Clear cell sarcoma of the kidney : Immunohistochemical study and flow cytometric DNA analysis of 7 cases

Choi, Yoon-Jung,Jung, Woo-Hee,Jung, Soon-Hee,Park, Chanil Yonsei University, College of Medicine 1994 Yonsei medical journal Vol.35 No.3

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

원룸형 다가구주택의 봄철 실내온열환경 평가

최윤정 충북대학교 교육 ·생활연구소 생활과학연구센터 2002 생활과학연구논총 Vol.5 No.-

The Purpose of this study is to evaluate indoor thermal environment of one-room type multi-family housing during springtime in order to propose design factors improving indoor environment. Physical thermal elements(indoor temperature, relative humidity, and globe temperature) in 4 subject houses selected considering of architectural factors were measured in May, 1999. Questionnaire survey for investigating thermal responses of 25 residents was carried out. The findings are as follows. 1) Indoor temperature and globe temperature are distributed 23.5~28.5℃, 23.5~28.5℃ for southern directions and 24.0~24.5℃, 24.0~24.5℃ for northern directions in a sunny day. Indoor temperature and globe temperature are distributed 22.5~25.0, 22.5~24.5℃ for southern directions and 23.0~27.5, 22.5~27.0℃ for northern directions in a cloudy day. Relative humidity are distributed 38.0~54.0%. 2) As thermal responses, 'neutral' on thermal sensation and 'slightly dry' or 'neutral' on humidity sensation show highest percentage. 3) Therefore, indoor thermal environment of one-room type multi-family housing during springtime is evaluated on the whole comfort condition. But southern direction house at midday is in somewhat hot and dry condition, and northern direction house is in somewhat cool condition all day.

아버지의 支配性(dominance)이 子女의 性役割 選好에 미치는 影響

최보가,張允玉,金貞姬 慶北大學校 師範大學 1987 敎育硏究誌 Vol.29 No.-

Sex-role development is one of the essential tasks of child development and a part of one's personality. Many studies have been undertaken to examine the children's sex-role preference and verified the difference between boys and girls. There are many factors that effect on the children's sex-role preference. For example, there is home environment that is included parents, -family structure, home's social level, brothers and sisters' formation and birth-rank,... etc. Also, there is social environment that is included peer, teacher and mass media. But we can expect that preschool children are most effected by parents. Thus the present study was undertaken to examine the influences of father dominance on preschool children's sex-role preference. This study is aimed to find out the follows facts. 1. Degree of father dominance that is perceived by child. 2. To find out father dominance has any influence on the boy's sex-role preference. To find out father dominance has any influence on the boy's sex-role preference under each of four lowranking domains, that is, decision-making, competence, nurture and limit setting. 3. To find out father dominance has any influence on the girl's sex-role preference. To find out father dominance has any influence on the girl's sex-role preference under each of four lowranking domains, that is, decision-making, competence, nurture and limit setting. The dependent measures are 1. Toy Preference Test. 2. Father dominance examination used Father Dominance Test (Henry, B. H.) Subjects were obtained from 100 boys and 100 girls, that they were all preschool children in Daegu. For statistical analysis, Mean, the Standard Deviation, t-test, one way ANOVA and Scheffe's test were used. The levels of significant were established at 0.05 and 0.01. The results were as follows 1. Generally, both boys and girls have perceived father dominant more than mother. In case of boys, they perceived father dominant more than mother in domains of decision-making and competence. In case of girls, they perceived father dominant more than mother in domains of decision-making, competence and nurture. 2. Father dominance perceived by young children had effects on boy's sex-role preference. In general, the higher father dominance was, the higher boy's masculinity was. In domains of decision-making, competence and nurture, father dominance have significant influences to boy's sex-role preference, but in domain of limit-setting, father dominance have no significant influence. 3. Father dominance perceived by young children had effects on girl's sex-role preference. In general, the higher father dominance was, the higher girl's feminity was. In domains of decision-making and limit-setting, father dominance have significant influences to girl's sex-role preference, but in domains of nurture and competence, father dominance have no significant influence on the girl's sex-role preference.

소형아파트 전면발코니에 의한 실내온열환경 조절효과

최윤정 충북대학교 교육 ·생활연구소 생활과학연구센터 2002 생활과학연구논총 Vol.6 No.1

This study is a preliminary research on redesigns and remodeling for environmentally friendly housing. The purpose of this study was to compare the effect of indoor thermal environment by having or not having the front balcony in apartment houses. The field measurements of the thermal elements were carried out at an ordinary house having the front balcony and a renovated house converting the front balcony into the livingroom. The measurement at two-subject houses were taken on simultaneously the 27th of May, 2001. The indoor temperature showed 24.0~26.5℃(average 25.7℃) at the ordinary house having the front balcony and 24.5~27.5℃(average 26.3℃) at the renovated house without the balcony. The indoor temperature of the renovated house was 0.6℃ higher than the average of the ordinary house. The globe temperature ranged 22.0~27.0℃(average 25.6℃) at the ordinary house, and 24.0~28.0℃(averag 26.9℃) at the renovated house. The globe temperature of the renovated house was 1.3℃ higher than the average of the ordinary house. It was found that the ordinary house was on the whole in the comfortable condition except for the mid-day. In the renovated house, however, higher temperature continued throughout the day time due to no block-effect of solar radiation. So, the renovated house seemed to be lower energy efficient for refrigerating. From the results of this study, it is undesirable to remodel or convert the front balcony into the livingroom.

초보선수 경기력 향상을 위한 심리적 준비의 응용 스포츠 심리학에 관한 고찰

최윤택,정대철 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The purpose of this paper is to help coaches and instructors to improve their beginning players' athletic abilities and skills by applying mental preparation method of the sports psychology. The applied sports psychology utilizes psychological knowledge to develop, implement, and satisfy the persons concerned to the sports. The applied sports psychology includes effective improvement of sports skills, motivation to practise and endure hard drills, dealing smoothly with private matters, efforts to become a better coach, and sports psyching. The sports psyching has a variety of strategies: centering to minimize problem thought that can distract players' attention right before the game and the self-statement coping-skills, centering to decrease excessive excitement or anxiety and the self-statement coping-skills plus gradual relaxation, centering to minimize partner's psyching-out and self-statement coping-skills, recalling the best performance' to escape from the slump, setting an actual short-term goal to minimize failure or disappointment, and the coach's using check-list that helps to detect their players' sports psyching skills used. The sports psyching is a mental technology to be mastered by each individuals hard training, The beginning players can access their maximum potential through the technology acquired by sports psyching practice.

한국인 제2형 당뇨병 환자의 골격근에서 인슐린 신호전달체계의 결함

최준혁,이관우,김효정,이동훈,이종우,김정은,엄현채,김경미,최성이,정윤석,김현만 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: 제2형 당뇨병에서 나타나는 인슐린 저항성은 간, 지방, 근육 같은 말초조직에서 인슐린의 작용이 떨어지는 것을 말한다. 제2형 당뇨병의 발생기전에 인슐린 저항성과 인슐린 분비능 저하가 같이 관여함은 잘 알려진 사실이다. 인슐린의 세포내에서의 저항성을 규명하기 위한 인슐린의 세포내 신호전달체계에 대한 연구가 활발히 진행되고 있으며 몇몇 연구에서 인슐린 저항성을 가진 골격근육에서 IRS와 관련된 PI3-kinase의 활성감소와 Akt kinase의 활성감소를 보고하고 있으나 아직까지 명확하게 그 기작이 설명되어지지 않고 있다. 본 연구에서는 정상성인, 제2형 당뇨병 환자를 대상으로 경구당부하검사 및 인슐린 클램프검사를 시행하고 인슐린 클램프 검사시 대상인의 근육을 채취하여 인슐린 신호전달 체계(IR-β, IRS, Akt(PKB, Rac) kinase, GSK-3)를 연구하였다. 방법: 연구대상자는 한국인으로서 경구당부하검사상 정상인 및 당뇨병 환자 각각 11명, 9명을 대상으로 하였으며, 정상인은 건강인으로 과거력상 당대사에 영향을 줄 질환이 없고, 현재 당대사에 영향을 줄 약물 복용 및 다른 소견이 없는 경구당부하검사상 정성 내당능을 보이는 대상자로 하였다. 당뇨병환자는 모두 제2형 당뇨병 환자로 이환기간이 만 5년 이내인 경우로 하고, 인슐린으로 치료하는 대상자는 제외하도록 하였다. 대상자의 연령, 체질량지수, 체지방량, 공복시 총콜레스테롤, 중성지방, 고밀도지단백 콜레스테롤 및 HbA1c, 인슐린, C-peptide를 측정하였고, "HOMA model"을 이용하여 베타세포의 기능와 인슐린저항성 정도를 평가하였다. 정상혈당클램프 검사(euhlycemic hyperinsulinemic clamp test)를 시행하고 인슐린 투입 전과 인슐린 투입 30분후, 두차례에 걸쳐 대퇴부 근육생검을 실시한후 western 법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 측정하였다. 결과: 정상인 11명과 당뇨병 환자 9명을 대상으로 하였으며 대상자의 평균 연령, 평균 체질량지수, 체지방량, 허리/엉덩이 둘레의 비(waist hip ratio; WHR)는 두 군간에 차이가 없었다. 평균 공복혈당은 정상군 98.0±0.3㎎/dL, 당뇨병군 208.1±16.5㎎/dL(p<0.05), HbA1c는 정상군 5.4±0.5%, 당뇨병군 9.2±0.6%(p<0.05)였다. "HOMA model"을 이용한 베타세포의 기능과 인슐린저항성은 정상군 56.4±8.5%, 1.4±0.2, 당뇨병군 72.2±52.3%(p<0.01), 10.2±6.3(p<0.01)였으며 정상혈당클램프 검사상 포도당 이용률은 정상군 8.2±0.6㎎/㎏/min, 당뇨병군 3.7±1.1㎎/㎏/min(p<0.01)로 정상군과 당뇨병군간에 유의한 차이를 나타내었다. Western blot법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 인슐린 투입전과 인슐린 투입 30분후 측정하였을 때 IR-β에서는 정상군이 103.9±2.3에서 241.3±18.6, 당뇨군이 108.9±2.2에서 198.7±6.3으로 증가하였다(p=NS). 이는 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 통계적인 차이가 없었다. IRS에서는 정상군이 111.6±7.3에서 295.6±17.2, 당뇨군이 114.5±6.1에서 222.0±23.2로 증가하였으며(p<0.05), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 24% 감소하였다. Akt kinase에서는 103.4±6.0에서 416.8±29.5로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 43% 감소하였다. GSK-3에서는 정상군이 107.7±6.7에서 595.7±28.1, 당뇨군이 104.3±4.8에서 443.3±12.9로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 25% 감소하였다. 결론: 제2형 당뇨병 환자에서 정상인과 비교하여 인슐린 자극후 IR-β는 인산화량의 증가정도가 큰 차이가 없었으나, IRS, Akt kinase, GSK-3에서는 인산화량의 증가 정도가 감소되는 것으로 보아 상위 인슐린 신호전단체계부터 결함이 있는 것으로 생각된다. Background: The glucose uptake rate is the limiting step in glucose utilization and storage. The failure of insulin to stimulate glucose uptake in muscle appears to be a primary defect of insulin resistance. This study was undertaken to examine the effect of physiological hyperinsulinemia on the phosphorylation of the insulin receptor (IR-β), insulin receptor substrate (IRS), Akt kinase and GSK-3 in isolated skeletal muscle, in people with type 2 diabetes(n=9) and control subjects(n=11). Methods: 75g OGTT and euglycemic hyperinsulinemic clamp test were done. And vastus lateralis muscle was obtained before and 30 min into the euglycemic clamp. Western blots were performed for tyrosine phosphroylation of insulin receptor substrate (IRS) and phosphorylation of the insulin receptor(IR-β), Akt and GSK-3. Result: There were no statistical differences in the mean age, BMI and body fat between the control subjects and diabetic patients. The fasting blood sugar and HbA_1c in controls and diabetic patients were 98.0±0.3 and 208.1±16.5ng/dl, and 5.4±0.5 and 9.2±0.6%, and 1.4±0.2 in the control subjects, and 72.2±52.3%(p<0.01) and 10.2±6.3(p<0.01) in the diabetic patients, respectively. The insulin resistance from the euglycemic hyperinsulinemic clamp test were 8.2±0.6㎎/㎏/min and 3.7±1.1ng/㎏/min in the control subjects and in the diabetic patients, respectively(p<0.01). Compared with the normal controls, insulin-stimulated IR phosphorylation was no different to that in the diabetic patients. However, insulin-stimulated IRS phosphorylation, insulin-stimulated Akt phosphorylation and insulin-stimulated GSK-3 phosphorylation were reduced in the diabetic patients compared with the normal controls by 24, 43 and 25%, respectively(p<0.05). Conclusion: In Korean type 2 diabetic patients, the insulin resistance may be due to the impairment of the upstream insulin signal molecular network. Further studies will focus on determining whether these signaling defects are the cause of the development of insulin resistance, or secondary to the altered metabolic state, associated with type 2 diabetes mellitus (J Kor Soc Endocrinol 17:685∼697, 2002).

硏究開發 프로젝트 選定評價模型에 관한 硏究 : 水産公共硏究機關의 硏究開發事業을 중심으로

崔正鈗,宋鶴鎭 釜山水産大學校 1992 論文集 Vol.48 No.-

This paper aims to examine and analyze the merits and demerits of the existing evaluation models and to contribute to the practical applications of the evaluation models appropriate to both business and public organization. This study classifies the existing models into four categories based on the criteria as follows ; 1) the characteristics of the model ; 2) the stepwise decision making ; 3) the ovjective ; 4) the development process. Furthermore, these models are divided into the following groups on the basis of the evaluation purpose ; 1) the screening model ; 2) the prioritizing model ; 3) the resource allocation model ; 4) the compound application model. This study is to study and aggregation model which enables the project manager to make a rational decision in project selection. The aggregation model is divided into sub-models according to the evaluation objects ; DAHS, DAHP, and DAHR model. DAHS model is for the screening of the proposed projects by using scoring methods based on Delphi and AHP methods. This sub-model is appropriate for eliminating the most undesirable from further consideration. DAHP model is for prioritizing the screened candidates. For the measure of goodness, the priority vectors are calculated (or generated) using AHP and Delphi method. DAHR model is studied by this paper for the R/D resource allocation using LP and 0-1 programming. This sub-model uses a utility value calculated by the priority vectors. The aggregation model is applied to the evaluation of a public research institute projects with a series of real data. Several conclusions are drawn from the analysis and evaluation of the projects. The DAHS model solves the problems posed by the subjectivity in determination of evaluating factors and their weights, which prevails in existing evaluation models. The priority of R & D project is decided by the of DAHP model, which makes mutual comparisions of the concerned elements. Therefore DAHP model is considered to be more rational than the existing ones. DAHR model helps to distribute the R & D resources effectively by means of LP and 0-1 programings using priority vector. The application of the priority vector for LP and 0-1 programmings according to partial or total implementation eases much of difficulties in computing the extent of contribution. Especially proposed model is known the be appropriate to eliminate the factors of subjective evaluation. In conclusion, proposed model is considered to be useful in practically serving the purpose of evaluation R & D projects for both business and public organizations.

저먼 세퍼드에서 발생한 내측 갈고리돌기 유합부전을 컴퓨터 단층촬영술을 이용하여 진단한 증례

황윤태,안지영,신희승,최호정,이영원 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2009 動物醫科學硏究誌 Vol.16 No.1

A 4-year-old male German shepherd dog with reluctance to exercise, swelling of bilateral elbow joint and general depression was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. Swelling, alopecia and lichenification of bilateral elbow joint were observed on physical examination. Osteophytes, sclerosis and joint mouse of bilateral elbow joint were found on radiography. Deformation of medical coronoid process and soft tissue density swelling at caudal part of bilateral elbow joint were also observed on radiography. Computed tomography revealed fragmented medial coronoid process and osteophytes of bilateral elbow joint. Therefore this case was diagnosed as fragmented medical coronois process and degenerative joint disease.

스쿠버다이빙 참가유형에 따른 라이프스타일에 관한 연구

윤상문,최정도 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

The purpose of this study was to investigate opportunities in the scuba diving market and examine the lifestyles of scuba diving customers based on the pattern of their participation in scuba diving in order to provide the important data for developing effective marketing strategies. The subjects included 843 scuba diving customers of scuba diving resorts or scuba diving pro shops in the Republic of Korea. They were asked to complete a survey at either a resort or a pro shop. The statistical analyses were performed by using the SPSS 10.0 software. The statistical techniques used for analysis were factor analysis, reliability analysis, frequency. One-way ANOVA, and Scheffe's post hoc test. Statistical significance was accepted at an alpha level of p<.05. The major findings of this study were as follows: First, individuals pursuing for health showed the highest participation in scuba diving at four times or more a week. It was followed by innovators who were very receptive to new ideas, individuals valuing social recognition, and individuals who were followers of fashion and trends. Second, individuals with less than 3 years of scuba diving experience were most often found among the followers, and followed by conservative people. Individuals with at least 11 years of scuba diving experience were most often found among the innovators, and followed by the individuals valuing social recognition. Third, individuals with advanced scuba diving skills were most often found among the individuals pursuing for health. It was followed by the innovators, and the individuals valuing social recognition. In the meantime, the beginners were most often found among the followers and the conservative people. Fourth, all different lifestyle groups showed significantly differences when they participated in scuba diving with their colleagues, friends or alumni. The individuals pursuing for health showed the highest difference and were followed by the innovators, the individuals valuing social recognition, the followers, and the conservative people. Fifth, the conservative group showed significantly higher interest in improving health and fitness as a reason to participate in scuba diving. The individuals valuing social recognition showed significantly higher interest in learning scuba diving skills, the followers participated in for social reasons, and the individuals pursuing for health and the innovators wanted to have a scuba diving career.