혈우병 소견을 가진 뇌출혈 환자 치험(治驗) 1례(例)

정인태,서병관,이현종,하지영,강미경,홍장무,백용현,박동석,최도영,Jung, In-tae,Seo, Byung-kwan,Lee, Hyun-jong,Ha, Ji-young,Kang, Mi-kyeong,Hong, Jang-moo,Baek, Yong-hyeon,Park, Dong-suk,Choi, Do-young 대한침구의학회 2003 대한침구의학회지 Vol.20 No.4

Objective : Hemophilia, a genetically determined disorder, is characterized by abnormality of the coagulation mechanism due to functional deficiency of a specific factor, namely VIII or IX. In this study, the effect of Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was evaluated. Methods : We treated him with acupuncture by stimulating Dong-Si acupuncture point(Yuk Wan) and assessed the effect by using manual dynamic evaluation of MRC(Medical Research Council) and Modified Barthel Index. Results : After treatment, the bleeding tendency was grossly reduced and bleeding lesion was absorbed gradually. And manual dynamic evaluation of the upper extremity increased from 4 grade to 5 grade. Conclusions : This result suggest that Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was effective. And futher studies are required to concretely prove the effectiveness of Dong-Si acupuncture therapy for treating hemorrhagic diseases.

사람 적혈구 조혈인자 DA-3585 의 토끼에 대한 단회 및 4주 반복투여 독성시험

조현(Hyeon Cho),김동환(Dong Hwan Kim),강경구(Kyung Koo Kang),백남기(Nam Gi Baik),김원배(Won Bae Kim) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.2

DA-3585, a biosynthetic recombinant human erythropoietin has been developed as a treatment for anemia associated with chronic renal failure in Dong-A pharmaceutical Co. Ltd. This study was carried out to assess its acute and subacute toxicities in rabbits. DA-3585 was intravenously administered to rabbits at dose levels of 6250, 12500 or 25000 IU/kg for single dose toxicity study and at dose levels of 100, 500 or 2500 IU/kg/day for 4-week repeated dose toxicity study. In the acute toxicity study, dose up to 25000 IU/kg had no adverse effect on the behavior or body weight gain. Pathological examinations revealed no abnormal gross lesions related to DA-3585. In the subacute toxicity study, all animals survived until termination of treatment. DA-3585 had no influence on clinical signs, food and water intake or on body weight changes. Hematological examination showed increases in the number of RBC, hemoglobin contents and hematocrit values with a dose dependent manner in the animals treated with DA-3585. Histopathological examination revealed erythroid hyperplasia in the bone marrow and extramedullary hematopoiesis in the liver. The changes detected in the hematological and histopathological examination presumably represent exaggerated pharmacological effects of erythropoietin. The NOAEL (no-observed-adverse-effect-level) of DA-3585 was estimated to be 100 IU/kg/ day under this study condition.

심연수 저작물의 서지학적 가치와 활용의 문제

김낙현(金洛炫) ( Kim Nak-hyeon ),유춘동(兪春東) ( Yoo Choon-dong ) 한국어문교육연구회 2021 어문연구(語文硏究) Vol.49 No.4

본고의 목적은 일제강점기 尹東柱와 더불어 대표적인 항일 시인으로 일컬어지는 沈連洙 시인 저작물의 書誌學的 가치와 그 활용의 문제를 논의하는 데 있다. 2000년 7월에 중국 용정에서 발굴된 심연수는 시를 비롯하여 시조, 소설, 수필 등 많은 문학 작품을 남겼다. 심연수가 남긴 문학 사료로는 원고류, 노트와 학습장류, 일기와 수첩류, 편지와 엽서, 도서와 사진, 기타 등으로 구분할 수 있다. 심연수의 자료는 대부분 육필원고로서, 작가의 자취가 고스란히 남아있는 草稿이다. 그가 남긴 이러한 각종 문학 사료는 심연수의 생애를 복원해 볼 수 있는 자료이자, 일제강점기 시인이자 문인으로서의 심연수의 모습을 再構해 볼 수 있는 자료이다. 현재 확인된 근현대문인들의 문학 사료의 경우, 심연수와 같이 다양한 자료, 생애 전반을 재구해 볼 수 있는 자료가 전무한 상황이다. 따라서 심연수의 文學 史料는 상당히 중요한 자료적 가치를 지닌 것으로서, 근현대문학 유산이라는 사실을 인식하고 문화재청의 등록문화재로 등록하여 보존, 관리, 활용할 필요가 있다. 심연수의 사료는 近代登錄文化財 등록을 위한 요건을 모두 갖추고 있기에 등록문화재로 등록할 필요가 있다. 현재 가장 시급하고 중요한 과제는 이미 DB로 구축된 상당수의 심연수 자료를 국가기관과 연계하여 자료를 공개할 필요가 있고, 近現代文獻 正理 및 保存의 관점에서 체계화하며, 차후 등록문화재로의 등록 준비를 하여 자료의 관리 방안과 연구 확대를 위한 노력이다. This paper aims to discuss the bibliographical value of the works of poet Shim Yeon-su, who is said to be a representative anti-Japanese poet along with Yun Dong-ju during the Japanese colonial period, and the problems faced in using his works. Excavated in Yongjeong, China in July 2000, Shim Yeon-su left behind many literary works, including poetry, novels, and essays. Literary materials left by Shim Yeon-su can be I have revised “divided into” to “categorized into” as a word choice revision since manuscripts, notebooks, diaries etc. are categories his work can be classified into. Please check for the intended meaning carefully. categorized into manuscripts, notebooks, study books, diaries, letters and postcards, books and photos, and others. Most of his materials are handwritten manuscripts, drafts in which his traces remain intact. The various literary materials he left behind are works that can reconstruct his life, as well as I have revised “appearance” to “identity” as a word choice revision since appearance only refers to the outward persona, while identity comprises of his thoughts and opinions that he must have produced through his poetry and writing. Kindly check for the intended meaning carefully. his identity as a poet and writer during the Japanese colonial period. I have revised this information heavily for structure, readability, language, grammar, and flow. Kindly check for the intended meaning carefully. In the case of the currently confirmed literary sources of modern and contemporary writers, there is no material available to reconstruct his entire life. Therefore, his literary works have considerable material value, and should be recognized as a modern literary heritage. Since his works meet all the requirements for registration as a modern registered cultural property, it should be registered with the Cultural Heritage Administration. This recognition shall result in its preservation, management, and utilization. The most urgent and important task at present is the disclosure of a considerable volume of deep training data already established as a Do you mean database? Please insert the full form since this is the first mention. DB in connection with national institutions, systematize it from the perspective of organizing and preserving modern and contemporary literature, and prepare for registration as a registered cultural property in the future. This statement is a bit abrupt, since there is no indication of a link to the previous sentence. Please consider providing some context here. It is an effort to manage data and expand research.

수종의 내부연결형 임플란트에서 연결부의 형태에 따른 응력분포의 유한요소 분석

정병현,이경제,강동완 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.2

Purpose: This study was performed to compare the stress distribution pattern of abutment-fixture connection area using 3-dimensional finite element model analysis when 5 different implant systems which have internal connection. Materials and methods: For the analysis, a finite element model of implant was designed to locate at first molar area. Stress distribution was observed when vertical load of 200 N was applied at several points on the occlusal surfaces of the implants, including center, points 1.5 mm, 3.0 mm away from center and oblique load of 200 N was applied 30º inclined to the implant axis. The finite element model was analyzed by using of 3G. Author (PlassoTech, California, USA). Results: The DAS tech implant (internal step with no taper) showed more favorable stress distribution than other internally connected implants. AS compare to the situations when the loading was applied within the boundary of implants and an oblique loading was applied, it showed higher equivalent stress and equivalent elastic strain when the loading was applied beyond the boundary of implants. Regardless of loading condition, the abutments showed higher equivalent stress and equivalent elastic strain than the fixtures. Conclusion: When the occlusal contact is afforded, the distribution of stress varies depending on the design of connection area and the location of loading. More favorable stress distribution is expected when the contact load was applied within the diameter of fixtures and the DAS tech implant (internal step with no tapering) has more benefits than the other design of internally connected implants. 연구 목적: 본 연구는 3차원 유한요소분석을 통해 특징적인 내부연결구조를 갖는 5종의 임플란트의 고정체와 지대주의 연결방식에 따른 응력분산을 알아보고자 하였다. 연구 재료 및 방법: 본 실험을 위한 유한요소모델은 하악 제1대구치부에 임플란트가 식립되고 상부구조물로 3형 금합금을 사용하는 것으로 가정하였다. 응력분산은 200 N의 하중이 교합면의 중심, 중심에 1.5 mm 외측, 중심에서 3.0 mm 외측에 수직으로 가해지고 임플란트의 장축과 30º의 각도로 경사하중이 가해지도록 하여 분석하였다. 유한요소모델에 대한 해석작업은 3G.Author (PlassoTech, California, USA)를 사용하여 이뤄졌다. 결과: 경사가 없는 내부계단 구조를 가지는 DAS tech의 임플란트의 경우, 내부연결구조를 갖는 다른 임플란트에 더 유리한 응력분산을 보였다. 하중이 임플란트 고정체의 외형선 이내에 가해지는 경우와 비교하여 외형선 바깥이나 경사력으로 전해지는 경우 더 높은 응력을 보였으며 하중조건과 관계없이 임플란트 고정체보다는 지대주에 더 큰 응력이 집중되었다. 결론: 교합력이 가해졌을 때 응력분산은 임플란트의 연결부의 형태와 하중이 가해지는 위치에 따라 달라졌으며 내부계단 구조를 가지는 DAS tech의 임플란트를 사용한 경우와 고정체의 외형선 이내에 하중이 가해졌을 경우에 더 유리한 응력분산을 보였다.

Scrub Typhus : 확진된 76예의 임상 소견에 대한 전향적 연구

김동민,김현리,박치영,윤성호,송현제,심수경 대한감염학회 2006 감염과 화학요법 Vol.38 No.4

배경 : Orientia tsutsugamushi에 의한 인체 감염은 혈액과 임파선을 타고 전신에 퍼져 혈관 염을 일으켜, 전신 장기의 침범 소견을 보인다. 그러나 아직 까지 전신장기 침범에 대한 임상 소견 및 검사 결과의 전향적인 추적 관찰에 대한 연구는 거의 없는 실정이다. 재료 및 방법 : 조선대학교병원에 내원한 환자 중 확진법(gold standard)인 간접형광항체법(IFA)으로. 확인된 76명의 환자를 대상으로 내원시 임상 양상 및 검사 결과의 평가 및 치료 후 검사 결과의 변화에 대한 전향적인 연구를 수행하였다. 결과 : 대부분의 환자에서 발열, 갈증, 전신 쇠약감, 두통을 호소하였으며, 특이 할만한 소견으로 현재까지 보고되지 않았지만, 대부분의 환자가 갈증을 심하게 호소한다는 것이다. 3명의 젊은 건강한 환자를 제외한 대부분의 환자에서 이러한 갈증 증상을 호소하였으며, 이러한 갈증은 발열이 호전되어도 지속되었으며, 퇴원 이후에 까지 지속되는 양상을 보였다. 혈액검사상 scrub typhus 초기에 나타날 수 있는 신기능 장애 및 간 기능 장애는 대부분 가역적으로 적절한 항생제 투여 후 모두 정상으로 회복됨을 확인할 수 있었다. 혈액 검사상 CRP, LDH, AST가 대부분의 환자에서 상승하였고, 특히 LDH의 상승이100% 환자에서 관찰된 것은 특이할 만 한데 적절한 치료후 CRP는 신속히 호전을 보이나, LDH는 서서히 호전됨을 확인하였다. DIC 검사상 DIC는 입원환자의 95.5%에서 확인되었으나, 비교적 일부의 환자에서 출혈 및 경색이 초래되는 것으로 생각된다. 결론 : Scrub typhus 초기에 나타 날수 있는 신기능 장애, 간기능 장애 및 DIC는 대부분 가역적으로 적절한 항생제 투여 후 모두 정상으로 회복되며, 이러한 관찰이scrub typhus 환자의 진단 및 임상 경과의 이해에 도움이 되리라 사료된다. Background : Orientia tsutsugamushi spreads to the entire body through the blood and lymphatics, and it induces vasculitis that results in the patients manifesting symptoms of systemic organ involvement. Materials and Methods : We conducted a prospective study to evaluate the clinical manifestations and the change of the laboratory results after instituting treatment for scrub typhus. Results : Most patients presented with fever (100%), malaise (96.1%) and thirst (96.1%). It was remarkable that most patients presented with severe thirst, except for 3 healthy, young patients. This thirst was persistent even after the resolution of fever. The renal and hepatic dysfunction were reversible after the administration of appropriate antibiotics. For the blood testing, it was deteded that the CRP, and LDH were elevated in most patients (95.9% and 100% respectively). DIC could be diagnosed in 95.5% of the patients at the time of admission Conclusion : Most patients presented with fever, malaise and severe thirst, and the renal and hepatic dysfunction were reversible after the administration of appropriate antibiotics. DIC was observed in most of our patients, but hemorrhage and infarction were not present. CRP showed a rapid improvement, nonetheless, the LDH and DIC test results improved slowly.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

자기자본 구성요소의 성장성에 대한 시장의 가치평가

金東憲 홍익대학교 경영연구소 2004 경영연구 Vol.29 No.-

Prior research reveals that the accrual component of profitability is less persistent than the cash flow component, and that investors fail to fully appreciate their differing implications for future profitability(Sloan 1996). However, accruals are a component of growth in net operating assets as well as a component of profitability. Just as I can disaggregate profitability into accrual and cash flow from operations, I can disaggregate growth in net operating assets into accruals and growth in long-term net operating assets. I can also disaggregate return on equities(ROE) into return on invested capitals(ROIC) and financial leverage effects. I find that, after controlling for current profitability, both components of growth in net operating assets-accruals and growth in long-term net operating assets-have equivalent association with one-year ahead return on assets. This result is consistent with conservative accounting and diminishing marginal return on investment. I also find that, after controlling for current profitability, financial leverages have positive association with one-year ahead return on equities.

80년대 이후 美ㆍ日ㆍ유럽 經濟關係의 변화에 따른 企業形態와 經營條件

鄭東鉉 釜山 大學校 經營 經濟 硏究所 1996 經營 經濟 硏究 Vol.15 No.1

1970년대의 세계경제 不況期 이후 격화된 경쟁이 자본의 국제화를 보편화시키면서 기업 경영의 효율화를 촉진하는 과정을 분석하는 과정을 분석한 논문이다. 각 국가가 처하고 있는 상황과 조건에 의해 규정되는 기업 및 기업경영의 특성이 상호 치열한 경쟁을 거치면서 비용절감과 생산성을 제고시키는 노력을 통해 점차 사라지면서 기업경영과 금융시스템, 자금조달방식의 제 측면이 동질화되어 가고 있다. 이것은 경제구조상의 각국의 차이점들이 기업활동의 세계화로 인해 동질화하는 가운데 기업조직이나 경영형태가 가장 효율적인 방식으로 표준화되어 가고 있음을 말해준다. 80년대를 지나면서 미ㆍ일ㆍ유럽에서 나타난 경영구조의 변화, 노사관계 및 노동시장구조의 변화, 정부의 적극적인 역할등이 그것을 가르키는 예들이다. 이것은 전세계적 규모에서 기업활동의 효율성이 증대되고 있음을 의미하는 것이다. 글로벌한 세계시장에서는 효율적이지 못한 기업이 받아야 하는 압박이 배가된다. 기업은 死活을 걸고 효율성 증대를 위해 노력하게 될 것이며, 이 과정에서 경영구조의 동질화가 가속화 된다. 이것은 단일한 동질적 세계시장이 형성되어 가는 과정이기도 하다.

고속철도 터널출구로부터 방출되는 충격성 소음에 관한 모형실험

김희동,이종수,신현승 安東大學 1995 安東大學 論文集 Vol.17 No.1

As a railway train enters a tunnel at high speed, a compression wave is formed in front of the train and propagates along the tunnel. The compression wave subsequently emerges from the exit of the tunnel and generates a pulse wave, which causes an impulsive noise. In order to clarify the acoustic characteristics of the noises, in the present study experiment was carried out by using the pulse waves emitted from an open end of a shock tube. Various pulse waves were obtained by controlling the compression wave formed in the tube. The results show that as the compression wave formed at tunnel exit becomes strong, the pulse wave emitted propagates with strong directional characteristics forward the axial direction of the tube, and that attenuation of the pulse wave propagating a ground surface can be reasonably predicted by a linear acoustic theory. Furthermore, the impulsive noise at far-field from the tube exit results in a sound level reduction of 6dB with a doubling of the propagating distance.

稅務計劃과 情報의 不確實性

金東律,吳賢美 釜山外國語大學校國際通商硏究所 1997 國際經營論集 Vol.12 No.-