달의 모양과 위치변화에 대한 개념 형성을 위한 달모양판의 개발과 적용에 관한 연구

유병태,한영욱 부산교육대학교 과학교육연구소 2006 科學敎育硏究 Vol.31 No.-

The purpose of this research is to design the moon-shape plate to teach "The Earth and the Moon" in the second semester of the third grade and to find its effectiveness for students to lay their conceptual foundation on the subject. The effectiveness of the moon-shape plate was investigated through an integrated science class in which students learned the shapes and positions of the moon using the device. The integrated science class was held at S elementary school in Busan. 4 classes of the 3rd grade were chosen and divided into two groups, which were a comparative group and an experimental groups., To find out the effects of the adaption classes, pre-tests and post-tests were executed on the concept of the changes of lunar shape and the position of the moon. The cognition for the practical use of the moon-shape plate in the experimental groups was summarized. The results are as follows. First, the moon-shape plate is easy to access and manipulate in 'The Earth and the Moon' class for the third grade students. It is very useful and practical as a learning instrument which is adjusted by the scientific theory. Second, the changes of the rising point of the moon by the lunar calendar are exactly and clearly understood. Third, with the comparison results on the moon position by daily observation and the moon-shape plate, the students can easily draw the right positions and shapes of the moon. Fourth, regardless of the weather condition, the moon-shape plate is very helpful to the learners-centered method. The experimental groups have more effective aspects by showing the meaningful results compared with the comparative ones learned with traditional ways.

간암세포에서 저산소증에 의해 유도되는 VEGF의 발현기작에 대한 연구

권유욱,배수경,김정애,김규원,박병채 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-

Puropse: Hepatocellular carcinoma (HCC), a typical hypervasculized tumor is very sensitive to hypoxia and vascular endothelial growth factor (VEGF) has previously been identified to be up-regulated in response to hypoxia in several cell types. However, the molecular mechanisms by which hypoxia is sensed by the cells remain enigmatic. To investigate whether calcium and AP-1 are involved in hypoxia-sensing mechanism, we performed following experiments. Materials and Methods: Hep3B cells were grown in hypoxic condition. To assess cell viability, MTT assay was performed. To investigate the effect of calcium and AP-1, northern blot analysis was performed after treatment with BAPTA/AM. Results: The expression of VEGF was significantly up-regulated by hypoxia in Hep3B, hepatocellular carcinoma cell line. The increased expression of VEGF induced by hypoxia was blocked by the addition of BAPTA/AM, a cytosolic calcium chelator to the media. In addition, we found that the expression of c-jun protooncogene was also up-regulated by hypoxia. Hypoxic increase of c-jun expression was also normalized by the treatment with BAPTA/AM. Conclusion: These results suggest that the increased expression of VEGF by hypoxia is mediated through the calcium and c-jun signalling pathway in the Hep3B human hepatoma cell lines.

간암세포에서 저산소증에 의해 유도되는 VEGF의 발현기작에 대한 연구

권유욱,배수경,김정애,김규원,박병채 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-

Purpose: Hepatocellular carcinoma(HCC),a typical hypervasculized tumor is very sensitive to hypoxia and vascular endothelial growth factor(VEGF) has previously been identified to be up-regulated in response to hypoxia in several cell types. However, the molecular mechanisma by which hypoxia is sensed by the cells remain enigmatic. To investigate whether calcium and AP-1 are involved in hypoxia-sensing mechanism, we performed following eaperiments. Materials and Methods: Hep3B cells were grown in hypoxia condition. To assess cell viability, MTT assay was performed. To investigate the effect of calcium and AP-1,northern blot analysis was performed after treatment with BAPTA/AM. Results: The expression of VEGF was significantly up-regulated by hypoxia in Hep3B, hepatocellular carcinoma cell line. The increased expression of VEGF induced by hypoxia was blocked by the addition of BAPTA/AM, a cytosolic calcium chelator to the media. In addition, we found that the expression of c-jun protooncogene was also-regulated by hypoxia. Hypoxia increase of c-jun expression was also normalized by the treatment with BAPTA/AM. Conclusion: These results suggest that the increased expression of VEGF by hypoxia is mediated through the calcium and c-jun signalling pathway in the Hep3B human hepatoma cell lines.

9-12%Cr강의 첨가원소 및 열처리에 따른 미세조직거동과 경도변화

주성욱,유정훈,신기삼,허성강,이재현,석진익,김병훈,김정태 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

9-12%Cr steel are getting increasing attention for expanded application as high temperature materials applicable for gas turbine compressors, steam turbine rotors, blade and casing. For efficient and extensive application of 9-12%Cr steel, the data in addition to the improvement of mechanical properties on the correlation of microstructural evolution and mechanical properties are inevitable and thus the investigation in this study is performed for the determination for the specimens heat-treated at 600, 650 and 700℃ for 1000, 3000 and 5000hrs. The microstructure of as-received specimen was tempered martensite, with a high dislocation density and secondary phases. Upon high temperature heat-treatment, the martensite lath got larger and dislocation density decreased resulting the reduction of the strength. In addition, sharp growth of secondary phases was observed in the specimen heat-treated at 700℃ for 5000hrs. A specimen aged at 600℃ and 650℃ Laves phase was observed. The hardness showed close relationship with the secondary phase particle and dislocation density.

최근 5년간 급성 A형 간염으로 입원한 환자들에 대한 입원 내용 분석

장재영,유병욱,조용진,오정은,홍성호,조주연 순천향대학교 의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.15 No.1

Abstract Background : Due to improvements in Korea's sanitary conditions, antibody rates to the hepatitis A virus is decreasing rapidly and admission due to the disease is increasing, Patients who were admitted for hepatitis A during the last 5 years were selected and yearly differences in admission, clinical picture, medical fees, and differences according to age and gender were analyzed. Methods : Patients who were admitted to the Seoul Soonchunhyang University Hospital during the 5 year period between May of 2003 and April of 2008 and tested positive for IgM anti-HAV were selected and their medical records retrospectively analyzed. Results : 156 subjects [91 male (58%), 65 female (42%) were selected. The average age was 29.2 years (range; 21.4-37), average admission period 12.6 days (range; 12.5-1 7.7) days, and average medical fees 2,295,151 (range; 932,097-3,658,205) KRW(Korean Won), Yearly incidence rates were as follows : 10 for May, 2003 to April, 2004, 14 for May, 2004 to April, 2005, 23 for May, 2005 to April, 2006, 69 for May, 2006 to April, 2007, and 41 for May, 2007 to April, 2008, The maximum value median of AST, ALT, and bilirubin during admission was 989 IU/L, 1999 IU/L, and 5.6 mg/dL each, Each factors were all positively correlated with the patient's age. Conclusions : Recent decrease in antibody positivity of the hepatitis A virus and subsequent surge of acute hepatitis A is a cause of rising socioeconomic costs. A large scale epidemiologic research on whether HAV vaccination should be made mandatory and health insurance applied seems to be needed. Key words : Hepatitis A, Age, Medical fees, Vaccination

傾斜진 두 平板이 結合된 直角모서리에서의 自然對流

權純錫,柳秉郁 동아대학교 공과대학 부설 한국자원개발연구소 1990 硏究報告 Vol.14 No.2

A Study has been conducted experimentally on natural convection heat transter characteristics for various position and various Rayleigh number at two inclined plates with the rectangular corner. The results are as follows : 1) The mean Nusselt number of Ra_(L)=1.550×10⁴ is 29.0% at θ=30°, 23.1% at θ=45°, 23.13% at θ=60° more than that of Ra_(L)=1.220×10⁴. 2) In case of Ra_(L)=1.550×10⁴, the mean Nusselt number is 52.4% at θ=30°, 71.2% at θ=45°, 74.2% at θ=60° more than the result of reference 8. 3) The mean Nusselt number of the plate in θ=45° is 51.5% at Ra_(L)=1.550×10⁴, 71.2% at Ra_(L)=1.550×10⁴ more than the result of reference 8. 4) In the plate of θ=60°, the mean Nusselt number of Ra_(L)=1.550×10⁴ is 25.6% more than that of Ra_(L)=1.550×10⁴.

월경주기 증상의 요인 분석

이수일,유태혁,강종선,안석철,이병욱,김헌,석재호 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.1

404 nurses and nurse-aids rated their experiences of 45 symptoms(Moos' Menstrual Distress Questionnaire) of the menstrual, premenstrual and intermenstrual phase on a 4 point scale separately. The 45 symptoms were inter-related and factor analyzed separately for each phase. six common clusters of symptoms emerged from 3 phases, which were labeled concentration, motor tension, pain, pleasurable affect, autonomic reactions and water retention. Four clusters of symptoms emerged from premenstrual phase. These clusters were labeled instabillity, withdrwal reactions, depression and headache. The factor named unpleasurable affect emerged from intermenstrual and menstrual phase. Above findings were differed from the results of Moos' study in which eight basically replicated clusters of symptoms emerged from three phases. Through discussion of validity of this scale, and differences between results of Moos' and this study, we came to the conclusion that sampling of subjects, prospective longitudinal symptoms reporting, amount of variance in a symptom over the course of menstrual cycle and proper choice of factor analysis method would be salient variables to construct valid scale for measuring menstrual cycle symptoms.

Escherichia coli 패혈증 환자에 합병된 대칭적 하지 말단 괴사증 1예

남해성,유진홍,권순석,민준기,조현선,박민경,심병주,남유정,이지인,김진수,길욱현,조근종,신완식 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

We have encountered a rare case of symmetrical peripheral gangrene complicating Escherichia coli sepsis in a 47-years-old male. He was successfully treated with antibiotics, anticoagulants, and vasodilator. To our knowledge, this is the first report on symmetrical peripheral gangrene complicating E. coli sepsis in Korea.

치료용 방사선의 입사각에 따른 광섬유 방사선량계의 체렌코프 빛 측정 및 분석

장경원,조동현,유욱재,신상훈,서정기,이봉수,박병기,문주현 제주대학교 방사선응용과학연구소 2008 방사선응용과학연구소논문집 Vol.22 No.-

In this study, we have measured scintillating light generated in a fiber-optic dosimeter by high energy photon and electron beams using a charge-coupled device. The intensity of Cerenkov lights are also measured and characterized as functions of incident angles and energies of the high energy beams from a clinical linear accelerator. To minimize or remove Cerenkov light, a simple subtraction method using a background optical fiber and wavelength discrimination method using optical filters are investigated. Also, the intensities of Cerenkov light induced by high energy photon and electron beams are compared.

동종 골수이식 후 만성 이식편대숙주반응 환자에서 발생한 폐렴구균에 의한 수막뇌염 1예

신완식,김병욱,유진홍,김동집,김춘추,박종원,이종욱,김동욱,강문원,김양리 대한감염학회 1993 감염 Vol.25 No.3

Graft-versus-host disease (GVHD) is a frequent complication after bone marrow transplantation. Infectious complications are common in GVHD patients due to defect in cell-mediated immunity. A rare case of S. pneumoniae meningoencephalitis occured in a patient with extensive form of chronic GVHD after allogeneic bone marrow transplantation. He was immediately treated with full dosage of ceftriaxone and ampicillin. He suffered from various complications such as sepsis, acute renal failure, atelectasis, and seizure. Despite of aggressive treatment, he died probably due to renal shutdown and massive subacute cerebral infarction of left cerebral hemisphere. This report showed two unusual and rare features. First, the infection site was CNS rather than respiratory system. Second, the causative organism was S. pneumoniae, which is rare cause of CNS infection in immunocompromised patients.