DJ-1/park7 modulates vasorelaxation and blood pressure via epigenetic modification of endothelial nitric oxide synthase

Won, Kyung Jong,Jung, Seung Hyo,Jung, Soo Hyun,Lee, Kang Pa,Lee, Hwan Myung,Lee, Dong-Youb,Park, Eun-Seok,Kim, Junghwan,Kim, Bokyung Oxford University Press 2014 Cardiovascular research Vol.101 No.3

<P><B>Aims</B></P><P>DJ-1/park7, a multifunctional protein, may play essential roles in the vascular system. However, the function of DJ-1/park7 in vascular contractility has remained unclear. The present study was designed to investigate whether the DJ-1/park7 is involved in the regulation of vascular contractility and systolic blood pressure (SBP).</P><P><B>Methods and results</B></P><P>Norepinephrine (NE) elevated contraction in endothelium-intact vessels in a dose-dependent manner, to a greater extent in DJ-1/park7 knockout (DJ-1/park7<SUP>−/−</SUP>) mice than in wild-type (DJ-1/park7<SUP>+/+</SUP>) mice. Acetylcholine inhibited NE-evoked contraction in endothelium-intact vessels, and this was markedly impaired in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP>. Nitric oxide (NO) production (82.1 ± 2.8% of control) and endothelial NO synthase (eNOS) expression (61.7 ± 8.9%) were lower, but H<SUB>2</SUB>O<SUB>2</SUB> production (126.4 ± 8.6%) was higher, in endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice than in those from DJ-1/park7<SUP>+/+</SUP> controls; these effects were reversed by DJ-1/park7-overexpressing endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice. Histone deacetylase (HDAC)-1 recruitment and H3 histone acetylation at the eNOS promoter were elevated and diminished, respectively, in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls. Moreover, SBP was significantly elevated in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls, but this elevation was inhibited in mice treated with valproic acid, an inhibitor of Class I HDACs including HDAC-1.</P><P><B>Conclusion</B></P><P>These results demonstrate that DJ-1/park7 protein may be implicated in the regulation of vascular contractility and blood pressure, probably by the impairment of NO production through H<SUB>2</SUB>O<SUB>2</SUB>-mediated epigenetic inhibition of eNOS expression.</P>

박춘무의 패션 디자인에 나타난 미적 특성 - 2010 FW ~ 2017 SS 컬렉션을 중심으로 -

박은경 ( Eun Kyung Park ) 한국디자인트렌드학회 2018 한국디자인포럼 Vol.23 No.4

연구배경 최근 세계적으로 한국 패션에 대한 관심이 높아지면서 한국 패션의 역사 기록과 특성에 대한 연구가 중요해지고 있다. 본 연구는 국제와 국내 무대에서 활발히 활동하고 있는 한국 중견 패션 디자이너 박춘무의 작품을 분석하고 디자인의 미적 특성을 밝혀 한국 현대 패션 역사의 일부를 기록하고 한국 패션의 정체성을 논의할 수 있는 자료를 제공하고자 하였다. 연구방법 본 연구는 인터넷 검색 사이트를 이용하여 박춘무 디자이너와 그의 컬렉션, 디자인에 대한 기사와 리뷰를 수집하였고, 그가 뉴욕패션위크에 참가한 2010 FW~ 2017 SS까지의 컬렉션 사진자료를 수집하여 디자인 특성을 실증적으로 분석하였다. 사진 자료는 여러 패션전문 매체 인터넷 사이트를 이용하여 수집하였고 컬렉션 주제와 영감, 조형 특성, 이미지를 분석하였다. 그리고 이를 기반으로 디자이너 작품세계의 미적 특성을 총체적으로 논의하였다. 연구결과 박춘무 관련 기사와 컬렉션 작품을 분석한 결과 그의 디자인에서 반복적으로 나타나는 대표 디자인 특성은 무채색과 모노톤, 구조적 라인과 비정형적 라인의 조화, 소재 대비와 혼합에 의한 조형 표현, 미니멀리즘, 모호한 성의 표현, 스포티즘, 그리고 한국적인 미학의 이미지 표현으로 나타났다. 결론 30년의 역사를 지닌 브랜드 디자이너 박춘무는 비교적 일찍부터 해외 진출을 시도하여 성과를 거두었고, 상업성과 디자이너 감성의 조율을 통해 성장하였다. 그는 아방가르드와 모던한 디자인 감성을 기본으로, 최근에는 한국적 감성의 도입을 시도하고 있다. 본 연구결과 박춘무의 컬렉션에 나타난 디자인의 미적특성은 ‘컨템포러리 아방가르드’,‘한국적 미학의 아방가르드’로 결론내릴 수 있었다. Background Recently, the record and research on the characteristics of Korean fashion is becoming important. The purpose of this study is to analyze the works of Korean fashion designer Park Choonmoo, who is actively engaged in international and domestic stage, to reveal her design aesthetic features. Methods This study collected articles and reviews on Park Choonmoo and her fashion collection, using an internet search site. And study analyzed the design of collection from 2010 FW to 2017 SS in New York Fashion Week. Collection photographs were collected from various fashion media web sites and brand facebook. The collection theme, inspiration, formative characteristics, and images were analyzed. Result The characteristics of Park’s design appeared as achromatic and monotone, harmony of structural line and irregular line, formative expression by mixture of material and material. Also images of minimalism, ambiguous sex expression, sportism, and expression of Korean aesthetics was appeared. Conclusion Park Choonmoo has been based on avant-garde and modern design sensibility, and recently she is trying to introduce Korean sensibility. As a result of this study, the aesthetic characteristics of the design shown in Park's collection appeared as ‘contemporary avant-garde' and ‘Korean aesthetic avant-garde’.

근린공원 환경의 만족도가 신체활동과 건강에 미치는 영향 - 창원시 성산구와 의창구를 대상으로 -

박경훈,이우성,김태환,김은정,Park, Kyung-Hun,Lee, Woo-Sung,Kim, Tae-Hwan,Kim, Eun-Jung 한국조경학회 2014 韓國造景學會誌 Vol.42 No.3

본 연구의 목적은 경상남도 창원시를 대상으로 근린공원 환경에 대한 만족도가 신체활동과 건강증진 목적의 공원이용횟수와 체질량지수(BMI)에 의한 건강수준에 미치는 영향을 분석하는 것이다. 설문조사는 창원시 성산구와 의창구 도심지역에 분포하는 8개 근린공원의 이용자와 그 주변에 거주하는 429명의 주민들을 대상으로 실시하였고, 설문분석은 근린공원 환경에 대한 만족도가 신체활동과 건강에 미치는 영향을 분석하기 위해 일대일대응 선형회귀분석을 활용하였다. 연구결과를 요약하면, 공원을 이용하지 않는 주된 이유는 시간적 여유의 부족, 공원까지의 이동거리와 소요시간, 공원 내 이용시설의 부족 등이고, 공원을 이용하는 주된 이유는 공원까지의 접근성, 걷기 또는 산책, 휴식시설, 수목이나 그늘, 운동공간의 다양성 등으로 나타났다. 공원 이용자의 경우, 공원에서 걷기나 산책을 가장 많이 하고, 주 2회 이상 평균 10분 정도 걸어가서 1시간 정도 운동을 하는 것으로 나타났다. 공원과 그 주변의 물리적 환경 중에서 집에서 공원까지의 거리와 이동하는 가로 환경에 대한 만족도가 높았고, 공원 내 수공간이나 볼거리 등에 대한 만족도가 낮게 나타났다. 다음으로, 운동목적의 공원이용 여부, 공원이용시간, 공원이용의 만족도와 건강증진 효과, 공원까지의 거리, 따른 건강증진 효과만이 유의수준 10% 이내에서 상호관련성이 있는 것으로 나타났다. 향후에도 공원의 신체활동과 건강 증진 효과에 대한 실증적 사례노약자들의 공원이용 편이성 등이 유의수준 5% 이내에서 신체활동과 건강증진 목적의 공원이용횟수에 긍정적인 영향을 보였고, 체질량지수와는 공원이용에 를 지속적으로 축적해 나갈 필요가 있으며, 이를 통해서 각종 개발용도로 전환되거나 그 면적이 축소되고 있는 도시지역의 공원 및 녹지공간을 보전 확대시켜 나가고, 신체활동 및 건강증진 장소로서의 기능을 제고하기 위한 공원계획 설계 요소를 도출하는데 근거 자료를 제공하는 것이 가능할 것으로 판단된다. The purpose of this study is to analyze the effects of satisfaction in neighborhood park environments located in the Changwon-si of Gyeongsangnam-do, South Korea, on physical activity, the number of parks used for health improvement, and health levels based on Body Mass Index(BMI). Accordingly, a survey was conducted of 429 nearby residents and users of eight neighborhood parks located in urban areas of Seongsan-gu and Uichang-gu in the Changwon-si. The correlation between the environmental perception of neighborhood parks and physical activity and health, which was observed in the survey results, was analyzed using one-by-one linear regression analysis. By summarizing the study results, it was found that the primary reasons for avoiding park use were lack of time, time and effort required to reach the park(i.e., distance from the park), and lack of facilities within the park. Conversely, the primary reasons for using the park included accessibility, walking or strolling, leisure facilities, trees or shade, and diversity in exercise areas. In the case of park users, walking or strolling was the most common activity in the park. On average, park users walked to the parks for 10 minutes and exercised for an hour at least twice per week. With respect to the physical environment of the parks and surrounding areas, park users showed a high level of satisfaction with the distance between their houses and parks and the street environment. On the contrary, they exhibited low levels of satisfaction with water spaces and sightseeing within the parks. Subsequently, it was shown that the number of people using the parks for physical activities and health improvement was positively influenced(within a 5% significance level) by the intent to use the park for exercise, time spent in the park, satisfaction with park use and health improvement, distance to the park, and the convenience of using the park for the elderly. However, only the health improvement gained from park use was found to exhibit a correlation with BMI at the 10% significance level. Continuous accumulation of practical case studies on physical activities in parks and their health improvement effects is required. Through this, park spaces that are under the threat of reduction or elimination owing to various development plans can be conserved and expanded. Furthermore, such case studies can be used to provide data as the basis for deriving park plans and designs that improve parks' functions as sites of physical activity and health improvement.

근린공원에 대한 환경지각이 이용자의 건강증진인식에 미치는 영향 - 창원시의 8개 근린공원을 대상으로 -

박영은,이우성,정성관,박경훈,Park, Young-Eun,Lee, Woo-Sung,Jung, Sung-Gwan,Park, Kyung-Hun 한국조경학회 2015 韓國造景學會誌 Vol.43 No.1

본 연구는 근린공원에 대한 이용자의 공원지각환경이 건강증진인식에 미치는 영향을 분석하기 위해 경상남도 창원시의 8개 근린공원을 대상으로 공원별 현장조사 및 설문조사를 실시하였다. 연구결과에 따르면, 먼저 공원별 공원지각환경에서는 대부분의 공원이 집에서 공원까지의 거리와 집에서 공원까지의 길 환경이 높게 평가된 반면, 수공간과 공원 내 다양한 볼거리는 충분하지 못한 것으로 분석되었다. 다음으로 23개의 지각환경 변수들을 요인분석한 결과, 경관성, 안락성, 접근성, 활동성, 편의성, 쾌적성의 6개 요인으로 분류되었다. 이를 토대로 건강증진인식과 지각환경요인과의 관련성을 분석한 결과, 8개 공원 중 4개 공원에서 지각환경요인이 신체적 건강증진인식에 유의한 영향을 주는 것으로 나타났다. 특히, 접근성과 활동성이 3개의 공원에서 영향력이 있는 변수로 분석되었다. 또한, 심리적 건강증진인식의 경우, 8개 공원 중 5개 공원에서 유의한 영향을 주는 것으로 나타났으며, 접근성이 4개의 공원에서 영향력이 있는 변수로 평가되었다. 이상과 같은 결과들은 기존의 공원 환경을 개선하고, 새로운 공원을 조성하고자 할 때 효율적인 기초자료로 활용될 수 있을 것으로 판단된다. The purpose of this study was to analyze the effect of environmental perception in neighborhood parks on user's recognition of health improvement. This study used objective field survey data and subjective user survey data at 8 neighborhood parks in Changwon City. According to the results, the perceptions of distance and street environment from home to park were evaluated highly but the perception of water spaces and various attractions within the parks were rated lowly in most of parks. As a result of factor analysis, 23 environmental perception variables were classified into 6 factors such as scenery, comfort, accessibility, activity, convenience and amenity. For the result of regression analysis between environmental perceptions and user's recognition of health improvement based on 6 factors, the recognition of physical health improvement was significantly influenced from environmental perception factors in 4 parks among 8 parks. 'Accessibility' and 'activity' were analyzed as the meaningful factors in 3 parks. Also, recognition of mental health improvement was significantly influenced from environmental perception factors in 5 parks among 8 parks and especially 'accessibility' was showed as the significant factor in 4 parks. The findings from this study can contribute to improve the physical environments of the present parks and can be a basic data for new park development.

환자, 간호사, 의사가 지각하는 교육요구도와 교육제공정도에 관한 연구

박인숙,문영숙,조미경,최은숙,이경숙,정길수 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

The purpose of this study was to provide the basic data for the planning of education of patients by exploring and comparing patients', nurses' and doctors' perception of the educational needs and degree of providing education. 66 hospitalized patients undergoing chemotherapy and 44 nurses, 42 doctors assigned for the direct care were sampled in 1 university hospital in Taejon from August 30, 1993 to September 30, 1993. For the comparing patients', nurses' and doctors' perecption of the educational needs and degree of providing education, the researcher used Kims' Educational need scale which is composed of 20 item Likert type 5 point scale. Data were analyzed by means of percentile score, SPSS, t-test, ANOVA, Pearson correlation. The result were as follows 1. Comparision of total Mean score patients', nurses' and doctors' perception of the educational need ordering nurses(M=4.0465), patients (M=3.9803), doctors (M=3.8309). The difference between the three group's total Mean score is showed no statistical significant difference. 2. Comparision of total Mean score patients' educational need, patients' percetion of nurses' and doctors' degree of providing education, patients' educational need is scored 3.9803, patients' perception of nurse is scored 2.3431, patients' perception of doctor is scored 2.5022. The difference between the patients' educational need and medical teams' degree of providing education is showed statistical significant difference(P<.001). 3. Comparision of total mean score nurses' educational need is scored 4.0465, nurses' perception of nurses' degree of providing education is scored 2.9920, patients' perception of nurses' degree of providing education is scored 2.3431. The difference of between the nurses' educational need and nurses' perception of nurses' degree of providing education is showed statistical significant difference(P<.001) 4. Comparision of total mean score doctors' educational need is scored 3.8309, doctors' perception of doctors' degree of providing eduation is scored 3.1726, patients' perception of doctors' degree of providing education is scored 2.5022. The difference of between the doctors' educational need and doctors' perception of doctors' degree of providing education is showed statistical difference(P<.001).

學部編纂『普通敎育唱歌集』연구

박은경 천안대학교 2001 천안외국어대학논문집 Vol.- No.1

This study researched Changga education of the flowering time from 1894 to 1910, Botong kyoyuk changgajib published in 1910. Botong kyoyuk chang-gajib was not expressed Korean emotion in either music nor words. Twenty-one songs which is excepted six songs introduced from the West among twenty-seven songs were composed with Japanese scale, and composed of 2/4 or 4/4 which is related to Japanese traditional time. Botong kyoyuk changgajib has an important influence upon Korean modern music. Botong kyoyuk changgajib was published in Korea first and to prevent to be sung patriotic Changga. Korean musical emotion became Japanize and westernize because of Botong kyoyuk changgajib. In fact, a preson in his seventieth who was educated in this period likes Japanese music. So, to remove this Japan musical emotion, we have to establish desirable Korean music culture as soon as possible.

Silaethene CL₂Si=CHCH₂?Bu의 엔반응 : Unsaturated Compounds of 14Group Elements(Ⅸ)

김정균,박은미,구미영,박경래,손병영 東亞大學校 大學院 1992 大學院論文集 Vol.17 No.-

Silaethene Cl₂Si=CHCH₂?Bu 1, generated as a reaction intermediate by the thermal elimination of LiX from Cl₃SiCHLiCH₂?Bu 2, combines with ene-component containing compounds(propene, 2-methylpropene, DMB) to give 40∼90% yield ene-products. They can be isolated and spectroscopic identified.

Analysis of Genetic Diversity of Korean Wheat Cultivars Using Microsatellite DNA Polymorphisms

Park,Yong-Jin,Cho,Gyu-Taek,Ma,Kyung-Ho,Lee,Sok-Young,Lee,Jung-Ro,Kim,Young-Chang,Cho,Eun-Gi,Kim Chang-Yung,Nam,Jung-Hyun,Rao,V,Ramanatha,Kang,Hee-Kyoung 한국자원식물학회 2004 Plant Resources Vol.7 No.2

Genetic background and phylogenetic relationships among 20 Korean wheat cultivars were assessed using microsatellites after amplifying with 13 SSR primer pairs. Average allele number per primer pair was 3.36. Genetic similarities for every pair of cultivars ranged from 0.42 to 0.97, with 0.69 of overall average. Korean cultivars were divided into two major groups based on microsatellite DNA polymorphisms. Group I consisted of relatively old cultivars developed until 1970s, and group II contained the recent cultivars developed during 1980s and 1990s. Amongst old elite cultivars/lines, ‘Yukseung 3’, ‘Norin 12’ and ‘Norin 72’ contributed most to the genetic background of cultivars belonging to group I, and ‘Norin 4’, ‘Norin 12’, ‘Norin 43’ and ‘Norin 72’ to group II, respectively. The phylogenetic relationship of Korean wheat cultivars was in accordance with the genealogical data of each cultivar. The genetic background of each cultivar was assessed from the point of breeding and germplasm management such as variety identification and duplicated accessions for assisting in developing a system for the registration of new variety based on the molecular characterization in future.

수직적 안모유형에 따른 치료 후 교합평면 안정성에 관한 연구

박정은,차경석,이진우,정동화 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.5

본 연구는 수직적 안모유형에 따른 치료 후 교합평면 변화양상을 조사하여 향후 적절한 치료계획과 기전의 설정에 도움이 되고자 시행하였다. 골격성 1급 부정교합으로 진단되어 비발치로 치료받은 성인 60명(남자 28명, 여자 32명)을 대상으로 하였으며, Ricketts법의 facial axis, facial depth, mandibular plane angle, lower face height, mandibular arc의 5개 항목을 이용하여 한국 성인의 정상교합자 통계치의 기준에 따라 short face type (1군), average face type (2군), long face type (3군)으로 분류하였다. 각 군의 치료 전, 치료 종료, 종료 후 1년의 측모두부 방사선사진 계측치를 비교 분석하였다. 1군은 치료 종료 시와 비교하여 유지기간에 일반적 교합평면각, 기능적 교합평면각, L6/L1, MP-L6 항목이 유의하게 감소하였고 (p<0.01) L1-FOP 항목은 유의하게 증가하였다(p<0.001). 2군은 유지기간에 유의한 변화를 보이지 않았으며 3군은 유지기간에 기능적 교합평면각이 유의하게 증가하였다(p<0.05). 기능적 교합평면각의 치료 후 변화량은 각 군 간에 유의한 차이를 보였으며 특히, 1군과 3군 간에 매우 큰 유의성을 보였다. 따라서 치아의 압하, 정출 및 치료 후 전치부 피개 등에 있어 유지기간 중 교합평면각 변화의 고려가 필요하다고 생각된다. Objective: The purpose of this study was to find changes in the occlusal plane related to different vertical facial patterns and suggest treatment goals and conduct possible treatment mechanisms. Methods: 60 adult patients (28 males, 32 females) who had been diagnosed as Class I skeletal malocclusion and treated without extraction were selected. Patients were divided into three groups; short face type (group 1), average face type (group 2) and long face type (group 3), using the data on normal occlusion of Korean adults. Results: The results were achieved by analyzing cephalometric tracings of each group at pre-treatment, end-treatment and post-treatment (about 1 year recall check). The inclination of the occlusion plane tends to gradually increase as the face becomes longer. In group 1, COP-X, FOP-X, L6/L1, MP-L6 were significantly decreased, and L1-FOP was significantly increased during the retention period (T3-T2). Group 2 showed no significant change. In group 3, FOP-X was significantly increased during the retention period (T3-T2). During the retention period, FOP-X showed significant change among each group, especially between group 1 and group 3. Conclusion: These results suggest that changes of occlusal plane inclination according to facial vertical pattern need to be considered during the retention period for intrusion, extrusion, and incisor overbite.

Alexander Scriabin의 작품에 나타난 PC-Set의 구조와 변형

박은경 신음악학회 2001 新음악논집 Vol.2 No.-

Alexander Scriabin (1872-1915) is an important and influential composer, musically and historically, but because of his unique style and expression, he was never the founder or member of a compositional school or movement. For this reason, he is considered as an unclassifiable composer and is isolated from other composers by many music scholars. However, more than half of a century after his death, his music is beginning to be recognized by musicians not only for performance but also for the analytical and historical studies. Based on gradual changes in his compositional techniques, his music can be divided into two stylistic periods: a tonal period (1903-1910) and an atonal period (1911-1914). During these periods, he tried to move away from tonality. He emphasized pitch organization, especially vertical, rather than horizontal, pitch-class sets relationships, and continuous transformations of the same sets rather than employing different sets. In this paper, Five Preludes, Op. 74, no.4 (1914), one of his last works, will be examined with a focus on the structure of pitch-class sets and their successive transformations throughout the piece. The objectives of this study are to find the sets he has used in the piece and their transpositional repetition, and to statistically show them in tables and figures.