珪酸마그네슘의 合成條件에 關한 硏究

전우정,신화우,최광식,안세민,이광표,장영수 원광대학교 식품약품안전성연구소 1993 食品藥品安全性硏究 Vol.6 No.-

Magesium twisilicate is mainly uaed as a nonsytemic antacid andabsrbent. Magnesium trisilicate when teeated with anacid sxuh as diluted hydrochloric acid in gastric juice decomposes to form Magnesium chloride and colloidal Silicates. 2MgO·3SiO_2 + 4Hcl - 2MgCl_2 + H_4Si_3O_8 (or 3SiO_2 + 2H_2O) Colloidal mixture The resultng colloidal silicates can protect ahe ulcer frdm further acid and peptic attack and possibly adsorb the pepsin. It is well known that yield of Magnesium trisilcate produced is greatly affected by the Synthesis condition such as the reactant concentration, reaction temperature and moleatio of reactant solutions as well as by the emperature at which the precipitate is dried and the temperature of washing water, etc. The purpose of this study is to investigate the optimum synthesis conditions of Magnesium trisilicate. A randomized complete block design suggested by G.E.P. Bdx and K.B. Wagnesium sulfate solution with Sodium silicate solution in this study. It was found that optimal synthesis conditidns were: Reaction temperature range : 57-90 ℃. Concentration range of reactants (Sodium silicate and Magnesium sulfate) : 19.1-29% molar ratio of the reactants. [Sodium silicate]/[Magnesium sulfate]: 1.47-1.80. temperature range of washing water: 45-48℃ and drying temperature range: 65-82℃ The antacidic activity of five Magnesium trisilicate samples which shows the maximum antacidic efficacy was tested by pharmacopeia acid consuming capacity test. The five Magnesium trisilicate samples were samples were identified by chemical analysis.

사망진단서(사체검안서) 상의 선행사인으로부터 사망통계의 원사인이 선정되는 비율 : 3개 대학병원에서 교부된 사망진단서를 중심으로

박우성,박석건,정철원,김우철,탁우택,김부연,서순원,김광환,서진숙,부유경 한국의료QA학회 2004 한국의료질향상학회지 Vol.11 No.1

Background : To exatnine the problems intolved in writing practice of death certificates, we cotnpated the determination of underlying cause of death for wital statistics using recorded underlying cause of death in issued death statistics. Methods : We collected 688 rnortality certificates issue in year of 2,000 from 3 university hospitals. And we also collected vital statistics from ministry of statistics. The causes of death were coded by experienced medical record wpecialists. And causes of death determined at ministry of statistics for national vita statistics were mapped to causes of death recorded at each death certificates. The rate that underlying causes of death for vital statistics were derived from underlying causes of death recorded at issued death certificaties sere analysed. Results : 64.5% of underlying cause of death for could be derived from underlying cause of death recorded at issued death certificates, 8.6% derived from intermediate cause of death, and 3.9% derived from direct cause of death. In 23% of cases, underlying cause of death could not be derived using issued death certificates. The rate that underlying cause of death for vital statistics could be derived from underlying cause of death recorded at death certificates was different between 3 university hospitals. Ane the rate was also different between death certificates and postmortem certificates. We classified the causes of death using 21 major categories. The rate was different between diseases or conditions tha caused death too. Conclusion : When we examined the correctness of death certificate writing practice using abpve methods, cortectness of writing could not be told as satisfactory. There was difference in correctness of writing between hospotals, between death certificates and postmortem certificates, and between diseases and conditions that caused death. With this results, we suggested some strategy to improve the correctness of death certificate writing practice.

Bromocriptine 과 Cyproheptadine 이 Corticotropin-releasing Factor(CRF) 로 자극된 ACTH 분비에 미치는 효과

김진우,최영길,김영설,김광원,김선우,양인명,윤현구,우정택 대한내과학회 1986 대한내과학회지 Vol.31 No.5

Our study was desinged to observe the ACTH response to ovine CRF in healthy men and to observe the effect of bromocriptine or cyproheptine on ACTH and cortisol response induced by ovine CRF in healthy men. We have hypothesis that if hromocriptine or cyproheptatine inhibits the secretion of ACTH induced by ovine CRF, they decrease the secretion of ACTH in the pituitary level. The result were followings: 1) Plasma ACTH reached a peak of 1.5 and 1.6 times the basal level in response to ovine CRF at 10 min, and 30 min, respectively and decreased to the basal level at 90 min. 2) Cyproheptadine or bromocriptine did not inhibit the response of ACTH to ovine CRF. 3) We suggest that cyproheptadine or bromocriptine does not inhibit the ACTH secretion in the normal pituitary gland.

初等學校 校庭內 生態園 造成技法 : With a Special Reference to Hu-am Elementary School in Yong-san gu, Seoul 서울 龍山區 厚岩 初等學校 事例를 중심으로

진시현,심우경,이광우 韓國植物ㆍ人間ㆍ環境學會 2000 인간식물환경학회지 Vol.3 No.1

이 논문의 연구목적은 초등학교내에 생태원을 조성함으로써 아이들에게 자연과의 접촉기회를 제공하고자 실시한 바, 그 결과는 다음과 같다. 1. 초등학교 교과서에 나타나는 모든 동, 식물의 종류 초등학교의 교과서 분석 경과 274종의 식물종과 227종의 동물종이 나타났으며, 가장 높은 빈도수를 나타낸 곤충은 나비 78회, 잠자리 64회, 개미 51회, 벌 41회, 그리고 매미가 31회의 순으로 나타났다. 이는 교과서별 학년별로 빈도수를 조사한 결과와도 비슷한 양상을 나타낸 것이다. 초등학교 교과서 중 자연과 과목의 교육내용을 살펴본 결과, 1∼2학년 과정에서는 학교내의 뜰과 화단의 4계절 변화를 관찰하고 3∼6학년 과정에서는 생태계 전반에 걸친 세부적인 내용을 공부하도록 교육내용이 설정되었음을 알 수 있었다. 2. 용산구에 있는 15개의 초등학교의 옥외환경 조사 용산구에는 15개 학교가 있고, 그들의 옥외환경의 형태는 교재원과 생산원의 두 가지 종류로 나타났다. 대부분의 학교가 이 두 가지 형태로 나타났으나 남정, 보광, 원효로, 한강 초등학교는 생태원의 시설중 소동물 사육장 시설이 없었고, 교재원의 시설도 빈약하였다. 사례지역인 후암 초등학교는 도시의 중심부에 위치해 있는 다른 초등학교와는 달리 풍부한 생물상을 가지고 있는 남산에 인접하고 있기 때문에 생태원으로서의 기능성이 있는 것으로 보여진다. 3. 사례연구와 생태원 조성계획 생태원의 조성방법으로서 우선, 사례지인 후암 초등학교 부지의 현황조사를 하였고, 두 번째로 4가지 곤충(나비, 잠자리, 벌, 매미)들을 유치하기 위한 식물들을 선별하기 위해 이들이 식이식물로 조사된 식물들 중에서 교과서에 나오고 사례지역에 적합하며 내공해성을 가지며, 자생종이 식물들을 선별한 결과, 나비, 잠자리, 새를 유치하기 위한 식이식물로 각각 44, 17, 16종이 선별되었다. 또한 이 학교의 건물이 도로와 맞닿는 점을 감안하여 건물옥상에 생물서식지를 조성함으로서 남산으로부터의 풍부한 생물종의 유입을 유도하고, 더 나아가 학교 내에 조성되는 생태원으로 자연스럽게 유도하고자 하였다. 따라서 옥상 위의 생물서식공간은 수변공간계획과 식재계획을 통하여 곤충류와 조류뿐만 아니라 다양한 생물종이 서식되도록 하였고, 이를 통해 초등학교 학생들은 자연과의 친밀한 접촉기회를 가지게 될 것이다. The purpose of this study was to offer the opportunity of contact with the nature to urban children by the creation of the biotope in the elementary school ground. The results for this study were as follow: 1. The kinds of animals and plants the elementary school textbooks were 275 species and 227 animals. The frequencies of insect species in the elementary school textbook were the butterfly(75), dragonfly(64), ant(51), bee(41), and cicada(31) in order. These results were analogous to the numbers in each textbook and grade. In the 'Nature' textbook of the elementary school, there were educational contents to observe the ground and garden in 1, 2 grade courses and to study the detail of ecosystem in 3-6 grade course. 2. Inventory of the out-door environments of 15 elementary schools in Young-san Gu, Seoul. The number of total elementary school in Young-san Gu were fifteen, which had two garden types appeared as nature study and experimental farm. Two types of gardens were appeared mostly in all the elementary school but Nam-jung, Bu-kwang, Wonhyo-ro, Sin-swang, and Han-gang elementary school didn't have the experimental farms and also have the poor facilities of the nature study gardens. Huam elementary school had the possibility of the biotope creation because it was connected to Namsan park which posseses the abundant biota in contrast to the others in the center of the city. 3. Case study and biotope planning. To create the biotope, the site analysis was carred out and then plant species for inducing 4 kinds of insect (butterfly, dragonfly, bee, and cicada) were selected under the criteria as pollution-resistant, the school tree and flower, tolerance, and original habitat. Consequently, the numbers of plants for inducing butterflies, dragonflies and birds were 44, 17, 16 species separately. Also, it was planned to the induce abundant biota to building's roof as stepping stone from Namsan. These two biotopes were planned to be a habitat of various biota in addition of the water pond and the planting plan. Through the biotope created by this plan, the students of the elementary school will have more opportunity of contact with the nature.

당뇨병 백서의 간세포에서 Glucokinase 활성도 및 유전자 발현에 대한 인슐린의 영향

강성이,팽정령,서광식,안규정,우정택,김성운,양인명,김진우,김영설,김광원,최영길 경희대학교 유전공학연구소 1993 遺傳工學論文集 Vol.5 No.-

목적 당대사의 조절 상태에 따른 생체 변화를 분자 수준에서 이해하고자 식이 조건을 달리한 정상 백서와 화학적으로 유도된 당뇨병 백서의 간조직에서 혈당수준과 인슐린치료 정도에 따라 나타나는 글루코키나제 활성도 및 유전자 발현을 분석하였다. 방법 스트렙토조토신 정맥투여 후 당뇨병의 유발을 확인하고, 인슐린을 1일 3회 3일간 복강내로 투여하여 상태를 안정시킨 후, 인슐린 투여군은 인슐린 투여 6시간이내에 그리고 인슐린 비투여군은 24시간 후 단두하여 채혈하고 복강을 열어 간조직을 채취하였다. 채취한 간조직에서 글루코키나제 활성도는 인산화된 포도당에서 NADH의 형성을 형광분광계로 측정하였으며, 글루코키나제 유전자 mRNA발현은 Northern 분석법을 이용하였다. 성적 정상 백서에서 공복상태와 식이를 섭취한 경우에 간조직의 글루코키나제 효소의 활성은 차이가 없었으나, 글루코키나제 유전자 mRNA 발현은 증가되었다. 당뇨병이 유발된 백서의 간조직에서 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA 발현은 정상 백서에 비하여 낮았다. 인슐린 투쳐 후 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA 발현이 증가되었고, 특히 혈당이 정상화된 경우에서 글루코키나제 유전자의 mRNA 발현이 증가도었다. 결론 인슐린에 의한 간조직에서 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA을 증가를 볼수 있었다. 당뇨병 백서에서 인슐린 투여 후에 혈당조절이 안된 경우 간조직의 글루코키나제 유전자의 mRNA 발현이 증가가 없는 것으로 보아 글루코키나제 mRNA의 발현에는 인슐린 이외의 다른 요소가 관여할 것으로 생각된다. The liver-specific hexokinase isoenzyme, referred to as glucokinase, is thought to play a key reglulatory role in hepatic glucose metabolism. The glucokinase gene is, therefore, of interest both because of its tissue-specific expression and because of the several regulatory processes that can be analyzed. The level of hepatic glucokinase activity appears to be determined essentially by regulation of the rate of enzyme synthesis, with insulin playing a leading role as an inducer. We investigated the role of insulin for the induction of glucokinase in the liver of diabetic rats. Experimental diabetes was induced by injection of streptozotocin 7 days before the experiment. Regular insulin was given by three days intraperitoneal injection at 8-h interval. The glucokinase mRNA in the liver was estimated by Nothern blot assay, as well as by fluorometric enzyme activity assay. Glucokinase activity was not reduced in the liver of normal fasting rats as compared to normal fed rats. And glucokinase activity was reduced in the liver of diabetic rats as compared to normal rats. In diabetic rats treated with insulin, glucokinase enzyme activity were increased. But glucokinase mRNA expression was only increased in normoglycemic diabetic rat with treated with insulin as compared to hyperglycemic rat. These data indicate that insulin stimulates hepatic glucokinase enzyme activity and mRNA expression. But other hormonal or metabolic factors may be contribute to regulation of glucokinase mRNA expression.

전자상거래 사업자의 자율규제 활성화방안

우광명 국제무역학회 2003 국제무역연구 Vol.9 No.2

국제적 특성을 가진 인터넷상의 전자상거래가 증가하면서 거래 과정에서 발생되는 제문제를 해결하기 위한 노력이 국제기구를 비롯하여 선진각국들을 중심으로 이루어져 오고 있다. 그럼에도 불구하고 아직까지 관련 문제들의 해결을 위한 법률제정이나 개정이 완료된 것은 아니다. 인터넷이 가지는 개방성, 국제성의 특징을 고려하여 전자상거래의 발전과 함께 소비자보호가 균형을 유지할 수 있는 효율적인 규제방식이 요구되고 있다. 이런 상황에서 최근 규제방식 중 하나인 자율규제가 소비자를 보호하는데 중요한 역할을 하는 것으로 인식되고 있다. 사업자의 자율규제가 정부영역에 의한 직접규제의 비효율성을 제거하는 대안이지만, 사업자의 자율규제만으로 소비자보호가 달성될 수는 없다. 따라서 전자상거래 사업자 자율규제의 효율성을 확보하기 위해서는 우선 자율규제 시스템 구축을 위해 정부간, 정부와 민간부문간, 민간부문간의 공동규제(co-regulation)방식이 절실히 필요하다. It is clear that the electronic or digital era is changing the roles of the government and the private sector. New technological developments will mean the private sector has a greater role in resolving some of the potential obstacles or market failures that electronic commerce raises. Direct government regulation - while sometimes necessary - often is not the best solution to consumer protection problems. Self-regulation can be an extremely effective way to protect consumers, particularly when it is complemented by carefully selected government law enforcement actions. We need to use all the tools available to us - consumer and business education, self-regulation by industry groups, and, when necessary, law enforcement action. But coordination of such solutions could be achieved by industry self-regulation. However, government input should, when required, consist of simple and predictable legal tools that are sensitive to the technology and to the pace of change.

RS485 직렬 통신 인터페이스를 이용한 BLDC 서보 전동기의 안전운전 영역에서의 운전에 관한 연구

우광준,김장기,황규범 단국대학교 1999 論文集 Vol.34 No.-

The servo motor systems is widely applied to the position and speed control system in modern process automation. In this paper, we design the H/W interface including RS232/485 converter and the control S/W interface including RS485 communication protocol for the real time operation of BLDC servo motor using half duplex asynchronous serial communication interface(ASCI). We confirm the servo operation for servo motor system in safety operation region by monitoring the servo status from the reply data of communication protocol and the possibility of real time operation in servo motor system using DIO method as well as ASCI method by the experimental results of proposed scheme.

규정된 이동점을 통과하는 로보트의 최소시간 궤도계산

우광방,김성신 연세대학교 대학원 1986 延世論叢 Vol.22 No.1

In order to speed up tobot motion and to decrease the execution of the given task, the present study designed to propose a method of calaulating a time schedule of positions, velocities, and accelerations along the some specified Cartesian knots in work space that the manipulator may adopt a minimum traveling time under the constraints. Picewise cubic polynomials are used to fit the sequence of joint displacements for each of the N joints. The obtained trajectories are continuous on the positions, velocities, and accelerations by taking into account the limitations of the joint velocities, accelerations, jerks, and torques. The flexible polyhedron search is utilized to calculate the optimum time interval between each pair of adjacent knots minimizing the total traveling time in which departure and arrival velocities, accelerations are equal to zero. The final trajectories pass by the given knots with a minimum traveling time and without overshooting nor wondering such that Robotic manipulator can be used more efficiently. Pascal programs are developed to implement the algorithm, and results are illustrated by means of the numerical of the Puma robot operation.

만성 B형 간염환자의 말초혈액에서의 바이러스의 검출 및 자매염색분체교환

최우익,김대광 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.5

Trapezoidal 구동형 브러시리스 직류 전동기의 최적 정류

禹廣俊,李現彰,庾正鳳 단국대학교 1995 論文集 Vol.29 No.-

In this paper, we analyze the optimal commutation of the trapezoidal driving brushless dc motor which has the trapezoidal flux in the airgap. On the basis of this analysis, we design the hard-wired digital-based optimal commutation control system of the trapezoidal driving brushless dc motor. The optimal commutation circuit consists of a commutation angle ROM, a commutation pattern ROM, and presettable counter. Preposed scheme is simple and quite adequate to the high speed operation. As the analysis shows, we confirm that experimental results show the improved driving characteristics, e. g., the torque is increased over all of the operating range, and the operating range is widely enlarged.