정상면역을 가진 성인에서 발생한 식도 방선균증

김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.

65세 이상의 노령층에서 고지혈증의 위험요인

김용배,장원기,황보영,김화성,안규동,이병국,이용진,김세훈,김승수,김승훈,김영록,김웅빈,이성수 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

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Exploring potential biomarker responses to lithium in Daphnia magna from the perspectives of function and signaling networks

Hyo Jeong Kim1,2,Jun Hyuek Yang,Hyun Soo Kim,Yeo Jin Kim,Wonhee Jang,Young Rok Seo,W. Jang,Y. R. Seo 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.1

I ntensive usage of electronic appliances containing lithium batteries causes an accumulation of e-trash. Environmental exposure to lithium batteries contaminates ecosystems. In air and water, the batteries form lithium hydroxide (LiOH) on their surfaces. LiOH enters the aquatic environment and contaminates the aquatic ecosystem by being absorbed into biological organisms. In this study, in order to identify meaningful potential biomarkers that appear in response to lithium, we measured significantly up- and down-regulated genes after LiOH exposure by conducting a microarray. In addition, we explored the functions of differentially expressed daphnia genes, and we conducted a comparative analysis in other species, Daphnia spp. to humans, then analyzed the signaling pathways using the human gene set derived from daphnia sequences that are differentially expressed in response to LiOH using the NCBI-BLAST tool and Pathway studio. As a result, we identified signaling pathways and suggested several potential biomarkers that are up- or down-regulated in response to lithium. This study may contribute to the development of a biomonitoring system which can detect the ecotoxicity of lithium. Furthermore, lithium toxicity in humans can be predicted, so the study may also provide potential biomarkers of lithium exposure in humans.

습관성 흡연여성에서 후측 수부에 발생한 Buerger씨병

김삼,이남호,육청미,최영진,백대균,홍경순,두영철,한규록,오동진,유규형,임종윤,이광학,이영 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.7

최대하 운동에 의한 피로도가 외발서기자세 균형에 미치는 영향

김영록,안연준,박승규 대불대학교 2003 大佛大學校大學院 硏究論文集 Vol.2 No.1

Fatigue is affected motor control, coordination and balance. This study recognize whether affect some balance of one leg standing by fatigue that do submaximal and is happened after exercise. It serve to measures and do maximum, strength of exercise measures heart beat same number and calculated target heart beat same number when is stable with maximum heart beat same number. This time, 5 minutes measured a rest after trouble very in couch of heart beat same number when maximum heart beat same number is stable being '220-ages' (maximum heart beat same number-heart beat same number when is stable) target heart beat same number is 0.85. When is stable serving to measure one leg balance is change after maximum low class exercise after and exercise 10 minutes after and measured change of balance with each mean value. This time, target heart beat same number for maximum low class exercise used heart of balance used active-balance system. Such measured value plain received figure using SPSS.

앉은 자세에서 척수손상환자의 전방도달(FR)거리와 일상생활수행(MBI) 점수와의 상관성

김영록 대불대학교 2000 論文集 Vol.6 No.1

This study was designed to evaluate the sitting balance and its relation to activities of daily living(ADL) in 27 spinal cord injuried(SCI) patients who were treated at the Yonsei Rehabilitation Hospital from July, 1999 to October, 1999. Sitting balance was measured by FR(Functional Reach) test and MBI(Modified Barthel Index) to evaluate activities of daily living. The FR mean score was significantly different between the cervical injuries and the thoracic injuries(p<0.001). The MBI mean score was significantly different between them(p<0.05). Correlation was statistically significant between the FR score and the MBI score(p<0.05). The results showed that comprehensive balance training of treatment approach for SCI patients had a significant effect on the improvement of ADL.

만성 활동성 간염에 있어서 Ursodeoxycholic acid의 치료효과

김성록,안병철,윤영미,탁원영,곽규식,최용환,정준모 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.4

The purpose of this study is to evaluate the clinical and biochemical effects of SGD-F^(R)(UDCA, Vitamin B_1, Vitamin B_2 complex) in chronic active hepatitis. Observed cases were given orally after each meal(three times a day) for 4 weeks. The results were as follows: 1. Among subjective symptoms, improvement rate showed in easy fatigability 86.7%, anorexia 68.0%, indigestion 80.0%, nausea and vomiting 72.7%, RUQ pain 83.3%. 2. Biochemical parameters such as SGOT, SGPT, showed to be improved significantly after the 4 weeks treatment.(p<0.01) 3. There was no specific side effect during the study period in all cases. In conclusion, SGD-F^(R) capsule may be safe and effective for chronic active hepatitis.

PC12를 이용한 신경세포 허혈모델에서 irp94 유전자의 발현

김승환,양영모,하영록,정성필,유인술,김인병 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: The ischemia responsive protein 94 kDa(irp94) gene belongs to the heat shock protein 110 family and was isolated in 1999 from rat brain by transiently induced forebrain ischemia. The PC12 cell is the pheochromocytoma cell line of rat, which is differentiated to a sympathetic neuron-like cell by the stimulation of a nerve growth factor. This study is to determine whether irp94 is expressed when an ischemia-like condition is induced by ATP depletion in cultured PC12 cells in vitro. Methods: PC12 cells were maintained as monolayer cultures in RPMI-1640 medium(Sigma) supplemented with 10% horse serum, 5% fetal bovine serum, 5 mg/ml transferrin, and 1 mg/ml insulin in a humidified 5% CO2 incubator at 37℃. The ATP depleting agent antimycin A was added at concentrations of 1, 2.5, and 5 μM to simulate ischemia, and 10 μg/ml of tunicamycin, which is expected to express heat shock protein maximally, was used as a positive control. The cells were harvested after a 60-minute incubation, and the total RNA was extracted. The reverse transcription polymerase chain reaction(RT-PCR) was performed to use 501 bp irp94 cDNA as a molecular probe, and the expression of irp94 mRNA was analyzed by northern blotting. Results: The irp94 mRNA expression was enhanced, compared to the negative control group, as the concentration of antimycin A was increased. Conclusion: This study suggests that irp94 mRNA expression is enhanced as the severity of ischemia is increased. Thus, it is possible to investigate the mechanism of ischemic neuronal injury indirectly by using this in-vitro model of neuronal ischemia.

위발성 위장관 악성림프종 환자에서 항암치료의 효과

김찬규,신영록,김현정,배상병,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Purpose: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), which is increasing in incidence, but there is no established optimal treatment modality. Thus, this study was investigated the clinicohistologic feature, the therapeutic modalities, and the prognosis for GI-NHL, as well as the factors affecting it. Methods: We retrospectively analyzed 45 patients who had been diagnosed as having GI-NHL and had been followed up from July 1994 to February 2005 at Soonchunhyang University Hospital. The patients were divided into groups according to the site of origin and to various other features, and the survivals of the various groups were compared. The modified Ann Arbor system and WHO classification were adopted for staging and histopathologic classification, respectively. Results: GI-NHL of the stomach, small bowel, ileocecal region, and colon occurred in 28 patients (62.2%), 5 patients (11.1%), 3 patients (6.7%), and 8 patients (17.8%), respectively, In one patient, the entire gastrointestinal tract was diffusely involved. The median age of patients was b5 years (25~78 years), and male-to-female ratio was 1:1.1. Fourteen patients were in stage Ⅰ, 24 in stage Ⅱ, 4 in stage Ⅲ, and 3 in stage Ⅳ. Surgical resection was performed in 19 patients, and combination chemotherapy was performed in 43 patients. Surgical resection only was performed in 4 patients, Chemotherapy only was performed in 26 patients. The expected overall 5 year survival of 45 patients was 39.6%, and there was a significant survival difference between the stages, but between sites of origin (p=0.842). The most important factors influencing the survival was the stage and other factors were not significant. Conclusion: The stomach was the most common site of GI-NHL. Most GI-NHL were localized Stage was the most important prognostic factor. However, Prospective randomized studies are needed to approve the therapeutic modality.

청각장애학생의 전정기능과 정적균형에 대한 연구

김영록,한경임 한국특수아동학회 2001 특수아동교육연구 Vol.3 No.-

본 연구는 청각장애 학생 32명의 전정 기능과 균형 능력에 관해 알아보고자 하였다. 청력의 손실은 신체 발달 능력의 지연을 초래하는데 그 가운데 전정 기능과 균형 능력에 많은 영향을 미친다. 따라서 청각장애 학생의 전정 기능과 균형 능력을 쉽고 간편하게 측정하는 방법과 그에 따른 결과를 제시하는 것은 청각장애 학생의 운동 교육에 중요한 자료가 될 것이다. 이러한 연구의 필요성에 따라 본 연구에서는 첫째, 보청기 유무에 따른 청각장애 학생의 균형 능력의 차이를 알아보았고, 둘째, 시각정보 입력의 유무에 따라 청각장애 학생의 균형 능력의 차이를 알아보았으며, 셋째, 발바닥 고유수용성 감각의 차이에 따라 청각장애 학생의 균형 능력의 차이를 알아보았다. 연구 결과 첫째, 보청기 착용 집단에서 안진의 지속 시간이 길어서(p<0.05) 청력 손실의 정도가 높을수록 균형 감각에 더 많은 영향을 미침을 알 수 있었다. 둘째, 시각 정보의 입력이 제공된 경우에 외발 기립 서기에 의한 정적 균형 수행 능력이 오래 지속(p<0.001)되어 시각이 청각장애 학생의 균형 능력에 밀접한 관련이 있음을 알 수 있었다. 셋째, 발바닥 고유 수용성 감각이 양호한 지면에서 외발 기립 서기에 의한 정적 균형 수행 능력이 오래 지속(p<0.01)되어지지 면의 안정도가 청각장애 학생의 균형 능력 지도에 중요함을 알 수 있었다. The purpose of this study was to investigate the vestibular function and static balance of students with hearing impairment. The subjects were 32(male 16, female 16) aged 11 to 19 with hearing impairment. Nystagumus testing was used to investigate the vestibular function and the one-leg standing method was used to investigate the static balance. The results were as follows: First, there were statistically significant differences on the vestibular function of students with hearing impairment in relation to with and without of hearing aids. This means the severer hearing impairment is, the severer vestibular function disorder is. Second, there was statistically significant difference on the static balance of students with hearing impairment in relation to with and without of visual input. This means the visual input is an important index of the static balance of students with hearing impairment. Third, there was statistically significant differences on the static balance of students with hearing impairment in relation to the difference of the proprioception of foot. This means the stabilization of base is important on the static balance ability of students with hearing impairment. As conclusion of this study, it is need to investigate the dynamic balance as well as the static balance of the more students with hearing impairment and to investigate the development of balance ability as the age of wearing of hearing aids in a following study.