훈기,유근종,박태봉,은재정,장남영 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

Numerical analysis is performed for magnetic and MHD flow fields in Electro-Magnetic(EM) pump. A finite volume method is applied to solve magnetic field governing equations and the Navier-Stokes equations. Vector and scalar potential methods are adopted to obtain the electric and magnetic fields and the resulting Lorentz force in solving Maxwell equations. The magnetic field and velocity distributions are found to be influenced by the magnitude of the Reynolds number and the phase of applied electric current. Computational results indicate that the magnetic flux distribution with changing phase of electric current is characterized by a pair of counter-rotating closed loops. The velocity distribution of the flow field is influenced on the intensity of Lorentz force.

한국산 약용식물의 화장품천연소재로서 응용에 관한연구

안봉전,이진태,이순애,곽재훈,박정미,이진영,박태순,손준호 경산대학교 생명자원개발연구소 2003 생명자원과 산업 Vol.7 No.-

Biological activities and application of sanguisorbae officinalis L. were investigated. In the enzymological physiological activities, the electron donating ability(EDA) was 54.92% in 10 ppm and it was over 90% over 50ppm and SOD-like activity was high as 65.36% in 1000 ppm, it was gradual increased. As inhibitory effect of xanthine oxidase, it was 17.90% in 200 ppm and a little low as 36.89% in 500 ppm and inhibitory effect of tyrosinase, it was a little low as 20.45% below 1000 ppm. As the result of measuring the lipid oxidation, all the concentrations of medical ion treatments had the ability to keep it from acidification and metal ion blocking effects about the lipid oxidation promoting factors(Fe^(2+) and Cu^(2+)), Fe^(2+) was better than Cu^(2+) and all concentrations of medical ion treatments was 40% in 50ppm. When it was applied into normal skin-softener it showed safe effect so that we can expect that as the natural material of cosmetics.

휘트니스 센터의 서비스 품질이 고객만족과 재구매 의도에 미치는 영향

김정훈,노영태,김성호,서봉한 釜山大學校 附設 體育科學硏究所 2004 體育科學硏究所 論文集 Vol.20 No.-

The purpose of this study was fitness club's services quality, the satisfaction of client, the record re-purchasing of client, to check connection was to supply primary data which was new clients occurred and the clients satisfied....

사후분해 시체에 대한 법의학적 접근

최영식,이상용,김유훈,조갑래,이봉우,양경무,정낙은,서중석,이한영,이원태,강현욱 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

Disposal of a homicide victim by dismemberment is rare, but individual cases are on record in most major medicolegal departments. Recognition of postmortem mutilation may be of importance in the interpretation of certain murders committed by sexual perverts and other mentally deranged individuals and sometimes performed for the sole reason of easier disposal of the body. Postmortem dismemberment is usually readily recognizable as such; The edges of the injuries are dry and lack evidence of bleeding. The joints may be disarticulated without fracture, or the use of an axe or saw may be evident from examination of bones. Parallel horizontal or oblique furrows in the bone surface are caused by skipping of the saw prior to establishing depth. Such patterns on the bone may assist in identifying the particular saw involved. So we report 25 dismembered corpses that autopsied in National Institute of Scientific Investigation. This paper can help in attempting to establish not only the first criminal investigation steps but also the medicolegal approach methods in unidentified and dismembered deaths.