전류 비유 모델에 의한 초등학생의 전류 개념 변화 분석

유병길,강인석,김병철,남만희,박선희,소하연,윤희정,이영아,이하룡,전병문,정승호 부산교육대학교 과학교육연구소 2000 科學敎育硏究 Vol.25 No.-

There exists a major impediment to learning electricity which may illuminate why direct presentation of scientists' ideas is too aggressive a strategy. This impediment lies in thinking that electricity is used up and in envisaging the light bulb as a consumer. This view is based on a powerful idea which summarises much of our experience; it declares that 'things get used up', 'you cannot get something for nothing', and 'intuitive thinking'. To replace this view with scientific view, we made the analogy model. It is suggested that the analogy model is more effective in teaching electricity circuits than conventional teaching method.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

Standardized protocol of blood pressure measurement and quality control program for the Korea National Health and Nutrition Examination Survey

Kim Hack-Lyoung,Park Sang Min,Cho In-Jeong,Kim Yu-Mi,Kim Dae-Hee,Sung Hye Kim,김광일,성기철,임상현,Shin Jinho,Yoonjung Kim,Kyungwon Oh,Lee Eun Mi 대한고혈압학회 2023 Clinical Hypertension Vol.29 No.-

Accurate blood pressure (BP) measurement is crucial for hypertension detection and management. The Korea National Health and Nutrition Examination Survey (KNHANES) assesses the health of Koreans using representative cross-sectional data. BP measurements were historically done with mercury sphygmomanometers for participants aged ≥10 years. However, KNHANES transitioned to Greenlight 300TM (mercury-free auscultatory device) in 2020 for participants aged ≥6 years and used dual devices (Microlife WatchBP Office AFIB and Greenlight) in 2021-2022. To ensure consistency, KNHANES will adopt Microlife as the unified BP device with Greenlight for device validation from 2023. Under the new protocol, participants aged ≥6 years will have their BP measured three times at 30-second intervals after a 5-minute rest under ambient temperature (20-25℃) and noise ≤65 dB. The average of the 2nd and 3rd readings will be used as the representative BP value. The quality control (QC) program involves four trained examiners passing the “quality control and assurance of BP measurement program” three times annually, and undergoing “video monitoring of weekly calibration process” once a year. Additionally, the QC team will conduct “on-site evaluations of BP measurement” at mobile examination centers three times a year. A Five-Step QC process for BP devices was also developed. This document outlines the standardized BP measurement protocol and rigorous QC program in KNHANES, aiming to ensure accurate and reliable BP data for epidemiological research and public health policymaking in South Korea.

A genome-wide association study identified new variants associated with the risk of chronic hepatitis B

Kim, Yoon Jun,Kim, Hwi Young,Lee, Jeong-Hoon,Yu, Su Jong,Yoon, Jung-Hwan,Lee, Hyo-Suk,Kim, Chung Yong,Cheong, Jae Youn,Cho, Sung Won,Park, Neung Hwa,Park, Byung Lae,Namgoong, Seok,Kim, Lyoung Hyo,Cheo Oxford University Press 2013 Human Molecular Genetics Vol.22 No.20

<P>Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, several genome-wide association studies (GWASs) of CHB identified human leukocyte antigen (HLA) loci, including HLA-DP and HLA-DQ in Asian populations, as being associated with the risk of CHB. To confirm and identify the host genetic factors related to CHB infection, we performed another GWAS using a higher-density chip in Korean CHB carriers. We analyzed 1400 samples from Korean population (400 CHB cases and 1000 population controls) using a higher-density GWAS chip [1 140 419 single nucleotide polymorphisms (SNPs)]. In subsequent replication analysis, we further analyzed in an independent study of a Korean CHB cohort consisting of 2909 Korean samples (971 cases and 1938 controls). Logistic regression methods were used for statistical analysis adjusting for age and sex as covariates. This study identified two new risk-associated loci for CHB on the HLA region of chromosome 6, e.g. rs652888 on euchromatic histone-lysine-methyltransferase 2 (EHMT2, <I>P</I> = 7.07 × 10<SUP>−13</SUP>) and rs1419881 on transcription factor 19 (TCF19, <I>P</I> = 1.26 × 10<SUP>−18</SUP>). Conditional analysis with nearby HLA CHB loci that were previously known, confirmed the independent genetic effects of these two loci on CHB.</P><P><B>Conclusion</B>: The GWAS and the subsequent validation study identified new variants associated with the risk of CHB. These findings may advance the understanding of genetic susceptibility to CHB.</P>

Effect of Boron Substitution on the Properties of NiZnCu Ferrite for Multilayer Chip Inductors

Sung Yong An,Soo Hwan Son,Sung Lyoung Kim,Jin Woo Hahn,Jeong-Wook Kim,Kang Ryong Choi,Sung Wook Hyun,Chin Mo Kim,Chul Sung Kim 한국자기학회 2010 한국자기학회 학술연구발표회 논문개요집 Vol.2010 No.12

The incidence and predictors of overall adverse effects caused by low dose amiodarone in real-world clinical practice

( Hack Lyoung Kim ),( Jae Bin Seo ),( Woo Young Chung ),( Sang Hyun Kim ),( Myung A Kim ),( Joo Hee Zo ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.5

Background/Aims: Most current knowledge regarding amiodarone toxicity derivesfrom clinical trials. This study was performed to investigate the incidenceand risk factors of overall adverse effects of amiodarone in real-world practice usinga large sample size. Methods: Between January 1, 2000 and March 10, 2012, a total of 930 consecutivepatients who had been treated with amiodarone for arrhythmia were reviewedretrospectively. An amiodarone-associated adverse event was considered in casesof discontinuation or drug dose reduction due to an unexpected clinical response. Results: The mean daily dose of amiodarone was 227 ± 126 mg, and the mean durationwas 490 ± 812 days. During the mean follow-up duration of 982 ± 1,137 days,a total of 154 patients (16.6%) experienced adverse effects related to amiodarone,the most common being bradycardia or conduction disturbance (9.5%). Major organtoxicities in the thyroid (2.5%), liver (2.2%), eyes (0.6%), and lungs (0.3%) wererare. All patients recovered fully without complications after amiodarone discontinuationor dose reduction. The only independent predictor of adverse effectswas the duration of amiodarone treatment (odds ratio, 1.21; 95% confidence interval,1.03 to 1.41; p = 0.016, per year). Conclusions: Low-dose amiodarone is well tolerated in a real-world clinical population. Further studies with a prospective design are needed to confirm thisfinding.

Lifestyle Modification in the Management of Metabolic Syndrome: Statement From Korean Society of CardioMetabolic Syndrome (KSCMS)

Hack-Lyoung Kim,Jaehoon Chung,Kyung-Jin Kim,Hyun-Jin Kim,Won-Woo Seo,Ki-Hyun Jeon,Iksung Cho,Jin Joo Park,Min-Ho Lee,Jon Suh,Sang-Yup Lim,Seonghoon Choi,Sang-Hyun Kim 대한심장학회 2022 Korean Circulation Journal Vol.52 No.2

With the recent rapid increase in obesity worldwide, metabolic syndrome (MetS) has gained significant importance. MetS is a cluster of obesity-related cardiovascular risk factors including abdominal obesity, atherogenic dyslipidemia, high blood pressure and impaired glucose tolerance. MetS is highly prevalent and strongly associated with an increased risk of developing diabetes and cardiovascular disease, putting a great burden on human society. Therefore, it is very important to reduce MetS risk, which can improve patients’ cardiovascular prognosis. The primary and most effective strategy to control each component of MetS is lifestyle change such as losing body weight, keeping regular exercise, adopting a healthy diet, quitting smoking and alcohol drinking in moderation. Many studies have shown that lifestyle modification has improved all components of MetS, and reduces the incidence of diabetes and cardiovascular disease. Here, the Korean Society of CardioMetabolic Syndrome has summarized specific and practical methods of lifestyle modification in the management of MetS in the healthcare field.

Cytidine deaminase polymorphisms and worse treatment response in normal karyotype AML

Hyo Kim, Lyoung,Sub Cheong, Hyun,Koh, Youngil,Ahn, Kwang-Sung,Lee, Chansu,Kim, Hyung-Lae,Doo Shin, Hyoung,Yoon, Sung-Soo Springer Science and Business Media LLC 2015 Journal of human genetics Vol.60 No.12

응급구조(학)과 학생의 메르스에 관한 지식, 태도 및 예방행위와의 관계

김성령(Sung-Lyoung Kim),유영건(Young-Gun Yoo) 한국산학기술학회 2020 한국산학기술학회논문지 Vol.21 No.5

본 연구는 응급구조(학)을 전공하는 학생들의 메르스에 관한 지식, 태도 및 예방행위와의 관계를 파악하여 메르스 예방교육에 대한 기초자료를 제공하고자 하였다. 연구방법은 2019년 11월 8일부터 2019년 11월 30일까지 P시 3년제 대학 응급구조과에 재학 중인 167명을 대상으로 하였고, 연구도구는 구조화된 설문지를 이용하였다. 연구결과는 SPSS/WIN 23.0을 사용하여 분석하였다. 대상자의 메르스 교육 경험은 경험자 74명(44.3%), 비 경험자 93명(55.7%)으로 경험하지 않은 대상자가 많은 것으로 나타났으며, 메르스에 관한 태도 항목에서는 ‘메르스 환자를 다룰 때는 반드시 개인보호장비를 착용해야 한다’에서 평균 4.54±0.87로 높게 나타났으며, 메르스에 관한 예방행위항목에서는 ‘평소보다 더 자주 손을 씻었다’에서 평균 3.82±1.06으로 높게 나타났다. 메르스에 대한 상관관계분석 결과 ‘친구 모임, 외식, 스포츠 관람, 쇼핑 등을 취소하거나 미루었다’ 한 항목에서 r=-.63, p<.004로 음(-)의 상관관계를 제외하고 모두 태도가 높을 수록 예방행위 수준이 높았다. 따라서 본 연구의 결과를 토대로 메르스에 대한 교육수준 및 지식수준을 향상시킬 수 있는 교육 프로그램의 개발이 필요하며, 메르스에 대한 체계적이고 반복적인 교육이 필요하다고 사료된다. This study was undertaken among students majoring in Emergency Medical Technology, to comprehend the knowledge, attitudes and preventivebehaviorsassociated with MERS.This study further provides basic data for education related to MERS prevention.A total of 167 students were enrolled in the study. Evaluation of MERS education revealed a higher number of inexperienced subjects: 74 experienced(44.3%) vs. 93 inexperienced(55.7%). Assessing theattitude items for MERS revealed that "have to wear personal protective equipment when dealing with MERS patients" ranked highest (average, 4.54 ± 0.87), whereas "washed my hands more often than usual" ranked highest (average, 3.82 ± 1.06) in the prevention items for MERS.Analyzing the correlation between attitude towards MERS and preventive behavior revealed that"canceled or delayed meeting with friends, eating out, watching sports, shopping, etc."showed that, although negatively correlated, a greater attitude showed a higher level of prevention (r=-0.63, p<0.004). Taken together, results of this study indicate the necessity to develop an education program that improves the level of education and knowledge about MERS, and to impart this education systematically and repeatedly.

구급대원의 출동벨에 대한 스트레스 인지 비교

김성령(Sung-Lyoung Kim),이남종(Nam-Jong Lee),신교석(Gyo-Seok Shin) 한국산학기술학회 2020 한국산학기술학회논문지 Vol.21 No.4

본 연구는 구급대원을 대상으로 현 출동벨에 대한 스트레스를 파악하고 출동벨에 대한 요구 및 개선점을 파악하여 현실적으로 적용 가능한 출동벨 변경을 위한 기초자료로 제공하기 위한 조사연구이다. 자료 수집은 2019년 8월 28일부터 9월 21일까지 자발적 의사에 의해 연구에 동의하는 대상자 267명을 대상으로 온라인 설문조사로 수집되었다. 연구도구는 구조화된 설문지를 이용하였다. 연구결과는 SPSS/WIN 23.0을 사용하여 평균과 표준편차, 백분율 및 빈도 분석, 독립표본 t-검정으로 분석하였다. 현 근무지의 구급 출동벨 유형은 복합형이 143명(53.4%)으로 가장 많았고 출동벨에 대한 부정적인 생각이 132명(49.4%)으로 높아 주기적인 교체가 필요하다고 사료된다. 상황별 스트레스로는 취침 중에 출동벨을 들었을 때 4.35±0.94로 가장 높았다. 일평균 구급출동 횟수에 따른 취침 중 스트레스에서는 9회 이상과 9회 미만 출동하는 그룹이 통계학적으로 유의미한 차이를 보였다(p<0.05). 구급대원이 원하는 출동벨의 유형으로는 "부드러운 음악"과 "자연의 소리" 등으로 현 출동벨의 교체를 원하는 비율이 168명(62.9%)으로 절반 이상을 차지하였고, 24개월 이내로 주기적인 출동벨의 교체를 원하는 비율도 163명(91.6%)으로 높기 때문에 출동벨에 대한 개선이 필요할 것으로 사료된다. This study was conducted to provide basic data for realistic applicable changes of sirens by identifying the stress due to the currently used sirens and the need for improving siren. The data was collected from an online survey of 267 subjects who voluntarily agreed to join this study from August 2019 to September, 2019. A structured questionnaire was used as a research tool. The results were analyzed by means and standard deviations, percentages and frequency analysis, and independent t-tests using SPSS. For the current workplace emergency siren type, it is believed that the number of hybrid formats was 143, the most negative opinion of the siren is high at 132, so periodic replacement is needed. For contextual stresses, the highest was 4.35 ± 0.94, when the siren was heard during bedtime. In the stress during sleep, which was based on the daily mean number of movements,, a statistically significant difference was shown between groups of 9 or more movements and below 9 movements (p <0.05). The type of siren paramedics wanted was "soft music" and "sound of nature". More than half of 168 people (62.9%) wanted to replace the current siren, and 163 (91.6%) wanted that periodically within 24 months. Therefore, it is necessary to improve the siren.