난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화

이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3

Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.

한국형출혈열 병원체 Hantaan virus에 대한 뇨의 살균작용

이호왕,백낙주,양상기 대한감염학회 1981 감염 Vol.13 No.1

Korean hemorrhagic fever(KHF) reported for the first time in Korea in 1951, althought it had previously been known from both Manchuria and Russia. Since that time it has been known as Korean hemorrhagic fever and has remained endemic near the Demilitarized Zone between North and South Korea. In 1976 and 1978, Lee et al reported the isolation of Hantaan virus, the etiologic agent of KHF, from the patients and Apodemus agrarius coreae collected in the endemic areas of KHF and developed Lee's method of serological diagnosis of KHF. Very recently, Lee et al demonstrated virus excretion in the urine of infected Apodemus agrarius for a long time. The urine from both Apodemus agrarius and susceptible human were examined its effect on the infectivity of Hantaan virus to Apodemus mice. The results are summarized as follows: 1) The urine from Apodemus agrarius rodent, the natural reservoir of Hantaan virus, had higher activity to inactivate the infectivity of Hantaan virus than that of human. 2) The urine from Apodemus agrarius just after sampling was pH 8.3 and it had stronger antiviral activity than the urine adjusted to pH 7.2. 3) pH of human urine just after sampling was 6.1 and this urine decreased 10~100 10? of the virus after 3 hours in room temperature, but the urine with pH 7.2 had no change to infectivity of the virus.

배양상태의 흰쥐 뇌하수체 앞엽에서 Neuropeptide Y 함유세포에 관한 면역조직화학적연구

이화영,김순회,이희래,어환,이왕재,백상호,이병란 대한해부학회 1996 Anatomy & Cell Biology Vol.29 No.3

의사 역행렬을 이용한 애니메이션의 초개인적 갈등(SPC) 강도 관련 다학제적 연구

김재호(Jae Ho Kim),장정양(Zheng Yang Zhang),왕위차오(Yu Chao Wang),장소은(So Eun Jang),이태린(Tae Rin Lee) 한국전시산업융합연구원 2017 한국과학예술융합학회 Vol.30 No.-

본 연구는 애니메이션 갈등의 VST 특징을 조사하고 강도를 측정한 이태린의 연구 결과에 대한 심화연구로 초개인적 갈등영상과 초개인적 갈등 값을 기반으로 시작되었다. 본 연구의 목적은 초개인적 갈등 강도 값(ESSPC)을 자동 계산하는 모델을 찾아내는 것이다. 따라서 본 논문에서 SPC 영상을 분석하였으며, ESSPC 값을 자동 계산하는 모델을 찾아내기 위해 의사 역행렬(Pseudo Inverse matrix)을 사용하였다. 연구결과 및 내용은 다음과 같다. 이들을 활용하여, 1)SPC를 분석하기 위한 20 개의 영상 Feature값을 제안하였다. 그리고 2)의사 역행렬(Pseudo Inverse matrix)을 사용하여 ESSPC 값을 자동 계산하는 선형모델을 찾아냈다. 그 결과로 3)제안된 시스템은 9.25%의 평균 자승오차의 제곱근 보이며, 그 효율성이 증명되었다. 이러한 연구결과를 바탕으로 이를 계속 발전시켜 성공적 애니메이션의 제작을 위한 자동 검증시스템을 개발하고자 한다. This study is an intensive study on Tae Rin Lee’s research results. A linear system for Estimating the Strength of Super Personal Conflict (ESSPC) in animations is proposed. Tae Rin Lee has extracted the Super Personal Conflict (SPC) shots of animations, and obtained the strength through the experts’ psychological test experiment. The purpose of this study is to find a model that automatically computes the superpersonal conflict intensity value (ESSPC). By utilizing these results, 1) 20 image feature vectors are suggested for analyzing the SPC, and 2) a linear system is found for auto-calculating ESSPC by using the pseudo inverse matrix. The proposed system shows 9.25% root mean square error and the effectiveness is proven.

한국형 출혈열 병원체 한탄바이러스의 조직배양 세포에서의 증식

박동욱,이호왕 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3

Korean hemorrhagic fever (KHF) was recognized for the first time in 1951 among United Nations troops and has remained endemic near the demilitarized zone between North and South Korea. But, recently it appears to have spreaded all over the World. In 1976 Lee & Lee succeeded in demonstrating an antigen in the lungs of the striped field mouse, Apodemus agrarius, which gave specifie immunofluorescent antibody reactions with sera from patients convalescent from KHF for the first time. In 1981 Lee et al. registered this antigen as Hantaan virus. Recently, French et al. reported a successful growth of the virus in A549 cells. This is the successful results on growth curve after inoculation of Hantaan virus into A549 cells which originated from alveoler epithelial cells of human lung cancer. The results are summerized as follows. 1. The propagation of Hantaan virus could be demonstrated in the cytoplasm of A549 cells on 3rd day after inoculation of the virus, about 60% of cells were infected on 5th day, 80% on 6th day and 100% on 8th day. Cytopathic effect was not appeared. 2. The viral antigens were appeared as a fine spots in the cytoplasm of cells by indirect immunofluorescent antibody technique and at times as a granule-like morphology. 3. The infected A549 cells with Hantaan virus can be used as an antigen for serologic diagnosis of KHF and there was no occurence of nonspecific reaction.

실험실 감염의 문제점

이호왕 大韓法醫學會 1985 대한법의학회지 Vol.9 No.1-2

미생물 실험실 안전에 관한 조사 연구 : Ⅲ. 실험실 생물재해 관리 Ⅲ. Control of Biohazard in the Laboratory

이호왕,김주성,정윤섭,정희영,장우현 대한감염학회 1990 감염 Vol.22 No.1

The response to an emergency resulting from an accident involving micro-organisms, whether in laboratory or during transit, needs to be graded according to the degree of hazard to human created by the circumstances of the accident and the properties of the organisms concerned. Kim and Lee(1988) reported 102 laboratory acquired infections among 2,417 laboratory workers during 1981-1985 in Korea. It is estimated 8.28 infections annually per 1,000 laboratory workers. A catagorization of micro-organisms by risk group is proposed for the purpose of accident management, and classification of etiological agents on the basis of hazard in Korea has published by Kim and Lee et al (1988) as a general reference for some laboratory activities utilizing infectious agents. This publication will provide specific descriptions of combinations of microbiological practices, safety equipments, and laboratory facilities and recommendations for use in four categories or biosafety levels of laboratory operations with selected infectious agents of man. Recommendations for biosafety levels for specific agents are made on the basis of the potential hazard of the agent and of the laboratory function or activity.

초기우식병소에 대한 레이저 fluorescence 의 광학적 탐지감도

이상호,이창섭,김왕근,김효석 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.1

The aim of this study was to evaluate the optical density of laser fluorescence for detection of incipient caries. Prepared and polished bovine enamel specimens were demineralized in a STPP solution for varying periods of time between 3 hrs. and 60 hrs. with an area of sound enamel retained on each specimen. The randomized specimens were analyzed for optical density of enamel deminaralization using laser fluorescence. The specimens were sectioned and examined lesion depth by posarizing light microscope. Results were analyzed statistically with SAS program. The results from this study can be summarized as follows: 1. Optical density measured by laser fluorescence and lesion depth measured by polarizing light microscope was increased as demineralization time was increased(p<0.001). 2. Between optical density measured by laser fluorescence and lesion depth measured by polarizing light microscope was correlated highly(γ≥0.74956, p<0.001). 3. Regressive equation was obtained in this study as follows. Y=[X-0.260851]/ 0.000271 (R-square : 0.5618, p<0.001) (X: DENSITY, Y: DEPTH) In summary, optical density measured by laser fluorescence would be within the range of possibility to quantitatively presume demineralization amount of incipient caries lesion.

치료 불응성 Still's병에서 자가 조혈모세포 채집시 사용된 G-CSF에 의한 급성 악화 1예

이재웅,박성현,왕준광,오호석,최정혜,배상철,이영열,김인순,최일영,안명주 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.2

치료 불응성 자가면역질환에서 고용량 항암화학요법 및 자가 조혈모세포이식술이 시행되고 있으나 조혈모세포 가동화 및 이식술 시 사용되는 G-CSF에 의해 오히려 기존의 자가면역질환의 증세가 악화되었다는 보고가 있다. 저자들은 만성적으로 재발되는 Still's병 환자에서 조혈모세포 가동화를 위해 사용한 G-CSF에 의해 자가면역질환이 급성 악화된 1예를 경험하였기에 보고하는 바이다. High-dose immunosuppressive therapy with autologous stem cell transplantation is an increasingly used treatment for severe refractory autoimmune disorder including multiple sclerosis, rheumatoid arthritis, juvenile chronic arthritis, systemic lupus erythematosus. Although the optimal method of collecting stem cell is not determined, G-CSF-based mobilization is generally considered safe. However, worsening of disease status was reported in autoimmune disease undergoing mobilization with G-CSF. We report a 24-year-old male with refractory Still's disease who developed acute disease flare after administration of G-CSF for stem cell mobilization.

韓國ベンチャ-企業の人的資源管理の實態 : Syswill社の事例を中心として

李鎭奎,李王鎬 韓日經商學會 2001 韓日經商論集 Vol.22 No.-

21세기 현대사회는 산업사회에서 지식, 정보화 사회로 급격히 변화함에 따라 보다 창의적이고 지식부가가치를 높이기 위한 기술 집약적이고 혁신적인 경제구도로서의 기업개편이 요구되어 지고 있다. 이에 대한 대안으로 벤처기업의 활성화를 들 수 있는데 우수한 벤처기업의 육성은 우리 경제가 글로벌 무한경쟁체제에서 살아남는데 무엇보다도 우선적인 과제임에 틀림이 없다. 벤처기업이 활성화되고 경쟁력을 갖추기 위해서 절실히 필요함에도 불구하고 종종 간과되는 부분이 인적자원관리의 문제이다. 전통적인 기업에 비하여 상대적으로 모든 자원 여건이 열악한 벤처기업에 있어서 가장 중요한 자산은 바로 창의적 이고 도전적인 인적자원들이며 이러한 인적자원을 어떻게 확보, 유지, 동기부여 시켜 역량을 최대한 발휘할 수 있도록 제반 환경을 조성하는 가는 벤처경영관리의 본질이자 요건이다. 그럼에도 불구하고 벤처기업에 있어 가장 취약한 부분 중의 하나가 인적자원관리에 관한 것이다. 초기 창업단계를 거쳐 더욱 성장할 수 있는 기술적 재정적 기반이 갖추어진 벤처기업들이 가장 어려움을 겪는 이 우수 인력자원의 확보, 유지 및 조직관리이다. 그러나 많은 벤처기업들이 이 단계에서 인적자원관리를 합리적으로 체계화하는 데 실패하게 된다. 또한 안정적 성장단계에 있어서도 지속적인 성장을 추구하기 위해 인적자원관리가 필요하게 된다. 이와 같이 현실적으로 벤처기업 인적자원관리 연구가 필요함에도 불구하고 벤처기업의 인적자원관리에 관한 연구가 활발히 이루어지고 있지 않다. 국내에서 수행한 대부분의 연구들은 디지털 시대 혹은 벤처기업이 추구해야 하는 인적자원관리의 기본 방향을 제시하는 것이 대부분이며 실제로 벤처기업의 인적자원관리 실태의 실증적 연구나 논의가 크게 부족한 상황이다. 본 연구는 이러한 문제의식에서 출발하여 현재 한국 벤처기업의 인적자원관리 현황과 실태를 사례를 통해서 검토하여 벤처기업의 인적자원관리를 보다 체계적이고 효율적으로 성장하기 위한 방안을 Syswill사의 사례를 통해서 제시하고자 한다. Key words : 벤처기업, 인적자원관리