퍼지 제어기를 이용한 차량의 자율주차 시뮬레이션

박재현,김승철,한창훈,박종오,임영도 東亞大學校 附設 情報通信硏究所 1998 情報通信硏究所論文誌 Vol.6 No.1

In a case of driving beginnners, it is very difficult to park a car perfectly because driver's knowledge makes more errors than intelligent mechanism when they are performed repeatedly. However skilled drivers be of experienced knowledge are able to park a car quickly. In this paper, we analyzed driving patterns of skilled drivers, designed the fuzzy controller to park based on it, and perform auto-parking simulation of a car using that controller.

Insulation Coating of Fe–Si–Cr Soft Magnetic Powder by Selective Oxidation

Jae‑Young Park,Kwangsuk Park,Bosung Seo,Julien O. Fadonougbo,Tae‑Wook Na,Ki Beom Park,Hyeon‑Tae Im,Nong‑Moon Hwang,Hyung‑Ki Park 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

This study examines the insulation coating technology of Fe–Si–Cr powder via selective oxidation annealing, which oxidizeselements selectively by controlling the oxidation potential. The study calculated the oxidation driving force of Fe, Si, andCr, and conducted a thermodynamic analysis of oxidation and reduction conditions according to temperature and oxidationpotential. Based on the results, a selective oxidation annealing was performed in an atmosphere in which Fe is reduced andonly Si and Cr are selectively oxidized. The oxidation potential was controlled through the partial pressure ratio of hydrogenand water vapor. The XPS analysis results confirmed that a Si and Cr complex oxide layer formed on the powder surfaceafter the selective oxidation annealing. Afterward, withstanding voltages were analyzed to evaluate the insulation property. Then, the withstanding voltage of the powder applying the selective oxidation annealing increased significantly comparedto that of the initial powder. Further analysis showed that the powder annealed in an air atmosphere had a significantly lowersaturation magnetic flux density than the initial powder, while the powder applying the selective oxidation annealing hadonly a slightly reduced saturation magnetic flux density.

Inhibition of oxidative stress induced‑cytotoxicity by coptisine in V79‑4 Chinese hamster lung fibroblasts through the induction of Nrf‑2 mediated HO‑1 expression

Hyeon‑Gyun Jo,Cheol Park,이혜숙,Gi‑Young Kim,Young‑Sam Keum,Jin Won Hyun,Taeg Kyu Kwon,Yung Hyun Choi,Su Hyun Hong 한국유전학회 2021 Genes & Genomics Vol.43 No.1

Background Coptisine is a natural alkaloid compound and is known to have multiple benefcial efects including antioxidant activity. However, whether it can protect lung fbroblasts from oxidative damage has not been studied yet. Objectives To investigate the potential inhibitory efect of coptisine against oxidative stress in V79-4 lung fbroblast cells. Methods V79-4 cells were treated with H2O2 (1 mM) in the presence or absence of coptisine (50 µg/ml), N-acetyl cysteine (NAC, 10 mM) or zinc protoporphyrin IX (ZnPP, 10 µM) for the indicated times. The alleviating efects of coptisine on cytotoxicity, cell cycle arrest, apoptosis, reactive oxygen species (ROS) production, DNA damage, mitochondrial dynamics, and inhibition of ATP production against H2O2 were investigated. Western blot analysis was used to analyze the expression levels of specifc proteins. Results Coptisine inhibited H2O2-induced cytotoxicity and DNA damage by blocking abnormal ROS generation. H2O2 treatment caused cell cycle arrest at the G2/M phase accompanied by increased expression of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP1 and decreased expression of cyclin B1 and cyclin A. However, these efects were attenuated in the presence of coptisine or NAC. Coptisine also prevented apoptosis by decreasing the rate of Bax/Bcl-2 expression in H2O2-stimulated cells and suppressing the loss of mitochondrial membrane potential and the cytosolic release of cytochrome c. In addition, the activation of nuclear factor-erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) was markedly promoted by coptisine in the presence of H2O2. However, zinc protoporphyrin IX, a potent inhibitor of HO-1, attenuated the ROS scavenging and anti-apoptotic efects of coptisine. Conclusions Based on current data, we suggest that coptisine can be used as a potential treatment for oxidative stress-related lung disease.

그레이브스병에서 치료에 따른 폐동맥압의 변화

남택만,조한수,이진서,송영림,김두만,두영철,박철영,정인경,홍은경,이성진,오기원,김현규,유재명,최문기,유형준,박성우 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.5

연구배경: 갑상선기능항진증에 의한 갑상선중독증 환자들은 호흡곤란을 호소하며, 그 원인으로 호흡근의 근력 약화, 좌심실부전으로 인한 폐모세혈관의 울혈, 기도저항의 증가, 갑상선종으로 인한 기관의 압박, 호흡기능 이상 등이 거론되고 있다. 폐동맥고혈압이 동반된 그레이브스병 환자가 여러 증례가 보고되었으며, 폐동맥고혈압 환자에게서 갑상선 자가항체와 갑상선기능저하증의 빈도가 높음이 알려지면서 갑상선중독증이 동반된 그레이브스병 환자에게서 관찰되는 호흡곤란의 한 원인으로 폐동맥압 증가가 작용할 가능성이 제시되고 있다. 이에 저자 등은 그레이브스병 환자를 대상으로 폐동맥압을 측정하고 치료 전후의 폐동맥압의 변화를 전향적으로 연구하였다. 방법: 갑상선중독증이 동반된 그레이브스병 환자와 정상 갑상선기능을 나타낸 대조군을 대상으로 갑상선기능검사 및 갑상선 자가항체를 측정하고, 심초음파를 이용하여 치료 전후로 폐동맥압을 측정하여 폐동맥압과 갑상선기능 및 갑상선 자가항체와의 관계, 폐동맥압의 변화 등을 관찰하였다. 결과: 1. 연구대상은 대조군 10명 (남녀비 1:9, 관해 상태의 그레이브스병 3명, 갑상선종 3명, 정상인 4명), 그레이브스병 환자 26명 (남녀비 7:19)이었다. 2. 대조군과 치료 전 그레이브스병 환자의 폐동맥압은 각각 23.5±2.32 mmHg, 29.6±10.3 mmHg이었고, 치료 전의 폐동맥압과 혈청 갑상선자극호르몬 결합억제 면역글로불린 (TBII) 농도는 유의한 양의 상관관계를 보였다. 3. 26명의 그레이브스병 환자 중에서 10명 (38.5%)이 폐동맥고혈압 (기준: 폐동맥압 > 30 mmHg)으로 진단되었다. 4. 치료 전후로 폐동맥압을 측정한 13명은 폐동맥압이 치료 전 29.6±10.3 mmHg에서 치료 후 폐동맥압 22.2±6.48 mmHg로 의미있게 감소하였다. 결론: 갑상선중독증을 보이는 그레이브스병 환자의 약 40% 정도에서 폐동맥고혈압이 발견되어 폐동맥고 혈압은 그레이브스병에 흔하게 동반하는 질환으로 생각된다. 향후 그레이브스병 환자에서 관찰되는 폐동맥압의 증가와 관련한 병인, 발생기전 및 임상적 의의 등에 대한 연구가 필요할 것으로 생각된다. Background: Exertional symptoms, dyspnea and impaired effort tolerance are common in patients with Graves' disease. Proposed explanations include: high-output left heart failure, ineffective oxygen utilization and respiratory muscle weakness. In addition, pulmonary hypertension has also been reported in patients with Graves' disease. A high prevalence of hypothyroidism and positive thyroid autoantibody were also observed in patients with pulmonary arterial hypertension. Therefore, the pulmonary artery pressure in patients with Graves' disease was evaluated. Methods: Two-dimensional and Doppler echocardiographic examinations (Hewlett Packard Sonos 2500) were performed to determine the pulmonary artery (PA) pressure in 26 Graves' disease patients, both before and after treatment (23 patients with propylthiouracil and 3 with RAI), and in 10 euthyroid controls. The changes in the PA pressure after treatment were evaluated in 13 patients with Graves' disease, who became euthyroid after treatment. Results: The pulmonary artery pressure was increased in the untreated Graves' disease patients compared to the normal controls (23.5±2.32 vs. 29.6±10.3 mmHg). 38.5% of the Graves' disease patients (10/26) showed pulmonary arterial hypertension (PA>30 mmHg) and the serum TBII level was higher in the Graves' disease patients with pulmonary arterial hypertension than in those with normal PA pressure (P<0.05). In the Graves' patients who became euthyroid after treatment, the PA pressure was significantly decreased. Conclusion: 38.5% of the untreated Graves' disease patients showed pulmonary arterial hypertension, and the pulmonary artery pressure was significantly decreased in those who became euthyroid after treatment. The pathogenesis and clinical importance of pulmonary arterial hypertension in Graves' disease requires further studies (J Kor Soc Endocrinol 18:465∼472, 2003).

外貨換算會計에 관한 小考

朴泳炳,崔震賢 釜山水産大學校 1983 論文集 Vol.31 No.-

The purpose of this paper is to discuss the nature of the translation problem, to point out defects of the traditional translation theory, to point out a conceptual flaw in the logic of the restate/translate method and to suggest a remedy for it. In the nature of the translation, we discuss the definition of translation, objectives of translation and elements of the translation problem. Accounting translation is the mathematical process of transforming accounting measures scaled in foreign currency units of measure to accounting measure scaled in domestic currency units. The translation of the financial statements of each component entity of an enterprise should accomplish the following objectives : 1) To provide information that is generally compatible with the expected economic effects of a rate change on an enterprise's cash flows and equity 2) To present the consolidated financial statements of an enterprise in conformity with Korean generally accepted accounting principles. 3) To reflect in consolidated financial statements the financial results and relationships of the individual consolidated entities as measured in their foreign currencies. 4) To evaluate the performance of foreign subsidiaries and/or branches or their managers. Elements of the translation problem are homogeneity in the measurement units and neutrality. True accounting translation must achieve homogeneity in the units which are employed to measure the results of business operations and the resulting financial position. And it must possess neutrality and therefore be relevant to whatever ends are selected by the multinational enterprise. Traditional translation theory can be viewed as resting upon two fundamental premises. The basis premise is that the objective of conducting foreign operations is to generate cash flows to the domestic parent. This premise implies maximization of remittable domestic currency values as the goal of the firm and its decision makers. The second premise implies maximization of remittable domestic currency values as the goal of the firm and its decision makers. The second premise, logically derived from this presumed objective, is that translation should measure levels and changes in remittable domestic currency value. Our analysis implies rejection of the first premise of traditional translation theory. Consequently, the second premise as well as the whole direction shaken in traditional reasoning(toward measurement) is rejected. Thus, the first premise of traditional translation theory can be replaced by a more fundamental premise : the purpose of conducting foreign operations is to maximize command over goods and services, the general asset expressed by all monetary units. In turn, the second traditional premise can be replaced by the following : the objective of translation is to standardise accounting measures taken of the size of specific foreign and domestic assets in terms of the magnitude of general asset held. Because the rate of inflation has recently been high and continues to raise sharply, especially in foreign countries, it is difficult to evaluate the performance of foreign subsidiaries and/or branches or their managers without adjusting for the effect of inflation. Also, if the financial statements of a subsidiary have to be consolidated with those of the parent company, translation of the financial statement of the foreign entity is inevitable. The issue is whether foreign currency statements should first be restarted and then translated or whether they should first be translated and then restated. The two different methods may be stated as follows; 1) Restatement/Translation Method(Method 1) Restate the foreign currency statements for changes in the foreign general price level. Then translate the restated balances at the current exchange rate. For short, this method may be described as "First restate, then translate." 2) Translation/Restatement Method(Method 2) Translate the foreign currency statement at exchange rates appropriate under generally accepted accounting principles. Then restate for changes in the domestic general price level. For short, this method may be described as "First translate, then restate." Now, the two methods of general price-level accounting for foreign operations may be evaluated in the light of the nature and objectives of general price-level accounting, translation and combination or consolidation. Finally, we propose that establishes the relationship between nominal money, nominal foreign currency, constant money, and constant foreign currency unit. Once these relationships are established, they can be used to translate as well as restate a financial statement from one currency to another as well as from one unit of measurement to the other. The advantage of this model is that it can obtain the same result whether nominal foreign currency were restated first for foreign inflation and then translated to constant money, or whether nominal foreign currency were translated first to nominal money and then restated for domestic changes in general price level.

Baculovirus를 利用한 Canine Parvovirus VP2蛋自質의 發現

朴鍾賢,宋載永,玄芳動,安動濬,姜永源,全茂炯,安壽煥 충남대학교 생물공학연구소 1998 생물공학연구지 Vol.6 No.-

국내에서 分離된 개파보바이러스주(V20주)의 VP2 遺傳子를 baculovirus system을 이용하여 발현시켜 다음의 結果를 얻었다. 1. 개파보바이러스의 VP2 유전자를 PCR에 의해 增幅하여 1755bp의 VP2遺傳子를 pUC19에 클로닝하여, 클로닝된 遺傳子를 polyhedrin promoter를 가지는 baculovirus expression vector인 pVL1393에 옮겨 VP2 발현벡터인 pVL1393-VP2를 얻을 수 있었다. 2. pVL1393-VP2 plasmid와 baculovirus DNA와의 homologous recombination에 의해 재조합바이러스인 VP2-BV를 얻을 수 있었으며, 그 발현효율은 2.000-5.000 HAU/0.05 ml이었다. 3. 免疫沈澱法에 의해 발현된 단백질은 개파보바이러스의 VP2단백질과 유사한 64 kb에 달하는 것이었으며, 血球凝集能을 지니고 있었다 4. 血球凝集能을 지닌 蛋白質이 여러 陽性血淸에 있어서 抗體수준을 測定할 수 있는지 개파보바이러스항원과의 相關性을 比較한 바 0.94 (n=125. p<0.01)의 相關係數를 보였다 5. 발현 VP2白은 virus-like particles를 形成하였으며, 그 크기로는 개파보바이러스와 비슷한 25 ㎚의 크기를 갖았다. Canine parvovirus(CPV) is a member of autonomous replicating parvoviruses and is aetiologically associated with enteritis and mycoarditis in puppies. The capsids of CPV are composed of three structural proteins: VP1, VP2 and VP3. The VP2 protein is the major component of capsid. The VP2 gene of a canine parvovirus. V20 strain isolated in Korea was cloned into baculovirus expression vector, and subsequently the VP2 protein was expressed by a recombinant baculovirus under the control of polyhedrin promoter. The recombinant VP2 protein expressed in Spodoptera frugiperda 9(Sf9) cells was detected by haemagglutination(HA) test and immunofluorescent antibody assay. Molecular weight of the recombinant VP2 protein expressed was estimated as 64Kd when tested by immunoprecipitation test using anti-CPV monoclonal antibody. In haemagglutination inhibition(Ⅲ) test. 8 HA units of the recombinant VP2 protein antigen was successfully utilized to determine a level of antibody against CPV in various positive sera. The recombinant VP2 protein showed also the capability to form virus like particles similar in size and appearance to the CPV virions.

젊은 남성에서 성정체성에 대한 고환의 영향 : 지역 기반 조사 Community-Based Survey

구자현,김민의,이남규,박영호 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.2

We investigated the influence of testis on the gender identity in late adolescent Korean males dwelling in a community. Of 27,202 men aged 20 years dwelling in the community, 2,700 men were randomly selected at a 10.0% sampling fraction. A total of 2,080 men who agreed to participate in the study and all volunteers underwent a standard evaluation. For the evaluation of influences of testis on the gender identity, we used the Bem Sex Role Inventory in the subjects who had testis torsion, testis injury of cryptorchidism as well as with no testicular disease. They were categorized as group 1; normal testis size, group 2; testis atrophy, and group 3; no testis in the scrotum. The median masculinity scores of group 1, 2 and 3 were not significantly different (group 1; 4.3 [3.65.0], group 2; 3.9 [3.1-4.5] and group 3; 4.6 [4.0-5.1], p=0.065). Regarding the femininity score, there were no differences among groups (group 1; 4.6 [4.0-5.1] versus group 2; 4.5 [3.9-4.8] and group 3; 4.6 [4.2-4.9], p=0.609). In group 3, the masculinity and femininity scores were not also different between of men underwent orchiectomy and did not undergo correction of cryptorchidism. We did not find the impact of testis on gender identity in our cohort. Additional research is needed to clarify the underlying psychopathology involved.

여성 하부요관석환자에서 무마취하 요관경하 배석술

박영호,송윤섭,임용순,김영호,이남규,구자현,서병욱,김민의,전윤수 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Although ureteroscopy(URS) has been used widely to remove ureteral calculi, there is an argument against the belief that anesthesia or admission is needed for URS. We evaluated the experience of URS without anesthesia in female patients. From September 1997 to July 1998, URS was performed in 31 female patients without anesthesia. EHL(Electrohydraulic Lithotripsy) was used in 21 patients with impacted or large stone over 5mm. All patients were given oral antibiotics for 3 days and follow-up KUB was taken to confirm successful removal of the stone one week after the procedure. Successful treatment was defined as complete removal of the stone or residual fragments less than 2mm. Overall success rate was 96.7%(30 cases among 31 cases). All but one patient tolerated with analgesia through the entire procedures. There were only minimal complications such as mild flank pain and hematuria. So, we recommend that non-anesthetic ureteroscopic removal of stone as the first choice for treatment of lower ureteral stones in female based on the minimal morbidity, high success rate and low cost.

Pocine Adenovirus-3의 E1B Region의 鹽基序列 分析

朴鍾賢,宋載永,李重馥,玄芳勳,安東濬,車相昊,裵用泰,姜永源,Reddy, P S,全茂炯,安壽煥 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

돼지 아데노바이러스(PAV-3). 6618주의 EIB region이 包含되어 있는 map unit 4.0에서 9.7까지의 유전자에 대한 1,984 bp의 염기서열을 決定하였으며, 이 結果를 알려진 여러 아데노바이러스 유전자와 비교하여 다음과 같은 결과를 얻었다. 1. PAV-3의 EIB유전자는 10개의 ORF로 구성되어 있으며, 그 중 아데노바이러스의 단백질과 유사성이 있는 것은 ORF1, ORF2 및 ORF3이었다. ORF1은 Ad41의 19kd 와 BAV-2에서의 EIB ORF2에서의 아미노산의 一致率은 각각 32%와 31%이었다. 2. ORF2는 Ad2 55kd protein과 tupaia adenovirus 44kd protein가 각각 34%로 아미노산 一致率이 가장 높았으며, Ad41의 52kd protein. BAV-3의 EIB ORF3에서도 33%의 一致率을 보였다. 3. ORF1은 61-666 uncleotide (606 bp), ORF 2에서는 429-1,850 uncleotide (1,422 bp)의 부위로 각각 202, 474 a.a로 構成되었으며, 예상되는 분자량은 20 kd와 52 kd이었다. 4. ORF3는 hexon-associated pIX유전자로 추정되며 내부에 1개의 polyadenylation signal(ATAAA)이 1938-1942 uncleotide에 위치하였으며, 이 부위는 TATA box (1937-1942 uncleotide)와 중복되어 존재하였다. Porcine adenovirus type 3 (PAV-3) does not cause severe infection in pigs. Adenovirus has been suggestive of live vaccine vector carrying foreign gene. One of insertion regions is delayed early (EIB) region. However, EIB region of PAV-3 has not been molecularly characterized to date. Nucleotide sequence of EIB of PAV-3 was determined. The EIB region was composed of 1,984 bp and located between 4.0 and 9.7 map units. Three potential open reading frames(ORFs) with low level of homology to other adenoviruses and a polyadenylation signal were identified in the rightward direction of genome. The nucleotide and the predicted amino acid sequences of EIB were compared to those of human and animal adenoviruses. One of the three potential ORFs. ORF1 encoded a polypeptide homologous to bovine adenovirus type 2(BAV-2) ORF2 and human adenovirus type 41(Ad41) 19 kd protein. ORF2 encoded a polypeptide homologous to human adenovirus type 2(Ad2) 55 kd protein, bovine adenovirus type 3(BAV-3) ORF3 and porcine adenovirus type 4(PAV-4) ORF2. The predicted protein of ORF1 had homology to those of Ad41 and BAV-2 with 32 and 31% respectively, whereas the deduced protein of ORF2 had homology to those of Ad2. BAV-3 and PAV-4 with 34, 33 and 29%, respectively.

선형 확산 결합을 이용한 카오스신호 발생회로 설계

박광현,권영도 大田産業大學校 1996 한밭대학교 논문집 Vol.13 No.0201

비밀 보호 통신에 카오스신호를 적용하기 위한 선형 확산 결합(coupled linear diffusion)을 이용하여, 궤도(trajec- tory)의 카오스적인 고유특성은 변함이 없고 주파수만 체배관계에 있는 두가지 카오스 신호를 발생시켰으며 수식적으로 증명하였다. 카오스 신호들을 발생시키기 위한 기본 카오스 회로로는 Chua 회로를 사용하였다. For the purpose of appling the chaotic signal in secure communication, two chaotic signals are generated by using the coupled linear diffusion in the relation of frequency multiplication without changing their own natural characteristics, and these are verified mathematically. Chua’s circuit is used as a basic chaotic circuit which generates the chaotic signal.