정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

보조자극분자를 이용한 암치료

장미라,윤희령,성인옥,정상원,김용찬,손정희,이혜영,강광일,백상기,김영상 충남대학교 생물공학연구소 2002 생물공학연구지 Vol.8 No.1

Tumor cells express tumor-associated antigen which can be target to the cytotoxic Tlymphocytes. CTL precursor activation requires antigen recognition and cytokine help from Th cells. In this pathway, the cross-presentation mechanism, professional antigen presenting cells first pick up tumor antigen and present the antigen to Th cells. Another pathway is to activate CTL precursor by the direct priming. The tumor cells, however, lack costimulatory signal, which is required for full activation. The lymphocytes recognized specific antigen without costimulatory signal resulted in anergy. Tumor cells engineered to express the costimulatory molecules are better immunogen and induce antitumor immunity. We will discuss the recent progress in tumor therapy using the costimulatory molecules on the basis of the direct priming mechanism.

탈아세틸화된 키틴이 백서 창상치유능에 미치는 영향

정상훈,조용남,조용우,고석원,위성신,유걸 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.5

Chitin and chitosan, polysaccharides made up of polymeric N-acetly glucosamine and D-glucosamine, are widely found in nature, forming the skeletons of crustaceans and insects, as well as the components of bacteria cell walls. Chitin and chitosan have been known to have many useful biological properties such as biocompatibility, biodegradability, antimicrobial activity, and wound healing. There properties have been known to be different depending on the degree of deacetylation of chitin, but it has not yet been fully evaluated. The purpose of this study was to evaluate the wound healing effect by the degree of deacetylation. Full-thickness skin incision was made on the backs of Sprague-Dawley rats. Three concentrations of powder, comprising 90% chitin, 50% chitin and 10% chitin, were separately embedded in the wounds of 3 rat groups. The wound-breaking strength and the collagen-hydroxyproline content of the skin at the wound sites were measured and histological examination was performed at postoperative 3, 7, and 10 days. The 50% chitin group had the highest tensile strenght of all groups. But the 50% chitin and 90% chitin groups had the lowest collagen hydroxyproline levels among all groups. The wounds treated with 50% chitin powder were completely reepithelialized and granulation tissue in the wound was observed 7 days after initial wounding. The arrangement of collagen fibers in the skin was ordered and similar to normal skin The 50% chitin powder is considered to be the most efficient wound healing accelerator among different concentrations of chitin powder.

持株會社論

鄭容相 釜山 外國語 大學校 1999 外大論叢 Vol.19 No.4

The purpose of this study is to find out desirable types of holding companies to fit each and every company through the analysis of the effects of various types of holding companies. Administrative effects imply merits, demerits and problems on holding company in relation to the restructuring of companies to accomplish more effective administration. legal effects imply the influence of lifting of a ban of holding company in An t i-Monopoly Law. And they apply to other laws, for instance, corporate law, securities exchange law, labor law, tax law, bankruptcy law and regulation law etc. Especially in corporate law, several difficult problems may be traced in articles of incorporation, methods of foundation, systems and the protection of shareholders and creditors of holding company or subsidiaries etc. And studies definition and the types of holding companies including the pure holding company and the operating holding company. And also analysis the merits, demerits and several administrative problems on holding companies, and find out which one is most suitable form to each company to obtain maximum utilities in administration. This thesis will provide some useful suggestions to settle administrative and legal problems.

La₂ O₃를 첨가한 Pb(Zr,Ti)0₃자기의 유전특성에 낟알 크기가 미치는 효과

金顯男,鄭相九,宋龍鎭 亞洲大學校 1986 論文集 Vol.9 No.-

Pb(Zr??Ti??)O₃ + lmol%La₂O₃ ceramics of which the mean grain sizes were 2.5, 2.8, 3.5μm respectively were prepared. The dielectric constant and the dissipation factor of them with evaporated gold electrodes were measured as a function of temperature. As the grain size decreases, the Curie temperature T?? increases slightly, the peak height of the dielectric constant curve decreases, and the peak width of the dielectric constant curve increases. The dielectric constant at room temperature remains constant regardless of the grain size. A model was followed which proposeds that each grain has a different phase transition temperature T?' and the distribution of T?' follows the Gaussian distribution. It was also assumed that each grain follows the Curie-Weiss law for T>T?' The relevant parameters were determined by the least square fit method by computer calculation. The above experimental results were explained by this model, and the variations of the parameters due to the variation of grain size were discussed. The dominant factor for the grain size e fects seems to be the inhomogeneity of the concentration of impurities.

산·염기 변화가 집토끼 유두근 막전압에 미치는 영향

정부근,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1983 中央醫大誌 Vol.8 No.1

The effect of acid-base on the electrical and mechanical properties of myocardial cells were investigated in the isolated right ventricular papillary muscle preparations of rabbits by measuring simultaneously isometric contraction and the action potential by glass microelectrode transducer in acidic or alkali conditions respectively. Results were as follow : 1. The acid condition decreased the isometric contraction and at the sametime increased the time to repolarize 90% of its action potential amplitude.(Repol 90%) from 234±9.1 msec of the control to 244±6.8msec(P<0.01). 2. The alkali condition, on the other hand, increased the isometric contraction and lengthened Repol 90% from 256±49.3 msec of the control to 286±75.2msec(P<0.1) but Repol 95% lengthened more prominently from 281±66.8msec of the control to 329±101.5(P<0.05). The above result suggests that acid and alkali decreased and increased slow inward current respectively to reduce and augment the isometric contraction. In acidic condition, the reduction in delayed outward current might also play a role in augmented action potential duration.

Optical Conherence Tomography를 위한 광 헤테로다인 간섭계의 원리 및 구성

정태호,박양하,오상기,김용평 慶熙大學校 레이저 工學硏究所 2002 레이저공학 Vol.13 No.-

Optical Coherence Tomography is a new medical dianostic imaging technology which can perform micron resolution cross-sectional or tomograpic imaging in biological tissue. Basically, Optical Coherence Tomography used the interference effect of Michelson interferometer. In this paper, we analyze the Optical Coherence Tomography system.

다발성 골수종으로 이행한 단일형질세포종 1예

정재용,모성환,기장도,문철호,김창욱,전용준,박유환,정춘해,오윤경 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

직무스트레스가 실업에 미치는 영향

정윤경,김형렬,박소영,홍정연,고상백,장세진 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.2

잔대(沙蔘)의 優良品種選拔에 관한 硏究

鄭大守,李龍鎬,朴尙奎 東亞大學校 1998 東亞論叢 Vol.35 No.-

These experiment were conducted to investigate the growth and characteristics of Adenophora triphylla DC, and to investigate of the seed germinationand rate and morphological characteristics of leaf and flower in the genus of it. The results were as follows. Germination rate of Adenophora triphylla DC was 87.2% and Among Adenophora species investigated, plant height, stem length, leaf number and rooting rate of A. divaricata var. manshurica Kitagawa were greatest. Flower stalk length of A. triphylla var. japonica hara was the large flower, while A. divaricata var. manshurica Kitagawa was small.