조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

고속가공에서 2중 신경망을 이용한 표면거칠기 예측과 가공DB 구축 효율화 방안

원종률,남성호,유송민,이석우,최헌종 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

In this paper, a double artificial neural network (ANN) approach and the efficient machining database building scheme are presented for the prediction of surface roughness in high-speed machining. In this approach, 4 machining parameters and used for the prediction of cutting force components, and the combinations of 4 parameters and the predicted cutting force components are finally used for the prediction of surface roughness. The experimental results comparing the these results with the predicted values using simple 4 input nodes have been also investigated to verify the effectiveness of the proposed approach.

腰痛을 同伴한 足下垂 患者 1例에 대한 臨床報告

김종국,유호상,윤일지,오민석 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

After treating a patient suffering from foot drop which is caused by peroneal nerve paralysis, some result are gained as follows. Patient, 73 years old women, was treated from June 7 to July 15 in oriental hospital of Daejeon University. This disease is foot drop is caused by peroneal nerve paralysis which paralyze tibialis anterior muscle, fibula muscle, and extensor musculi of foot. Peroneal nerve contains nerve root of L4, L5, S1 and S2. Foot drop correspond to flaccidity-syndrome(^ISE). Flaccidity-syndrome(?/症) means that the muscle and the pulse of body is relaxed and the limbs become week and the man have a difficulty to move for oneself. The cause of this case on oriental medicine is Yin-deficiency of liver and kidney. Treatments which was based on cause of oriental medicine - herb medication, acupuncture treatment, electronic acupuncture treatment and moxibustion - have a good effect to patient.

디지털콘텐츠를 위한 백업 시스템의 설계 및 구현

윤종현,이석재,유재수 충북대학교 컴퓨터정보통신 연구소 2005 컴퓨터정보통신연구 Vol.13 No.2

첨단 IT기술의 발전으로 유무선 통신망을 통하여 다양한 환경에서 사용되는 대용량 디지털콘텐츠들이 급증하고 있다. 또한 기하급수적으로 늘어나고 있는 디지털콘텐츠를 한정된 저장 공간에 효율적으로 저장하기 위한 콘텐츠기반 저장기술에 대한 연구가 활발히 진행되고 있다. 이와 함께 불시의 사고에 의한 디지털콘텐츠의 손실을 방지하기 위해서 지속적인 데이터 백업의 중요성 또한 증가하고 있다. 본 논문에서는 디지털콘텐츠의 특성을 고려하여 데이터 입출력 I/O 크기 단위로 콘텐츠를 객체화하고 유일한 ID를 부여하여 백업 장치에 저장하는 시스템을 설계하고 구현한다. 제안하는 백업 시스템은 중복되어 발생하는 데이터는 하나의 사본만 백업하고, 이를 공유함으로써 백업되는 데이터의 양을 효과적으로 감소시킨다. With the development of IT technology, the amount of digital contents used in various environments of wired and wireless networks have been increased hugely and rapidly. Also, many researches have been done to process a contents-based storage technology that saves the digital contents in limited storage. To protect the loss of the digital contents by the sudden accident, continuous data backup is required. In this paper, we design and implement the backup system that stores digital contents in backup storage by objectifying the contents with a unit of I/O size and giving them the unique ID using the properties of digital contents. The backup system reduces the amount of backup data by backuping and sharing the only one copy of the backup data.

당뇨신발용 혁의 개발에 관한 연구

이종석,이종철,김명웅,최순복,김영길,유은일 한국공업화학회 2003 응용화학 Vol.7 No.1

The whole process of manufacturing diabatic leather for upper and lining is investigated into raw skin, pelt wet bule, crust leather and finished leather It is tried to make the more functional upper leather and lining leather in the whole leather process by the use of developed recipr. The lower chrommed wet blue for upper and lining is developed through tanning process. The air-permeability of crust leather for upper and lining is incerased through miling The hygiene of finished leather for upper and lining is increased by the of antibacterial and deodorization agents. The upper leathe and lining leather through these have the more improved physical properies of the finished leather than those through other treatments.

江地開發이 地域社會發展에 미친 影響에 關한 比較硏究 : 테네시江 事例와 4大江 流域 開發計劃을 中心으로

金裕赫,琴東信,石琮顯 단국대학교 법정대학 지역개발학과 1982 地域開發論叢 Vol.3-4 No.-

Forced eruption을 이용한 매복 전치의 치험례 : FORCED ERUPTION FOR IMPACTED ANTERIOR TOOTH

공석배,김종수,유승훈 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

영구 전치의 매복은 제 3대구치나 견치에 비해서 드물게 나타나지만 학령기 아동에서 관찰할 수 있다. 매복치아의 원인은 외상, 공간 부족, 치아의 맹출 경로상에 위치하는 과잉치, 유치의 치근단 감염 등 다양하다. 매복된 치아는 부정교합과 인접치아의 치근 흡수, 낭종 등의 병적 변화를 유발할 수 있으므로 임상적 검사와 방사선학적 검사를 통해 정확한 위치를 확인하고, 적절한 치료계획을 통해 정상 맹출을 유도하여야 한다. 매복된 치아가 병적 변화를 일으킨 경우나 인접치에 손상을 주었을 경우에 발치를 시행하게 된다. 그러나 교정적 견인을 통해 기능과 심미성을 회복시켜 줄 수 있으므로 조기 발견과 발견시의 올바른 진단과 치료 계획을 수립하는 것이 중요하다. 교정적 견인시에는 매복치를 배열할 공간의 확보와 고정원에 대한 고려가 선행되어야 한다. 견인시 적절한 방향의 힘을 통해서 치근의 흡수 등의 부작용이 일어나지 않도록 해야 한다. 본 증례는 매복된 전치들을 forced eruption을 통해서 정상적인 맹출 방향으로 유도한 치험례이다. Impaction of permanent incisor occurs rare than the canine & third molar. But it s often observed in school age child. The causes of impaction are trauma, space deficiency, mesiodens, infections of root apex, etc. In spite of elimination of cause, normal eruption of impacted tooth is rare. Though eruption is normal, the position of tooth will be incorrect. Because the impacted tooth results in malocclusion, root resorption of adjacent tooth, pathologic cystic change, it should be confirmed the precise position by clinical and radiographic exam and found the correct location by appropriate treatment plan. In case of pathologic change of impacted tooth and injury to adjacent tooth, it will be extracted. But through orthodontic retraction, the function and esthetics of tooth can be restored. It is important that impacted tooth should be detected early and diagnosed correctly, and appropriate treatment plan should be made. Before impacted tooth is retracted, the considerations of space for alignment and anchorage should be preceded and through appropriate force and mechanics, the side effects, for example, a root resorption should be minimized. In this study, we guided impacted tooth to normal position by using a forced eruption.

성인 급성 림프구성백혈병 고위험군에서 일차관해시 동종 및 자가 조혈모세포이식의 성적 비교 : 단일기관 치료경험 A Single Center Experience

이석,민우성,민창기,김동욱,이종욱,김유진,박은정,박윤희,김춘추 대한조혈모세포이식학회 2000 대한조혈모세포이식학회지 Vol.5 No.2

배경:성인 ALL에서 동종 조혈모세포이식은 전처치요법 및 이식편대백혈병 효과에 의한 효과적인 백혈병세포의 제거가 가능하다는 측면에서 활발히 시행되고 있으나 자가 조혈모세포이식과 화학요법과의 비교 연구에서는 대상환자의 다양성 등으로 인하여 상이한 결과가 보고되었다. 그러나 최근 진단당시 환자의 임상적·세포생물학적 특성 및 관해유도요법 후의 백혈병세포의 제거 속도 등을 기준으로 한 위험인자가 정의되면서 이를 근간으로 위험도에 따른 관해 후 치료방침의 결정이 타당성 있는 접근방법으로 제시되고 있고, 특히 고위험군에서의 동종 조혈모세포이식의 역할이 강조되고 있다. 방법: 성인 ALL 고위험군에서 일차 완전관해시 동종 조혈모세포이식의 역할을 규명하기 위해 최근 5년간 가톨릭의대 조혈모세포이식센터에서 ALL로 진단 후 일차 완전관해 상태에서 동종 및 자가 조혈모세포이식을 시행받고 임상적 특성과 세포면역학적 특성 및 세포유전학적 검사결과가 모두 확인 가능하였던 환자 중 고위험군에 해당된 50례를 대상으로 후향적 분석을 시행하였다. 고위험군은 진단시 연령이 30세 이상인 경우, 백혈구수가 30,000/μL 이상인 경우, 관해유도기간이 30일 이상 소요된 경우, Ph 혹은 t(4;11)이 동반된 경우 중 하나 이상의 인자를 갖고 있는 경우로 정의하였다. 결과: 대상환자의 중앙연령은 30세(15~43세)이었고, 남녀 비는 27:23이었다. FAB 분류상 L1 29례(58.0%), L2 21례(42.0%)였으며, precursor B-lineage 항원이 양성인 경우는 36례(72.0%), T-세포 항원이 양성인 경우는 9례(18.0%), 골수구계 항원이 동시에 발현된 경우는 5례(10.0%)였다. 세포유전학적 검사상 23례(46.0%)에서 불량한 염색체유형 [Ph 19례, t(4;11) 4례]이 동반되었다. 전체 환자 중 31례에서 동종 조혈모세포이식을 시행하였으며, 19례에서는 자가 조혈모세포이식이 시행되었다. 동종 및 자가 조혈모세포이식 환자군간의 임상적 특성은 양군간의 유의한 차이가 없었다. 대상환자의 중앙 추적관찰기간은 27개월(7~72개월)이었고, 전체 환자의 2년 무병생존율 및 전체생존율은 각각 59.0±7.6%, 68.2±7.1%이었다. 조혈모세포이식에 따른 치료성적을 비교한 결과 전체생존율은 동종 조혈모세포이식군 71.4±8.6%, 자가 조혈모세포이식군 62.7±12.4%로 양군간의 유의한 차이가 없었던 반면, 재발율은 동종 조혈모세포이식군에서 유의하게 낮은 빈도를 보였으며(25.8% vs 52.6%, P=0.05), 무병생존율에 있어서도 각각 70.6±9.0%, 42.1±12.2%로 동종 조혈모세포이식군에서 보다 높은 경향을 보였다(P=0.07). 이식 후 생존율에 영향을 주는 위험인자를 분석한 결과, 진단시 연령, 백혈구수, 관해유도기간에 따른 차이는 관찰되지 않았다. 다만 Ph 혹은 t(4;11)이 동반된 경우에서 무병생존율이 동종(28.5±16.0% vs 94.4±5.4%, P=0.0002) 및 자가 조혈모세포이식군(18.1±11.6% vs 80.0±17.8%, P=0.0046) 모두에서 유의하게 감소되었다. 결론: 본 연구를 통하여 일차관해시 조혈모세포이식을 시행받은 고위험군 성인 ALL에서는 관해 후 치료법으로써 동종 조혈모세포이식이 우선적으로 고려될 수 있는 치료법임을 확인할 수 있었다. 이는 추후 국내에서도 보다 장기간의 추적관찰을 통한 전향적 임상연구를 시행하여 보다 정립된 관해 후 치료방침의 결정 필요성을 제시하였다는 측면에서 임상적 의의가 있을 것으로 사료된다. Background:Optimal postremission therapy remains controversial in adult patients with acute lymphoblastic leukemia (ALL). In this study, we compared allogeneic bone marrow transplantation (alloBMT) with autologous peripheral blood stem cell transplantation (autoPBSCT) using the result of the human leukocyte antigen typing (HLA). Methods:Patients were eligible if they were in first remission (CR1) and had either: adverse cytogenetics [Philadelphia chromosome (Ph), t(4;11)], age >30 years, required more than 1 induction course to achieve remission (time-to-CR1 >30 days) or presenting WBC >30,000/μL. From July 1994 to June 1999, 50 consecutive adult patients with high-risk ALL underwent HLA-matched alloBMT (n=31) or autoPBSCT (n=19) at the Catholic Hemopoietic Stem Cell Transplantation Center. Results:There were 27 males and 23 females with median age 30 (range, 15~43) years. The distribution of phenotype was as follows: L1 (n=29), L2 (n=21), precursor B (n=36), T (n=9), myeloid marker coexpression (n=5). Adverse cytogenetic abnormalities at diagnosis were shown in 23 (46.0%) cases. All pretransplant characteristics were well balanced between these two groups. Most patients were treated with total body irradiation containing regimen as part of the conditioning. With a median follow-up of 27 months in both groups, disease-free survival (DFS) and overall survival probabilities at 2 years were 59.0±7.6% and 68.2±7.1%, respectively. The relapse rates were significantly different between alloBMT and autoPBSCT groups (25.8% vs 52.6%, P=0.05). There was no significant difference in overall survival between the two groups. However, alloBMT had a trend toward better DFS (70.6±9.0% vs 42.1±12.2%, P=0.07). None of the pretransplant characteristics significantly affected outcome after transplantation, except adverse cytogenetics. Prognosis of ALL with Ph or t(4;11) was significantly poorer than that of the remaining high-risk ALL patients (P<0.01). Conclusion: We conclude that alloBMT appears to be more effective than autoPBSCT in prolonging initial CR for high-risk ALL patients. Prospective studies addressing additional clinical variables are needed to guide clinical decision making about transplant choices for adult patients with ALL. New therapeutic strategies for the management of ALL with adverse cytogenetics will be also required.

적외선 체열 촬영을 이용한 당뇨병성 족부질환의 예측

김종문,이정모,김종훈,김석주,유두식,이수영 대한체열학회 2003 대한체열진단학회지 Vol.3 No.1

월경주기 증상의 요인 분석

이수일,유태혁,강종선,안석철,이병욱,김헌,석재호 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.1

404 nurses and nurse-aids rated their experiences of 45 symptoms(Moos' Menstrual Distress Questionnaire) of the menstrual, premenstrual and intermenstrual phase on a 4 point scale separately. The 45 symptoms were inter-related and factor analyzed separately for each phase. six common clusters of symptoms emerged from 3 phases, which were labeled concentration, motor tension, pain, pleasurable affect, autonomic reactions and water retention. Four clusters of symptoms emerged from premenstrual phase. These clusters were labeled instabillity, withdrwal reactions, depression and headache. The factor named unpleasurable affect emerged from intermenstrual and menstrual phase. Above findings were differed from the results of Moos' study in which eight basically replicated clusters of symptoms emerged from three phases. Through discussion of validity of this scale, and differences between results of Moos' and this study, we came to the conclusion that sampling of subjects, prospective longitudinal symptoms reporting, amount of variance in a symptom over the course of menstrual cycle and proper choice of factor analysis method would be salient variables to construct valid scale for measuring menstrual cycle symptoms.