18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

선천성 완전방실차단이 동반된 신생아 루프스 1예

정재현,이은지,이은주,황진원,송영진,최병진,김일환,김종윤,허민영,김동욱 인제대학교 2009 仁濟醫學 Vol.30 No.-

Neonatal lupus is a rare syndrome occurring In neonates with tranplacentally acquired maternal autoantibodies, In particular anti-SSA/Ro-SSB/Ra antibodies. Manifestations include congenital heart block, cutaneous lesions, thrombocytopenia, neutropenia, pulmonary or neurological disease and hepatitis. The non-cardiac manifestations resolve by 6 months of age, congenital heart block is irreversible. We experienced a case of neonatal lupus with congenital complete heart block in a newborn of asyptomatic mother with anti-SSA/Ro-SSB/Ra antibodies.

위치 제어계에서 신경망에 의한 2 자유도 PID 제어계의 구성

허진영,하홍곤,고태언 동의대학교 산업기술개발연구소 2000 産業技術硏究誌 Vol.14 No.-

Many industrial control system often use PID, I-PD in sort of the conventional control system method. But it is difficult to control a satisfactory response in variable load and changing parameter, can not have the both purpose of setpoint tracking and disturbance rejection at the same time. Therefore we propose 2-DOF(Degree of Freedom) PID controller ebust for tracking function in the target value point as well as removal disturbance. In this paper construct to 2-DOF PID control system in the position control system at D.C servo motor. first construct 2-DOF PID controller by a neural network. 2-DOF parameter (α, β, γ, η ) is tuned by the back-propagation algorithm of neural network. we consider the 2-DOF control system in the position control system and verify availableness of proposal method through the result of computer simulation.

지역사회 구강진료기관 치위생사 집단의 직무만족에 관한 조사

허희영,오정숙,성진효,김동기 조선대학교 구강생물학연구소 2002 Oral Biology Research (Oral Biol Res) Vol.26 No.2

This study is intended for suggesting some methods or measures to improve the working environment and dental service consequently by finding out general characteristics and various factors that affects the job satisfaction in the organization according to dental hygienists' job peculiarities and supplying dental hygienists' improvement in quality and good dental treatment with dental hygienists who work in the dental clinics in the community as study objects. In this study, to research and analyze dental hygienists' job satisfaction to improve dental hygienists' job satisfaction and promote efficiency in personnel management, 50 dental clinics where there were more than 5 dental hygienists were chosen at random and 250 dental hygienists who work there were given questionnaires and the questionnaires were analyzed and finally the result was as follows. Firstly, there are some general characteristics. The ages of 2.0~2.5 cover 68% of the dental hygienists. The unmarried occupied 81.2%. The size of the working place is the dental clinic(joint opening of a dental clinic), which occupied 54.2%. Secondly, there is a meaningful difference working ability, a sense of belonging and job stability or potentiality in case of job characteristics according to the marriage or singleness, and the married questionees are higher than the unmarried ones in the average value in all question sections. Thirdly, in case of the working Place that affects dental hygienists' job satisfaction there is a difference in the working region and no difference in the working place. Fourthly, it was found out that the difference between variables according to the region is meaningful. In working ability and job stability or potentiality, there is a meaningful difference according to the region. Lastly, the things that should be improved in the dental clinics are guarantee of job stability or potentiality, harmony in the group, publicity work, geographical conditions, improvement in dental treatment level, degree of reliability and kindness for patients , equipment. and finally hygiene.

세균성 키토산 가수분해효소의 부분적 특성

허승만,고영환,하진환,김재하 제주대학교 생명과학연구소 1999 제주생명과학연구 Vol.2 No.-

chitosan은 D-glucosamine이 β-(1→4) 결합으로 중합된 homopolymer로 chitin을 탈아세틸화(deacetylation)하여 제조된다. chitin은 갑각류의 껍질이나 곤충의 외피, 사상균체의 세포벽을 구성하고 있다. chitin, chitosan 또는 그 분해산물이나 유도체들의 산업적 효율성이 밝혀지면서, 이에 대한 연구가 활발히 이루어지고 있다. 그 중의 한 분야가 효소 분해법을 이용한 chitosan oligomer(chitosanoligosaccharides)의 생산이다. 본 연구에서는 chitosan을 분해하는 미동정 세균의 배양액으로부터 chitosan 가수분해효소(chitosanase)를 분리·정제하여, 주요 특성을 조사하였다. 세균의 무세포 배양액을 한외여과기(NMWL, 1K)로 여과하여 저분자량의 화합물을 제거한 다음 황산암모늄을 가하여 90% 포화시키고, 침전된 단백질을 회수하여 gel permeation chromatography(sephadex G-10과 G-100)로 chitosanase를 정제하였다. 정제전 효소의 비활성은 5.8U/mg 이었으나 정제과정을 통하여 9.7U/mg으로 증대되었다. 정제 전후를 통하여 SDS-PAGE 법에 의한 단백질의 분석과 효소활성 염색으로 한 종류의 chitosanase가 확인되었으며, 그 분자량은 약 30,000dalton 이었고, subunit는 한 종류인 것으로 추정되었다. chitosanase에 의한 기질의 분해산물을 한외여과와 TLC로 분석한 결과, 이 효소는 이량체에서 육량체까지의 chitosanoligosaccharides를 생산하였으며, 단량체를 생산하지 않는 특징이 있었다. 효소반응 최적온도는 40℃이었고, 50℃ 이상에서는 효소의 활성이 급격히 저하되어, 비교적 열안전성이 낮았다. 또한, 이 효소는 pH 5.0∼9.0 범위에서 1시간 방치해도 활성변화가 미미하여, 비교적 광범위한 중성영역에서 안정하였다. Chitosan is a polymer of D-glucosamine linked by β-(1→4) covalent bonds. It is obtained through deacetylation of chitin that occurs mainly in the shells of crustaceans and the exoskeletons of insects. It is also found in fungal cell walls. Having relatively rich natural resources, chitin and their derivatives are widely utilized in industries. Among those are chitosanoligosaccharides that are reported to have several biological functions. The production of chitosanoligosaccharides requires hydrolysis of chitosan by an acid or an enzyme. A chitosanase, the chitosan-depolymerizing enzyme, was purified from unidentified bacterial culture and its characteristics were determined. Cell-free culture of the unidentified bacterium was filtered with ultramembrane(NMWL, 1K) to remove low molecular weight compounds. Ammonium sulfate was added to the filtrate at the level of 90% saturation to induce precipitation of proteins. The precipitated proteins were desalted with sephadex G-10 column and fractionated through sephadex G-100 gel permeation chromatography. Specific activity of the enzyme before purification was 5.8 units/mg and was increased up to 9.7 units/mg through purification procedures. SDS-PAGE analysis of proteins and enzyme activity staining revealed only one kind of chitosanase in the bacterial culture. Its molecular weight was about 30,000 dalton with one kind of subunit. The catalytic unit could highly be a monomeric protein. TLC-analysis of enzymatic hydrolysis products of chitosan showed that the enzyme generated dimeric through hexameric oligomers of D-glucosamine without producing monomeric D-glucosamine. Its optimum temperature for catalytic activity was 40℃ and the catalytic activity dropped rapidly at the temperatures higher than 50℃, which reflected its low heat stability. The enzyme was stable for at least one hour at neutral pH ranges from 5.0∼9.0.

사마귀류 추출물의 생물학적 활성 비교

허진철,황재삼,강석우,윤치영,이상한 慶北大學校農業科學技術硏究所 2007 慶北大農學誌 Vol.25 No.-

In order to investigate the availability of insect resources for agrobiotechnological or medical purposes, we examined antioxidant (DPPH and FRAP assay) and cell viability by oxidant stress and NO inhibition assay by treatment of the extracts of Statilia maculata Thunberg, Tenodera angustipennis Saussure and Tenodera aridifolia Stoll. We found that Tenodera angustipennis Saussure and Tenodera aridifolia Stoll extract (DW, etanol, methanol) had high levels of anti-oxidant activity, whereas Tenodera aridifolia Stoll extract showed increased cell viability by hydrogen peroxide and inhibition of NO production. These findings suggest that Statilia maculata Thunberg, Tenodera angustipennis Saussure and Tenodera aridifolia Stoll, extract have potentials to be developed for agrobiotechnology or medicinal use, indicating that mechanistic study including inhibition against molecular inflammation will show a possibility for the development of useful insect resources.

지치 발거 후 안면부에 발생한 방선균증의 치험례

하지영,김일규,오성섭,최진호,오남식,차상권 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

Actinomycosis is chronic, granulomatous, suppurative and fibrosing disease caused by Actinomyces. Actinomyces are anaerobic, G(+), non-acid-fast, branched, filamentous bacteria. The most commonly found microorganism is Actinomyces israelii. Common site for isolation of actinomyces are dental plaque, dental caries, calculus, and tonsillar crypt. A breach in the integrity of the mucosa by direct trauma or following a fracture, tooth extraction, root canal therapy or some intraoral surgical procedure is thought to be the most likely portal of entry. This is a case report of 23 years old male with cervicofacial actinomycosis developed after extraction and treated with surgical excision and antibiotics.

낙동강 상수원수의 오존처리 효과 : II. 회분식 오존처리에 의한 휘발성유기화합물 및 조류제거 효과 II. Removal of VOCs and Algae in Raw Water by Conducting Batch Test of Ozonation Experiments

임영식,이홍재,이도진,허종수,손보균,조주식 한국환경과학회 2002 한국환경과학회지 Vol.11 No.12

This study was carried out to evaluate the pollutant removal efficiencies of the advanced drinking water treatment using ozonation process. For raw water, Nakdong River was used. By conducting batch test of ozonation efficiencies of the ozonation were 94 to 92%, respectively. Removal efficiencies of single VOC compound or mixed VOC compounds in the raw water were 80% to 90% by the ozonation with 2 mg/ℓ dosage and 10 minutes contact time. Removal efficiencies of ABS by the ozonation with 1 mg/ℓ, 3 mg/ℓ dosage and 20 minutes contact time were 83% to 96%, respectively. Almost 67% of chlorophyll-a at the concentration of 38.㎍/ℓ was removed by ozonation at ozone dosage of 1mg/ℓ for 20 min. considering the efficiency of ozone utilization and water treatment, the most effective ozonation could be obtained with high ozone dosage and short and short contact time.

단백질 수준이 흰쥐의 철, 구리 및 아연의 대사에 미치는 영향

高鎭福,許英姬 新羅大學校 1989 論文集 Vol.28 No.-

This thesies is focused on the effects of alternate changes of dietary protein levels on iron., copper and zinc metabolism in mature(18-month-old) male rats. In the experiment, the rats were fed on diets of various protein levels for 4 weeks:(1) Group Ⅰ,Ⅱ and Ⅲ received diets of 8%, 16% and 24% protein respectively throughout the experiment; (2) Group Ⅳ received alternate 3-day diets of 8% protein and 1-day diets of 24% protein throughout the experiment: and (3) Group Ⅴ received alternate 3-day diets of 24% protein and 1-day diets of 8% protein throughout the experiment. The iron concentrations of the heart of rats in Group Ⅱ and of the muscles of those in Group Ⅲ proved to be lower than those in the other groups, at the end of 4-week's experiment. The iron concentration of serum was significantily higher in Group Ⅰ than those in other groups. Group Ⅲ was highest of all the groups in the copper concentrations of kidney, muscle, and serum and the femur zinc concentration. However, neither the constancy of a protein level nor the alternate changes of protein levels affected the iron concentrations of liver, kidney, and spleen, the copper concentrations of liver and heart, and the zinc concentrations of serum and spleen. The experiment also proved that the increased proportion of dietary protein did not change the rates of apparent absorption of iron, copper and zinc.

하악골 골절후의 골치유과정에 있어서 방사선학적 추적조사

최진영,김명호,허경희,서병무,이종호,정필훈,김명진 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The results of radiographic study of healing of fractured mandible are often inconsistent with clinical evaluation of bone healing pattern of it. In addition, there is inconsistency between radiographic studies. We think if such inconsistency is resolved, clinical assessment combined with radiologic evidence can be used to guide to more accurate clinical management. The purpose of this study is to evaluate radiological healing pattern of mandible, and to apply its result to clinical use. Panoramic view was used to analyze the change of radiographic finding in 35 patients (27 male, 8 female, ranging 17 to 53 years old) treated for mandibular fracture at the department of oral & maxillofacial surgery, SNUH in the period 1991 to 1998, Patients are all treated by rigid internal fixation using monocortical miniplate. Within 9 weeks, no change is observed at fracture site. Osteogenic change is observed at various time interval (3 to 21 weeks). We have found radiographic change of healing is observed 4 to 6 weeks later to clinical healing, According to this result, we recommend radiographic follow-up at 4 week, 10 week, 10 month.