Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

경제성 항목을 이용한 기존 업무용 건축물의 효율적 그린화 방안

김진아,강미선 대한건축학회 2005 대한건축학회논문집 Vol.21 No.3

In this paper, we suggest development of economic factors of environmental performance rating system for existing buildings. This paper is focused on the criteria regarding costs incurred from relationship between worker productivity and building operation. Since the increased worker productivity is closely linked to improved worker health, worker's health substantially affects building operations which can be assessed in terms of operation costs. No matter what level of certification a building receives, any kind of the suggested standard will significantly reduce the building's impact on the environment. The results of the paper can be applicable to the existing office buildings by providing existing owners and operators with a tool kit for systematically reducing the environmental impacts of their buildings, which eventually leads to cost reduction in both daily and yearly bases.

CDMA 시스템의 Ec/Io 개선을 위한 순방향 채널의 전력분배에 관한 연구

김선미,최동유,류광진,박창균 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.2

This study defined the way to distribute power of forward channel and suggested a new model for prediction power in order to minimize the deterioration of call quality and performance in the CDMA mobile communication system of narrow band using 1.2288MHz of narrow band. Each change in Ec/Io was measured for the factors affecting wireless environment(e.g. the changes in power of overhead channel, the changes in a number of call channel, and the increase in interference from the additional facilities of adjacent base station or other systems) to know the influence on the wireless environment of forward link. The new way for power distribution to a base station in operation and its validity was checked by comparing before and after test.

생활습관요인과 자가인식 건강상태의 관련도 포지셔닝

김명선,손미란,전진호,유병철 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background : This study purposed to propose the fundamental data to develop the proper health promotion program through observation about the current status, lifestyle behaviors and results of health examinations of public personnel in Busan Metropolitan City. Methods : Subjects were 988 public services (683 male, 305 female) who were employed in City Hall of Busan Metropolitan City. We investigated the relation between lifestyle behaviors and self recognized health status using health examination in 2006. Data analysis on multiple logistic regression and multi-dimensional scaling were done using SPSS win(ver 12.0k) program. Results : The proportion of above 50 years old age are 47.1% in male and 59.7% in female. There are 10.2% in male and 15.8% in female with family history of hypertension, and 8.5% in male and 14.5% in female with family history of diabetes mellitus. There are 37.7% in male and 12.1% in female with obesity, and 10.6% in male and 7.7% in female with abnormal liver function. The disease suspicion rate for male was 1.8%, and 4.6% for female. Risk of hypertension in male was 3.7 times greater than in female and risk of diabetes mellitus in males was 5.0 times greater than in female. By questionnaire 71.8% in male and 78.3% in female had been thought themselves to have disease. Both male and female participants were more likely to think themselves with disease according to disease history of diabetes mellitus, liver dysfunction and hypercholesterolemia. Also aging is interfered that self-recognized health status. Conclusion : Self recognized health status was associated with diabetes mellitus, liver dysfunction, hypercholesterolemia, family history of chronic disease and aging in public employee of Busan Metropolitan City. This association point that there is need for continuous education and effort to modify their life style.

두경부 마사지가 중환자실 환자의 수면과 불안에 미치는 효과

김미용,전선영,송윤희,최은진,김재희,김미성,주명순,김남선 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study was to apply head and neck massage to patients in intensive care unit and to inventigate the effect of that massage on sleep and state anxiety. Method: The subjects in this study were 27 patients who were admitted in medical intensive care unit. The study was performed from June thru September of 2005 on the One-group pretest-posttest design and the sleep, state anxiety of the subjects were measured before and after head and neck massage. For data analysis, paired t-test and Pearson correlation coefficient were utilized. Result: The first hypothesis that the subjects might have a better sleep after being exposed to head and neck massage was accepted. The second hypothesis that the subjects might feel less state anxiety afrer being exposed to head and neck massage was accepted. The third hypothesis that the sleep of the ICU patients maight be correlated to their anxiety was accepted, as there appeared correlation between their sleep and anxiety. Conclusion: Head and neck massage is identified as one of independent nursing interwentions to improve the sleep of ICU patients and ease their anxiety, and it is necessary to apply it to clinical practices.

3차 병원의 병동에서 시행된 심폐소생술의 분석

류진호,정경운,위준선,문정미,전병조,문원식,김용권,소정일,허탁,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Although cardiopulmonary resuscitation(CPR) is a very effective therapy in cardiac arrest, it is hard to prove the true effectiveness of CPR. Several studies about out-of-hospital and emergency department CPR exist, but only a few reports about in-hospital CPR are available. This study was designed to investigate in-hospital cardiac arrest, to analyze the result of CPR, and to evaluate the problems associated with in-hospital CPR. Methods: A clinical analysis of 71 cases of in-hospital CPR announcement from January 2000 to August 2000 was performed. The initial rhythm on cardiac arrest, return of spontaneous circulation(ROSC), and the survivals were analyzed in the case of the 46 true cardiac arrest patients. Results: During 8 months, there were 71 cases of in-hospital CPR announcement. Among them, there were 46 cases of true cardiac arrest and 25 cases of non-cardiac arrest. Of the 46 true cardiac-arrest cases, 27(58.7%) experienced ROSC, 15(32.6) survived for over 24 hours, and 7(15.2%) survived to be discharged. The initial rhythms on cardiac arrest were 30 cases(65.2%) of asystole, 14(30.4%) of PEA(pulseless electrical activity), and 2(4.3%) of ventricular fibrillation, with ROSC being 17 cases(56.7%), 9(64.3%) and 1(50.0%) cases and discharged survivors being 4 cases(13.3%), 3(21.4%) and 0(0.0%) cases, respectively. Conclusion: Extraordinarily high proportions of asystole and PEA were seen in the initial rhythm of cardiac arrest, and those were associated with high survival rates. Although further study is needed to evaluate the course leading to this high proportion of asystole and PEA, this result suggests that if the EMS system in the hospital is activated promptly and systematically, a better outcome will be achieved in case of cardiac arrest with asystole and PEA.

비휘발도를 이용한 정압하의 기액평형치 추산 가능성

박소진,오종혁,도미선 忠南大學校 産業技術硏究所 1994 산업기술연구논문집 Vol.9 No.2

The possibility of the correlation and the prediction of vapor-liquid equilibrium(VLE) data by using the relative volatility was analysed. This analysis was carried out for the two different binary groups. The one is for the same binary systems which VLE data were determined at different pressure, and the other is for the different binary systems, one of which component have the same functional group, at the same pressure. The VLE data have been recalculated using a relative volatility which was derived in this work for 18 binary systems and compared with the literature values. The result of the comparison showed a rare possibility of correlation and prediction of the VLE data.

장애 영유아 가족지원 방안 연구

이미선,김경진 국립특수교육원 2000 연구보고서 Vol.- No.1

본 연구에서는 유아특수교육에 있어 가족참여 및 이를 위한 지원의 중요성을 인식하고, 장애아동 가족의 효율적 참여를 위한 가족지원 방안을 제시함으로써 궁극적으로 장애아동 가족이 장애아등의 발달을 촉진하고, 그들 자신의 요구를 스스로 충족시킬 수 있는 능력을 갖추도록 하는데 목적을 두었다. 이와 같은 목적을 달성하기 위해 본 연구에서는 우리 나라와 외국의 장애 영유아 가족지원 정책과 실천에 관한 문헌을 분석하고, 우리 나라 장애아동 가족을 대상으로 심층 면담을 실시하였으며, 문헌 및 심층 면담 분석 결과를 토대로 우리 나라 장애아동 가족지원의 방안을 다음과 같이 제시하였다. 첫째, 장애아동 친육에 있어 가족의 효율적인 참여를 확대하며, 이를 위해 장애아동과 개인별 가족의 특성 및 자원 등을 고려하여 가족의 참여 수준과 방법을 다양화한다. 둘째, 장애 영유아 가족이 원하는 경우, 가족진단을 실시하고, 이 결과에 따라 장애영유아의 현재 수준, 가족의 자원 ·우선 순위 관심사, 장애 영유아 및 가족의 주요 성취 목표, 담당교사 이름 등의 내용을 포함한 개별화가족지원계획(IFSP)을 개발·실시하는 것을 적극 권장한다. 셋째, 유아특수교육기관 뿐 아니라 국 ·공립기관 및 민간단체는 장애아동, 부모, 형제의 특성, 성별, 연령, 지역사회 실정 등에 따라 다양한 과정의 가족교육 프로그램을 실시한다. 가족교육은 인터넷 방송이나 원격교육 등 다양한 방법을 도입하여 실시하며, 유아특수교육기관을 다니지 않은 장애 영유아의 가족들에게도 개방하여 실시한다. 넷째, 유아특수교육교사 및 관련 전문가들이 가족 중심의 유아특수교육 실시할 수 있도록 가족참여와 이를 위한 지끈의 중요성, 개별화된 가족참여와 지원을 제공하는데 필요한 지식과 기술을 습득할 수 있도록 하며, 이를 위해 기존의 직전교육 및 현직연수프로그램을 수정·강화한다. 다섯째, 유아특수교육기관, 특히 다양한 인적·물적 자원을 갖추고 있는 특수학교는지역사회 내 관련 공공·민간기관이나 단체들에서 제공하는 장애아동 및 그 가족에 대한 지윈을 가족에게 연계하고, 범주별로 제공되는 다양한 자원을 조정하며, 지역사회내의 다양한 지원을 가능한 한 유아특수핀육기관이라는 단일한 장소에서 통합하여 제공하도록 한다. 여섯째, 장애영아에 대한 조기중재의 중요성 및 교육의 기회균등 보장, 장애아동 가족이 갖는 경제적 불이익 등을 고려하여 현재 보육의 대상인 O~2세 장애영아에게는무상교육을, 현재 무상교육 대상이나 무상교육의 혜택을 많이 받지 못하고 있는 3~5세장애유아의 교육은 의무교육으로 한다. 일곱째, 장애아동을 부양하는 가족에게 장애아동 부양 수당, 세금 감면 등의 경제적지원, 의료비 및 보조장구 지원, 장애아동 보육지원 및 기타 상담, 가사 보조 등과 같은다양하고도 실제적인 지원을 확대한다. 여덟째, 정부, 지방자치단체, 지역사회 내의 유아특수교육기관이나 관련 기관에서는장애아동의 부모집단, 형제지원 집단, 아버지 집단과 같은 자조집단을 육성하고 장려하여 이들 집단의 구성원들이 스스로 정보를 교환하고, 상호 지원을 하며, 스스로의 권익을 옹호하는 활동 등을 할 수 있도록 한다. 아홉째, 정부, 지방자치단체 및 지역사회 내 유아특수교육기관이나 관련 기관에서는장애아동 및 그 가족이 정상화된 사회에 진정으로 통합되고 잘 적응할 수 있도록 장애아동 및 그 가족에 대한 다양한 인식 개선 활동을 전개하며, 이들에 대한 종합적인 지원과 서비스의 필요성 및 가치를 인식시켜 이들에 대한 지원적인 환경을 창출하고 조성 한다. 마지막으로, 유아특수교육에 있어 우리 나라 현실에 맞는 장애아동 가족의 효율적인참여 및 이를 위한 지원 전략과 IFSP의 개발 및 실시 모형 등을 도출하고, 이를 널리보급하기 위해 시범 프로그램을 운영하며, 장애아동 출현률 조사에 장애아동 뿐 아니라 그 가족의 실태에 관한 조사를 포함시켜 이 조사결과를 근거로 장애아동 및 그 가족에대한 중재 혹은 지원정책 방안을 수립하도록 한다. 또한 이제까지 언급한 장애아동 가족에 대한 다양한 지원을 실현하기 위해 관련 법규 및 제도를 제정하거나 개정하며, 이러한 법규정의 실천을 보장하기 위해 필요한 예산을 확보한다. 장기적으로는 가족지원을 통합적으로 시행하기 위해 기존의 장애아동가족지원 관련 법규들을 보완, 정리하거나 장애아동가족지원법을 새로이 제정한다. Based on the acknowledsernent that family participation in the education of their young children with disabilities has positive influences on their development and therefore. supports for increasing effective family participationare very important, the purpose of the current study is to provide strategies for supporting the families of young children with disabllities in order to empowerfamilies to effectively participate in educating their children with disabilities, and ultimattly. enable them to facilitate the development of young children with disabilities and meet their needs. In order to accomplish the purpose of this study. the study analyzed and reviewfd literature on policies and practices in family support of Korea and 3foreign advanced countries. and implemented in-depth interview to the familiesof young children with disabilities which are enrolled in institutions for earlychildhood special education, including special schools for children with mentalretardation, physical disabilities, visual impairments, hearing impairments. and autistir'disorders. respectively. special classes in kindergartens. and earlychildhood special education programs in welfare facilities and private institutions both of which are not formally approved by the government. Based on theresults of analyzine !iterature and in-depth interview materials. the currentstudy provided strategies for supporting families of young children with disabilities as follows: First, family participation in early childhood special education has to beexpanded, but the levels and methods of the participation must to diversifiedaccording to the characteristics and resources of each family. Second. if families want family assessment. it has to be carried out and basedon the assessment results, it is recommended that Individualized Family Support Plans(IFSPs) should be developed and implemented, and include the followingcontents: the current level of young children with disabilities: resources, priorities, and concerns of their families: objectives of children and theirfamilies; and names of teachers in charge of the development and implementation of IFSPs. Third, national, public and private organizations as well as institutions for early childhood special education should provide a range of family education programs. considering the characteristics, age. and sex of children with disabilities and their family members, and current conditions of communities. When family education programs are implemented. various methods have to be used. including internet and teleconference communication systems. In audition, the programs should be also available to family members whose children or siblings are not yet enrolled in institutions for early childhood sfecial education. Fourth. teachers and other professionals involved in early childhood special education have to be provided with programs for teaching the importance of family participation and supports for facilitatine family participation, and knowledges and shills necessary to implement IFSPs. Therefore, existingpre-service and in-service training programs should be improved and strengthened. Fiftlh. institutions for early childhood special education. especially special schools with a range of staff members and facilities have to link supports fromrelated-organizations in communities to families of young children with disabilities, coordinate various resources which are provided catesorlcally. And make efforts to provide them in one place(j.e. special school). Sixth, considering the importance of early intervention for infants and toddlers with disabilities. guarantee of the equal opportunity to be educated, and economic disadvantages of the families of children with disabilities. 0 to 2 years of young children who are regarded as child care target populations under the currert regulations have to be provided with free education. and 3 through 5 years of young children who are regulated as free education tareet populations must be provided with compulsory education. Seventh, various and practical supports have to be offered to the families of young children with disabilities, including financial support such as child-rearing allowallces and reduction of and exemption from taxes, assistive equipments, child care, counseling, and household assistance. Eighth, central government and local governments. communities, institutions for early childhood special education. and related agencies have to promote and encourage a range of self-groups such as the groups of parents and siblings so that they exchange information, support each other, and advocate their rights. Ninth, central government and local governments, communities, institutions for early childhood special education, and related agencies should develop strategies for improving people's attitudes towards children with disabilities and their families, and create and facilitate the supportive environments by giving infornlation and materials regarding the necessity and value of comprehensive suppcrts and services for the purpose of their more integration into and adaptation to normalized society than before. Finally, models for family participation appropriate to the current status in Korea and strategies for supporting the participation. and IFSP development and implementation must be devetoped. Model, programs have to be operated to evaluate and distribute them. In addition, future incidence survey of children with disabilities moat include items regarding the current status of families of children with disabilities. and based on the survey results. policies in supports and interventions for children with disabilities and their families must be designed. Moreover, for the purpose of providing a range of supports for families of young children with disabilities. related-regulations and systems have to enactedor revised. and financial arrangements for carrying out such regulations have to be made. In the long run, existing regulations on family support should be supplemented or a new family support act be enacted in order to provide comprehensive and coordinated family support programs.

공동주택 사전성능평가를 위한 성능평가 시스템 개발에 관한 연구

강미선,이상현,김하나,엄혜진 대한건축학회 2003 대한건축학회논문집 Vol.19 No.10

The purpose of this study is to propose an evaluation framework for Collective Housing and to develop the Design Evaluation System. The Performance Evaluation System of Collective Housing in the Design Development Stage evaluates its design results by running CAD program. The results are automatically reflected in the design process. The scope of this study will be limited to the contents within the Barrier Free Design. Running the design evaluation program requires the conversion of design forms and design checklist to computerized ones. To efficiently conduct this process, First, organize the existing guideline of the Barrier Free Design. Second, define attributes of each part in Building Data Model with the analysis of the checklist. Third, develop the Performance Analysis agent that compares Building Data Model with translated checklists. Finally, verify the efficiency of the Performance Evaluation System by seeking experts' advice on the result of the program.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.