新制酸劑로서의 Sodium Aluminosilicate의 製造에 關한 硏究

申和雨 圓光大學校 1978 論文集 Vol.12 No.-

The purpose of this investigation was to determine the optimum condition for the synthesis of a new antacid sodium aluminosilicate by Box-wilson design of experiment. Sodium silicate and aluminum sulfate as a soluble aluminum salt were used to prepare the sodium aluminosilicate. It was found that sodium aluminosili cate prepared at the higher reactio temperature, the higher reactant concentration, the lower mixing ratir (Sod. silicate/Al. Sulfate), and the lower dryingtremperature meets the official specification as an antacid. It was also foungt that sodium aluminosilicate prepared by the optimum Condition was superior to magnesium trisilicate (u.s.p.) and was more or less excellent compared to commercially avilable Aluminum magnesium metasilicate in the antacid acttion.

히드로탈시트의 최적 합성조건

신화우,박형민,안세민 대한약학회 1999 약학회지 Vol.43 No.6

Hydrotalcite was prepared by reacting with sodium carbonate, magnesium oxide and aluminum sulfate solutions in this study. The optimum synthesis conditions based on the yield of the product were established by applying Box-Wilson experimental design. It was found that the optimum synthesis conditions of hydrotalcite were as follows; reacting temperature : 48~63$^{\circ}C$, concentration of reactant solution : about 20%, molar concentration ratio of two reactants [MgO]/[Al. sulfate] ; 7.35~8.1, temperature of washing water : 34.4~37.4$^{\circ}C$, drying temperature : 74~81.5$^{\circ}C$. The physicochemical properties of hydrotalcite as medicine were studied by use of chemical analysis, D.S.C. thermogram, bulk volume test and acid consuming capacity measurements.

BOX-Wilson 실험계획법에 의한 인산알루미늄의 최적합성조건에 관한 연구

신화우,강태욱,안세민 원광대학교 식품약품안전성연구소 1992 食品藥品安全性硏究 Vol.5 No.-

Aluminum phosphate is used as an antacid in pharmacy as the gel or dried gel, must meet specified neutralization rate and acid consuming capacity criteria. This nonadsorbable antacid has been used in place of aluminum hydroxide gel where loss of phosphate may be a problem to the patient. Since aluminum phosphate gel is regenerated in the intestine, endogenous phosphate is spared. The acid-consuming ability of aluminum phosphate is based on the release of phosphate anion : AlPO_4 ?? Al^3+ + PO^3-, PO^3-_4 + H_3O^+ ?? HPO^2-_4 + H_2O, HPO^2-_4 + H_3O^- ?? H_2PO_4 + H_2O. Aluminum phosphate gel was synthesized by reacting aluminum chloride as a soluble aluminum salt to sodium phosphate in this study ; AlCl_3 + NaPO_4 → AlPO_4↓ + 3NaCl. The optimum synthesis conditions based on the yield of product were investigated by applying Box-Wilson experimental design. It was found that optimal synthesis conditions were as follows ; Reaction temperature;90∼98℃, Concentration of two reactants;15.3∼15.5%, Concentration ratio of two reactants, [Na_3PO_4]/[AlCl_3];1.48∼1.49, reaction time;10minutes, drying temperature of product;60∼70℃.

Thiocarbamyl Enoxacin 유도체의 합성 및 항균작용

신화우,고무수,정동훈,최광식,임철부 원광대학교 식품약품안전성연구소 1991 食品藥品安全性硏究 Vol.4 No.-

Treatment of 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine-3-carboxylic acid (Enoxacin) with alkyl(or aryl) isothiocyanates which obtained from alkyl(or aryl) amines afforded six 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-alkylthiocarbamylpiperazinyl)-1, 8-naphthyridine-3-carboxylic acids and five 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-arylthiocarbamyl piperazinyl)-1, 8-naphthyridine-3-carboxylic acids. The compounds synthesized were evaluated for their antimicrobial activities, in vitro, against Escherichia coli 6-PE-4, Bacillus subtilis 74-51, Proteus vulgaris 78645, Klebsiella pneumoniae JYA-78314, Staphylococcus aureus 79110 and Pseudomonas aeruginosa 8765-1 p_2.

Box-Wilson 計劃法에 依한 炭酸마그네슘의 製造條件에 關한 硏究 : (1報) 黃酸마그네슘으로 부터 製造 (Ⅰ) Preparation from Magnesium Sulfate

申和雨 圓光大學校 1980 論文集 Vol.14 No.2

Medicinal magnesium Carbonate is a basic hydrated magnesium carbonate or a neutral hydrated magnesium carbonate of very indefinite composition. It has been known that the composition of magnesium carbonate is greatly affected by the concentration, temperature, and mole-ratio of reactant solutions, and also by the temperature at which the precipitate is dried and the temperature of washing water. The purpose of this study is to determine the optimum preparation condition of medicinal magnesium carbonate. A randomized complete block design suggested by G. E. P. Box and K. B. wilson was applied for this purpose. Medicinal magnesium carbonate was prepared by reacting magnesium sulfate and sodium carbonate solutions in this study. The optimum preparation condition of magnesium carbonate obtained from this study is as follows; 1) reacting temperature range is 57-67˚C, 2) Concentration range of reactant solutions is 13-17%, 3) mole-ratio (MgSO₄/Na₂Co₃) is 1.0-1.3, 4) drying temperature range is 84-100˚C, 5) temperature range of washing water is 36.5-41.5˚C.

규산마그네슘의 최적합성조건

신화우,박인현,Shin, Wha-Woo,Park, In-Hyun 대한약학회 2000 약학회지 Vol.44 No.6

Magnesium trisilicate was prepared by reacting Magnesium sulfate solution with Sodium silicate solution in this study. The optimum synthesis conditions base on the yield of the product were established by applying Box-Wilson experimental design. It was found that the optimum synthesis conditions of Magnesium trisilicate were as follows; Reacting temperature : $57{\sim}90^{\circ}C$, Concentration of reactant solution : $19.1{\sim}20.0%$, Molar concentration ratio of two reactants : [Sod.silicate]/[Mg.sulfate] : $1.47{\sim}1.80$, Temperature of washing water : $45{\sim}48^{\circ}C$, Drying temperature : $65{\sim}82^{\circ}C$. The antacidic capacity of the five Magnesium trisilicate samples which shows the maximum antacidic efficacy was tested by pharmacopeia acid consuming capacity test. The five Magnesium trisilicate samples were identified by chemical analysis.

Box-Wilson 計劃法에 依한 炭酸마그네슘의 製造條件에 關한 硏究 : (2) Preparation from Magnesium Chloride

申和雨 圓光大學校 1982 論文集 Vol.16 No.2

In the previous paper, it has been reported that preparation from magnesium sulfate. It has been known that the composition or particle size of magnesium carbonate is greatly affected by the concentration. temperature. and mole-ratio of reactant solutions as well as the temperature at which the precipitate is dried and the temperature of washing water. The purpose of this study is to determine the optimum preparation condition of medicinal Magnesium Carbonate. A rabdomized complete block design suggested by G. E.P. Box and K. B. Wilson was applied for this purpose. Medicinal magneslum carbonate was prepared by reacting magnesium chloride and sodium carbonate solutions in this study. The optimum preparation condition of magnesium carbonate obtained from this study is as follows; 1) The reacting temperature range is 50~63℃ 2) The concentration range of reactant solutions is 16.5~50%, 3) The optimum mole-ratio(MgCI₂/Na₂CO₃)is 0.6~1.38, 4) The drying temperature range is 75~100℃, 5) The temperature range of washing water is 28~32℃.

苦汁으로 부터 炭酸마그네슘과 酸化마그네슘의 最適合成條件에 關한 硏究

鄭東燻,辛宗根,申和雨 圓光大學校 1989 論文集 Vol.23 No.2

고즙과 탄산나트륨을 원료로 1)반응액의 온도, 2)반응액의 농도, 3)혼합비율(〔Bittern〕/〔Na₂CO₃〕), 4)작용시간 및 5)건조온도를 합성요인으로 하여 Box-Wilson 실험계획법에 의해 탄산마그네슘의 최적합성조건을 추구하고 그 중 우수제품에 대해 D.S.C.를 측정하여 이를 기준으로 하소시켜 산화마그네슘을 제조하여 용적시험, 제산도시험 및 광학현미경사진을 관찰한 결과 1. 탄산마그네슘의 최적합성조건의 범위는 ①반응액의 온도범위는 50∼70℃ ②반응액의 농도범위는 고즙은 37.3∼38.1%, 탄산나트륨은 9.9∼10.3%, ③혼합비율(〔Bittern〕/〔Na₂CO₃〕)의 범위는 1.485∼1.503, ④작용시간의 범위는 10∼12분, ⑤건조온도의 범위는 73∼83℃이다. 2. 시료탄산마그네슘의 D.S.C.측정결과 75℃정도에서 결정수의 이탈로 보이는 흡열Peak를 나타냈고, 290℃정도에서 구조수의 이탈로 생각되는 흡열Peak를 나타냈으며, 408℃정도에서 탄산깨스의 이탈로 생각되는 흡열Peak를 나타냈다. 3. 탄산마그네슘의 하소온도는 500∼600℃가 적당하겠으며, 용적시험결과는 모두 경질품이었고, 시판품보다 모두 용적시험치가 큰 결과를 나타냈다. 4. 제산도시험의 결과는 시판품의 제산능보다 모두 크며 광학현미경사진에 의한 관찰을 하였다. Optimal Synthesis Condition of Magnesium Carbonate were investigated from the viewpoint of bulkiness according to a randomized complete block design proposed by G.E.P. Box and K.B. Wilson. Bittern and Sodium Carbonate were utilized as reactants in order to prepare Magnesium Carbonate. It was found that optimum temperature range of reactant solutions was 50∼70℃ and the optimum concentration range of the reactant solutions was 37.3∼38.1%(Bittern), 9.9∼10.3%(Sodium Carbonate), on the viewpoint of bulkiness. The optimum mole ratio of Bittern to Sodium Carbonate was in the range of 1.485∼1.503and the optimum reacting time range was 10∼12minutes. The optimum drying temperature range was 73∼83℃. Magnesium Oxide comes two types of granules when prepared by calcination of Magnesium Carbonate. The outcome of D.S.C. indicated a desolvation of Magnesium Carbonate occurred at about 75℃. The dehydration of the compound ceased at about 290℃ and the decarboxylation ceased at about 408℃. The physical and chemical properties of Magnesium Oxide as medicine were studied by use of Volume Test, Optical microscopic photographs and Acid Consuming Capacity measurments.

합성규산 알루미늄의 최적합성조건

신화우(Who Woo Shin),서민재(Min Jeo Seo),정동훈(Dong Hoon Chung) 대한약학회 2003 약학회지 Vol.47 No.1

Synthetic aluminum silicate was prepared by reacting aluminum sulfate solution with Sodium silicate solution in this study. The optimum synthesis conditions based on the yield of the product were established by applying Box-Wilson experimental design. The results were found to be as follows; Reactant temperature : 57~72oC Concentration of two reactants : 10~17.6%, Mole ratio of two reactants, [Sod. Silicate]/[Al. Sulfate]. : 4.6~5.0, Temperature of washing water : 25~40oC, and Drying temperature of product. 50~65oC. The physical and chemical properties of synthetic aluminum sitlcate as medicine were investigated by means of chemlcal analysis, adsorption test and acid consuming capacity measurements.

규산알루민산마그네슘의 합성조건과 유동학적 특성

신화우(Wha Woo Shin),정동훈(Dong Hoon Chung) 대한약학회 1995 약학회지 Vol.39 No.1

Aluminum magnesium silicate was synthesized by reacting the mixed solutions of sodium aluminate and magnesium chloride with sodium silicate solution in this study. The optimal synthesis conditions based on the yield of the product has been attained according to Box-Wilson experimental design. It was found that the optimal synthetic conditions of aluminum magnesium silicate were as follows: Reaction temperature=69~81oC; concentration of two reactants, sodium aluminate and magnesium chloride= 13.95~14.44w/w%; molar concentration ratio of the two reactants, [NaAlO2]/[MgCl2]=3.63~4.00;reaction time=12~15 min;drying temp. of the product=70~76oC. Aluminum magnesium silicate synthesized under the optimal synthesis condition was dispersed in 0.75, 1.0 and 1.5w/w% aqueous solution or suspension of six dispersing agents, and the rheological properties of the dispersed systems prepared have been investigated at 15oC and 25oC using Brookfield LVT Type Viscometer. The acid-consuming capacity of the most excellent product was 272~278ml of 0.1N-HCl per gram of the antacid. The flow types of 5.0w/w% aluminum magnesium silicate suspension were dependent upon the kind and concentration of dispersing agents added. The apparent viscosity of the suspension was generally increased with concentration of dispersing agents and was not significantly changed or decreased as the temperature was raised. A dispersing agent, hydroxypropyl cellulose suspension, exhibited an unique flow behavior of antithixotropy. The flow behavior of the suspension dispersed in a given dispersing agent not always coincided with that of the dispersing agent solution or suspension itself.