토끼에서 근육주사시 입자 크기에 따른 amoxicillin의 비교 약물동태학

박승춘,윤효인,오태광,장범수,배순이,조준형,정상희,이내경,김민규 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-

To investigate the pharmacokinetic difference between the two amoxicillin (AMX) particles in rabbits after intramuscular injection (i.m.), both of AMX-S (particle size: 10 ㎍) and AMX-L (particle size: 100 ㎍) were injected into New Zealand White rabbits (1.2±0.3 ㎏) at a dose rate of 10 ㎎/㎏ of body weight. In this study, serum AMX concentrations were detected by microbiological assay with E. coli BE 1186 which shows high antibiotic sensitivity. After i.m. administration, AMX-S and AMX-L were best fitted as 1-compartment model with the absorption and elimination phase. The biological half-life (T_1/2, _k10) of AMX-S is 4.06±1.09 h and that of AMX-L 4.76±0.69 h. The serum maximal concentration time (T_max) of AMX-S and AMX-L were 0.88±0.17 h and 0.77±0.11 h, respectively. Maximal AMX concentration (C_max) (AMX-S: 5.71±0.62 ㎍/㎖, AMX-L: 5.04±0.25 ㎍/㎖) in serum showed a significant difference (p<0.05). In terms of bioequivalance, however, there was no difference between the two AMX's after i.m. injection in the basis of C_max and AUC.

SiO₂첨가물질이 SnO₂계 가스 센서의 안정성에 미치는 영향

박광묵,민봉기,최순돈,남효덕 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

사회환경교육의 교육과정 표준화 모형 및 통합프로그램 개발연구

박석순,최돈형,성효현,허명,강명희,이숙임,남상준 이화여자대학교 환경문제연구소 1998 이화환경연구 Vol.2 No.-

This paper presents the development of standardized modules and an integrated program which will be used for social environmental education. The study objectives are to develop modules which are based on various environmental topics, to relate the regional environmental topics to the educational modules and program, and to include the demand of students in the modules and program. Literature and questionary surveys, as well as, module development method were utilized as research tools. The titles of developed modules are "The Green Plant Earth," "Unexpected Resources: Save Resources and Recycle", "Water as the Mother of All Lives", "The Blue Sky with Clean Air", and "Soil as the Home of All Living and Non-living Things". It is hoped that the developed modules and program are utilized as course materials and curriculum for social environmental education in various educational institutes. The study results will be materialized as multimedia in near futher.

학교 건물의 냉난방방식에 관한 연구

박승익,박효순 우송대학교 부설 산업연구원 1999 산업연구 Vol.1 No.2

. Indoor environment of classroom of most elementary schools in Korea have not been maintained Properly during the heating and cooling seasons. The study aimed to suggest a design guideline helpful for improving school's thermal comfort and energy efficiency. The study carried by the field survey and computer simulation of the model schools and the weak and strong points are compared with the different heating & cooling systems. Various heating and cooling systems are suggested for the schools as the site location, climatic condition and the size of schools.

E. coli 과량발현을 통한 B형 간염 바이러스 preS1 유도체의 안정한 동위원소 N의 치환

박병관,김세하,한규훈,김선영,홍요정,이시형,한동설,김순종,박진구 木浦大學校基礎科學硏究所 1997 基礎科學硏究誌 Vol.15 No.-

We have used molecular biology technique to label the side chains and backbone of HBV preS1(1-56) with stable isotope (??) during E. coli over-expression and purified the protein to near homogeneity. The expression level of ?? labelled preS1(1-56) seems to be ∼15% of the total protein. to characterize the secondary structure of the labelled protein, circular dichroism was used. In different buffer conditions including pH 3.3 and pH 7.4 the protein seems to be devoid of any stable secondary structure probably suggesting that the N-terminal portion (preS1(1-56)) of HBV preS1 might be unstructured before binding to its target cells.

두경부에서 생긴 림프종에서 EBV와 HTLV-1의 검색

박준식,정효순,권성우,이상숙 경북대학교 병원 2003 경북대학교병원의학연구소논문집 Vol.7 No.1

Background and Objectives : Extranodal non-Hodgkin's lymphoma(NHL) of the head and neck(H&N) accounts for 10-20% of all cases of NHL. Despite their frequency, the cause of these lymphomas is still poorly understood. Recently, the role of viral origin in NHLs, including Epstein-Barr virus(EBV), as the main cause of sinonasal lymphomas of T/NK cell phenotype and HTLV-1 as a cause of acute T-cell lymphoma/leukemia has been well documented. We investigated the clinicopathologic findings, immunophenotypic profile, and status of EBV and HTLV-1 DNA of patients with H&N lymphoma. Materials and Methods : Twenty-seven patients with NHL of H&N region were studied. There were 15 males and 12 females with the median age of 50 years. All patients were reclassified according to the Working formulation(WF) and REAL classification. EBV genome DNA and HTLV-1 RNA were surveyed by PCR assay using formalin-fixed and paraffin-embedded tissue blocks. Results : The tonsil was the most commonly involved site(44.4%) followed by nasal cavity(18.5%), nasopharynx(18.5%) and orbit(7.4%). Immunophenotyping revealed 19 cases of B cell lineage, 7 cases of T cell lineage and one case of null cell type. Most of B-cell lymphomas were diffuse large cell lymphomas(58%). Tonsillar lymphomas were all B-cell origin. Four of the five nasal cavity lymphomas and one nasopharyngeal lymphoma showed an angiocentric T/NK cell phenotype with strong association with EBV. EBV genome was detected in 15 of 26 H&N NHLs(57.7%). Seven of 19 B-cell lymphomas(36.8%) and all T/NK or null cell type lymphomas were positive for EBV DNA. However, there was no HTLV-1 positive cases found. Conclusions : It could be concluded that the high incidence of EBV of angiocentric T/NK-cell lymphomas of the nasal cavity may indicate a probable role of EBV in the development of these lymphomas.

하악과두 골절 치료에 있어 보존적 치료와 외과적 치료의 비교

박인순,이철우,여환호,이효빈,김영균,변웅래 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1

The authors investigated the 17 patients with the condylar fractures of the mandible who were admitted in Dept. of Oral and Maxillofacial Surgery, Chosun University, Dental hospital from 1990 to 1993 and could be taken follow-up above 6 months. Helkimo's clinical dysfunction index and mandibular mobility index were applied to the evaluation of the patients and the obtained results were as follows. 1. Mean maximal mouth opening was 38.4mm in the conservative group, 41.3mm in the surgical group and that showed no statistically significant difference.(P>0.05) 2. Clinical dysfunction index was higher in the surgical group than in the conservative group but .that showed no statistically difference.(P>0.05) 3. The extent of maximal mouth opening was increased gradually throughout the follow-up period. 4. Both groups didn't show severe clinically dysfunction.

윤곽선 추출 및 부영상 분할을 이용한 프랙탈 영상 압축에 관한 연구

박철우,최환언,조철효,김순백,김두영 東亞大學校 附設 情報通信硏究所 1995 情報通信硏究所論文誌 Vol.3 No.1

This paper suggests the method to shorten the search area by using edge detection and subimage partition. For the purpose reduce encoding time, The Domain areas are reduced 1/64 by partitioning original image to subimage, and classified them into edge area and shade area to that detect only the area in the same class. for achieving an encoding with good fidelity, tried to differ the search method as the threshold value of edge which is included in subimage, and compared the compression rate and fidelity when set the size of range block as 4×4 and 8×8.

한국 초기 근대 무용 연구 : 조택원, 최승희의 작품을 중심으로

박연진,김효순,정은주,문희숙 경희대학교 체육과학연구소 2000 體育學論文集 Vol.28 No.-

Many changing mankind's thought and recognition have affected our history, it is same that dance has become a new concept-dance art under the concept that experiment of a new formality and change are creation. Dancer's feeling is exposed through dance is a phenomenon of carrier which independently embodies self. Dance is a harmony between time and space and a harmony made by rhythmic movement and dance composition. Dance is an art expressing feeling and some situations intentionally dr not by moving its body. The way of communication has been changed since the introduction of the New Dance. In traditional dance, there was no sharply defined boundary to divide spectators and performers, that is, the object and the subject of communication. With the New Dance, there established modern theatres, which separated performers from spectators. With the New Dance, the dance itself became interpretive activity. The New Dance remodelled the traditional dance and introduced some element of ethnic dance from other countries. For example, the costume became so diversified in the New Dance that the range of expression also became expanded greatly.

마늘 잼의 저장과정 중 성상변화

박혜민,곽효순,김소희,문미아,오만진 충남대학교 농업과학연구소 2008 농업과학연구 Vol.35 No.2

In order to make a functional jam containing garlic, sugar, acid and pectin were mixed with garlic and concentrated by heating the mixture under atmosphere or vacuum conditions. And changes of some physico-chemical properties of the garlic jam(i.e., color, textural properties, vitamin C) were investigated during storage at 30℃. It was found that lightness(L) was higher in sample of vacuum concentration than that in atmosphere concentration and redness(a) and yellowness(b) were higher in sample of atmosphere concentration. During the storage lightness was found to decrease for all samples with more drastic decrease in sample of atmosphere concentration where browning was more severely observed after 8 weeks of storage. In terms of textural properties, hardness, chewiness and gumminess were higher in sample of atmosphere concentration than that in vacuum concentration. And springiness and cohesiveness were higher in sample of vacuum concentration. Although sensory score for garlic jam found to be lower than that for the existing strawberry jam, the present garlic jam might have high marketability if considering its physiological value. 마늘을 이용한 기능성 잼을 제조하기 위하여 마늘에 당, 산, 펙틴을 첨가하고 평압과 감압에서 농축하여 마늘잼을 제조한 후 색도, 조직특성을 조사하고 30℃에서 저장하면서 색도, 조직의 변화, 비타민 C의 변화를 측정한 결과는 다음과 같다. 원료마늘의 일반성분은 수분 57.2%, 탄수화물 23.6%, 조단백 1.9%, 조지방 0.75%, 회분0.93%이었고 비타민 C는 8.4 mg/l00g이었다. 명도는 진공농축한 것이 평압농축한 것보다 높았고 적색도와 황색도는 평압의 것이 높았다. 저장기간에 따라 명도는 모두 감소하였으나 평압에서 농축한 것이 감압보다 크게 감소하였으며 갈변화가 저장 8주에는 심하게 나타났다. 마늘잼의 조직특성은 hardness, chewiness, gumminess는 평압농축이 감압농축에 비하여 높았고 springiness, cohesiveness는 평압농축이 낮았다. 마늘잼의 기호성은 딸기잼에 비하여 떨어지지만 기능성을 감안할 때 시장성이 매우 높을 것으로 판단한다.