폐경 후 여성의 심혈관질환 예방을 위한 식사중재에 대한 준수도(adherence) 평가

정경아,김상연,우정익,장유경 漢陽大學校 韓國生活科學硏究所 2001 韓國 生活 科學 硏究 Vol.- No.19

The purpose of this study is to assess the adherence to dietary intervention for prevention of coronary heart disease (CHD) in postmenopausal women by observing changes of antioxidant vitamins and fatty acid composition in dietary intake and seam level. The subjects with hypercholesterolemia (TC≥240mg/dl) were treated with one of hormone replacement therapy (HRT group), dietary intervention (DIET group) or combination of hormone replacement therapy and dietary intervention (HRT+DIET group) for 12 weeks. The results were as followed. Mean daily nutrient intakes were not significantly changed in the HRT group, but were significantly changed in the DIET group and the HRT+DIET group. Especially, dietary vitamin A and E intakes were increased from less than 75% to more than 90% of RDA for Korean in the two groups. With changes of dietary intakes, serum vitamin A and E levels were also significantly increased in the DIET group and tended to increase in the HRT+DIET group. Dietary fatty acid composition was also not significantly changed in the HRT group, but was significantly chanced in the DIET group and the HRT+DIET group. With changes of dietary fatty acid composition, serum phospholipid fatty acid composition was significantly changed in the DIET group and the HRT+DIET group although there was tendency of returning to initial value after 12 weeks. Judging from changes in serum phospholipid fatty acid composition, subjects' adherence to dietary intervention tended to decrease after 12 weeks. However, the changes of antioxidant vitamins and fatty acid composition in dietary intake were compatible with the changes of those in serum level, and we can conclude that dietary intervention was adhered quite well by subjects.

Correlating Structural Changes and Gas Evolution during the Thermal Decomposition of Charged Li_<i>x</i>Ni_0.8Co_0.15Al_0.05O₂ Cathode Materials

Bak, Seong-Min,Nam, Kyung-Wan,Chang, Wonyoung,Yu, Xiqian,Hu, Enyuan,Hwang, Sooyeon,Stach, Eric A.,Kim, Kwang-Bum,Chung, Kyung Yoon,Yang, Xiao-Qing American Chemical Society 2013 Chemistry of materials Vol.25 No.3

<P>In this work, we present results from the application of a new in situ technique that combines time-resolved synchrotron X-ray diffraction and mass spectroscopy. We exploit this approach to provide direct correlation between structural changes and the evolution of gas that occurs during the thermal decomposition of (over)charged cathode materials used in lithium-ion batteries. Results from charged Li<SUB><I>x</I></SUB>Ni<SUB>0.8</SUB>Co<SUB>0.15</SUB>Al<SUB>0.05</SUB>O<SUB>2</SUB> cathode materials indicate that the evolution of both O<SUB>2</SUB> and CO<SUB>2</SUB> gases are strongly related to phase transitions that occur during thermal decomposition, specifically from the layered structure (space group <I>R</I>3̅<I>m</I>) to the disordered spinel structure (<I>Fd</I>3̅<I>m</I>), and finally to the rock-salt structure (<I>Fm</I>3̅<I>m</I>). The state of charge also significantly affects both the structural changes and the evolution of oxygen as the temperature increases: the more extensive the charge, the lower the temperature of the phase transitions and the larger the oxygen release. Ex situ X-ray absorption spectroscopy (XAS) and in situ transmission electron microscopy (TEM) are also utilized to investigate the local structural and valence state changes in Ni and Co ions, and to characterize microscopic morphology changes. The combination of these advanced tools provides a unique approach to study fundamental aspects of the dynamic physical and chemical changes that occur during thermal decomposition of charged cathode materials in a systematic way.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2013/cmatex.2013.25.issue-3/cm303096e/production/images/medium/cm-2012-03096e_0014.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm303096e'>ACS Electronic Supporting Info</A></P>

경직성 뇌성마비아동의 반사적 움직임 감소를 위한 신체정렬기법의 효과

장경호(Kyung Ho Chang),정유진(Yu Jin Jung) 한국사회체육학회 2011 한국사회체육학회지 Vol.0 No.44

Children with spasticity cerebral palsy were participated in an Ideokinesiology program to decrease oe control primitive reflexes such as ATNR, Moro reflex, and Righting reflex. An experimental research with 12 subjects in experimental group and 18 subjects involved in a control group were conducted for 10 weeks. Using the QUEST and the BOTMP, subjects` mobility of upper extremity includes hands, neck, arms, and upper body were measured. Results was indicated that subjects` reflexes with hands, neck, and upper body were significantly decreased. However, reflexes with arms were not changed. The Ideokinesiology with image of body parts was an effective methodology to control impropriate mobilities for primitive reflexes of child with cerebral palsy.

SNS의 뉴스 콘텐츠 이용동기가 뉴스 콘텐츠 유형별 이용량에 미치는 영향 : 참여행위의 매개효과 검증을 통하여

장지연(Ji Yeon Chang),전가영(Ka Young Jeon),유세경(Sae Kyung Yu) 한국언론정보학회 2020 한국언론정보학보 Vol.104 No.-

본 연구는 변화하는 미디어 환경에서 사람들이 어떠한 목적을 가지고 소셜미디어에서 뉴스를 이용하는지 이용 동기를 알아보고, 대표적 콘텐츠 유형별 이용량에 영향을 미치는 이용자 참여행위의 매개효과 검증을 실시했다. 연구 결과, 유튜브 뉴스 콘텐츠를 이용하는 사람들은 다양성을 충족 받고자 하고, 자신과 유사한 견해를 가진 뉴스를 추구한다는 동기가 강했고, ‘좋아요’표시나 댓글 쓰기, 공유 행위 등 참여행위의 매개 효과를 검증한 결과, 유튜브 뉴스 콘텐츠 이용량에 유사견해의 추구 동기는 매개효과가 없는 직접효과만이 유의하고, 다양성 추구의 동기는 참여행위가 매개되지 않으면 이용량을 예측할 수 없는 완전매개효과가 있는 것으로 나타났다. 카드뉴스 콘텐츠에서는 편리성 및 맞춤제공의 동기와 습관적 소비 동기가 요인으로 추출되었지만 이용자 참여행위는 이용량에 대해 유의한 효과 없이 이용 동기가 이용량에 모두 직접적 영향을 미쳤다. 소셜미디어에 원문 그대로 재매개되는 언론사 뉴스 콘텐츠의 경우 다른 유형과는 차별적으로 시의성 충족의 동기가 가장 중요했다. 최근에 일어난 이슈를 실시간으로 소비하고자 하는 욕구와 더불어 의견 교환 및 견해의 비교 동기 역시 유의하게 나타나 기성 매체의 콘텐츠가 소셜미디어 플랫폼에서 새로운 의미로 재가공된다는 점을 확인했다. 재매개된 언론사 뉴스 이용량에 시의성 충족의 동기는 매개효과가 없는 직접효과만 유의했고, 의견교환 및 견해의 비교 동기는 이용자 참여행위의 완전매개효과를 확인했다. 이 연구는 소셜미디어를 활용한 뉴스 콘텐츠 생산과 유통, 소비과정에서 이용자들의 이용 동기와 참여행위를 고려한 전략을 모색할 수 있도록 돕고, 소셜미디어 뉴스의 균형과 조화를 위한 자료를 제공했다는 점에서 의의가 있다. This study identified the motivations for using 3 different news content types on social media platforms and verified mediating effects of user participatory behaviors that affect the usage of each news content type. Studies have shown that those who use YouTube news content have strong motivation to ‘seek for diversity’ and to ‘pursue news with similar views’. In addition, participatory actions: such as ‘like’, ‘writing comments‘ and ‘sharing‘ mediated ‘seeking for diversity’ motivation and the usage of YouTube news. However motivation for ‘pursuing news with similar views’ had no mediating effect. Card news usage showed that the motivation for ‘convenience and curation’ and ‘habitual consumption’ found to have strong positive relation, but the user participatory behavior had no significant mediating effect on the amount of use. Unlike other news contents, original news that are re-mediated via social media showed to have a positive relationship with the motivation for ‘timeliness’ and ‘exchanging opinions and comparing views’. This result confirmed that as original news content transported into social media, even if the content do not change the meaning for the usage change. The motivation for meeting ‘timeliness’ was only noted to have direct effects towards the usage without any mediated effects, but the motivation for ‘exchanging opinions and comparing views’ confirmed the complete mediating effect of user participation. The research is meaningful in that it helped to explore strategies that took into account users’ motives and participation in the process of producing, distributing and consuming news content using social media.

Endoscopy and Imaging Modalities/Basic Science of Gastrointestinal Disorders/Miscellaneous : Changing Pattern Of Digestive And Liver Disease In Korea, 1990-2006 Year; A Single Center Study

( Jung Hyun Kwon ),( Sang Woo Kim ),( In Sik Chung ),( Myung Gyu Choi ),( Kwan Woo Nam ),( Jung Pil Suh ),( Jae Hyuck Chang ),( Won Haing Hur ),( Yu Kyung Cho ),( Jae Myung Park ),( In Seok Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: Westernization in many Asian countries have changed lifestyles and diets, so once rare diseases have now become prevalent. The aim of this study is to investigate the changing pattern of digestive and liver disease in Korea, from 1990 to 2006. Methods: We extracted data specific gastrointestina (GI) disease based on the International Classification of Diseases code from the in-patients records at the Kangnam St. Mary`s Hospital in 1990, 1996 and 2006. This hospital is a tertiary-care hospital in Seoul, Korea, which has a capacity of 800 beds. Results: The admission rate for GI disease increased between 1990 and 2006. Overall in-patients were 1,623 persons in 1990, 2,368 persons in 1996 and 4,166 persons in 2006. The mean age of in-patients increased as time went by. A stomach cancer was the most common diagnosis during all periods, but its prevalence has decreased. Colon cancer ranked the 7th in 1990, but markedly increased and now ranks the second. The third was a hepatocellular carcinoma. The bile duct and gallbladder cancer, pancreas and esophageal cancer ranking followed with little interval change. In cases of cancer patients, a regular admission dramatically increased for chemotherapy. The number of patients admitted with pre-malignant neoplasm of stomach and colon increased remarkably with the development of endoscopy. The liver transplant, inflammatory bowel discase, and reflux esophagitis emerged form mid-1990s with greater frequencies, yet much below the levels found in the West. The admission rate for peptic ulcer, especially ulcer bleeding remained relatively stable, despite a decreased rate for ulcer perforation. Liver cirrhosis, hepatitis, cholelithiasis with cholecystitis-cholangitis, appendicitis, hemorrhoid and gastritis all decreased. Conclusions: The stomach cancer is the leading cause of admission, despite a recent decline. Colon cancer showed a marked rise. The liver transplant, inflammatory bowel disease and reflux esophagitis were new diagnosis with an increased tendency.

영양소와 암에 관한 문헌적 고찰

장유경,이성우 漢陽大學校 韓國生活科學硏究所 1986 韓國 生活 科學 硏究 Vol.- No.4

Most Cancers in man are caused by environmental factors. It is rather surprising that wide spread interest in the role of human diet in cancer etiology has developed recently, since the ingestion is such an obivous route for carciongens or their precursors to enter the body. In this review, attention will focus on the relationships between nutrients in diet and cancer, especially the influence of nutrients on cancers. 1) The inhibitory effects of caloric restriction could be due to a lack of energy for either tumorigenesis or mitosis of latent cancer cells. However, severe caloric restriction is not a practical method for the prevention of human cancer. 2) High protein diet increases the incidence of the [spontaneous tumors. But it has protective effect from incidence of cancer with dietary manipulation or chemically induced cancer when caloric intakes are controlled to maintain the same body weights in animals. A critical decrease in protein reduces the incidence of cancer. 3) High fat diet may provide a suitable environment for developing latent tumor cell and spontaneous tumors. An increased level of polyunsaturated fatty acids in serum might inhibit the action of the immunological system to cancer and savor tumorigenesis. 4) Retinoids are most effective in inhibiting mammary carcinogenesis when administered shortly after carcinogen treatment. α-Tocopherol (vitamin E) has been known to be an effective naturally occuring antioxidant capable of providing protection to tissues from the damaging effects of feeding polyunsaturated fat. Ascorbic acid has been shown to effectively block this spontaneous conversion to nitrosamines from nitrites or nitrates in foods. Selenium has the chemopreventive ejection due to change of chemical carcinogen induced tumorigenesis metabolism. It is related to maintain high levels of glutathion peroxidase. 5) Dietary fiber can reduce contact between the bowel mucosa and a potential carcinogen, by diluting the intestinal contents and by decreasing transit time. It can adsorb potential carcinogens, making them less available It can also affect bacterial action on carcinogen precursors by these metabolisms.

식이중 단백질과 에너지 수준이 흰쥐의 성장과 혈액성분에 미치는 영향

장유경 漢陽大學校 韓國生活科學硏究所 1987 韓國 生活 科學 硏究 Vol.- No.5

In order to investigate the effect of dietary protein and energy on growing female and male rats, Sprague-Dawley 90 female rats and 54 male rats of 3 weeks old weighing approximately 70-80 g and 65-75 g, respectively, were subjected to feeding trials for 8 weeks and then subsequently to metabolic trials for 2 weeks. Three dietary energy levels (3200, 3600, 4000kcal ME/kg) were employed and each energy level contained three protein levels (15, 25, 35% of 3600kcal ME/kg) and three fat levels (10, 20, 40% of 3600 kcal ME/kg) by addition of an appropriate amount of carbohydrate and the following results were obtained. (1) The body weight gain of female rats was highest for LPHE ration but that of male rats was highest for LPME ration. The weight gains both of female and male rats were not affected by the level of protein. Food effeciencies both of female and male rats were improved as the levels of energy increased, and the food efficiency of female rats was affected by the level of protein, whereas that of male rats was not. Protein efficiencies of female and male rats were highest at low protein level and tended to decrease as the level of protein increased, but that of female rats was highest at high energy level, while that of male rats was highest at medium energy level. (2) According to the analysis of blood serum after feeding trials for 8 weeks, the content of serum glucose of female rats has shown no definite trend by protein and energy levels. However, that of male rats increased as protein level increased but has not shown a trend as energy level increased. The serum protein contents both of female and male rats were not affected by protein level, but that of female rats incrased slightly as energy level increased, whereas that of male rats was not influenced by energy level. The serum urea nitrogen contents both of female and male rats increased as protein level increased but, as energy level increased, that of female rats decreased while that of male rats has not shown a definite trend. The contents of serum cholesterol both of female and male rats have shown the lowest value at high energy level. The content of serum triglyceride of female rats trended to decrease as protein level increased, but that of male rats has shown to be lowest at protein level. From the above-mentioned experimental results it may be concluded that the best formula of diet of growing female rats may be composed of low protein (13%) and high energy levels (4000 kcal/kg) whereas that for male rats may be composed of low protein (13%) and medium energy levels (3600 kcal/kg), since all the efficiencies of food, protein and energy have shown to be best at these levels. Blood composition of female rats at LPHE ration ; serum glucose : 147.20mg/100ml, serum protein; 9.92mg/100ml, serum urea nitrogen ; 8.41mg/100ml, serum cholesterol ; 52.95mg/100ml, serum triglyceride : 137.83mg/100ml. Blood composition of male rats at LPME ration ; serum glucose: 182.18mg/100ml, serum protein ; 11.81mg/100ml, serum urea nitrogen ; 11.94mg/100ml, serum cholesterol ; 83.08mg/100ml, serum triglyceride ; 167.58mg/100ml.

Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

곡류 중의 섬유질이 흰쥐의 무기질 흡수율에 미치는 영향

정경아,장유경 漢陽大學校 韓國生活科學硏究所 1996 韓國 生活 科學 硏究 Vol.- No.14

This study was performed to investigate the effect of cereal fibers on mineral apparent absorption in rats. Male Sprague-Dawley rats weighing 180±4g were divided into five groups by completely randomized block design : R, BR, B, W and F. Each group fed a diet containing a kind of cereal among rice (R), brown rice (BR), barley (B), whole wheat (W) and wheat flour (F) for 5 weeks. The results were summarized as follows : 1) Food intake, weight gain and feed efficiency ratio were not significantly different among the groups 2) Fecal Ca was significantly the most in the W group compared to the others. And Ca apparent absorption was significantly lower in the W, B and BR group than in the other two groups. 3) Fecal P was significantly more in the W, B and BR groups than in the other two groups. And P apparent absorption was significantly lower in the W, B, and BR groups than in the other two groups. 4) Fecal Mg was significantly more in the W, B, BR groups than in the other two groups. And Mg apparent absorption was significantly lower in the W, B, BR groups than in the other two groups. 5) Fecal Zn was significantly the most in the W group compared to the others. And Zn apparent absorption was significantly the lowest in the W group compared to the others. 6) Comparing absorption of minerals at the first and last week, absorption of minerals except Zn was increased at the last week. From the results of this study, we can decide that cereals containing much insoluble dietary fiber can interrupt the apparent absorption of minerals

동종 조혈모세포이식 후 발생한 치명적 홍역 폐렴 1예

백창렬,이동건,최정현,정현화,조유경,박훈준,이승훈,박윤희,이교영,민우성,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

As a result of the enlarging pool of unvaccinated children and young adults, there has been an increase in measles in our countries. In these situation, it has been reported that measles associated pneumoinia is easily complicated with fatal respiratory failure, espycially in immunocompromised patients. Herein we report the case of lethal measles pneumonia after allogenic hematopoietic stem cell transplantation in adults proven by autopsy. Recently, one case of measles was encountered in 39-year-old female patients after allogenic bone marrow transplanted case (chronic myelogenous leukemia), who progressed into interstitial pneumonia pattern, despite treatment including antibiotics, immunoglobulin. The patient died of giant cell pneumonia compatible with that of measles which was comfirmed in the section of necropsy lung specimen. (Korean J Infect Dis 33:301∼309, 2001)