Protective Effect of Baicalin Against Carbon Tetrachloride–Induced Acute Hepatic Injury in Mice

Park, Sang-Won,Lee, Chan-Ho,Kim, Yeong Shik,Kang, Sam Sik,Jeon, Su Jin,Son, Kun Ho,Lee, Sun-Mee The Japanese Pharmacological Society 2008 JOURNAL OF PHARMACOLOGICAL SCIENCES Vol.106 No.1

<P>This study examined the effects of baicalin, a bioactive flavonoid isolated from <I>Scutellariae Radix</I>, on carbon tetrachloride (CCl<SUB>4</SUB>)-induced liver injury. Mice were treated intraperitoneally with 0.5 ml/kg CCl<SUB>4</SUB> and different groups of animals received 25, 50, 100, and 200 mg/kg baicalin. At 24 h after the CCl<SUB>4</SUB> treatment, the level of serum aminotransferases and lipid peroxidation was significantly elevated, whereas the hepatic glutathione content was decreased. These changes were attenuated by baicalin. The histological studies showed that baicalin inhibited the portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia, which are the three most common characteristics of CCl<SUB>4</SUB>-induced liver damage. The serum level and mRNA expression of tumor necrosis factor-α were markedly increased by the CCl<SUB>4</SUB> treatment but suppressed by baicalin. The mRNA and protein expression levels of inducible nitric oxide synthase and heme oxygenase-1 increased significantly at 24 h after the CCl<SUB>4</SUB> treatment. Baicalin attenuated the increase in the protein and gene expression of inducible nitric oxide synthase but augmented the increase in those of heme oxygenase-1. These findings suggest that baicalin protects hepatocytes from the oxidative damage caused by CCl<SUB>4</SUB>, and this protection is likely due to the induction of HO-1 expression and the inhibition of the proinflammatory mediators.</P>

남매에서 발생한 심한 용혈성 빈혈과 간경변증을 동반한 Wilson 병 2례

노영일,박동호,서우철,문경래,박상기,박영봉,이미숙,전호종 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

We experienced two case of Wilson's disease in female and male sibling. The first case was a 10 year-old female who showed jaundice. pancytopenia and cirrhotic change in liver biopsy. She died 10 days after diagnosis. The second case of 7 year-old male showed specific symptoms and revealed increased AST/ALT, low serun copper level and increased 24 hour urinary copper excretion level He is being treated with D-penicillamine and follow up examinations.

자연산 점몰개, Squalidus multimaculatus Hosoya et Jeon의 새인두흡충, Clinostomum complanatum (Rudolphi, 1814) 감염

박명애 ( Myoung Ae Park ),서정수 ( Jung Soo Seo ),정승희 ( Sung Hee Jung ),최희정 ( Hee Jung Choi ),전은지 ( Eun Ji Jeon ),지보영 ( Bo Young Jee ),이완옥 ( Wan-ok Lee ),우승호 ( Sung Ho Woo ),이은혜 ( Eun Hye Lee ) 한국어병학회 2011 한국어병학회지 Vol.24 No.2

경상북도 영덕군의 하천에 서식하는 점몰개 spotted barbel gudgeon (Squalidus multimaculatus Hosoya et Jeon)의 근육에서 새인두흡충 Clinostomum complanatum (Rudolphi, 1814)의 피낭유충이 발견되었다. 감염된 점몰개는 "yellow grub"인 기생충의 피낭유충으로 인해 표면이 울퉁불퉁하게 보였으며, 수면위에 힘없이 유영하였고 일부 폐사한 개체도 발견되었다. 분리된 탈낭유충의 형태는 혓바닥 모양이었으며, 크기는 2.85~5.89 mm×0.8~1.99 mm였다. 어체당 1~98 개의 피낭유충을 분리하였으며 평균 감염수는 25개로 나타났다. 특히, 성어크기인 평균 7 cm 정도의 점몰개는 100% 감염되어 있었다. 본 연구는 한국의 자연수계에 서식하는 어류에서 C. complanatum 의해 질병이 발생하고 폐사가 일어난 첫 보고이다. The metacercariae of Clinostomum complanatum (Rudolphi, 1814) were isolated in the whole body muscle of wild freshwater fish, spotted barbel gudgeon (Squalidus multimaculatus Hosoya et Jeon) from the local river in Yeongdeok, Gyeongsangbuk-do, Korea. The infected fish with bumpy body surface by "yellow grub" showed erratic swimming behavior and some fish were died. The isolated excysted metacercariae were tongue shaped and 2.85~5.89 mm × 0.8~1.99 mm in size. 1~98 metacercariae were isolated in individual fish and mean infection intensity was 25. All examined adult spotted barbel gudgeon sizing 7 cm in body length were infected. This is the first report of disease outbreak and mortality caused by C. complanatum infection in wild freshwater fish in Korea.

계룡산국립공원의 나비류 군집에 관한 연구

전성재 ( Sung Jae Jeon ),조영호 ( Young Ho Cho ),한용구 ( Yong Gu Han ),김영진 ( Young Jin Kim ),최민주 ( Min Joo Choi ),박영준 ( Young Jun Park ),남상호 ( Sang Ho Nam ) 한국환경생태학회 2012 한국환경생태학회지 Vol.26 No.3

고도의 변화는 종 다양성 및 풍부도 그리고 생물 종 구성에 있어 매우 중요한 역할을 하는 요인으로 최근에는 나비를 비롯하여 곤충의 고도에 따른 분포 형태에 관하여 많은 관심이 집중되고 있다. 본 논문에서는 계룡산국립공원의 고도에 따른 나비분포를 조사하여, 종 보전 및 효율적인 관리방안을 제시하고자 하였다. 본 연구에서는 고도가 증가함에 따라 종과 개체수가 감소하는 경향이 나타났으며, 이는 수관울폐로 인한 그늘의 증가가 원인일 것으로 사료된다. 고도의 영향 이외에도 종의 분포에 영향을 주는 요인을 분석한 결과, 경사도 및 식생군락 그리고 수계거리가 종의 분포 변화와 상관관계가 있는 것으로 조사되었다. 이러한 종들은 먹이식물과 밀접한 관련이 있으므로 추후에 숲 내부의 변화를 감지하는데 적합한 생물지표종을 선정한다면 시간과 비용을 감소시킬 수 있을 뿐만 아니라 효율적인 생물다양성 평가를 내릴 수 있을 것으로 판단된다. 또한 추후에 기후 및 미기후, 그리고 먹이식물과 같은 환경요인들의 자료를 축적하고 정량화 할 경우 나비 분포를 예측할 수 있어 종 보전에 있어 더 효율적이라고 사료된다. Altitude is a factor that plays an important role in the diversity, richness and composition of species. Recently, much attention has been paid to the distribution of butterflies and insects according to altitude. The purpose of this article is to propose a method to preserve and manage species efficiently by reviewing the distribution of butterflies according to different altitudes in Mt. Gyeryong National Park. This study found that the number of species and individuals decreased as the altitude increased, possibly due to the increased amount of shade caused by the crown density. When analyzing the factors influencing the distribution of species other than altitude, it was found that the slope, vegetative colonies and hydrosphere distance were correlated with the change in species distribution. As these species are closely related to food plants, it may save time and reduce the cost as well as allow an efficient evaluation of the bio-diversity if these species are selected as biological indicator species suitable for detecting the changes in the forest. It is judged to be a more efficient means of species preservation to accumulate and quantify the materials regarding environmental elements such as the climate, microclimate and food plants, as this would allow the butterfly distribution to be estimated.

Arthroscopic Excision of Heterotopic Ossification in the Supraspinatus Muscle

Lamees A. Altamimi,Erica Kholinne,Hyojune Kim,Dongjun Park,In-Ho Jeon 대한견주관절의학회 2020 대한견주관절의학회지 Vol.23 No.1

Heterotopic ossification is formation of bone in atypical extra-skeletal tissues and usually occurs spontaneously or following neurologic injury with unknown cause. We report a 46-year-old female with right shoulder pain and restricted range of motion (ROM) for 3 months without history of trauma. Magnetic resonance imaging (MRI) showed a lesion within the rotator cuff supraglenoid. Excisional biopsy from a previous institution revealed a heterotopic ossificans (HO). Following repeat MRI and bone scan, histopathology from arthroscopic resection confirmed an HO. The patient demonstrated improved pain and ROM at follow-up. Idiopathic HO rarely occurs in the shoulder joint, and resection of HO should be delayed until maturation of the lesion to avoid recurrence. The current case showed that arthroscopic HO resection provides an excellent surgical view to ensure complete lesion removal and minimize soft tissue damage at the supraglenoid area. Furthermore, the minimally invasive procedure of arthroscopy may reduce rehabilitation time and facilitate early return to work.

3관능성 BPA-3MA를 기질로한 광중합형 치면열구전색재의 물성 연구

박경준,김경남,안광덕,김광만,한동근,전호욱 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.2

The BPA-3MA(bisphenol-A trimethacrylate) in which one of two hydroxy group was substituted by methacrylate was synthesized by reaction of Bis-GMA with methacryloyl chloride. To investigate the possibility to apply BPA-3MA as matrix of composite resin or pit and fissure sealant, BPA-3MA(3MA) or Bis-GMA(GMA) as matrix, TEGDMA as diluent, CQ as photosensitizer, EDMAB as photoinitiator and 5㎛ pyrogenic silica as filler were used for making experimental sealants. In addition, these experimental sealants were compared to a commercial Concise L/C White sealant(CLW, 3M Co, U.S.A.) for flexural strength, diametral tensile strength, amount of abrasion, surface hardness, water sorption and solubility, and degree of conversion. The flexural strength of CLW was the highest value but there was not significant difference with 3MA. Diametral tensile strength of all 3 groups were similar(p>0.05) and the amounts of abrasion of 3MA and GMA were less than that of CLW(p<0.05). The surface hardness of 3MA was higher than that of GMA(p<0.05) but similar to that of CLW. The water sorption of 3MA was less than that of GMA and CLW(p<0.05) and the solubilities of 3MA and CLW were than that of GMA(p<0.05). GMA and CLW were relatively polymerized well as compared to 3MA. From these results, pit and fissure sealant using trifunctional BPA-3MA as matrix had superior physical and mechanical properties to existing Bis-GMA sealant. Furthermore, it will be possible to develop composite resin having superior properties to existing composite resin.

한ㆍ미ㆍ일 물류기업의 M&A 장기성과에 관한 실증적 연구 : 재무적 성과 분석을 중심으로

전호진,박영태 韓國東北亞經濟學會 2008 동북아경제연구 Vol.20 No.2

In this paper, we investigated M&A long-term performance especially focusing on the financial performance. In this paper, we used the event study method which measures a firms value, profitability, stability and growth which calculated by financial ratio analysis. The event study window is 1, 2, 3years before the event date(O day) and 1, 2, 3years after the date. The empirical study used the t-test for 4, 56, 36 samples which was derived from KOREA, U.S., JAPAN, was made with the use of firms value, profitability, stability and growth which calculated by financial ratio analysis. We found that after M&A, tobin'Q, market value was higher than before and after M&A, profitability, growth was higher than before M&A, but current ratio and quick ratio was lower than before except debt ratio. Judging from this, we can conjecture that in case of M&A, there was a positive effect on the firm value, profitability and growth. Therefore, we infer that economics of scale, economics of scope and synergy effect coexisted in M&A between logistics firms. Actually, we conjecture that acquirer firms, using a M&A, find theirs way into new world market, network and gain first mover advantage.

팜유와 대두유가 유과 바탕의 품질과 저장성에 미치는 영향

전예정,김중만,황호선,송영애,박효숙 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.1

The shelf0life of Yugwa(Busuge)is very short because of the low oxidative stability of soybean oil which is conventionally used as the frying oil of Yugwa base with porous structures. To identify the possibility of replacing soybean oil with palm oil whose oxidative stability is high. POV(peroxide value). AV(acid value), colorness(L, a and b), hardness and sensory characteristics during storage of the Yugwa base fried with the soybean oil and palm oil stored in the anaerobic packaging or the aerobic packaging at 10 and 30℃ for 75 days were measured. POV and AV of the Yugwa base fried with palm oil were significantly lower than those of Yugwa fried with the soybean oil. Hardness and colorness were not different each other and, sensory evaluation was slightly higher than that fried with soybean oil. Lipid absorption amount was not significantly different between the Yugwa base fried with palm oil and the one fried with soybean oil.

플라즈마 산화 처리된 65/35황동의 산소 분압별 부식특성에 관한 연구

박창규,안승호,김정구,정윤모,한전건 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.4

Brasses are the most widely used copper-based alloys because of the good corrosion resistance, formability, high strength and excellent hot-working properties. However, dezincification occurs when one or more components of an alloy are more susceptible to corrosion than the rest and, as a result, are preferentially dissolved. In order to enhance the corrosion resistance, the oxide film was deposited on the 65/35 brass by pulsed dc plasma oxidation with various pressure. The corrosion behavior of plasma oxidized brasses with various oxygen pressure was investigated by electrochemical methods (potentiodynamic polarization test, potentiostatic test, electrochemical impedance spectroscopy) and surface analyses (x-ray diffraction, scanning electron microscopy, auger electron spectroscopy, electron probe micro analyzer). Particular attention was paid to the effects of oxygen pressure and oxide thickness on the coating properties related to the corrosion behavior. From the results of electrochemical test, it was found that the oxidized brass under condition of 1.5 Torr oxygen pressure was effective in improving corrosion resistance. It was attributed to the protective oxidized layer (ZnO). Finally, an optimized oxidation condition for corrosion protection was found to be 1.5 Torr oxygen pressure and 1 pun thickness. (Received September 3, 2004)

관상동맥질환자에서 경흉부 도플러 심초음파를 이용한 좌심실 확장기 기능의 평가 : 좌심실 확장기 장애 형태에 따른 분류

전희경,윤호중,유기동,박지원,전두수,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.1