정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

경북지역 안경원 개설에 필요한 요건 분석 연구

박수봉 ; 이채호 ; 김진숙 김천대학교 2001 김천대학교 논문집 Vol.22 No.-

This study showed purchase of glasses, the position on shops, working condition of opticians, financial administration affairs using questionaire, which offers research data basis on marketing plans of optician's shop opening condition.

향기요법이 통증을 주소증으로 입원한 환자의 수면장애에 미치는 영향

박수곤 ( Soo Gon Park ),양미성 ( Mi Sung Yang ),김오영 ( Oh Young Kim ),조희근 ( Hee Guen Jo ),최진봉 ( Jin Bong Choi ),김선종 ( Sun Jong Kim ),설재욱 ( Jae Uk Sul ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.4

Objectives :The purpose of this study is to investigate the effects of aroma therapy on sleep disorder patients with musculoskeletal pain. Methods :The 44 patients were divided into 2 groups: Experimental group(Exp. group) was treated with aroma therapy and control group was treated except aroma therapy. To evaluate the efficiency of aroma therapy, the Korean sleep scale A(Jin-Joo Oh, Mi-Soon Song, Sin-Mi Kim. 1998) and visual analogue scale(VAS) were applied before treatment and after 5 days treatment. Results :1. The Experimental group has improved statistical significance in sleep disorder score as compare to the control group. 2. The improvement of sleep disorder score of Exp.group has difference according to impression. 3. The improvement of sleep disorder has an effect on pain decrease. Conclusions :Aroma therapy has effects of improvement on sleep disorder with musculoskeletal pain.

유리전박 피판을 이용한 효과적인 경부식도 재건술

변진석,백봉수,박준식 大韓成形外科學會 1990 Archives of Plastic Surgery Vol.17 No.5

Treatment of cancer of the cervical aerodigestive tract is a challenging problem due in part to the difficulty in reconstruction and subsequent reestablishment of pharyngoesophageal continuity. From May 1, 1989 to Feb 1, 1990. 4 patients underwent immediate reconstruction utilizing free forearm flap transfers following resection of pharyngoesophageal neoplasm. An island flap was condition, connected to the radial vascula pedicle by fasciocutaneous branches, to reflect the condition of a hidden fabricated free forearm flap. Stricture is the most troublesome complication in a conventional free forearm flap. Two small triangular flaps were designed and inserted in both lateral esophageal wall defects to prevent circular contracture. The outer layer sutures were anchored to surrounding rigid structures to withstand shrinkage and circular contraction. The problem of stricture was solved by these improved procedures. This one-stage, less invasive, easily monitored operation for pharyngoesophageal reconstruction can be considered useful in place of a free jejunal transfer.

자일리톨 농도가 식중독 균의 생장에 미치는 영향

노봉수,김진은 서울여자대학교 자연과학연구소 2003 자연과학연구논문집 Vol.15 No.-

The effect of xylitol on growth of foodborne pathogens was investigated at various concentration of xylitol comparing with sucrose concentration. As foodborne pathogens E.coli 0157, Salmonella typhimuriutn, Staphylcoccus eureus, and Bacillus cereus were used. As xylitol concentration increased, growth of foodborne pathogens were decreased. At 30% of xylitol growth of Stsphylcoccus sureus, and Bacillus cereus were not found. Growth of four kinds of foodborne pathogens were inhibited less than 20% of xylitol concentration. Xylitol inhibited more than sucrose for growth of foodborne pathogens.

관광객의 환경의식이 생태관광태도에 미치는 영향

조진희,김수봉,김용범 한국환경과학회 2004 한국환경과학회지 Vol.13 No.1

Regarding to the ecotourism for environmental conservation, tourists's consciousness and attitude on environment should be dealt with importantly more than the mass tourism. The purpose of this study is to identify the effects of the tourist's environmental consciousness on the ecotourism attitudes. As a result, it was analysed that the more people had interested in environmental problems, positive activities in the environment, the more people had the ecotourism attitudes. This suggested that for development of the ecotourism, it were needed to change tourist's attitude to friendly environment, to make higher consciousness about environmental conservation.

Meprobamate Chlorpromazine 및 電擊療法이 白鼠의 Estrous Cycle에 미치는 影響

羅鳳鎭,金恩洙,朱鍾球,金光日 大韓神經精神醫學會 1966 신경정신의학 Vol.5 No.1

The cyclical activity of the Sprague-Dawley strain rat was observed under the various conditions of administration of meprobamate, chlorpromazine and EST, using the vaginal smear technique. The experimental groups were as followings; GroupⅠ Normal control rats GroupⅡ Rats administered with meprobamate in doses of 60㎎/㎏/day GroupⅢ Rats administered with meprobamate in doses of 400㎎/㎏/day GroupⅣ Rats administered with meprobamate in doses of 400㎎/㎏/day and chlorpromazine, 20㎎/㎏/day GroupⅤ Rats administered with meprobamate in doses of 60㎎/㎏/day and chlorpromazine, 20㎎/㎏/day GroupⅥ Rats administered with meprobamate in doses of 60㎎/㎏/day and chlorpromazine, 5㎎/㎏/day GroupⅦ Rats administered with meprobamate in doses of 60-400㎎/㎏/day combined with EST. In Group Ⅱ and Ⅲ, the average length of the estrous cycle was 9.64 and 10.02 days, which revealed the significant prolongation in comparison with 4.9 days in the normals. Group Ⅳ and Ⅴ showed complete cessation of estrous state of the cycle. Group Ⅵ had irregular cyclical activity, showing 14.4 days interval of the cycle. Group Ⅶ had complete cessation of estrous stage of the cycle immediately after EST. It seems significant that meprobamate has an effect on the cyclical activity of the estrous cycle, which is increased if combined with chlorpromazine or EST.

형태적 정량법에 의한 췌장내분비선의 연구 : 임신, 수유 및 수유금지가 미치는 영향 Effects of Pregnancy, Lactation and Suppression of Lactation

김경수,이원복,라봉진 중앙대학교 의과대학 의과학연구소 1981 中央醫大誌 Vol.6 No.4

The hypertrophy of pancreatic islets of pregnant rats is caused by the increased uptake of food due to fetal demand and by the increased hormonal secretions, estrogen and progesterone. These hormones are closely related with the growth of breast, and the maximal growth results from a combination of prolactin and growth hormone in addition to them. Prolactin continues to secrete during lactation after parturition. Expecting the islet changes after parturition in that reason, this experiment is designed to observe the effects of the pregnancy, lactation and suppression of lactation. Those changes are studied quantitatively by calculating the percentage of endocrine tissue, according to the method of Cardell, on sections stained with hematoxylin and eosin. Results obtained are as follows: 1. The islets have normal appearance. But in the full term and lactation groups there are islets, large round or irregular in shape. 2. The percentage of endocrine tissue of the full term is 7.66±3.12 which shows significant increase in comparing with the control. 3. The percentage of endocrine tissue in the group of lactation for 20 days shows 6.86±2.34 which is relatively significant increase (P<.025). 4. In the group of lactation for 40 days the percentage of endocrine tissue shows 7.80±4.19 but it is not significant to compare with the control. 5. in the group of suppressed lactation for 20 days, the percentage is 4.55±1.43 that shows the decrease in comparing with the full term and seems to restore to the control. (P<.025). Above results show not only the hypertrophy of pancreatic islets in pregnancy but do also the same change during lactation, and the possible causes are discussed.

Cement 風化에 依한 Mortar 强度의 變化 및 물 Cement 比가 Concrete 强度에 미치는 影響

鄭鳳守,黃龍鎭 진주산업대학교 1969 論文集 Vol.3 No.-

本試險 結果는 여러가지 實驗施設과 使用器具의 不充分等 限定된 與件下에서 實施하였기에 많은 未備點과 充分한 結果를 가져 오지를 못하여 부끄럽게 생각하며, 다만 아래와 같은 몇가지는 말할 수가 있다. 1. Cement는 風化程度에 따라서 强度變化率에 顯著한 差異를 가져왔다. 壓縮强度에 있어서 材令 7日에서는 未風化된 Cement와 20日, 30日 및 40日間 自然狀態로 風化시킨 Cement를 各各 比較하여 보면 13.2%, 35.7%, 및 44.6%의 低下率을 가져왔고, 材令 28日에서는 14.0%, 17.0% 및 21.9%의 低下率을 가져왔다. 引張强度 역시 많은 低下率을 나타내고 있으니 破袋된 洋灰나 長期間 貯藏된 것을 使用할 때는 事前에 强度試險을 實施하여 使用해야 할 것이다. 2. Concrete 强度에 가장 많은 影響을 주는 것은 Water-cement ratio로서 比率이 增加되면 强度는 低下率이 높아진다. Water-cement ratio가 50%인 때를 基準으로 하여 55%, 60%, 65% 및 70%일 때와 壓縮强度의 低下率을 比較해 보면 6.3%, 16.3%, 24.4% 및 38%로 나타났으며 材令 28日에서는 8.2%, 15.5%, 19.3% 및 21.0%의 低下率을 나타내었으니 工事를 始作하기 前에 반드시 Slump test를 實施하여 Water-cement ratio를 正確히 使用함이 좋지 않을까 생각된다.

터널 및 地下採掘 現場에서의 V-CUT심빼기를 應用한 長孔發破에 對한 硏究

金益壽,鄭義鳳,金琮鈗,金鎭錫 三陟大學校 産業科學技術硏究所 2002 産業科學技術硏究論文集 Vol.7 No.1

This research is on developing a new blasting technique which will complement the problems of the ordinary burn-cut blasting technique. This new technique employ a v-cut long hole blasting technique. the on-site testing of this v-cut technique has shown a number of advantages to the ordinary burn-cut blasting technique. When tested on the whole-section digging on the large section of a standard mining hole. the v-cut technique has shown the equivalent result to the ordinary burn-cut technique. However, the v-cut technique is more effective than the burn-cut technique, since it makes drilling simpler, and reduces both cost and amount of construction time.