脊椎에 轉移한 肝細胞性 肝癌 1例

李濟赫 中央醫學社 1976 中央醫學 Vol.30 No.5

A case of malignant tumor of lower thoracic spines which, originated from primary hepatocellular carcinoma is presented. Previous reports are reviewed and history, pathology, diagnosis and treatment are discussed:

가토(家兎) 및 묘(猫)에서의 두개내압항진(頭蓋內壓亢進)에 의한 혈압반응(血壓反應)에 관하여 -Reserpine 및 6-Hydroxydopamine의 영향(影響)-

이제혁,Lee, Je-Hyuk 대한약리학회 1977 대한약리학잡지 Vol.13 No.2

1) 마취가토(痲醉家兎) 및 묘(猫)에서 경뇌막외강(硬腦膜外腔)을 통(通)한 가압방법(加壓方法)으로 두개내압상승(頭蓋內驅上昇)과 혈압(血壓) 및 심박(心搏)과의 관계(關係)를 조사(調査)하였다. 2) 양동물(兩動物)에서 두개내압(頭盞內壓)을 상승(上昇)시켜 두개내압(頭蓋內壓)과 혈압(血壓)의 차(差)가 아주 적어지면 현저(顯著)한 혈압상승(血壓上昇)이 나타났다. 3) 양동물(兩動物)에서 두개내압(頭盞內壓)이 혈압(血壓)보다 높아지면 현저(顯著)한 혈압하강(血壓下降)과 현저(顯著)한 일시적(一時的)인 심박감소(心搏減少)가 나타났다. 4) Reserpine 처리동물(處理動物)에서는 두개내압상승(頭蓋內驅上昇)은 혈압하강(血壓下降), 심박감소(心搏減少)를 일으켰다. 5) 6-Hydroxydopamine 처리(뇌내)동물(處理(腦內)動物)에서는 두개내압상승(頭蓋內驅上昇)에 의한 혈압상승(血壓上昇)은 비처리동물(非處理動物)에 비(比)하여 약(弱)하였다. 6) Reserpine 처리동물(處理動物)의 측뇌실내(側腦室內)에 norepinephrine을 투여(投與)한 후(後)에는 두개내압상승(頭蓋內驅上昇)은 현저(顯著)한 혈압상승(血壓上昇)을 일으켰다. 7) 두개내압상승(頭蓋內驅上昇)에 의한 혈압상승(血壓上昇)은 두개내압상승(頭蓋內驅上昇)으로써 뇌내(腦內) noradrenergic neuron이 자극(刺戟)되여 norepinephrine 유리(遊離)가 증가(增加)한 결과(結果) 일어나는 것으로 추리(推理)하였다. 1) The relationship of arterial blood pressure and heart rate with raised intracranial pressure induced by the epidural balloon method was investigated in anesthetized rabbits and cats. 2) In both animals marked increase of the blood pressure was observed when the intracranial pressure became close to the blood pressure. 3) In both animals marked decrease in the blood pressure and transitory marked decrease in the heart rate were observed, when the level of the intracranial pressure exceeded that of the blood pressure. 4) In reserpinized animals raised intracranial pressure produced decrease in the blood pressure and heart rate. 5) During raised intracranial pressure, the 6-hydroxydopamine-treated (by intracerebral administration) animals showed increase of the blood pressure less than control animals. 6) The depressor response to raised intracranial pressure in the reserpinized animals was reversed to the marked pressor one by the administration of norepinephrine into the lateral ventricle. 7) These results suggest that the pressor response to raised intracranial pressure is due to the increase of norepinephrine release resulted from local stimulation of the central sympathetic neurons by the raised intracranial pressure.

PEG 분해균주의 분리와 PEG film의 상용성에 관한 연구

이제혁,정성제,이준열,전억한 경희대학교 부설 식량자원개발연구소 1993 硏究論文集 Vol.14 No.-

PEG를 sole carbon과 energy source로서 이용하는 미생물을 자연계에서 분리하였고, PEG의 분자량이 높아질수록 그 분해 미생물의 수가 감소하는 것을 확인하였다. 또한, liquid culture로서 PEG농도를 감소시키는 미생물을 선별하였고, 분해율은 PEG 8000이 약 18.8%였으며 PEG 10000은 약 25.4%인 것으로 조사되었다. PEG film의 제조를 위해 EMAA 및 EAA와의 상용성을 적외선 분광(IR) 스펙트럼을 사용하여 조사한 결과, EMAA와 EAA의 카르보닐기와 PEG의 에테르기와의 강한 수소결합이 형성으로 blend film제조시 상용성이 있는 것으로 확인되었다. Several strains capable of degrading PEGs(Polyethylene Glycols)were isolated and investigated for their biodgradation ability of PEGs. Microorganisms screened for the biodegradation studies were those grown on the PEG used as a sole carbon and energy source. It was known that the number of microorganisms decreased when grown on the high molecular weight of PEG(e.g. 20,000). A liquid culture was carried out with such microorgaisms and resulted in the decrease in PEG concentration meaning that PEG was degraded in the reactor. The biodegradability was found to be about 18.8% for PEG-8000 and 25.4% for PEG-10000, respectively. For the manufacture of biodegradable PEG film, EMAA/PEG and EAA/PEG blending ability was investigated with IR spectrum and showed that it was possible to produce blending film.

두부 외상 환자에서 CPK Isoenzym의 의의

이제혁,류재광,김재휴,김봉환 全南大醫大 1983 전남의대학술지 Vol.20 No.1

Penicillium janthinellum의 사멸균체를 이용한 염료의 제거

이제혁,전억한 경희대학교 생명자원과학연구원 1997 硏究論文集 Vol.18 No.-

사멸균체를 사용한 염료의 흡착율은 배지환경의 pH 감소에 따라 증가하여 pH 2의 경우 염료 Appolocion H-E7B의 흡착ㄹ은 pH6에서 보다 약 60배의 초기 흡착율이 증가하였고, 온도는 높을수록 염료의 흡착율이 증가하여 실험 조건중 가장 높은 온도인 40℃에서 흡착ㄹ이 가장 양호하였다. 종래의 염색폐수 처리 방법으로 처리가 어려운 reactive염료의 흡착율이 우수하였고, 또한 혼합 염료도 흡착율이 양호하여 성상이 불균질한 염색 폐수의 처리에 적용 가능성이 긍정적이었다. 사멸균체에 detergent를 첨가할 경우 염료의 흡착이 저해되는데, 이것은 detergent가 균체의 염료의 결합 부위와 경쟁적으로 결합하여 흡착능을 저하시키는 것으로 사료되며, 각종 금속 ion의 존재시에도 사멸균체에 의한 염료의 흡착에는 거의 영향을 미치지 않아 각종 이온들이 복합적으로 함유된 염색폐수의 처리에도 Pen. janthinellum의 사멸균체가 적합한 것으로 사료된다. It is difficult to remove dyes which are major pollutants in the texile industries. The biosorption was carried out with dead biomass which were prepared by drying and grinding process of harvested microbial cells. The maximum biosorption was obtained with dead cells at pH 2.0 and 40 C. The initial biosorption rates were found to be 0.06, 0.086, 0.079(mg/gㆍmin) for each Apollocion Red H-E7B, Apollofix Red SF-3B, and Apollocion Red H-E3B, respectively. The effects of detergents and ions on the initial biosorption rates were also investigated to gain higher efficiency of dye removal since wastewater contains some ions and detergents. However, detergents added to the modified cells reduced dye biosorption rate and ions used also had no influence on the dye biosorption rates.

염료 분해능 곰팡이의 분리 및 분해능 조사

이제혁,황규대,전억한 경희대학교 환경연구소 1994 環境硏究 論文集 Vol.5 No.-

Dyes released into the environment from textile waste water are considered to be a serious polution problem because of the wide spread into environment with a variety of colorants. 12 strains of the dye-degradable fungi were isolated from the soil. Among 12 stains, F-2 showed the highest degradability if dye, was selected for the further dye-degradation study. As a result of the submerged culture of fungi, F-2, in the media containing dye stuff, the specific peak(542㎚) of dye in media was diminishd as cultibation time goes by. The optimum pH and temperature of F-2 were 7-8 and 30℃, respectively. More than 80% of dye in the reactor was removed within 48hts and the agatation speed in the reactor was shown to be optimal at this experoment. It is considered that after waste treatment of the textile waste water by F-2, drained water will not effect th pH of an aquatic condition.

한련초 에탄올 추출물의 항산화 효과

이제혁 덕성여자대학교 교육연구소 2008 植物資源硏究誌 Vol.7 No.-

Eclipta alba 1., a Compositae family, which is an annual plant in Korea. Eclipta alba L. has non-toxicity in human and has anti-carcinogenic activities against uterine cancer, esophageal cancer, and skin cancer. And Eclipta alba L. improve the kidney function. So far, there has been minimal research regarding antioxidant and anti-inflammatory activities of Eclipta alba L. ethanol-extract. Therefore I investigated the antioxidant activities of Eclipta alba L. ethanol-extract prior to anti-inflammatory research. Antioxidant activities were measured by reactive oxygen species (ROS) and reactive nitrogen species (RNS) radical scavenge. DPPH radical scavenging and reducing power assay was performed for ROS quenching activity, and nitric oxide (NO) scavenging assay was done for RNS quenching activity. Hydrogen donor activity of Eclipta alba L ethanol-extract to DPPH radical was approximately 63% and 30% remaining radicals at 31.25 and 62.5 ㎍/ml in a concentration-dependant manner. Approximately more than 90% DPPH radical quenching activity was shown at 125 ㎍/ml of Eclipta alba L. ethanol-extract (EC_(50) = 39 ㎍/ml at 0 - 1,000 ㎍/ml). Reducing power of Fe^(3+) of Eclipta alba L. ethanol-extract was increased as extract increased, consistent to DPPH radical scavenging activity. However Eclipta alba L. ethanol-extract had no NO radical scavenging activity. From this report, Eclipta alba L. ethanol-extract have prominent scavenging activity on ROS, but not on RNS. In early stage of inflammatory response, Eclipta alba L. ethanol-extract is expected to have inhibitory effects of iNOS and COX-2 expression and cellular adhesion by antioxidant properties.

자연분해성 Polymer blend와 이 blend의 생분해에 관한 연구

이제혁,이준열,전억한 경희대학교 환경연구소 1993 環境硏究 論文集 Vol.4 No.-

Several strains capable, of degrading PEGs(Polyethylene Glycols) were isolated and studied for their biodegradation ability of PEGs. We have isolated the strains that used the PEG-compounds as a sole carbon and energy source. We have screened the strains that reduced the concentration of PEGs in the liquid culture. The biodegradability was about 18.8% in PEG-8000 and 25.4% in PEG-10000. In order to produce PEG-film, EMAA/PEG and EAA/PEG blending ability was tested with 1R spectrum. Therefore, the blend was possible to be produced. EMAA/PEG and EAA/PEG blend film were produced and tested on the biodegradation ability. As a result that was tested with ASTM method, it was found that some of the blend films have the biodegradability. And we have tested identification of cells used in this experiment. Cells were identified as Pseudomonas species and Flavobacterium species.

PEG 분해균주의 분리, 동정 및 PEG Film 상용성에 관한 연구

이제혁,이준열,전억한 한국산업미생물학회 1994 한국미생물·생명공학회지 Vol.22 No.3

PEG를 탄소원과 에너지원으로서 이용하는 미생물을 자연계에서 분리하였고, PEG의 분자량이 높아질수록 분해 미생물의 성장이 감소하였다. 또한, 액체배양 실험에서도 PEG 농도가 감소하였다. 동정 실험결과 Flavobacterium sp.인 것으로 조사되었다. 분해율은 PEG 18500이 약 18.8%였으며 PEG 10000은 약 25.4%인 것으로 조사되었다. PEG film의 제조를 위해 EMAA 및 EAA와의 상용성을 적외선 분광(IR) 스펙트럼을 사용하여 조사한 결과, EMAA와 EAA의 카르보닐기와 PEG의 에테르기와의 강한 수소결합의 형성으로 블랜드 필름의 제조시 상용성이 있는 것으로 확인되었다. Several strains capable of degrading PEGs(Polyethylene Glycols) were isolated and investigated for their biodegradation ability of PEGs. Microorganisms screened for the biodegradation studies were those grown on the PEG used as a sole carbon and energy source. It was known that the number of microorganisms decreased when grown on the high molecular weight of PEG. A biodegradation of PEG was investigated with such microorganisms in the reactor and resulted in the decrease in PEG concentration meaning that PEG was degraded in the reactor. This microorganism was identified as Flavobacterium sp. The biodegradability was found to be about 18.8% for PEG-8000 and 25.4% for PEG-10,000, respectively. For the manufacture of biodegradable PEG film, EMAA/PEG and EAA/PEG blending ability was investigated with IR spectrum and showed that it was possible to produce blending film.

총 페놀, 플라보노이드, 항산화 활성에 대한 당의 첨가 효과

이제혁,김청송 한국식품영양학회 2021 한국식품영양학회 학술대회논문집(학술심포지움) Vol.2021 No.11