건강식품 바이탈 및 비지놀의 抗疲勞 效果에 관한 연구

정경수,김혜경,김희수,김계양,곽영숙,김학범 충남대학교 약학대학 의약품개발연구소 1993 藥學論文集 Vol.9 No.-

As a result of extensive research efforts on the oriental medicinal herbs, some of their interesting biological activities have been elucidated. In the present study, antifatigue effects of two natural food supplements consisting of oriental herbs, Vital and Vigilor, were investigated using the ICR mice. The mice were fed with antibiotic-free normal mouse feed containing Vital or Vigilor for 14,28, or 31 days and then subjected to forced swim tests. In a test carried out in melting-ice water, Vital and Vigilor significantly increased the exhaustion times of the 28 day-fed mice by 26.9 % (p < 0.01) and 16.2% (p < 0.05), respectively. However, in the other test performed at 15±0.5℃ using 31 day-fed mice, Vigilor failed to increase the exhaustion time significantly (at p< 0.05), while Vital showed antifatigue effect by increasing the swimming time by 29.9% (p<0.01). Neither of Vital nor Vigilor exerted antifatigue effects in a swim test carried out on day 14 after the initiation of feeding. These results suggest that Vital and Vigilor exhert antifatigue effets when administered for a sufficient period of time by enhancing the health of the host animals.

초등학교 고학년 학생의 구강보건에 관한 인식 및 행동

김영경,문혁수,정재연,한수진,이병진,김은경,정혜련 韓國學校保健學會 2001 韓國學校保健學會誌 Vol.14 No.1

The purpose of this study was to collect basic data for the development of effective oral health education program in elementary school. The subjects in this study were 604 fourth-year, fifth-year and sixth-year students of an elementary school in Seoul. Oral health awareness and behaviors were surveyed and analyzed. The findings of this study were as follows: 1. The most common time for toothbrushing was after dinner(62.0%) and before bedtime(62.3%). By school year, the largest number who brushed their teeth after dinner were fourth and fifth graders while the greatest number who did so after breakfast were sixth graders Seventy-four percent of respondents brushed the teeth twice or more a day. By school year, the fifth-year students brushed their teeth the least while girls outperformed the boys in daily toothbrushing frequency(p<0.05). Regarding the intake of cariogenic food, 62.1% took that kind of food once or more a day. By school year, the fifth graders took the most (p<0.05), and girls took more cariogenic food than the boys(p<0.05). 2. Ninety percent of the respondents had visited a dental clinic. By grade, the sixth-year students had visited a dental clinic more frequently and girls more frequently than boys. Eighty percent of the respondents visited a dental clinic to receive treatment but just 12.3% visited a dental clinic to prevent oral diseases. Concerning the fetor of dental treatment only 14.4% expressed fear. School year made no difference, yet the percentage of girls who experienced fear was higher than that of boys(P<0.05). Regarding preventive treatment, 39.7% experienced pit and fissure sealing and 24.2% experienced the application of fluorides. All the students hadn't much experience in preventive treatment regardless of school year -- gender didn't make a difference. 3. Fourty-six percent of respondents had a preference for the fluoride mouth rinsing program; 38.4% wanted that grogram to continue. As to the reason for preference, 38.2% preferred it because of the prevention of dental caries, 43.0%, the largest percentage, didn't favor it because they found it too much trouble to do(some of the respondents gave two different answers). 4. Despite an increase in the frequency of toothbrushing at the right time, they still took cariogenic food frequently Their visit to a dental clinics also aimed at treatment more than at prevention, and they had very narrow experience of preventive treatment. Furthermore, the fluoride mouth rinsing program failed to draw their interest. Therefore, it is recommended that a successful real health education program should be developed.

양무운동 후기 중국지식인의 서구 의원제에 대한 인식 : 早期維新派를 중심으로

金卿惠 中韓人文科學硏究會 2000 한중인문학연구 Vol.4 No.-

中文要旨 19世紀60年代以後, 淸政府已受到西方列强兩次鴉片戰爭的嚴重打擊, 又受到太平天國和捻軍起義的嚴重威脅.通過內外雙重危機, 淸政府一是親眼看到了西方"船堅砲利"的威力, 二是親身感到階級矛盾的尖銳.正是在面臨"數千年來未有之變局"的背景下, 淸政府部分開明官僚開始興辦洋務, 極力推行練兵制器.70年代中後期, 在多數人眼里, 中國自强的唯一道路仍然是辦洋務, 但 不能應付"地球中之第一大國而受制小夷"的局面, 洋務運動所標榜的"求强","求富"逐漸變成了一句空話.作爲一批先進的知識分子, 早期維新派開始看出洋務運動的一些問題, 批評洋務派的軍事工業是"僅襲皮毛".在尋 自强的出路中, 他們看到了中國與西方的差距, 認識到西方國家之所以富强, 其根本原因在于實行君民共主的議院政治. 他們考察了西方國家政治制度的歷史和現況, 比較了中西政治制度的得失, 認識到中國政治的根本問題卽在封建君主專制制度所造成的 "上下不通"的危害, 于是對封建專制制度進行了大膽的揭露和批判.他們從君民關係, 特別是 "上下不通"的角度來批評封建專制制度.他們認爲, 封建君主專制制度使君,官,民之間隔 太深, 這是造成中國貧困弱後的主要根源.對君主專制制度的懷疑和否定, 使他們向往西方"君民不隔, 上下一心"的議院制度, 進而 主張要想得民心, 挽救民族危機, 就必須變革封建專制制度, 設立議院, 使君民一體, 上下同心.早期維新派在介紹西方議院制時, 賞議院制的兩種作用.第一, 議院是通君民之情者.他們認爲"議院"的作用在于改善封建政治中"君民隔 "的弊病, 其主要目的是爲了"上下相通", "君民一體".第二, 議院是改善官場弊病之道.他們注意到, 由于議院制度的推行, 使西方各國的官僚機構旣不龐大, 又效率顯著, 幾乎沒有淸朝官場中的一切弊病.議院制能根絶官場的一切弊病, 是 因爲具有"公擧","衆寡以爲進退"的良好原則.總之, 西方議院制度是能 實現"公是公非"的合理的社會機制.早期維新派積極宣傳西方議院制的同時, 竝主長在中國實行議院制.不少早期維新派人士都提出了在中國設"議院"的具體方案.他們都認爲西方的模式不太合適中國的情況, 需要有所改變. 何啓,胡禮垣主張把議院與科擧制聯在一起; 陳熾主張把議院制與鄕官制混在一起; 宋恕把議院制與舊官僚制,科擧制混在一起; 湯震主張把議院制與舊官僚機構融爲一體; 陳 把議院制與幕僚制混雜一起.他們對議院的産生,組織,功能等, 都有所討論. 他們所設計議院的目的在于廣開言路, 通上下之情, 而調整和改善君,官,民三者之間的非正常的勸力關係.還有, 他們曾注意到西方政治制度中的三權分立原則, 而初步地介紹進中國來.但他們十分淸楚, 按中國的情況來看, 最需要和有可能實現的, 不是效 西方議院制, 而是建立一 具有"通下情"作用的政治機構.在當時歷史條件下, 早期維新派勇敢地揭露出君,官,民三者之間的非正常的勸力關係, 主張在中國實行"君民共主"的議院制度, 從而改善和調整不均衡的勸力關係.這具有不可忽視的啓蒙意義.

Conjugated Linoleic Acid가 3T3-L1 세포의 증식, 분화, 사멸 및 지질분해에 미치는 영향

김혜경 가톨릭대학교 생활과학연구소 2009 생활과학연구논집 Vol.29 No.1

Conjugated linoleic acid(CLA)는 리놀레산의 위치 및 기하이성질체로 실험동물에서 체지방 증가를 감소시키는 것으로 알려져 있다. 본 연구는 CLA가 지방세포주인 3T3-L1 세포에서 세포 증식, 지방 합성, 세포 사멸 및 지질 분해에 미치는 직접적인 영향을 조사하기 위한 목적으로 실행되었다. 세포는 0.2mM의 α-tocopherol을 함유한 50, 200uM 농도의 CLA 또는 알부민 운반체를 대조군으로 처리하였다. CLA는 지방전구세포의 preconfluent 단계와 postconfluent단계의 증식을 농도의존적으로 억제하였고 성숙한 지방세포의 살아있는 세포 수를 감소시켰다. Postconfluent 단계의 지방전구세포와 성숙한 지방세포는 CLA처리 24시간, 48시간 후에 세포사멸이 관찰되었다. AdipoRed™ 분석법으로 측정한 지방 축적 정도는 CLA에 의해 소폭 감소하는 경향이 있었고, 성숙한 지방세포는 CLA 처리에 의해 기초지질분해가 증가되었다. 이 결과들은 CLA가 지방세포 증식억제, 세포 사멸 유도, 세포 내 지방 축적 감소, 지질 분해에 직접적으로 작용함을 나타낸다. Conjugated linoleic acid(CLA), a group of positional and geometric isomers of linoleic acid, has been shown to decrease body fat gain in rodents. The objective of this study was to determine the direct effects of CLA on proliferation, adipogenesis, apoptosis, and lipolysis in 3T3-L1 adipocytes. Cells were treated with 50, 200 u㏖/L CLA containing 0.2m㏖/L α-tocopherol or bovine serum albumin vehicle as a control. CLA treatment inhibited proliferation of preconfluent and postconfluent preadipocytes dose-dependently and decreased viability of mature adipocytes. Postconfluent preadipocytes and mature adipocytes demonstrated apoptosis after 24 and 48h CLA treatment. Adipogenesis monitored by AdipoRed™ assay was modestly decreased and basal lipolysis was increased by CLA treatment. These results show that CLA decreases fat gain by inhibiting proliferation, inducing apoptosis, attenuating adipogenesis, and promoting lipolysis.

學衝硏究

金惠經 한국중국문화학회 1995 中國學論叢 Vol.4 No.-

토끼 해마손상이 흔적조건화의 습득과 소거에 미치는 영향

김혜경,김기석 한국심리학회 1989 한국심리학회지 생물 및 생리 Vol.1 No.1

토끼의 순막반응을 사용한 흔적조건화의 습득과 소거에 해마손상이 미치는 효과를 알아보고자 하였다. 해마손상동물과 모의시술 통제동물은 7일간 흔적조건화 훈련을 받았고, 3일간 소거시행을 받았다. 해마손상은 흔적조건화 습득에는 아무런 영향을 주지 않았으나 소거시행에는 영향을 주어, 해마손상동물은 모의시술 통제동물에 비해 평균 조건반응율이 높았다. 통제동물의 경우 소거시행시에 반응개시 시간이 점점 늦어지는데 반해 해마손상동물은 조건화시행때의 반응개시시간과 비슷한 수준을 계속 유지하였다. 이같은 결과는 해마가 흔적조건화에 필수적으로 관여하는 구조물은 아니지만 소거에는 관여한다는 것을 나타내며, 시간정보처리면에서 해마가 부적절자극을 배제하는 주의과정과 관련되어 있음을 시사한다. Effects of hippocampal lesions on the acquisition and extinction of classical trace conditioned responses were examined using the rabbit nictitating membrane preparation. After the lesion, rabbits received trace conditioning for 7 days and then were given extinction sessions for 3 days. During the trace conditioning, hippocampal lesion had no effect on the acquisition of response and onset latency. During extinction, however, the hippocampal lesioned rabbits showed significantly more responses than those of the sham-operated ones. And the lesioned showed no change in mean response latency, while the sham-operated exhibied progressive increase in the latency. The results suggest that hippocampus is not necessary for trace conditioning but involved in extinction process. Discussion was made within the context of the temporal processing approach which involves the hippocampus in attention process that enables the organism to learn to ignore irrelevant stimuli.

볼링후 발생한 전골간신경 증후군-증례 보고-

김혜경,이희숙,박준명,정광익,박동식 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.4

동진강 정읍천 유역 오염부하량 평가

이경보,김종천,박지혜,이덕배,김종구 한국환경농학회 2004 한국환경농학회지 Vol.23 No.1

하천 수질관리 대안을 제시하고자 동진강에 영향을 가장 크게 미치는 정읍천을 대상으로 2002년 1월부터 2003년 12월까지 점 및 비점 오염원으로부터 수질오염물질의 부하량, 유출 경로 등을 평가하였다. 계절별 수질 변화는 pH 범위가 6.87∼7.53으로 봄의 pH 범위가 컸으 며, EC 농도는 정읍천 중류가 높았으며, 상류유역은 83∼95㎲/㎝ 범위를 나타냈고, 계절별로 가을에 517㎲/㎝로 가장 높았다. BOD의 농도는 상류유역에서 0.61∼1.27 ㎎/L로 Ⅰ급수 수 질은 나타내었으나, 중류와 하류에서는 Ⅲ등급 수준이었다. T-N의 농도는 정읍천 중류 유 역이 6.10∼10.84㎎/L로 가장 높았고, T-P의 농도는 타오염물질에 비해 농도의 편차가 컸으 며, 특히 중류에서 T-P의 농도가 0.41∼0.98 ㎎/L로 높았다. BOD의 배출부하량은 J4 유역에서 553 ㎎/day로 가장 많았고 T-N 발생부화량은 가축, 인 구, 토지이용, 산업의 순으로 컸으며, T-N 배출부하량은 인구 및 산업에 의한 것은 J4 유역, 가축과 토지이용에 의한 부하량은 J5, J6유역에서 높았다. T-N의 유달부하량은 하류 유역에 서 높았으며, T-P의 유달 부하량은 BOD, T-N에 비하여 유달부하량이 낮았고 유달율은 6∼38% 범위를 나타냈다. The influence of pollutant loads on the water quality in Jeongeupcheon of Dongjin river was evaluated from Jan. 2002 to Dec. 2003 for two years. The range of pH in water was 6.87-753. The EC level in upstream ranged from 83 to 95 us/cm with the highest value in autumn. The BOD level in upstream ranged from 0.61 to 1.27 ㎎/L, which would be Ⅰ grade according to water quality criteia by Ministry of Environment, but that in downstream was Ⅲ grade. The average T-N level in midstream range from 6.10 to 10.84㎎/L which was the highest values throughout the stretch of the river. The average T-P levels ranged from 0.41mg to 0.98㎎/L. Jeongeupcheon was suitable for the agricultural usage based upon one year analysis of river water quality. The effluent loads of BOD was high in midstream(J4) with 553 ㎏/day. The major sources of T-N loads were livestock, population, land use, and industry in order. The effluent loads of T-N was high in J4 by population and industry while that of T-N was high in J5 and J6 by livestock and land use. The delivered loads of T-N was high in downstream. The delivered loads of T-P was low as compared with those of BOD and T-N. The delivery ration of T-N ranged from 6 to 38%.

캡슐내시경과 단일풍선 소장내시경으로 진단된 공장의 간질종양 1예

송도경,심기남,태정현,김경진,송명은,송하응,윤혜원,정가영,정정화 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors that arise in the wall of the gastrointestinal tract. We report a case of obscure gastrointestinal bleeding due to a GIST of the jejunum successfully documented by videocapsule endoscopy (VCE) and single-balloon enteroscopy (SBE). A 36-year-old man with hematochezia was referred for further evaluation of no evidence of bleeding focus on esophagogastroduodenoscopy and colonoscopy. A VCE showed a suspicious ulcerative hyperemic mass that located in about 1 hour apart from duodenal second portion. SBE revealed a nonbleeding 4×2 cm mass with an ulcer at the proximal jejunum. The patient underwent laparoscopic resection without complication. Histological examination revealed a well circumscribed, dumbbell-shaped firm mass comprised of spindle cells. Immunohistochemical staining for CD 117 was diffusely positive, whereas staining for S-100, CD 34 and MIB-1 was all negative. It was confirmed to be a low-grade GIST at the proximal jejunum.

일차의료에 내원한 성인에서 대사증후군의 유병률 및 관련 요인에 대한 연구

박혜순,신호철,김병성,이가영,최환석,신정아,남윤덕,배상필,천경수 대한비만학회 2003 The Korean journal of obesity Vol.12 No.2

연구배경: 심혈관 질환은 치근 국내에서 그 발생률과 유병률이 급증하여 점점 중요한 국민 건강 문제로 대두되고 있다. 2001년 NCEP ATP Ⅲ에서는 대사증후군에 대해 임상적으로 손쉽게 적용할 수 있는 기준을 제시하면서 심혈관 질환의 주 관리 차상으로 취급하였다. 본 연구에서는 일차의료에서 대사증후군의 유병률을 파악하고, 대사증후군과 관련된 요인을 규명하여 한국인에게 적절한 대사증후군 관리전략을 개발하고자 하였다. 방법: 전국 9개 병·의원 가정의학과에 내원한 20세 이상 80세 미만 성인에서 건강 문제와 무관하게 연속적 조사를 시행하여 총2,134명이 연구에 참여하였다. 대사증후군에 대해서 복부비만은 남자 ≥ 90cm, 여자 ≥ 80 cm으로 하였고 다른 위험인자들은 NCEP ATP Ⅲ의 기준에 따라 정의하였다. 신체 계측, 심혈관 위험인자를 측정하고 생활 습관을 조사하여 대사증후군의 유병률과 관련 요인을 파악하였다. 결과: 일차의료에 내원한 성인에서 대사증루군의 유병률은 남자에서 31.3%, 여자에서 29.5%로 나타났으며, 연령이 증가할수록, 비만도가 증가할수록 대사증후군의 유병률이 높아지는 경향을 나타냈다. 남자에서는 연령, 고소득, 비만, 과다 음주. 과다 흡연이 대사증후군의 관련 요인으로, 여자에서는 연령, 무직, 비만, 심혈관 질환의 가족력, 중등도의 스트레스가 관련 요인으로 나타났다. 결론: 대사증후군은 일차의료에 내원하는 성인 중 비교적 흔하게 나타나는 건강 문제로 약 30%의 유병률을 보였다. 일차의료에서 무증상 성인에게도 허리둘레 측정, 심혈관 위험인자 검사 등 대사증루군의선별검사에 의한 조기 발견과 예방적 차원의 관리가 필요하다고 하겠다 Backgroud: Cardiovascular disease is becoming an important national health issue since its recent increase in incidence and mortality. Despite the significant increase in mortality rate of cardio-vascular disease in Korea, there have been no specific studies concerning metabolic syndrome. The aim of this study was to assess the prevalence of metabolic syndrome and to evaluate the associated factors among adults who visited the primary care. Methods: A total of 2,134 subjects aged 20-79y were recruited from nine primary care clinic. The metabolic syndrome was defined by NCEP ATPⅢ criteria, however, abdominal obesity was assessed by ≥90cm in men and ≥80 cm in women. Anthro-pometric variables and cardiovascular risk factors were measured, and lifestyle factors were assessed through a questionnaire. Results: The prevalence of metabolic syndrome was 31.3% and 29.5% in men and women, respectively. The risk factors associated with metabolic syndrome, in common for both genders, were found to be age, and obesity. Excessive alcohol intake, and heavy smoking were also found to be risk factors of metabolic syndrome in men whereas moderate stress and family history of cardiovascular disease served as risk factors in women. For both genders, greater increase in body weight correlated with higher risk of metabolic syndrome. Conclusion: The prevalence of metabolic syndrome is presumed to be high considering the fact that it is commonly encountered in primary care, therefore a screening program for prevention and management of metabolic syndrome is required.