Role of glucosylceramide in vascular smooth muscle cells function

Seok-Jon Suh,Cheorl-Ho Kim 한국당과학회 2008 한국당과학회 학술대회 Vol.2008 No.1

Glucosylceramide synthase (GCS) catalyzes glycosylation of ceramide and produces glucosylceramide. Ceramide accumulation in cells induces apoptosis, and its glycosylation make it possible to escape from ceramide-induced apoptosis. In some cases, it was reported GCS can lead to multidrug resistance of cancer cells and its depletion cause neuronal defect in brains. Previous report indicates Glycolipids, especially glucosylceramide (GluCer), Lactosylceramide (LacCer) and GM3 ganglioside was accumulated in atherosclerotic lesion. In the atherosclerosis, TNF-α was a prominent inducer of proliferation and migration of vascular smooth muscle cells (VSMC). Reasonably TNF-α does not stimulate apoptotic signals in VSMCs. In our results, we found TNF-α induced the expression of GCS and stimulated ganglioside production in HASMCs. GCS expression was inhibited by a MAPKinase inhibitor, U0126. In addition, PDMP, a GCS inhibitor, suppressed the TNF-α induced proliferation of HASMCs. Taken together, it is supposed GCS is a gatekeeper of TNF-α induced cell proliferation and ganglioside production in atherosclerotic lesion.

허혈성 심질환에서 산화된 저밀도 지단백과 염증지표에 관한 연구

서존 ( Jon Suh ),변정득 ( Jeong Duk Byun ),온영근 ( Young Keun On ),현민수 ( Min Su Hyon ),김성구 ( Sung Koo Kim ),권영주 ( Young Joo Kwon ) 대한내과학회 2003 대한내과학회지 Vol.64 No.5

목적 : 허혈성 심질환의 발생기전에 산화된 저밀도 지단백 및 관상동맥의 염증이 관여하는 것으로 알려져 있다. 이에 산화된 저밀도 지단백과 염증지표들을 허혈성 심질환의 표현군에 따라 비교하였다. 방법 : 142명의 대상환자들을 대상으로 관상동맥 조영술을 실시하였고, 107명의 허혈성 심질환(안정형 협심증 58명, 불안정형 협심증 30명, 급성 심근경색증19명)환자와 관상동맥 조영술상 관상동맥 질환이 없는 35명을 정상 대조군으로 분류하였다. 각 임상적 분 Background : There is increasing evidence that inflammation is an important determinant of the development of atherosclerosis and that oxidation of low-density lipoprotein (LDL) obviously plays an important role in the pathogenesis of atherosclerosis. We

Performance Comparison of Tracking Filters in Terms of Predicted Hitting Point

Suh, Tae-Il,Kim, Eui-Jin,Lee, Bum-Jik,Ryu, Jon-Ha,Lee, Sung-Eun 제어로봇시스템학회 2010 Transaction on control, automation and systems eng Vol.12 No.1

This article describes the performance comparison of several tracking filters from the viewpoint of gun fire control. It is common that filter performance can be represented by the RMSE of the current state. However, for the design of a gun fire control system, the performance of the tracking filter in terms of prediction is more important since the current state proceeds with a designed dynamic model to a certain future which is used for the final gun order. It is shown that the predicted results amplify the current state RMSE and can be a good measure.

Direct Confinement of Individual Viruses within Polyethylene Glycol (PEG) Nanowells

Suh, K. Y.,Khademhosseini, A.,Jon, S.,Langer, R. American Chemical Society 2006 NANO LETTERS Vol.6 No.6

인터넷 중독 예방 프로그램의 효과

박민수(Minn Suh Park),전덕인(Duk-In Jon),홍현주(Hyun Ju Hong),정명훈(Myung Hun Jung),홍나래(Narei Hong) 대한사회정신의학회 2017 사회정신의학 Vol.22 No.2

연구목적 : 인터넷이 보급되면서 인터넷 중독의 피해가 확산되고 있고, 청소년기는 중독에 대해 취약한 시기이기에 인터넷 중독에 대한 예방 책이 중요하다. 본 연구는 기존 인터넷 중독 예방 프로그램의 효과를 초등학교 고학년 학생 집단을 대상으로 중독 증상의 정도와 양상의 변화를 통해 확인하고자 했다. 방 법 : 경기도 1개 시의 5개 초등학교에 소속된 4, 5학년 초등학생 대상으로 인터넷 중독 예방 프로그램을 시행하였다. 이중 프로그램 시행 전, 직후 2번에 걸쳐 청소년 인터넷중독 자가진단 척도(KS-II)을 작성한 556명을 대상으로 분석을 시행하였다. 일반 사용자군, 위험 사용자군으로 나눠 일상생활 장애, 가상적 대인관계 지향성, 금단, 내성의 척도 내 4가지 영역에 대해 독립표본 T검정과 반복측정 분산분석을 시행하였다. 결 과 : 프로그램 시행 후 일반 사용자군과 위험 사용자군 모두 일상생활 장애, 가상적 대인관계 지향성, 금단, 내성 등 전 영역에 걸쳐 통계적으로 유의하게 점수가 감소하였다. 일상생활 장애, 금단, 총점의 경우, 두 군 사이의 상호작용 효과가 나타나 일반 사용자군에 비해 위험 사용자군에서 점수가 더 감소하였다. 결 론 : 인터넷 중독 예방 프로그램이 인터넷 중독 위험 사용자군과 일반 사용자군에서 인터넷 중독에 대한 인식 정도를 변화시키는 것을 통해 중독 증상의 정도와 양상에 영향을 준다는 것을 청소년 인터넷 중독 자가진단 척도의 변화로써 확인할 수 있었다. 또한 그중에서도 일상생활 장애, 금단 및 총점의 경우, 위험 사용자군에서 특이적으로 점수를 더욱 감소시킨다는 것을 알 수 있었다. Objectives : While Internet is being spread, the problems of internet addiction is also increasing in the world. Because adolescent is fragile to addiction, internet addiction prevention is important. This study tries to check the effect of the established internet addiction prevention program for elementary school students with change of addiction-related symptoms. Methods : The internet addiction prevention program was run for 4th and 5th grade students of 5 elementary schools in 1 city of Gyeonggi-Do, Korea. 556 participants completed Internet Addiction Scale for Adolescent (KS-II) before and after the 3-session program. We divided the participants into 2 groups, normal user group and risky user group, and conducted independent T test and repetitive ANOVA over 4 domains, disturbance in daily life, cyber world oriented, withdrawal symptom, and tolerance. Results : Over all domains, each score was statistically lowered in both normal user group and risky user group after the program. Due to interaction effect, score of disturbance in daily life, withdrawal symptom, and total score was decreased more in risky user group than in normal user group. Conclusion : This study showed that the internet addiction prevention program which would change the level of knowledge about internet addiction in normal user group and risky user group could affect severity and aspects of addiction symptom with change of score of self-report scale. Also, especially in disturbance in daily life, withdrawal symptom, and total score, decrease of the score decreased more than other domain.

Factors predictive of cardiac events and restenosis after sirolimus-eluting stent implantation in small coronary arteries

Lee, Cheol Whan,Suh, Jon,Lee, Se-Whan,Park, Duk-Woo,Lee, Seung-Hwan,Kim, Young-Hak,Hong, Myeong-Ki,Kim, Jae-Joong,Park, Seong-Wook,Park,, Seung-Jung WILEY-LISS 2007 CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS Vol.69 No.6

<B>Objectives:</B><P>Predictors of cardiac events and restenosis after sirolimus-eluting stent (SES) implantation in small coronary arteries were evaluated.</P><B>Background:</B><P>Although SES implantation has markedly reduced the risk of restenosis, small vessel disease remains a major cause of SES failure.</P><B>Methods:</B><P>We prospectively investigated the factors predictive of cardiac events and restenosis in 1,092 consecutive patients who received SES implantation for 1,269 lesions in small coronary arteries (≤2.8 mm). Follow-up angiography at 6 months was performed in 751 patients with 889 lesions (follow-up rate 70.3%).</P><B>Results:</B><P>Restenosis (diameter stenosis ≥ 50%) was angiographically documented in 65 patients with 77 lesions (8.7%): 55 focal (71.4%), 8 diffuse (10.4%), 2 diffuse proliferative (2.6%), and 12 total (15.6%). Lesion length, stent length, reference artery size, and in-stent restenotic lesions were univariate predictors of restenosis. By multivariate analysis, lesion length (OR 1.04; 95% CI 1.02–1.05; P < 0.001) and in-stent restenotic lesions (OR 3.38; 95% CI 1.80–6.35; P < 0.001) were significant independent predictors of restenosis. During follow-up (23.2 ± 7.9 months), there were 17 deaths (5 cardiac and 12 noncardiac), 5 nonfatal Q-wave myocardial infarctions, and 42 target lesion revascularizations. The cumulative probability of survival without major adverse cardiac events (MACE) was (96.6 ± 0.6)% at 1 year and (95.1 ± 0.7)% at 2 years. In multivariate analysis, lesion length (HR 1.04; 95% CI 1.01–1.07; P = 0.004) and in-stent restenotic lesions (HR 3.29; 95% CI 1.58–6.86; P = 0.001) were independently related to MACE.</P><B>Conclusions:</B><P>SES implantation in small coronary arteries is safe and effective, with lesion length having a major impact on restenosis and MACE. © 2006 Wiley-Liss, Inc.</P>

Successful Transcatheter Closure of A Web- Shaped Patent Ductus Arteriosus Using Amplatzer Duct Occluder Via Retrograde Wire- Assisted Approach

김정훈,김미정,김윤정,정인현,JON SUH,김상현,송종민,강덕현,홍명기,송재관 한국심초음파학회 2007 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.15 No.4

Long-term clinical outcomes after sirolimus-eluting stent implantation for treatment of restenosis within bare-metal versus drug-eluting stents

Whan Lee, Cheol,Kim, Sang-Hyun,Suh, Jon,Park, Duk-Woo,Lee, Seung-Hwan,Kim, Young-Hak,Hong, Myeong-Ki,Kim, Jae-Joong,Park, Seong-Wook,Park, Seung-Jung Wiley Subscription Services, Inc., A Wiley Company 2008 CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS Vol.71 No.5

<B>Background:</B><P>Sirolimus-eluting stents have been increasingly used for treatment of restenosis after implantation of bare metal stents (BMSs) or drug-eluting stents (DESs), but little is known regarding their long-term outcomes.</P><B>Methods:</B><P>We compared long-term clinical outcomes in 295 patients treated with sirolimus-eluting stents for post-BMS (n = 224) vs. post-DES (n = 71) restenosis. All follow-ups were at least 12 months, and the primary endpoint was major adverse cardiac events (MACE), defined as cardiac death, nonfatal myocardial infarction (MI) or target lesion revascularization (TLR).</P><B>Results:</B><P>Baseline characteristics were similar between the two groups, except that mean lesion length (28.0 ± 16.2 vs. 19.5 ± 13.6, P < 0.01) and mean stented length (35.4 ± 19.2 vs. 25.7 ± 14.7, P < 0.01) were significantly longer in the post-BMS group. Major in-hospital complications occurred in 2 patients. During a mean follow-up of 31.3 ± 11.1 months, there were 9 deaths (4 cardiac, 5 noncardiac), 3 nonfatal MIs, and 25 TLRs. Late stent thrombosis was documented in 2 patients (1 in each group). There were no between group differences in cardiac or total deaths, but there were trends toward less frequent cardiac death/MI or TLR in the post-BMS group. The cumulative probability of MACE-free survival was significantly better for the post-BMS group (95.0% ± 1.5% vs. 87.3% ± 4.0% at 1 year; 93.0% ± 1.7% vs. 81.0% ± 5.2% at 2 years; Log Rank P = 0.016). In multivariate analysis, post-DES restenosis was the only significant predictor of MACE (OR 3.29, 95%CI 1.13–9.61, P = 0.029).</P><B>Conclusions:</B><P>Sirolimus-eluting stents were effective for treatment of in-stent restenosis, but post-DES restenosis was associated with poorer outcomes than post-BMS restenosis. © 2008 Wiley-Liss, Inc.</P>

Development of New Endovascular Devices for Aneurysm Treatment

Zhen Yu Jia,Hai Bin Shi,Shigeru Miyachi,Sun Moon Hwang,Jae Jon Sheen,Yun Sun Song,Joong-Goo Kim,Deok Hee Lee,Dae Chul Suh 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.1

Since the first use of the Guglielmi detachable coil system for cerebral aneurysm embolization in 1990, various endovascular methods have been developed to treat large numbers of aneurysms. The main strategic and technical modifications introduced to date include balloon-assisted coilembolization, stent-assisted coil embolization, flow diverters, and flow disrupters. The development and introduction of such devices have been so persistent and rapid that new devices are being approved worldwide even before the earlier ones become available in some countries. However, even if some patient populations may possibly benefit from earlier introduction of new devices, the approval authorities should balance the available evidence of the safety and effectiveness of novel devices. This review aims to provide an overview of the recent innovations in endovascular treatment of cerebral aneurysms and a brief review of market access policies and regulations for importing high-risk medical devices, such as those used for endovascular aneurysm management, which correspond to class III devices, as defined by the U.S. Food and Drug Administration. We focus on the current situation in Korea and compare it with that in other Asian countries, such as China and Japan.

Cinical and Angiographic Outcomes of Drug-Eluting Stents Implantation in Patients with End-Stage Renal Disease

Hye-Sun Seo,Chul Kim,Eun-Jung Kim,Bo-Yeon Kim,Suh Jon,Hye-Sun Seo,Yoon-Haeng,Cho,Nae-Hee Lee 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.2

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