간내 담관암의 초음파 및 전산화 단층촬영소견 : Ultrasound and CT Findings

김완진,김표년,김일영,홍현숙,이혜경,권귀향,김기정 순천향대학교 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

Assessment of In Vitro Assay System for Thyroid HormoneDisruptors Using Rat Pituitary GH3 Cells

Hee Jin Kim1,Hae Young Park1,Jeonga Kim1,Il Hyun Kang2,Tae Sung Kim2,Soon Young Han2,Tae Seok Kang2,Kui Lea Park2,Hyung Sik Kim1 한국독성학회 2006 Toxicological Research Vol.22 No.4

The development of in vitro assays has been recommended to screening and test-ing the potential endocrine disruptors (EDs). These assay systems focus only on identifying thethe thyroid hormone (TH) disruptors. The aim of this study was to evaluate a test system to detectTH disruptors using rat pituitary tumor GH3 cells. The test system is based on the TH-dependentincrease in growth rate. As expected, L-3,5,3-triiodothyronine (T3) markedly induced a morphologicalchange in GH 3 cells from flattened fibroblastic types to rounded or spindle-shaped types. T3 stimu-lated GH3 cell growth in a dose-dependent manner with the maximum growth-stimulating effect9 M. In addition, T3 increased the release of growth hor-mone and prolactin into the medium of the GH3 cells culture. Using this assay system, the TH-dis-rupting activities of bisphenol A (BPA) and its related compounds were examined. BPA,dimethylbisphenol A (DMBPA), and TCI-EP significantly enhanced the growth of GH3 cells in therange of 1 × 10-5M to 1 × 10-6M concentrations. In conclusion, this in vitro assay system might bestandardization before it can be used as a broad-based screening tool.

韓國氣功 定立을 위한 方向設定에 관한 硏究

金永明,金相奎,申舜植 동아대학교 스포츠과학연구소 2000 스포츠科學硏究論文集 Vol.18 No.-

Qigong is on the developmental stage and is expanding to the entire world, while it acknowsedges to the West as a universial method of human healthy-longevity. The conception of health known to thr west is based on the providence of modem civilization and science focusing on the physical practices, however, which usually limit the projected effective execution itself. Recently the eastern method of more effective physical-mental training was explored and by which is replaced for the human-healthy longevity in human life. The western standard form and its criterion was established through researches done by the scheme of biological-medical science, effectively it is revolutionizing forward the the eastern medical science as a formal integration of psychology, physiology and the social environmental elements. According to the eastern thought human life is a unified form of mental and physical integration. In China, the government actually supports in official for the development of qigong so that it is activated, practically suggested and progressed lively throughout the nation. Qigong in Korea is activated today. It will be expanded further from now on. Qigong is considered as a method of natural healing, physical theraphy and healthy longevity while giving attention to a lot of people in our country. As they demand qigong in daily lives, there increased the amount of service institute In our community. However, they are not qualified enough both of the knowledge and practical technique. In a future it may cause social problems and there need countermeasure. Therefore, the government must consider about certain problems such as Qigong clinics and its practicioners, which need to be examined before approval, and should enact the national policy and system so that Qigong in korea can be identifie as physical activity for all, as well as systematically established for a way of national health.

취학전 아동의 체력 실태와 평가

권영옥,김동권,민춘기,이용인,전종귀,진윤수,홍성표 忠南大學校體育科學硏究所 1995 體育科學硏究誌 Vol.13 No.1

The purpose of this study was analyze children's Physical Fitness and basic rate by observing the change in the heart rate of the 1230 children of five of six years of age. Following conclusions were obtained The muscular strength was relatively low according to places. And the muscular strength of boys was higher than that of girls. The flexibility of girls was higher than that of boys according to places and sexes. The muscular endurance, power, balance and agility of boys were higher than those of girls according to places and sexes. Thus the development of physical fitness was improved with their ages, the physical fitness for physique seemed rather low. So the programs of physical plays for children's physical fitness ought to be developed and physical play showed to be done at kindergarten school.

숯가루와 송염으로 난치병 예방 및 치료에 대한 문헌연구

조원민,김귀원,조영희 釜山大學校 師範大學 1999 교사교육연구 Vol.41 No.-

The purpose of this study was to investigate on the disease prevention and treatment by charcoal and perfect salt. There are many medicine treatments to cure disease. Some treatments were useful to cure and some were useless. Those were limitations in medical treatments. In some diseases many doctors have been abandoned the patients to cure inspite of all efforts, but in the natural therapies, many patients got better to normal body conditions. Chacoal and perfect salt was investigated among the many natural therapy.① These two therapies were successful to cure the surgery and internal diseases. The methods of treatment were drinking water with the powder in internal diseases and using the powder packs in surgery. The effects of charcoal and perfect salt was both useful to clean up the blood and made got the men healthy to prevent and cure the diseases. In charcoal the reaction time in absorption and excretion was rapid. In perfect salt, electric actions maintain the proper pH7.4 and full vitality on metabolism, nerve system and muscles. So these were the source to make the healthy men and prevent and treat the diseases.

감나무탄저병에서 분리한 Gloeosporium kaki의 2계통

崔貞植,李貴宰,金炯武,蘇仁永 全北大學校 1993 論文集 Vol.35 No.-

A anthracnose symptom at persimmon tree was found out in the field, Chonju in Chonbuk province and Haenam Experiment Station in Chonnam province in 1991 and 1992. The cultivated character and the pathogenicity of the fungi were as follows : These fungi, Gloeosparium kaki which were isolated from the anthracnose were classified into strain Ⅰ and Ⅱ by the cultivated characteristics. The size of conidia in strain Ⅰ was 22.5 × 6.82 ㎛ and that of strain Ⅱ was 20.3 × 6.2 ㎛. In a PDA, the colour of strain I was light brown and made a central zone. The colour of strain Ⅱ was black brown and deep grey and didn't make a central zone. The pathogenicity of strain Ⅰ was similar to strain Ⅱ in the leaf, branches.

고등학교 육상 선수와 일반 학생의 콜레스테롤 조성에 관한 비교 연구

남태호,황영성,김귀원 釜山大學校 附設 體育科學硏究所 1993 體育科學硏究所 論文集 Vol.9 No.-

Background : This study was designed to investigate on cholesterol composition between athletes and common students. Method : The subjects of this study are nine athletes and random selectional ten students in B high school. BMI, % Fat, TC, HDL-c and LDL-c were measured and compared, and correlation and difference between each variable was investigated. Results : Between the player group and the control group, BMI has significant difference (p<.05), and in the control group, BMI and % Fat have significant correlation. In the player group, there is a significant correlation between TC and TC/HDL-c (P<.01), and in the control group, there is a very significant correlation (P<.001). The correlation between LDL-c and LDL-c/HDL-c in the player group is significant (P<.01), and one of the control group is very significant. (P<.001) There is no significant correlation of HDL-c, LDL-c, TC/HDL-c, LDL-c/HDL-c in the player group, on the other side, there is each significant correlation by the level of P<.05, P<.001, P<.001 in the control group. There is no statistically significant difference in HDL-c, LDL-c between the player and the control group, but from the mean of them, the player group has higher level of HDL-c (0.3 mg/dl), and lower level of LDL-c (0.9 mg/dl) than control group. And the player group has higher 5.0 mg/dl TC than the control group. nificant.(P<.001)

지문과 정신분열증

우숙희,정국동,최송표,조근자,양은진,김수일,박경란,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Fingerprint patterns of 333 schizophreniacs who met with the diagnostic criterias of International Pilot Study of Schizophrenia except items associated with chronicity in exclusion criteria were studied, and the following results were obtained. 1. The frequency distribution of the fingerprint patterns in the 333 schizophreniacs was ulnar loop, whorl, twinned loop, arch, radial loop in order in both control and schizophrenia groups. 2. Finger ridge counts of both sexes were decreased significantly in schizophrenia group. 3. Dissociation of fingerprint pattern in the schizophrenia group was 51.1%, which was far greater than 6.25% of control group. Number of dissociation was greatest in the thumb, followed by index, middle, ring, and little finger in order. According to the above results, it is considered that both the number of finger ridges and degree of dissociation of fingerprint patterns were closely related with schizophrenia. Analysis of fingerprints and palmprints with the aid of chromosomal analysis would contribute the early diagnosis and prevention of schizophrenia.

상악 결손부 수복을 위한 측두피판의 이용

정창주,진국범,이동근,윤성필,김귀희,김영조 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1

The functional deformity following removal of the maxilla is considerable, especially following maxilla cancer excision. Rehabilitation of oral and maxillofacial region used to be very difficult with prosthesis or traditional flaps. Temporal muscle and fascia flaps have been described for immediate reconstruction following hemi-maxillectomy, but not total maxillectomy. The muscle and superficial fascia of the temporal area differ in their physical characteristics, vascular supply and clinical applications. Both can be employed independently or simultaneously as regional flaps in the reconstruction of a variety of complex craniofacial defects. Four case is presented in which 3 case maxilla cancer, one case non-union after maxilla fracture, and all case showed successful use of this flap. Only one patient developed partial necrosis of the flap ; significant necrosis did not occur in any other patient. This present paper reviews the anatomy, surgical technique and utilisation of temporal muscle and fascia flaps.

BGJ398, A Pan-FGFR Inhibitor, Overcomes Paclitaxel Resistance in Urothelial Carcinoma with FGFR1 Overexpression

Kim, Se Hyun,Ryu, Haram,Ock, Chan-Young,Suh, Koung Jin,Lee, Ji Yun,Kim, Ji-Won,Lee, Jeong-Ok,Kim, Jin Won,Kim, Yu Jung,Lee, Keun-Wook,Bang, Soo-Mee,Kim, Jee Hyun,Lee, Jong Seok,Ahn, Joong Bae,Kim, Kui MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.10

<P>Paclitaxel (PTX) is commonly used to treat urothelial carcinoma (UC) after platinum-based chemotherapy has failed. However, single-agent taxane therapy is not sufficient to inhibit tumor progression and drug resistance in advanced UC. Epithelial-to-mesenchymal transition (EMT) induced by fibroblast growth factor receptor (<I>FGFR</I>)1 signaling has been proposed as a mechanism of PTX resistance, but it is unclear whether this can be overcome by <I>FGFR1</I> inhibition. The present study investigated whether <I>FGFR1</I> overexpression contributes to PTX resistance and whether <I>FGFR</I> inhibition can enhance PTX efficacy in UC. The effects of PTX combined with the <I>FGFR</I> inhibitor BGJ398 were evaluated in UC cell lines by flow cytometry; Western blot analysis; cell viability, migration, and colony forming assays; and RNA interference. PTX+BGJ398 induced cell cycle arrest and apoptosis in UC cells with mesenchymal characteristics was accompanied by downregulation of <I>cyclin D1</I> protein and upregulation of gamma-histone 2A family member X and cleaved poly(ADP-ribose) polymerase. Additionally, PTX+BGJ398 synergistically suppressed UC cell migration and colony formation via regulation of EMT-associated factors, while <I>FGFR1</I> knockdown enhanced the antitumor effect of PTX. These findings provide a basis for development of effective strategies for overcoming PTX resistance in UC through inhibition of <I>FGFR1</I> signaling.</P>