젊은 남자에게 발생한 통상성 간질성 폐렴과 동반된 폐암 1예

박종숙,이준혁,박성우,장안수,박춘식,박재성,백상현,고은석,신화균 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Usual interstitial pneumonia(UIP) is relatively rare disease of lung parenchyme under the age of 50. Lung cancer is reported to occur as a complication of UIP, but has not been reported in young age patient with UIP in Korea. A 35-year-old man was admitted to the hospital because of dyspnea, cough and mild fever. He had been suffered from dyspnea during 3 years. The dyspnea worsened recent 1 month ago. He had been treated with pneumonia at another hospital during 4 months before this admission. Chest radiographs and High resolution CT showed subpleural and basal dominant reticular opacities in both lung with no change until now. He was smoker and his occupation was car engine-man dealing with benzene. UIP is suspected by history and radiologic findings. Operation for open lung biopsy was performed to obtain lung specimen via video-assisted thoracoscopic surgery. Patient's pathologic examination showed UIP combined with adenocarcinoma in RLL superior segment and posterobasal segment and RLL lobectomy was done. After operation, the patient has been in cancer free condition so far. We report a case of UIP combined with lung cancer in young man with brief review of the literature.

정규화 반경벡터 함수에 기반한 2D-형태 정보검색

박혜진,이상학,이광재,장민혁,박종안 朝鮮大學校 電子情報通信硏究所 2003 電子情報通信硏究所論文誌 Vol.6 No.2

형태 정보는 컨텐츠 기반 하의 시각적 특징 중의 하나이며 영상 정보검색에서 광범위하게 사용된다. 본 연구에서는 물체 윤곽선의 반경 벡터함수를 이용한 스타형 및 비스타형 2D 형태인식을 위한 효과적인 알고리즘을 제안한다. 알고리즘에서 무게중심은 형태의 기준점이 되며 축의 중심으로부터 반경벡터는 주요 특징벡터가 된다. 이를 위한 코너 포인트는 노드로 표시되고, 정규화 거리는 중심점에서 노드까지의 상대적 거리비로 규정한다. 데이터베이스에서 유사 물체와 조회 물체 사이의 중심에서 코너 거리까지의 기하학적 거리가 형상 정합을 위한 유크리드 거리 값으로 정합평가에 이용된다.

인공관절 치환술 후 발생한 대퇴 골절 치료에서 금속판 내고정의 문제점

박명식,최병완,배현경,박종혁 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목 적: 최근 빈도가 증가하고 골절양상도 복잡해지는 인공관절 수술 후 발생한 대퇴 골절의 발생 빈도와 금속판을 이용한 치료 시의 문제점을 문헌 고찰과 함께 보고하고자 한다. 대상 및 방법: 1985년부터 1998년까지 시행된 1,275 (1,188 일차 치환, 97 재치환술)례의 고관절 치환술 시행 환자 중 52명에서 발생한 52ㄹㅖ의 대퇴부 골절을 대상으로 조사하였다. 이를 안정성 여부와 스템 끝 주위의 골절 위치에 따라서 근위부 (Ⅰ), 중심부 (스템 주위) (Ⅱ), 언위부(Ⅲ)로 구분하였고 이를 다시 비전위성 (A), 전위성 (B), 불안정성 삽입물 (C)으로 세부나였다. 치료의 방법으로 삽입물이 안정성을 가진 근위부 골절 (제 1형)에서는 부목 고정이나 환상 강선 고정을 시행하였으며, 스템 끝 (제 2형)이나 원위부 (제 3형) 골절에서는 금속판과 나사못 등을 사용하고 대퇴골 과상부인 슬관절 주변의 골절인 경우 외고정 장치 장착을 하였다. 금속판 고정을 한 경우는 골이식술을 시도하였다. 결 과: 인공관절 치환 후 발생한 골절의 빈도는 4.1%이었고, 이 중 술 중 골절은 1.5%, 술 후 골절은 2.6%이었다. 골절의 평균 유합기간은 3.1개월이었다. 금속판을 이용하여 치료한 경우 2례의 불유합과 3례의 재골절 중 1례는 골절 유합 후 보행 도중 낙상에 의하여, 1례는 골절부 유합 후 금속판 제거 후 발생하였으며, 1례는 체중 부하 도중 발생한 골절이었다. 제 Ⅲ형 골절의 경우 전례에서 스템의 이완 소견은 볼 수 없었다. 결 론: 저자들은 인공고관절 치환술 후 발생한 대퇴골 골절 치료에서 금속판 내고정 후 5례의 비교적 많은 합병증을 경험하였다. 이 중 2례는 부적절한 짧은 금속판의 선택과 조기 보행, 나머지 3례는 금속판 및 나사못과 관련된 골절로서 스트레스가 집중되는 부위인 대퇴 스템 원위단이나 금속판의 근위부는 재골절의 위험이 있으므로 골절의 치료에 있어서 골이식이나 긴 금속판 사용, 골유합시까지 외부충격에 보호 등으로 재골절의 위험 빈도를 해결해야 한다. Purpose: The purpose was to evaluate the postoperative periprosthetic femur fracture of hip arthroplasty and relative problems of management using plate fixation. Material and Method: We reviewed 37 cases of femoral fractures out of 1,270 (1,183 primary hips and 97 revision hips) hips which received hip arthroplasty during the observation period(1985~1998). We classified them according to the stability and the location of the fractures related to the stem tip: Proximal (Ⅰ), middle (around stem)(Ⅱ) and distal(Ⅲ). Then we subclassified the fractures as cortical perforation or a fissure, undisplaced (A), displaced(B) and unstable prosthesis (C). we managed periprosthetic fracture with splint applied or cerclage proximal fracture (type Ⅰ), plate fixation and bone grafts in the step tip(type Ⅱ) or distal fracture (type Ⅲ). Un unstable fractures, we revised them with long fluted stems. Result: The average union time is 3.1 months (range, 2~6.2 months). After management of fracture with plate showed 5 complications, two nonunion and three refractures. The causes of nonunion are weight bearing and a too short plate. The causes of refracture are screw fixation and empty hole just distal to stem tip. The other caused by the roles of stress riser in proximal screw of blade plate in management of supracondylar fracture. Conclusion: We recommend the use of cerclage band system of fixed in a more proximal site in long plate and bone graft. In unstable prosthesis, we had taken a best results after revised with distal fluted stem, in which we don't need further distal stability like a additional cerclage or locking screw and additional bone graft.

Work Sampling 기법에 의한 철근콘크리트 작업의 작업분석

朴鐘奕,姜仁錫,李培浩 중앙대학교 기술과학연구소 1989 기술과학연구소 논문집 Vol.19 No.-

The present study was intended to find the method of improving productivity at construction work sites by employing and adapting the work measurment techniques. The study includes analysis of individuals worker's activities and work time distribution, and evaluation of work time-rates. The study adapted the work sampling method which is known to be simple and easy to use for the intended purposes and applied the method to the most typical construction operation of reinfored concrete structure works at an on-going building construction site. The operation comprises the work processes of form erection, steel bar installation and concrete placing. The study reveal that the actual working time rates, contributed to the effective work contents range from 22 to 42 percent of the total work time which are quite below the generally accepted standard of 55 percent. Assuming that the results of the study are typical in the construction industry of KOREA today, it is suggested that the improvement of productivity in construction work site requires better preplanning of work processes in such a way as to eliminate or reduce ineffective time contents to reasonable levels.

염색체이상에 관한 연구(611례 분석)

박종우,구선회,민혁기 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

From March, 1988 to October, 1993, we studied chromosomal analysis from peripheral blood to investigate chromosomal abnormalities in 611 patients showing multiple congenital anomaly, growth or mental retardation, repeated pregnancy losses, infertility, amenorrhea, pubertal failure, ambiguous genitalia, fetal anormaly, malignant disease and others. 82 chromosomal abnormalities were recognized as follows. 1. The rate of chromosomal abnormality is 13.2%. Among them, autosomal abnormality is 67% and sex chromosomal abnormality is 33%. 2. 22 cases of 47, XY,+21, 21 cases of 47, XX,+21, 3 cases of 46, XX, t(14;21)(qll;qll), and 1 case of 46, XX, t(15;21)(q11;q11) were found in Down syndrome. 3. 13 cases of 45, X, 4 cases of 46X, i(Xq), 2 cases of 46X, i(Xq)/45, X, 1 case of 45, X/46, Xr(X), and 1 case of 45, X/47, XXX were found in Turner syndrome. 4. 6 cases of Kleinfelter syndrome were found. 5. 4 cases of reciprocal translocation, 3 cases of Robertsonian translocation and 2 cases of ring chromosomes were found.

청미래덩굴의 뿌리에서 추출한 조분획의 항균활성

박인호,권혁동,이원구,송종호 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.1

청미래덩굴(Smilax china L.)의 뿌리에서 추출한 methanol, n-hexane, chloroform 및 수용성 추출물의 항균활성을 Agrobacterium rhizogenes, Agrobacterium tumefaciens, Candida utilis, Saccharomyces cerevisiae, Bacillus megaterium, Bacillus natto, Bacillus subtilis 및 Escherichia coli에 대하여 disc diffusion과 broth dilution method로 조사하였다. Methanol추출물은 A. rhizogenes, A. tumefaciens, B. megaterium 및 B. subtilis 대하여 항균활성이 나타났고, 수용성 추출물은 B. megaterium와 B. subtilis에 대하여 항균활성을 보였으나 hexane과 chloroform 분획물은 항균활성이 없었다. 또한 수용성 추출물은 800ppm 농도에서 현탁배양중인 A. rhizogenes, A. tumefacience, B. megaterium 및 B.subtilis에 대하여 각각 80, 40, 20, 81%의 성장 억제를 보였고, 특히, 동일 농도의 수용성 추출물을 재첨가한 경우 B. subtilis의 성장이 완전히 억제되었다. Gas chromatography/mass spectrometry에 의한 추출물의 분석 결과, 그 주요 구성 성분은 5-(hydroxymethyl)-2-furancarboxaldehyde(46.95%), 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one(21.08%) 및 2-furancarboxaldehyde(5.85%)였다. Antimicrobial activity of four extract fractions from the root of Smilax china L.(Liliaceae) was investigated by diffusion and broth dilution methods against several microorganisms, Agrobacterium rhizogenes, Agrobacterium tumefaciens, Candida utilis, Saccharomyces cerevisiae, Bacillus megaterium, Bacillus natto, Bacillus subtilis and Escherichia coli. Methanol extract exhibited potent antimicrobial activity against A. rhizogenes, A. tumefaciens, B. megaterium and B. subtilis. However, hexane and chloroform extracts did not show antimicrobial activity against the test microorganisms. Aqueous extract inhibited growth of the tested microbial strains. The relative growth inhibition of A. rhizogenes, A. tumefaciens, B. megaterium and B. subtilis were 80, 40, 20, 81% at 800㎍/mL, respectively. Methanol extract was analyzed by gas chromatography/mass spectrometry(GC/MS). Major components were determined to be 5-(hydroxymethyl)-2-furancarboxaldehyde(46.95%), 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one(21.08%) and 2-furancarboxaldehyde(5.85%).

Transthyretin의 Glutathione 자동산화 촉진작용

박종근,정신,김재휴,김수한,강삼석,이제혁,안봉환 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.8

When reduced glutathione(GSH) was incubated at neutral pH and at 37°, its concentration decreased slowly with formation of oxidized glutathione(GSSG). Autooxidation of GSH was accelerated by Cu^(2+) and Hg^(2+), but not by other common mono-, di-, and tri-valent cations. Transthyretin was found to stimulate autooxidation of GSH in the presence or absence of Cu^(2+) and Hg^(2+). EDTA inhibited perfectly the autooxidation of GSH regardless of the presence of transthyretin. The stimulating activity of transthyretin was maximal at pH 7.0, declining progressively with increase or decrease of pH from 7.0. Sulfhydryl-blocking agents such as p-hydroxymercuribenzoic acid and Nethylmaleimide markedly inhibited the stimulating activity of transthyretin. Transthyretin stimulated autooxidation of other sulfhydryl compounds such as clithiothreitol and cysteine. However, it did not show a significant effect on autooxidation of sulfhydryl group of egg albumin and eye lens proteins. And transthyretin did not cause any oxidative change to thyroxine(T₄), 3, 5, 3Ltri iodo thyronine(T₃) and 3, 3: 5~triiodothpnine(rT₃) bound to it in the presence of GSH and Cu^(2+). The above results suggest that transthyretin may play a role in regulation of oxidized status of sulfhydryl groups in blood plasma and cerebrospinal fluid

농산물 소독과정에서 브롬화메틸에 노출된 근로자에게 발생한 신경병 2례

박태혁,김정일,손지언,김종국,김형수,정갑열,김준연 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.4

목적 : 농산물 소독과정에서 브롬화메틸에 노출된 근로자에게 발생한 신경병 2례 보고. 방법 : 피로감, 전신무력감, 어지럼증, 보행장애 등의 증상을 주소로 내원한 브롬화메틸을 사용하여 방역작업에 종사하는 건강한 20세와 18세의 근로자를 대상으로 혈액검사, 신경정도 및 근전도검사, 뇌자기공명영상 등의 임상검사와 작업력조사를 시행하였다. 결과 : 1례에서 뇌자기공명영상에서 연수와 소뇌의 양측 측충부의 고신호강도가 관찰되었고 11일 후의 추적조사에서 동일 부위의 고신호강토가 감소된 소견이 관찰되었으며 뇌병증으로 최종 진단되었다. 다른 1례는 신경전도검사에서 다발성 신경병 소견과 뇌유발전위검사에서 우측 하부 뇌간부위 병소가 관찰되었고 뇌병증 및 말초신경 병으로 최종 진단되었다. 결론 : 근로자들의 증상은 소독과정에서 브롬화메틸 노출로 인한 신경 병으로 판단되며 훈증소독과방역작업에 종사하는 근로자들의 실태조사와 안전에 대한 대책이 시급하다고 하겠다. Objectives : To report two cases of neuropathy due to methyl bromide intoxication. Methods : Workers, engaged in the fumigating process, complained fatigue, general weakness, ataxia, and hypersomnia. We evaluated them with blood tests, neurophysiologic studies and MRI and investigated their occupational history. Results : Increased signal intensities were found in the medulla oblongata and paraver mian of cerebellum in MRI and after 11 days, high signal intensities were reduced in the following MRI. In the other case, polyneuropathy and rlght lower brainstem lesion were observed In the NCV and BAEP studies. Conclusions : We confirmed that worker's symptoms were related to methyl bromide exposure in the fumigation. It is necessary that we should evaluate present condition of fumigating process and prepare appropriate methods to protect workers engaged in the fumigation.

마늘成分이 肝 Glutathione S-Transferase 및 Glutathione peroxidase 活性에 미치는 影響

朴鍾珉,李相日,金善業,許瑾,金碩煥,徐赫珪 嶺南大學校 環境問題硏究所 1985 環境硏究 Vol.5 No.2

Garlic (Allium sativum L.) is a widely distributed plant used in all parts of the world not only as a spice but also as a popular remedy for several thousand years Recent studies have shown that garlic components may regulate the many metabolism in liver. Therefore, the present work was undertaken to study the effect of garlicjuice, allicin fraction and heat-treated allicin fraction on the hepatic glutathione s-transferase and glutathione peroxidase which protect against toxic compound and lipid peroxide in liver. The results obtained were summarized as follows. By the treatment of garlic juice, glutathione s-transferase and glutathione peroxidase activity was increased in hepatic cytosolic fraction compare with control group. The enzyme activtiy is more increased by treatment with boiled garlic juice compared with fresh garlic juice in rats. The effect of allicin fraction and heat-treated allicin fraction on the hepatic glutathione s-transferase was observed that these components inhibited the enzyme activity in vitro, whereas the enzyme activity was strongly inhibited heat-treated allicin fraction than allicin fraction. These observation led us to conclude that the garlic components which are a stable substance in heat may regulate the hepatic glutathione s-transferase and glutathione peroxidase activity.

정신질환자 수용시설환자의 정신과적 입원치료 경험 유무에 따른 비교연구

박민철,오상우,권혁일,박남진,김종주 圓光大學校 醫科學硏究所 1986 圓光醫科學 Vol.2 No.2

We have visited the asylums in Chollapukdo for two months since March of 1985. We conducted a comparative study between the patients who has been previously hospitalized and who has not been hospitalized for psychiatric problems. We individually interviewed 489 patients using the interview schedule. The results are shown as follows: 1. The group who were young, single and highly educated have been more hospitalized than the groups who were old, married and little educated. However, no significant difference was made by sex and districts. 2. The group who lived alone or were deserted from the family has been rarely hospitalized. 3. The group, who has been entered the asylum by the family or who explained the reason as treatment, has been more hospitalized previously than the group entered by the others or who said that they came due to alcohol. 4. While the group who has been hospitalized showed tendency to accept having their psychiatric disorders, but the group who has not been hospitalized showed tendency to deny having their disorders. 5. The group who named their disorders psychoses or schizophrenia has been more hospitalized than the group who named them alcoholics. 6. The group hospitalized previously has been also treated in other ways besides psychiatric treatment, and chronic patients with the duration of more than three years has been relatively hospitalized previously. 7. While the group who has been previously hospitalized was relatively indicated for hospitalization, but the other group was not relatively indicated.