마이크로에멀젼으로 제제 설계된 피록시캄 외용제의 약물동력학적 특성 및 약효 평가

윤범진,박은석,지상철 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-The pharmacological activities and pharmacokinetic aspects of a topical microemulsion (KDPM) containing 0.5% piroxicam were evaluated after its topical application compared with a commercially available 0.5% piroxicam gel (R gel). When the pharmacological activities were evaluated with the carrageenan-induced paw edema model, KDPM showed 55.6% edema inhibition, while R gel resulted in 37.1%. With the adjuvant-induced arthritis model, KDPM also resulted in the better pharmacological activities than R gel. The relative bioavailability of KDPM based on R gel was 176% in rabbits.

회맹장 및 대장을 침범한 장 결핵에 있어서 바륨을 이용한 방사선 이중조영촬영 소견에 대한 연구

진용현,전혜정,이용근,강철호,조성범,김윤환,박철민,차상훈,김일영,이혜경 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

To determine the characteristic double contrast barium enema findings of ileo-cecal and colonic tuberculosis and to make differential diagnosis from other bowel inflammatory disease. Sixty-seven patients confirmed as ileo-cecal and/or colonic-tuberculosis in six hospitals were evaluated retrospectively. The diagnosis was proven by endoscopic biopsy, surgery, and clinical follow up. Nine of 67 patients were excluded because radiologic findings were normal though endocopic biopsy examinations resulted in tuberculosis. Histopathological diagnosis were madein 58 cases as follows: endoscopic biopsy(n=29), operation(n=12), follow up examination(n=14), tissue culture(n=1), laparoscopic biopsy(n=2). There were 30 men and 28 females. The mean age were 36 yrs(range:16-67), 34 patients were in the second and third decade. The distribution of lesions, morphological characteristics, mucosal changes, ulcer shape and depth, associated with other tuberculous lesion, multiplicity were retrospectively analyzed in the findngs of double contrast barim enema. The commonest clinical symptoms were abdominal pain(n=35, 60%) and diarrhea(n=18, 31%). The chest radiography revealed association of pulmonary tuberculosis in 39 cases. Tuberculous lesions of other organs except chest were present in five cases. Double contrast barium enema findings showed a thickening and irregularity of intestinal mucosal fold(n=29, 50%), bowel contraction and/or shortening(n=26, 45%). There were small, nodular, superficial ulcers in the case of ulcer depth less than 2 mm in the depth. As many as 39 cases(67%) in this series had two or more lesions in the intestinal tuberculosis. The involved segment revealed symmetrical feature(n=21, 36%). Inflammatory pseudopolypoid lesions were noted in 30 cases(52%). The ileo-cecal region was involved in 38 cases(66%). The ascending colon(n=25, 43%) was the second commonest site with or without contiguous cecal involvement. Lesions in terminal ileum, ileo-cecal valve, transverse colon, descending colon and appendix were seen in 19, 18, 18, 12 and seven cases, respectively. Among 18 cases of ileo-cecal valve lesions, there were incompetency in nine cases(16%) and wide gapping in four cases(7%). In 14 cases, tuberculous enterocolitis was diagnosed by clinical follow-up and double contrast barium enema study. 12 out of 14 cases, the findings of double contrast barium enema of tuberculous enterocolitis were normalized after anti-tuberculous medication. However, two cases showed more aggravated state than before due to inappropriate treatment. Double contrast barium enema plays an important role in the diagnosis of tuberculous enterocolitis, determines the type, site and extent of the involvement and helps in treatment guide by using sequential studies.

Graphitized Carbon Black 을 이용한 Diazepam의 微量分離分析에 관한 硏究

李明然,尹範鎭 成均館大學校 科學技術硏究所 1987 論文集 Vol.38 No.1

Graphitized Carbon Black(GCB) is norpolar adsorbent which adsorbs selectively aromatic compounds having polarizable functional group such as -NO_2, -C1, and -phenyl. The adsorptivity and desorptivity of GCB were examined using diazepam as a model compound to characterize GCB as a solid matrix in the enrichment of trace compounds from biological matrices. Using property that diazepam is insoluble in water adsorption coefficient and adsorption capacity per g of GCB were determined. Breakthrough curves were examined from elution chromatographic mode and frontal chromatographic mode to determine breakthrough volume and know diazepam is quantitatively adsorbed on GCB irrespective of volume of water to get rid of interferants. Human serums spiked with known amounts of diazepam were analyzed and recovery was 91.9%(R. S. D. 1.0%).

니켈촉매를 이용한 메탄의 부분산화에 의한 합성가스 제조

김상범,신기석,박은석,곽윤철,천한진,함현식 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.1

메탄의 부분산화에 의하여 힙성가스를 제조하였다. 촉매는 니켈 담지 촉매를 사용하였으며, 담지된 니켈의 양은 10-15 wt%이었다. 담체로는 BaO, CaO, MgO를 사용하였다. 촉매는 함침법으로 제조하였으며, 반응은 CH_4:O_2의 비가 2:1, 1 atm, 750℃에서 수행하였다. 반응결과, MgO를 담체로 사용하였을때 가장 좋은 촉매활성을 보여주었으며, 니켈의 담지량이 13 wt%일때 촉매의 활성이 가장 좋았다. 이 13 wt% Ni/MgO 촉매의 경우 80%의 메탄 전화율과 93% 및 94%의 CO 및 H_2 선택도를 각각 얻을 수 있었다. 또한 이 촘매는 약 180시간 정도의 반응 후에도 촉매의 활성이 감소하지 않았다. 논란 중인 반을 기구에 대하여 조사해 보기 위하여 펄스방식으로 반응물을 투입하며 촉매 상 · 하층의 온도를 측정하였고, 반응시간에 따른 반응물과 생성물의 몰수 변화, 그리고 O_2-TPD 실험을 수행하였다. 그 결과 메탄으로부터 합성가스가 생성되는 경로는 2단계반응으로써 메탄이 완전 산화되어 CO_2와 H_2O가 생성되고, 이 생성된 CO_2 및 H_2O가 미반응 메탄과 각각 개질반응을 하여 합성가스가 생성됨을 알 수 있었다. Synthesis gas producution by partial oxidation of methane has been investigated using BaO, CaO and MgO supported Ni catalysts. The catalysts were prepared by the impregnation method. The reaction was carried out at I atm, 750℃, and CH_4:O_2=2:1. The highest catalytic activity was obtained with MgO support when Ni loading was 13 wt%. With the 13 wt% Ni/MgO catalyst, methane conversion was 80%, and CO and H_2 selectivities were 93% and 94%, respectively. The activity of the catalyst remained nearly constant after 180h of the reaction. To investigate the reaction mechanism of this reaction, the temperature of the actalyst bed at top and products were determined with time; and O_2-TPD experiment was carried out. From the results, it is deduced that the reaction takes place by a two-step reaction-first, total oxidation of methane to CO_2 and H_2O takes place, and then the produced CO_2 and H_2O are further reacted with CH_4 to give synthesis gas.

국제스포츠 정보 시스템의 현황 분석

육조영,윤찬호,김범수,노덕선,이무연,배진희,이승훈 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

Information has become a strategic tool with progress of sports science and sports technology. Demand on sports information is spreading to leisure, recreation, sociology, science of nutrition, psychology, sports medicine, sports therapy, prophylactic medicine, alternative medicine, sports industry and sports nature etc. if on line data base can be manipulated freely then acceleration and quality improvement of the study in this field can be effected and it is possible to gain new insight for receiving latest information But next problem is cost for use. For this reason this author summarized quick and effective on lline search points as follows: 1. Data base should be chosen with clear purpose for its use. Conduct prior investigation on contents and fee system of data base. With the same data base fee system may be differed depending on distributor therefore it is necessary to try different distributors at first as much as possible. 2. Prior to starting on line search prepare search method. If on line is started and then search method is checked than quickly telephone charge will go up. Search method should be prepared in advance by thinking sufficiently of what theme is to be searched. 3. Look for good advisor: lf there is no advisor nearby then the best thing is counselling with the person in charge for the distributor. If the result of search is stored at floppy disk by "downloading" then even after communication line is cut off it will be possible to print out anytime. 4. In this study the author explained about on-line search of lterature data line but recently it is possible to search overseas sports news or information on rate of victory or defeat of prfessional footbali etc. in real time. In Japan it is possible to search feature articles of Nihon Kesai or Asahi (except culture and sports column) by on-line. However in our country there are not many data bases in the field of sports and physical education which can be on-line searched. Our country belongs to up per level in the world in terms of study of sports science and technology and we are attracting attention from countries in Asia and from different parts of the world and the task facing us now is developing independent and unique data base for our country.

全羅南北道 水域의 管束植物相과 그 分布

吉奉燮,尹敬源,盧範鎭,金昌煥 圓光大學校 基礎自然科學硏究所 1989 基礎科學硏究誌 Vol.8 No.3

全甫北 地域에 있는 6個 江과 고 流域에서 水生植物, 濕生植物과 水邊植物을 조사하였더니 水生植物은 57種類, 濕生植物은 74種類, 水邊植勃 123種類로 나타났다. 이들을 다시 分類하면 56科 145屬 190種 1亞種 27變種 1品種 總 219種類가 된다. 水生植物 中에는 抽水植物이 52.6%', 浮葉植物 21.7%, 沈水植物 19.3%, 浮水植物이 7%를 차지하고 있었다. 이들 中 頻度가 비교적 높은 식물은 검정말, 개구리밥, 노랑어리연꽃이었고 全般的으로 볼 때 優占襪은 검정말이었으나調査地點別로 差異가 있었다. 生物量(g/m^2)은 마름 2,935,5, 물잔디 1.050, 검정말 877.7, 물닭개비 847.1, 애기가래 806.9의 순으로 生量平均値를 기록했고, 乾量(g/m^2)으로는 마름225.4, 물잔디 90.3, 검정말 86.6, 대가래 78.6이었다. 調査地域 中에서 保護할 價値가 있는 곳은 耽津江이고, 植物은 여러곳에 나는 것으로 자라풀,노랑어리연꽃, 순채를 들 수 있다. To investigate the rearing environment of aquatic vascular plants and thechange of its spontaneity, field work was carried out in 6 rivers and theirdrainage basins located in Cholla-nam-but-do area. The flora was composed of 56 families, 145 genera, 190 species, 1 subspecies,27 varieties and 1 forms or 219 taxa; 57 species of hydrophytes, 74 of hygrophytes and 123 of waterside plants, Among hydrophytes emerged plant (E,52.6%), floating-leaved plant (FL,21.7%), submerged plant (S,19.3%) and freefloating planktonic plant (FP, 7%) were occupied, respectively. Dominant species was Hydrilla verlicillaia, but differed according to investigated. A significant place obseryed was Tamjin river and species to beprotected were Hydrocharis dubia, Nympkoides pellata and Braenia schreberi.

동일한 시료에 대한 국내 기관간의 STR 분석결과 비교 : STR 유전자좌 분석법의 표준화 설정을 위하여

박종태,신경진,양윤석,우광만,이숭덕,이승환,이정빈,정연보,조승희,한길로,한면수,홍승범 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

This paper described a collaborative exercise intended to see what kinds of short tandem repeat (STR) loci are used in different DNA typing laboratories in Korea and to compare their results for the demonstration whether uniformity of DNA profiling results from different laboratory could be achieved in Korea Laboratories were asked to test five tissue DNAs using methods routinely used in each laboratory and to report the results to the coordinating laboratory. The exercise demonstrated that each laboratory was using different STR loci for the typing with different STR numbers,2 VNTRS,36 STRs and amelogenin in total, and the direct comparison of the results from all the laboratory for the 18 loci could not be done as only one laboratory submitted typing results. Among 21 loci for which several laboratories submitted typing results, results for 14 loci were the same and results for the other 7 loci were different depending on the participating laboratory. D1S80, F13A01, D16S539, D21S11, D18S51, D3S1744 were the loci with different typing results. Even in the cases where commercial kits were used, the results were not the same depending on the machines used, that is the capillary electrophoresis or the gel based electrophoresis. The reason for the different results, points about the standardization of the methods arid the profiling data were described.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

마이크로에멀젼으로 제제 설계된 피록시캄 외용제의 약물동력학적 특성 및 약효 평가

윤범진(Bum Jin Yun),박은석(Eun Seok Park),지상철(Sang Cheol Chi) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.1

The pharmacological activities and pharmacokinetic aspects of a topical microemulsion (KDPM) containing 0.5% piroxicam were evaluated after its topical application compared with a commercially available 0.5% piroxicam gel (R gel). When the pharmacological activities were evaluated with the carrageenaninduced paw edema model, KDPM showed 55.6% edema inhibition, while R gel resulted in 37.1%. With the adjuvant-induced arthritis model, KDPM also resulted in the better pharmacological activities than R gel. The relative bioavailability of KDPM based on R gel was 176% in rabbits.

Hepatitis B : Comparison of treatment responses between Lamivudine + adefovir combination and entecavir single for Lamivudine or adefovir resistant chronic hepatitis B patients. (초)

( Yu Jin Hah ),( Yoo Jin Lee ),( Dong Chun Kim ),( Yun Jung Kim ),( Hae Jin Seo ),( Tae Yul Kim ),( Sun Young Lee ),( Eun Soo Kim ),( Kyung Sik Park ),( Kwang Bum Cho ),( Byung Kuk Jang ),( Jae Seok H 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)