정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Benzo(a)pyrene에 의해 유도된 간기능 장해에 미치는 세신 추출액의 영향

정영건,권오진,윤수홍,이송애,이주영 효성여자대학교 부설 한국환경위생연구소 1993 환경위생연구 Vol.3 No.1

탄소화합물의 불완전 연소 및 열분해에 의해 생성되는 다환방향족 탄화수소로 간 실질세포에서 cytochrome P_450에 의해 산화되는 간장해 물질인 benzo(a)pyrene으로 유도한 rats의간독성 발현에 미치는 세신 수침액의 예방 및 치료 효과를 실험한 결과 세신 수침액의 투여는B(a)P 투여로 현저하게 증가된 혈청 및 간장의 transaminase 활성을 유의성 있게 감소시켰으며 그효과는 조직에서 보다 우세하였다. 그러나 세신 수침액이 B(a)P투여로 증가한혈청 total cholesterol과 phospholipid 함량을 감소시킬 수는 있었지만 그 효과는 약하여 지질대사에는 세신의 작용이 미미할 것으로 보인다. Effects of Asiasari Radix, which is herbal drug used frequentlyin the oriental prescriptions, water extract on the liver-protective activities wereinvestigated in the rats. Asiasari Radix water extract, when administered intothe gastric intubation, produced liver-protective effect against benzo(a)pyreneinduced liver damage. The results obtained from enzyme assay, measurement of serum and liveralanine aspartate aminotransferase(AST, ALT) and lipid composition indicatedthat Asiasari water extract showed significant liver-protective activities againstbenzo(a)pyrene-induce hepatotoxicity.

교정학적 적용을 위한 초내식성 스테인리스강의 특성

오근택,김금진,황충주,박용수,김경남 大韓齒科器材學會 2001 대한치과재료학회지 Vol.28 No.3

Various kinds of orthodontic appliances have been developed for ideal tooth movement during orthodontic treatment. The orthodontic appliances made of metals are bands, arch wires, brackets and miniscrews as orthodontic anchorage. Generally, these appliances are made of stainless steel, pure titanium, Ni-Ti and TMA with the proper biocompatibility. However, localized corrosion of these materials can frequently occur in the particular environment. Super stainless steels, recently developed, have good corrosion resistance to reduce metal ion release induced by many kinds of corrosion. Recently, it has been reported that nickel ion release from orthodontic appliances affect the prevalence of nickel sensitization; however, there has been some controversy about nickel hypersensitivity to orthodontic appliances containing nickel. The purpose of this study was to evaluate and compare the microhardness, nickel ion release, corrosion resistance and cytotoxicity of 4 types of super stainless steels and 316L stainless steel as the control group according to nickel contents, and to determine the acceptability as the new material for various kinds of orthodontic appliances. All super stainless steels showed higher microhardness than 316L stainless steel, SR-3Mo showed especially the highest microhardness. In anodic polarization test, corrosion resistance was high in order of SR-50A, SFSS, SR-6DX, 316L stainless steel, SR-3Mo. There was no increase in nickel ion release from SR-50A, SR-6DX, 316L stainless steel with immersion time in artificial saliva; whereas there was some increase from SFSS and SR-3Mo with immersion time. All super stainless steels showed very low cytotoxicity regardless of nickel contents although SR-3Mo showed relatively higher cytotoxicity than the others. It is concluded that SR-50A among super stainless steels has the highest corrosion resistance and biocompatibility. It is undesirable to consider the alloys with high nickel content to release lots of nickel ion.

초내식성 스테인리스강 선재와 브라켓의 내식성 및 금속 이온 용출 특성

오근택,정경진,황충주,박용수,김경남 大韓齒科器材學會 2001 대한치과재료학회지 Vol.28 No.4

Metallic orthodontic appliances are known to release metal ions in an oral cavity. It is not advisable that toxic corrosion products derived from the appliances is absorbed into the body. Metal ions release from orthodontic appliances is known to have large effects on the result of orthodontic treatment and systemic health. Metal bracket and wire were made of super stainless steel(S32050) with high corrosion resistance. The corrosion resistance and ion release property of S32050 and conventionally used appliances were examined. Four types of wire were ligated in either super stainless steel(SB) or Tomy bracket(TB) with O-ring, and then each group was immersed in an artificial saliva at 37℃ for 12 weeks. Amount of released metal ions was measured with immersion time by graphite furnace atomic absorption spectroscopy and surface morphology was investigated. S32050 showed the low passive current density of about 1 μA/㎠ and the stable passive region to a high potential in artificial saliva. S32050 appliances did hardly release nickel ions in artificial saliva. S32050 wire(SRW) and NiTi wire(NW) didn't show significant difference of Ni ion release with immersion time, meanwhile, Remanium wire(RW) showed significant difference in 12 weeks. Ni ion releasce from the brackets didn't show any significant difference with immersion time and between SB and TB. Amounts of Ni ion released from TB-SRW showed significant difference in 12 weeks, those from TB-RW showed significant difference from 4 weeks later and highest release among all groupsin12weeks. TB-NW released little Ni ion for all immersion time and showed significant difference from 4 weeks later, TB-TW(TMA wire) showed significant difference in 12 weks. SB-SRW didn't show any significant difference and SB-RW signigicant difference in 12 weeks,but lower compared with TB group. SB-NW and SB-TW didn't show any significant difference. Corrosion products didn't be observed in mostly groups during the immersion time, except that in TB-RW, they were observed on the bracket surface between O-ring and wire from 8 weeks later. Super stainless steel wire had good corrosion resistance compared with stainless steel wire, and it is believed that it can be used as orthodontic material for bracket and wire.

정신지체 및 청각장애학생의 花色선호에 관한 연구

정진자,오찬교,김은일 韓國植物ㆍ人間ㆍ環境學會 1999 인간식물환경학회지 Vol.2 No.3

This study is an investigation of mentally retarded and hearing impaired students about their preferential flower colors after showing flowers and interview. The aim of this study is getting fundamental data for introduction of gardening therapy. The results indicate that they had different preference for flower colors according to kinds of handicap. Color preference differed according to the age of subjects and kinds of objects.

식육에서 분리한 Enterobacteriaceae의 분포에 대하여

정영건,권오진 효성여자대학교 부설 한국환경위생연구소 1991 환경위생연구 Vol.1 No.1

경산지역 시판식육의 위생학적인 측도를 추구코저 112시료의 식육을 채취하여 205주의 En-terobacteriaceae를 분리하고 이중 특징적인 102주를 선별 동정하여 본 실험에 이용하였으며본 분리균들의 식육에서의 분포는 다음과 같았다. (1) 24주의 Proteus 중 21주는 돈육, 3주는 우육에서 유래 되었다. (2) 8주의 Klebsiella중 7주는 돈육, 1주는 우육에서 유래 되었다. (3) 14주의 Providencia rettgeri중 11주는 돈육, 3주는 우육에서 유래 되었다. (4) 1주의 Serratia, 2주의 Morganella morganii, 2주의 Enterobacter aerogenes 및 2주의 Yersi-nia는 돈육에서 유래되었다. (5) 28주의 E.coli 중 21주는 돈육, 7주는 우육에서 유래 되었다. (6) 20주의 미동정된 균중 14주는 돈육, 6주는 우육에서 유래 되었다. On the purpose to evaluate hygienic measurement for meat on themarket near Gyongsan province, 112 of meat samples were randomly taken forour tests and 205 isolates of Enterobacteriaceae were recovered from them.Among 205 of isolates of Enterobacteriaceae typical 102 strains of them wereselected and used on this survey. Identified 102 strains of Enterobacteriaceae were originated from the meatsamples followed : (1) 24 strains of Proteus were recovered from the meat samples that 21 strainsof them were from porks and 3 strains of them were from beeves. (2) 8 strains of Klebsiella were recovered from the above same kinds of samplesthat 7 strains of them were from porks and 1 strain of them was from beef. (3) 14 strains of Providencia rettgeri were recovered from the above same kindsof samples that 11 strains of them were from porks and 3 strains of themwere from beeves. (4) 1 strain of Serratia, 2 strains of Providencia stuartii, 1 strain of Morganella morga-nii, 2 strains of Enterobacter aerogenes and 2 strains of Yersinia were recoveredfrom porks. (5) 28 strains of E. coli were recovered from the meat samples that 21 strainsof them were from porks and 7 strains of them were from beeves. (6) 20 strains Unidentified were recovered from the above same kinds of samplesthat 14 strains of them were from porks and 6 strains of them were frombeeves.

성장호르몬과 프로락틴을 분비하는 뇌하수체 선종이 동반된 Albright증후군 1예

오효정,김용성,신진호,김하영,박병현,조정구 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

구강으로부터 분리한 Micromonospora aurantiaca 인공치태 형성에 미치는 영향

정진,양규호,오종석,박진경,김선미 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.3

The critical etiologic factor in the development of dental caries is dental plaque. The main component of dental plaque is the mutan produced by streptococcus mutans. The following results were obtained by using blue mutan to assess the factors affecting the mutan-digesting activity of micromonospora aurantiaca isolated from oral cavity. Micromonospora aurantiaca digested more blue mutan in the minimal essential broth at pH 7.0 than at pH5.5 or 8.5, and at 37℃ than at 32℃ or 42℃. Blue mutan was similarly digested at the range of lmM to 16mM of CaCl₂and 0.1mM to 6.4 mM of MgCl, while being significantly digested at the concentration of 2.5mM of KCL. When the concentration of glucose was decreased in the minimal essential broth, the digestion of blue mutan was increased, When the culture supermatant of Micromonosoira ayrabtiaca in the broth with 1% glucose or 0.5% mutan was mixed with 2× BHLYS broth containing 0.5% yeast extract and 10% sucrose, the formation of artificial plaque on the orthodontic wires by streptococcus mutans was inhibited(p<0.05). These results indicated that the production of mutanase was identified in the culture supernatant of Micromonospora aurantiaca, suppressing the formation of artificial plaque by streptococcus mutans.

격자형 구조물의 웹 파손에 관한 유한요소해석

정진오 순천대학교 공업기술연구소 1994 工業技術硏究所論文集 Vol.8 No.-

A finite element analysis was performed using the non-linear program ADINA to determine the patch load carrying capacities of webs in the cellular structure which consists of two skin flanges and connection webs. Compressive patch loads of various lengths were applied to the flange directly over the webs, with non-rotational(foundation) or rotational(docking) boundary condition imposed. Eight-noded shell elements were used to model the 3-dimensional cell-type structure, and the buckling load and the ultimate load were sought for the webs with or without initial imperfections. The I-sections similar to the cell-type structure were analyzed together, and results were compared to the AISC design loads. The membrane action of the flanges in the cell-type structure was found not only to fix the movement of the web in its out-of-plane direction but also to give somewhat degree of non-rotational constraint. Thus, the membrane action gave the additional load carrying capacity to the similar I-sections. As the length of load patch increased, failure mode changed from web yielding to web crippling, and to web shear, as was expected from the AISC criteria for I-sections. The ultimate load of the cell-type structure followed the AISC design load for the I-section, but the ultimate load for the docking turned out to be much smaller than the ultimate load for the foundation. The buckling load was sensitive to the initial out-of-flatness of the web, but the ultimate load was not significantly influenced by the initial imperfections. The calculated ultimate loads in the present modelling were somewhat smaller than the AISC nominal strength, or test results by Schnider et al. This gap was considered to be attributable to the load patch which may increase the effective thickness of the flange in the test by several times.

중·고등학교 아랍어 교재 집필 및 교재 내용에 관한 연구 보고서

오명근,송경숙,전완경,사희만,이규철,조희선,정규영,최진영 한국아랍어아랍문학회 1999 아랍어와 아랍문학 Vol.3 No.1