국산 Lidocaine 알칼리화를 위한 Bicarbonate 혼합시 침전유발 최소량에 대한 고찰

이선호,김현수,곽인숙,안원식,최관호,김광민,손민제 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.39 No.5

Background : When local anesthetics for regional anesthesia is used, usually small amounts of bicar-bonate are added for rapid onset. This addition gives the mixed solution a more alkaline pH. The following result is an increased unionized form of the local anesthetic and rapid penetration of the drug into tiissue. Unfortunately, no data about adequate mixing volumes of domestic lidocaine and bicarbonate is available. Methods : We examined six mixing pairs of two kinds of 2% lidocaines and three kinds of 8.4% bicarbonates for minimum volumes of bicarbonate to cause a precipitation of 2% 20 ml lidocaine. Results : The mean volumes of bicarbonate to cause precipitation were 1.54 ml for Kwang-Myung lidocaine with Kwang-Myung bicarbonate, 2.90 ml for Kwang-Myung lidocaine with Dae-Won bicarbonate, 2.73 ml for Kwang-Myung lidocaine with Je-Il bicarbonate, 0.97 ml for Je-Il lidocaine with Kwang-Myung bicarbonate, 1.26ml for Je-Il lidocaine with Dae-Won bicarbonate and 1.39 ml for Je-Il lidocaine with Je-Il bicarbonate. Conclusions : We conclude that the Kwang-Myung lidocaine and the Je-Il lidocaine could cause precipitation when mixing with a smaller bicarbonate volume than foreign textbook recommended. (Korean J Anesthesiol 2000; 39: 726-729)

시간축이동법을 이용한 발전기 보수유지계획의 수립에 관한 연구

이동인,김영훈,이광식,도대호 嶺南大學校 工業技術硏究所 1993 工業技術硏究所論文集 Vol.21 No.2

The proper resource allocation is a very important topic in power system problems, especially in operation and planning. One of such problems is optimal maintenance in operation and planning. The least cost should be the subject to be pursued in this study. A simulation model of a probablistic operation which is called cumulant method, is applied to the problem of optimal maintenance scheduling. A new technique called time axis shift method is developed. This method is similar to dynamic programming successive approximation.

평면연삭버어의 가공조건에 의한 영향

이광영,옥철호,서영백,박흥식,전태옥 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.2

This study has been carried out to prevent and decrease the grinding burr under various working conditions; number of grinding passes, depth of cut, hardness of the materials and work speed. Grinding wheel is WA grinding wheel and workpieces are SM45C, SS41, SCM23 and STS 304. The results of tained from this study are as follows; The length of gringing burr increased with increasing grinding passes and it has nothing to do with materials and heat treatment. The size of grinding burr increased with increasing grinding depth and feed speed. The size of grinding burr decreased with increased cross setion and of workpiece. According as the hardness of material was increased, the width of grinding burr decreased conspicuously owing to suppression of plastic zone of burr root part.

體育敎育의 理解에 觀한 調査硏究 : Focusing on the students of girls' high school 女高生 中心으로

李면榮,申光植,安洵換 덕성여자대학교 학생생활연구소 1987 學生生活硏究 Vol.7 No.-

The purpose of this study is to find how the students of girls' high school understand physical education. Conclusions are as follows. 1. Most students understand that physical education is an education for the whole person who is well balanced in a body and mind. And they think that physical education is health education through physical activities. 2. Students recognize that physical education is good for the healthy growth of body and mind. 3. Students show the difference of attitude according to the physical condition and the favorite sport. 4. Students are not concerned about an interest of physical education. 5. Some studnts like the class of physical education because of mental health it brings. But others do not like it because of their physical weakness. 6. In a school life, physical education gives a positive attitude, cooperation, power of conbination and a diversion. And its role is to raise effieiency to other lasses. 7. Students point out that the quality of physical education (the teaching method and contents)should be improved. 8. Students say that the dificiency of equipment checks the efficient physical education. 9. Students say that the possession of equipment does not fulfill. 10. Most students like to have physical education lesson on Saturday, Wednesday and Monday. 11. Students like to have physical education in the afternoon than in the morning. 12. Students want to learn tennis and swimming. But they can't learn it because there is no equipment in the school.

동종골수이식 후 혈당 및 혈중 지질농도의 변화양상 및 관련인자

이원영,강무일,오은숙,오기원,손현식,윤건호,차봉연,이광우,손호영,강성구,신완식,민우성,김춘주 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.6

연구배경:골수이식은 비교적 젊은 연령의 환자들을 대상으로 하며 면역억제제의 사용기간이 비교적 짧으므로, 주로 고령의 만성 질환 환자에서 시행되는 고형장기이식에서와는 달리 당대사 및 지단백 대사에 있어서 많은 차이점이 있을 것으로 추측된다. 저자들은 전향적 연구를 통하여 골수이식 후 시기별로 혈당 및 혈중지단백 변화 양상을 알아보고 이와 관련된 임상인자들을 규명하고자 하였다. 방법:1998년 10월부터 1999년 8월까지 가톨릭대학교 성모병원에서 동종골수이식을 시행한 환자들 중 43명을 대상으로 이식 전 및 이식 후 1, 2, 3, 4주와 3개월, 6개월에 공복 혈당, 혈중 총 콜레스테롤, 중성지방, 고밀도지단백을 측정하여 골수이식 후 시기별 변화를 관찰하고 여러 임상인자들에 따른 차이를 알아보았다. 결과:1. 공복혈당은 골수이식 수 첫4주 동안 상승하였고 이후 감소하였으나 이식 6개월 시점의 평균 공복혈당은 이식 전보다 유의하게 높게 관찰되었다. 혈중 총 콜레스테롤은 이식 후 1주에 최고치를 형성하였고 이후 기저수준으로 회복되었다가 이식 수 3,6개월에 다시 증가하여 기저치에 비해 유의하게 높았다. 혈중 중성지방은 이식 후 1개월까지 유의하게 증가하였고 이후 감소하여, 3,6개월에는 기저치와 유의한 차이가 관찰되지 않았다. 혈중 고밀도지단백은 이식 후 2,3주에 이식 전보다 유의하게 감소하였고 이후 이식 전 수준으로 회복되었다. 혈중 저밀도지단백은 총 콜레스테롤의 변화와 매우 유사하였다. 2. 골수이식 후 6개월 시점에서 공복 혈당이 126㎎/dL이상인 환자는 7명(16%)이었다. 이들 환자들과 공복혈당 126㎎/dL 미만의 환자 36명을 비교한 결과, 공복혈당이 126㎎/dL 이상인 환자군에서 스테로이드 평균 투여량이 많았고 고밀도지단백이 유의하게 낮았다. 3. 이식편대숙주질환이 발생한 환자는 그렇지 않은 환자보다 이식 후 1, 2, 3주 및 6개월의 총 콜레스테롤이 더 낮았고, 3개월의 공복혈당이 더 높았다. 혈연골수이식 환자군은 비혈연골수이식 환자에 비해 투여된 스테로이드 용량이 더 적음에도 불구하고 이식 후 1, 2, 3주 및 6개월의 총 콜레스테롤 수치가 더 높았다. 스테로이드 고용량 투여군(하루 평균 7.5㎎기준)은 저용량군보다 이식 후 3개월 시점의 공복혈당이 더 높았으나 나머지 시점의 혈당, 혈중 지질농도에 있어서는 유의한 차이가 관찰되지 않았다. 결론:골수이식 후 초기시기에 주로 당 대사 및 지질대사이상이 관찰되며 이는 면역억제제 투여와 관련이 있음을 알 수 있었다. 면역억제제가 고용량 투여되는 합병증 발생 시 이들 대사이상에 관심을 기울여 대처해야 할 것이다. Background: In bone marrow transplantation(BMT), recipients are usually younger and immunosuppressants are open used in shorter period than in solid organ transplantation. Therefore, there might be a difference in glucose and lipid metabolism between BMT and solid organ transplantation. However, the serial changes of metabolic parameters following BMT have not been studied. Therefore, the aim of this study is to investigate the serial changes of blood glucose, lipids and the putative factors that are related with these changes after BMT. Methods: We have prospectively investigated 43 patients who underwent allogeneic BMT. Fasting plasma glucose(FPG), total cholesterol, triglyceride and high-density lipoprotein(HDL) were measured before BMT, and at 1, 2, 3, 4, 12 weeks and 6 months after BMT. The serial changes of these metabolic parameters according to clinical factors including type of BMT, mean daily steroid dosage, and occurrence of graft versus host disease (GVHD) were examined. Results: 1. Mean FPG level increased during 4 weeks after BMT and remained above basal value at post-transplant 6 months. Total Cholesterol level was increased during initial 4 weeks after BMT and was above basal value at post-BMT of 3 and 6 months. Triglyceride level was progressively increased during initial 4 weeks after BMT, but returned to basal value there after. HDL-cholesterol level was significantly decreased during initial 4 weeks after BMT, but returned to basal value there after. 2. Patients with FPG above 126 mg/dL and the other patients, the former received larger amounts of daily steroid and had lower HDL-cholesterol level. 3. The changes of metabolic parameters were different according to type of BMT, steroid dose, and occurrence of GVHD. Conclusion: Although there was increase of FPG, TC, TG and decrease of HDL-C during initial 4 weeks after BMT, these metabolic changes recovered slowly thereafter. Immunosuppressants are thought to be associated with these changes. Further observation will be needed for the long-term effect of BMT on metabolic changes(J Kor Diabetes Asso 24:689~698, 2000).

세포질내 정자주입법(ICSI)에 있어서 정자흡입 및 난자내 주입방법에 관한 연구

이택후,김항진,송건호,김대근,전상식,박윤규,서태광,전병균,류은경,이은숙,문진수,김광철 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Study on Method of Sperm Aspiration and Injection into an Oocyte in Intracytoplasmic Sperm Injection(ICSI) Immobilization of spermatozoa prior to intracytoplasmic sperm iniection(ICSI) sometimes results in crooked tail and this makes it difficult to aspirate sperm into an injection pipette tail first. Head-first sperm aspiration into an injection pipette avoid this problem due to the bigger size of the sperm head. The effect of head or tail-first sperm injection into an oocyte on fertilization cleavage, percentage of grade I embryos and development to blastocyst stage in ICSI program has been studied. A single living immobilized spermatozoa from oligoasthenozoospermic patient was injected into an oocyte head-first or tail-first according to the treatment. Eighteen hours after microinjection, oocytes ware inspected for survival and fertilization Fertilized oocytes with two pronuclei were cultured in 30μl drop of mHTF supplemented with 10% heat-inactivated follicular fluid(FF) at 37℃. On day 2. embryo transfer was performed with cleaved embryos. The remaining 2-8 cell stage embryos were co-cultured with BRL cells in mHTF + 10% FF for 72 hours and the developmental stage was observed. The data were analyzed by Analysis of Variance. A total of 164 oocytes from 36 cycles were assigned to earth treatment and ICSI was performed(88 head-first, tail-first). The rates of normal fertilization were 81.8% and 76.3% for head-first and tail-first, respectively. Of the fertilized oocytes, the percentage of cleaved embryos and the percentage of grade 1 embryo among cleaved embryos were 88.9% and 68.8%, 93.1% and 74.1% for head-first and tail-first, respectively. Of the 2-8 cell embryos cultured, 44.4%(16/36) and 50.0%(10/20) for head first and tail first, respectively developed to blastocyst stage. There were no differences in fertilization, cleavage, rates of grade 1 embryos, and development to blastocyst stage. In conclusion, head-first or tail-first sperm injection into an oocyte in ICSI program does not affect fertilization and subsequent embryo development to blastocyst stage in vitro.

IgA 腎病症에 對한 病理學的 및 免疫病理學的 硏究

이종대,서광선,이충식 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

A clinicopathologic analysis for 88 cases of IgA nephropathy has been carried cut from a series of 333 renal biopsy specimens which were studied at Department of Pathology, College of Medicine, Chungnam National University, during a period of 54 months from October 1983 to March 1988. The results were as follows: 1. IgA nephropathy was 26.4% of renal biopsy specimens and 30.4% of primary glomerulonephritis. It was common in young adults and 77.3% of patients were between 16 years and 39 years. Male to female ratio was 1.1 : 1. 2. Modified classification of Meadow et al. for Henoch-Schoenlein nephritis was adopted for the histologic grading of glomerular lesions. The result was as follows; Grade I 5.7%, Ⅱ 46.6%, M 45.5%, Ⅳ 1.1%, an V 1.1%. The clinical class was possible in 70 cases; Class B38.6 %, C 61.4%. 97.1% of these. 70 cases were within the histologic Grade Ⅲ. 3. The results of immunofluorescent study were as follows; All cases showed granular mesangial deposits of IgA. Complement 3 was found, in same manner as IgA, in 83 0%, fibrinogen 23.9%, IgM 18.23%, and IgG 3.4%. 10.2% of these cases showed clumps of fluorescent deposits involving the mesangium and continuous loops. 4. Among the chief complaints on admission, gross hematuria was observed in 59.1%, microscopic hematruia 39.8%, and proteinuria 69.3%, including nephrotic range protein uria 6.8%. Along the histologic grading, the frequency of gross hematuria was different, as follows; Grade I 100.0%, Grade Ⅱ 65.9%, and Grade Ⅲ 47.5%. Statistically, these differences were significant(P<0.01) On serologic study, hepatitis B surface antigen was positive in 6.7% and level of serum IgA was significantly increased in 27.6%.

중국 포양호 주변의 농경지 현황 및 수질 오염 부하량

이종식,정구복,윤순강,정광용,于傳驥,劉文祥 한국국제농업개발학회 2002 韓國國際農業開發學會誌 Vol.14 No.4

중국 최대의 담수호로 장강을 통해 서해로 유입되는 포양호의 특성, 주변의 농경지 토양환경, 시기별 포양호 수질변화 및 유입되는 각 수계별 수질오염 부하량 등을 검토하였다. 1. 포양호는 주변 지역의 벼 재배와 홍수 조절에 중요한 역할을 하며 최근 간척과 침척토의 침적 등에 의하여 면적이 매년 축소되고 있다. 2. 아열대 기후에 속하여 연평균 강우량이 1,570㎜ 수준으로 비교적 많으나 연 중 분포가 평준하지 않고 월별 차이가 커서 시기별로 호수의 수표면적 및 저수량의 변화가 대단히 크다. 3. 주변 지역의 농경지는 큰 오염원이 없어 비교적 오염되지 않은 토양이며, 오염도가 심한 농경지는 호수 유역의 전체 농경지 면적중 0.22%로 광산 인근 토양이 구리와 황으로 오염되어 있다. 4. 포양호에 직접 유입되는 COD부하량은 시기별로 홍수기가 371.9톤/일로 갈 수기 273.9톤/일에 비해 많았다. 요인별로는 산업체에서 기인되는 양이 가장 많았으며, 유입되는 수계별로는 감강으로부터 유입되는 오염 부하량이 가장 많았다. Water in Poyang lake, which is one of the biggest lake in China, flows into Yellow Sea through the Changjiang River. In this paper, water quality characteristics and loading amount of contaminants of Poyang Lake area were investigated. Poyang lake has a important role to rice cultivation and flood control in the basin of the lake. However, the area of the lake has been reduced gradually by land reclamation and sedimentation. This area belongs to the subtropical zone and the average rainfall is near 1,570㎜, which is relatively higher than other region in China. The surface area and the volume of storage water of the lake is very changeable following to the big different monthly rainfall. Agricultural field near the lake is not contaminated comparatively because there is little source of contamination near the Poyang lake. About 0.22% of the total agricultural field near the lake were heavily contaminated by copper and sulfur originated from metal mines. Inflow loading amount of COD(chemical oxygen demand). Compared to other sources of contamination such as municipality, livestock, and nature, industrial source of COD to Poyang lake were the greatest. Ganjiang stream was the highest for the loading amount of COD to Poyang lake among 5 streams.

중범위 이상 회전근 개 파열 환자의 관절경적 봉합술 : 견봉성형술의 역할 The Role of Acromioplasty

이광원,김갑중,이항호,김병성,김하용,최원식 대한견.주관절학회 2003 大韓肩.주關節學會誌 Vol.6 No.2

골수이식 후 골밀도 및 골대사의 변화 : 2년 추적관찰 2-Year Prospective Study

이원영,강무일,오은숙,오기원,한제호,손현식,윤건호,차봉연,이광우,손호영,강성구,신완식,민우성,김춘추 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5