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정재연,최재유,JIE CHENG,박민성,조성인,현진호,박성하 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2011 NANO Vol.6 No.5
This paper presents a strategy for the signal enhancement of surface plasmon resonance biosensors using colloidal gold nanoparticles and a silica layer. We describe the method for the deposition of a silica-stabilized gold nanoparticle layer on a gold film, namely an enhanced surface plasmon resonance chip. This chip shows significant changes in its surface plasmon resonance signals when biomolecules are attached to its surface as compared to a normal gold surface. These characteristics are closely related to the surface plasmon resonance effect as determined using prostate-specific antigen. The detection limit of the enhanced surface plasmon resonance chip is determined to be 0.01 ng/mL for a prostate-specific antigen immunoassay. The use of an enhanced surface plasmon resonance chip makes it possible to enhance signals 1000-fold compared to the signals obtained by conventional surface plasmon resonance sensing. The enhancement of the surface plasmon resonance spectral shift results from the coupling of the surface and particle plasmons through the application of a silica-stabilized gold nanoparticle layer on the gold surface.
정재연,조성원,Jeong Young Choi,Jung A Lee,Min Ho Kim,Jong Eun Lee,Ki Baik Hahm,김진홍 대한의학회 2007 Journal of Korean medical science Vol.22 No.3
Recovery from hepatitis B virus (HBV) infection depends on the cellular immune responses. Chemokines and their receptors play significant roles in immune defense. This study was undertaken to investigate the association between HBV infection and single nucleotide polymorphisms (SNPs) of genes for the chemokines and their receptors. Between March 2002 and February 2004, a total of 957 single ethnic Korean patients were enrolled into two different groups; ‘‘HBV clearance group’’ (n=350), who have recovered from HBV infection, and ‘‘HBV persistence group’’ (n=607), who were repeatedly HBsAg-positive. The HBV persistence group was subdivided into ‘‘inactive carrier’’ and ‘‘HBV progression group (chronic hepatitis and cirrhosis)’’. We assessed polymorphisms in regulated and normal T-cell expressed and secreted (RANTES) at position -403, monocyte chemoattractant protein- 1 (MCP-1) at position -2518, CCR2 V64I, CCR5 -2459, CXCR1 S276T and CXCR4 I138I using single primer extension assay. Genotype distributions of the ‘‘HBV clearance versus persistence group’’ and ‘‘inactive carrier versus HBV progression group’’ were compared. On the basis of unconditional logistic regression analysis with adjustment for age and sex, no statistically significant association with susceptibility to persistent HBV infection was observed with RANTES -403, MCP-1 -2518, CCR2 V64I, CCR5 -2459, CXCR1 S276T, and CXCR4 I138I polymorphisms. In addition, no association of analyzed SNPs with HBV disease progression was found.
Biomorphic C/SiC 복합재료의 기계적 물성 연구
정재연,우경식 한국항공우주학회 2012 한국항공우주학회 학술발표회 논문집 Vol.2012 No.4
본 논문에서는 Biomorphic C/SiC 복합재료에 대하여 단위구조해석을 수행하였다. 소나무와 뉴송을 탄화하고 실리콘을 함침해 제조한 복합재료의 미세조직을 사각배열과 육각배열로 가정해 단위구조를 정의하고 등가물성치를 계산하였다. 단위구조의 크기가 동일하지 않은 경우도 고려하였고, 또한 공극에 배열에 따른 물성치의 변화를 monte carlo 시뮬레이션을 통해 조사하였다. In this paper, mechanical property of biomorphic C/SiC composite was calculated by unit cell analysis. The microstructural arrangement of materials, carbonized pine which was impregnated with silicon, was idealized as square and hexagonal arrays. Unit cell was then defined and equivalent elasic constants were calculated. A single and double unit cell structures were considered. The effect of void distribution was also studied by monte carlo simulation.
간 질환 보험급여 기준의 현재와 미래 : B형간염의 치료약제의 아시아 각국의 보험급여 현황과 우리나라의 실정 및 전망
정재연 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.2
Chronic hepatitis B (CHB) is a serious health problem in Korea and other Asian countries. In the last years, treatment of CHB has considerably improved. Several agents are currently approved for the treatment of CHB: pegylated interferon alpha 2a, lamivudine, adefovir, entecavir, telbivudine and tenofovir. The treatment recommendations from the 2011 Korean Association for the Study of the Liver guideline on the management of CHB have been updated to incorporate new therapeutic options. One of the critical challenges is the relatively high cost of antiviral drugs and lack of adequate reimbursement for treatment makes adherence to guidelines impossible. Here we review medical insurance reimbursement policy in Korea and other Asian countries focusing on the antiviral drugs for the treamtment of CHB patients.
정재연,최설,윤정대,한수지,강동훈 한국항해항만학회 2013 한국항해항만학회 학술대회논문집 Vol.2013 No.춘계
항만 VTS와 연안 VTS는 소속, 관제 구역, 주로 제공되는 서비스의 내용 등의 차이를 가지고 있다. 하지만 연안 VTS는 남해를 시작으로 전국으로 확장할 계획을 가지고 구축중이다. 그 결과 인접 VTS인 항만 VTS와 뗄 수 없는 사이가 되어버렸다. 여수는 항만 VTS와 연안 VTS가 동시에 시행되는 지역으로, 내년에는 인접 VTS인 통영 연안 VTS가 개국 될 예정이다. 반년 이상 운영되면서, 현재 가지고 있는 문제점에 대해 같이 생각해보고, 양 VTS간의 연계 필요성 및 방안에 관해 생각해보는 시간이 되었으면 한다.
정재연 한국일본어문학회 2011 日本語文學 Vol.51 No.-
?科書は一般的に?材の一つであり、?家の?育課程の目標の?現を目指して?育現場で?師と?生の?授?習活動に影響を?える公式的な資料と定義される。?家の明示した?育課程の?容によって?系的に作成され、?育?と時代精神を表しているといえる。また多くの?師たちは?育課程を?科書を通じて認識して?育課程を?行し、?授·?習活動を案?しながら評?資料を提示しているので、?科書の役割はだんだん重要になっている。でも、現在他の外?語?係の?科書に比べてみると日本語のほうは短編的な?容に?する分析?究は多いが、?科書の全?像が調べられる?合的な?究は少ない?態である。本稿はこのような日本語?育の現?において、?授·?習活動に良い?科書を採?し?育現場に必要な?科書を執筆するために、日本語科目の特性を生かした判?基準を作成して提示し、?科書の問題点を把握して?育現場に相?しい?科書の製作環境作りに役立つ評?指針を提案するのに目的をおいた。それで中等?校の日本語?科書の評?基準開?を行うための段階としてまず?材と?科書の定義、?科書と日本語?育課程との?係をはっきりし、今まで??で?表された日本語?科書に?する?究や日本語·英語及び他の外?語の?材や?科書などの評?モデルに?する先行?究、マルチメディア日本語?材に?する先行?究などを?集して?討し、それから?家の公式的な評?基準ともいえる?科書の?定審査基準·執筆上の有意点も詳しく分析し調査してみた。評?領域を決めるには日本語科目の特性を?考し、?育課程の順守側面、?容?系側面、?習者側面、?師側面、編集·外形的側面のような5つの側面を考慮した。それから各領域別に評?項目を作り、1次評?基準と2次評?基準という予備基準モデルを作成してみた。最後にこの二つのモデルに基づいて現在日本語?育に携わっている?師たちを?象にして第7次?育課程の高校「日本語1」?科書を適用し、?際の評?にあたって予想される問題点、修正や削除、補充を要する項目の確認を依?した。その結果、最善の中等?校の日本語?科書評?基準の試案を提案した。