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T-2 Toxin이 병아리 비장세포의 유전질 발생에 미치는 영향
전향숙,정덕화,이서래 이화여자대학교 생명과학연구소 1994 생명과학연구논문집 Vol.5 No.-
시험관 내에서 T-2 toxin이 병아리 비장세포의 blastogenesis에 미치는 영향을 살펴본 결과, B-cell mitogen인 lipopolysaccharide및 T-cell mitogen인 concanavalin A자극에 대해 T-2 toxin의 농도가 증가함에 따라 억제정도가 증가하는 경향을 나타내었다. 노출시기를 달리하여 T-2 toxin을 투여한 병아리 비장세포에서 mitogen 자극에 대한 반응을 알아 본 결과, 부화하기 전과 후에 계속 T-2 toxin에 노출시킨 실험군은 가장 영향을 많이 받은 것으로 나타났고 부화전 혹은 부화후 어느 한 시기에만 T-2 toxin에 노출된 실험군은 비교적 영향을 적게 받는 것으로 나타났다. The effects of T-2 toxin of mitogen-induced blastogenesis of chick splenic cells were investigated. The[^3H]thymidine incorporation in splenic cells stimulated by lipopolysaccharide and concanavalin A were equally inhibited as the concentration of T-2 toxin was increased. The effective dose of T-2 toxin causing a 50% reduction of[^3H]thymidine incorporation was inbetween 1.0 and 5.0 ng/㎖ for both mitogens. Mitogen-induced blastogenesis in chick splenic cells showed differences among experimental groups with different exposure time of T-2 toxin, exhibiting the most inhibition in the experimental group exposed to T-2 toxin at both embryonic and chick periods.
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전수경,김재진,나종범,김규혁 한국목재공학회 2002 목재공학 Vol.30 No.4
본 연구는 수액치환법을 이용한 침엽수 간벌소경재나 미(저)이용 활용수재의 산지 보존처리 기술을 개발하기 위하여 수행되었다. 본 논문에서는 증산법과 원구법을 이용한 3종 침엽수와 3종 활엽수의 방부제, 난연제, 치수안정제 처리 가능성을 조사하여 보고한다. 수종과 처리약제의 조합에 관계없이 원구법이 증산법에 비하여 약제의 목재내 침투가 양호할 뿐만 아니라 약제의 침투가 균일한 관계로 수분 이동경로를 이용한 처리재 생산은 원구법의 사용이 바람직하였다. 원구법 처리는 수관부를 절단한 후 실시하기 때문에 증산법에 비하여 처리가 용이할 뿐만 아니라 벌채 및 조재 후 산지의 일정 장소로 운재 후 처리를 실시하기 때문에 증산법과 비교할 때 집약적 처리로 단위시간당 처리재 생산량이 높고 산지 환경오염 문제도 예방할 수 있는 장점이 있다. This research was carried out to develop field treatment techniques of thinned small diameter softwood logs and less utilized hardwood logs using sap displacement method. In this paper, we report the feasibility of using transpiration method and butt-end method for the treatment of three softwood species and three hardwood species with preservatives, fire-retardant chemicals, and dimensional stabilizer. Butt-end method was effective as a field treatment technique compared to transpiration method when considered the treatability, easiness of treatment, productivity of treated wood, and environmental aspects related to chemical treatment, regardless of the combination of wood species and chemicals.
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全秀淵,鄭鍾秀 昌原大學校 産業經濟硏究所 1987 産經硏究 Vol.4 No.-
Individual income tax takes a leading part of tax system in developed country. It applies to a recognized measure of ability to pay. As a direct tax, it can take account of the taxpayer's needs as indicated by the number of his dependents and other personal circumstances, it is adaptable to progressive rates. In practice, individual income taxes of many countries depart from the ideal in important respects. Individual income tax of Korea was designed as developed countries in a basic structure. But it has done function poorly because it played an important role of economic development and tax system changed from direct system to indirect system. This study attempts to provide several matter for the improvement of individual income tax reform. First, the korea tax statutes do not attempt a general definition of income. They rely mainly on the enumeration of items to be included, excluded or deducted. However, the statutory listing is not exhaustive. So, many important items that qualify as realized income are committed from the tax base in Korea. Second, the fundamental problem in the tax treatment of the family is that no tax system can simultaneously achieve increasing marginal tax burdens unchanged upon with equal incomes. Present law takes family tax with individual filing. Under progressive rates, it is not ability to pay. Third, deductions in Korea code include premium, medical expense and educational fee and earned income deduction. Personal exemptions include self, spouse and impediment exemption. However, These are constant before tax code revision. Deductions are need to choose standard or itemized. Fourth, the present law characterized by highly progressive bracket rates up 55 percent which, because of deficient of taxable income, are not reflected in a corresponding set of average or effective rates.
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진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과
정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2
Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.
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황춘수,장통일,임현교 한국안전학회 2003 한국안전학회지 Vol.18 No.2
In recent years, the Korean Army made use of fork-lifters or conveyors when loading and/or unloading military material in order to prevent accidents and to promote efficiency of military material handling activities. However, in troops smaller than battalions, manual material handling activities are still committed for many reasons. In this thesis, a brand new loading/unloading device for efficient military material handling for manual workers was developed, and its validation study was conducted through objective assessment based on electromyography, subjective assessment based on Body-Map technique developed by Corlett and Bishop, and finally work performance comparison. The results of EMG analysis showed that muscular workload improved by 24% when using the device compared to manual work without the device, and complain of each body part was remarkably reduced. In addition, remarkable effectiveness enhancement was observed in the work performance. Consequently, it could be concluded that ergonomic devices like one developed in this research should he studied further in the ergonomic sense as well as in the economical sense.
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국내 조혈모세포이식 환자에서 Human Cytomegalovirus gB 유전형의 분포와 질환과의 연관성 : 예비 보고
최수미,김진희,이동건,박선희,최정현,유진홍,박철민,이종욱,민우성,황응수,신완식,김춘추 대한감염학회 2007 감염과 화학요법 Vol.39 No.2
목적 : 사람 거대세포바이러스(Human cytomegalovirus, 이하 HCMV) glycoprotein B (gB)는 UL55 유전자에 의해 부호화되는 당단백으로, UL55 유전자의 염기서열변화에 따라 4가지 유전형으로 나뉜다. 본 연구에서는 국내 조혈모세포이식 환자들에서 HCMV gB 유전형의 분포와 그 특성을 알아보고, gB 유전형에 따라 특정 HCMV 질환 발생과 연관이 있는지 그 임상적 의미를 분석해 보고자 하였다. 재료 및 방법 : 동종 조혈모세포이식 환자 52명의 혈액검체 94개에 대해, Chou 등이 제시한 방법에 따라, 먼저 UL55 유전자 부위를 nested PCR로 증폭한 후, RsaI과HinfI으로 Restriction fragment length polymorphism(RFLP) 분석을 시행하였다. 결과 : gB type 1은 73.1% (38/52), gB type 2는 13.5%(7/52), gB type 3는 1.9% (1/52), gB type 1과 type 2에 의한 혼합감염은 9.6% (5/52)로 나타났다. gB type 4는 관찰되지 않았다. 1명(1.9%)에서 gB 유전형을 결정할 수 없었는데, RFLP 패턴으로 보아 Trincado 등이 제시한 gB type 7에 해당하는 것으로 생각되었고, 이 새로운 아형에 대해서는 현재 염기서열 분석 중이다. 52명 중 5명(9.6%)에서 HCMV 질환이 발생하였고, 3명에서 HCMV 폐렴, 1명에서 망막염과 위장관염, 나머지 1명에서 망막염이 발생하였다. 5명 중 HCMV 질환과 관련하여 사망한 예는 없었고, 감염된 HCMV는 모두 gB type 1이었다. HCMV gB유전형과 HCMV 질환 발생 사이에 유의한 연관성은 없었고, 단일 주에 의한 감염과 혼합감염에 따른 HCMV 질환발생 사이에도 유의한 연관성은 관찰되지 않았다. 자료 분석 중 gB type 2에 감염되어 있던 환자에서 gB type 1에 재감염 되면서 발열, 간효소 수치 상승 및 pp65 HCMV 항원혈증이 나타난 예가 있었다. 결론 : 연구결과 gB type 1이 아주 우세하고, gB type 4는 검출되지 않았으며, 혼합감염의 빈도가 비교적 낮은 분포를 보였다. 이는 외국의 보고와는 다른 국내 조혈모세포이식 환자에서의 독톡한 감염 양상으로 추정된다. 본 연구에서 HCMV gB 유전형과 질환 발생과의 연관성을 밝힐 수는 없었으나, HCMV 유전형에 대한 연구는 바이러스 감염의 발병기전이나 전파 경로 및 양식과 같은 역학적 연구에 중요한 자료가 될 것이다. 현재 더 많은 수의 조혈모세포이식 환자를 대상으로 연구가 진행 중에 있으며, 앞으로 다른 질환군의 환자나 건강한 잠복 감염자에서의 추가 연구가 필요할 것으로 생각된다. Background : Human cytomegalovirus (HCMV) glycoprotein B (gB) is the major envelope glycoprotein, encoded by the UL55 gene. Based on sequence variation in the UL55 gene, HCMV can be classified into four gB genotypes. Previous studies have suggested an association between HCMV gB genotypes and clinical outcome in the immunocompromised hosts. The goal of this study was to determine the distribution of HCMV gB genotypes and the effect of gB genotype in the developement of HCMV diseases in hematopoietic stem cell transplant (HSCT) recipients in Korea. Materials and Methods : DNA was extracted from 94 blood specimen of 52 allogeneic HSCT recipients with HCMV infection. HCMV gB genotype was determined using polymerase chain reaction to amplify a region of UL55, followed by restriction fragment length polymorphism (RFLP) analysis based on RsaI and HinfI digestion. Results : The distribution of gB types were as follows: gB1, 73.1% (38/52) of patients; gB2, 13.5% (7/52); gB3, 1.9% (1/52) and mixed infection (gB1 and gB2), 9.6% (5/52). While gB4 was not detected, a new genotype (described as gB7 by Trincado et al, 2000) was identified on the basis of their RFLP pattern. During average 708 days’ follow up period, HCMV diseases developed in 5 patients. All of them had gB1 genotype. There was no statistically significant association between the incidence of HCMV diseases and the gB genotypes. Re-infection with gB1 strain was detected in one patient who had been previously infected with gB2. This episode was associated with fever, elevated liver enzyme and positive antigenemia. Conclusion : HCMV gB1 was the dominant genotype and no gB4 was detected in allogeneic HSCT recipients in Korea, which is an unique pattern compared with the previous reports. Although we can not find significant association between the HCMV diseases and the gB genotypes, genotyping of HCMV will serve in the study of pathogenesis and transmission of this virus in transplant patients. Further study is underway with large study population.
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김용수,소용성,김천학 중앙대학교 건설환경연구소 2001 環境科學硏究 Vol.12 No.2
본 연구는 통계자료를 통해 건설재해 및 가설재해에 관한 현황을 조사하고, 가설재 제조 및 임대 · 유통업체와 가설재 사용업체를 중심으로 가설재 사용실태에 대한 설문조사 및 사례조사를 실시하여 가설재 사용실태에 관한 가설재해의 원인을 파악하고 가설재해 예방에 관한 개선방안을 제시하였고, 그 결과는 다음과 같다. 1.가설재 제조 및 임대 · 유통업체의 경우 가설재 제조 및 임대 · 유통업체의 문제점은 불량 가설재의 불법유통으로 인한 가설재 제조업체의 경영악화와 영세 가설재 임대 · 유통업체의 난립으로 인한 유통과정에서의 가설재 품질저하 그리고, 가설재 성능 검정제도의 미흡으로 나타났다. 그에 대한 개선방안으로는 가설재 제조업체의 제도적인 육성, 임대 · 유통업체에 대한 허가기준 강화, 그리고 가설재 성능 검정제도의 보완과 재사용가설재의 명확한 사용기준 마련을 들 수 있다 2.가설재 사용업체의 경우 가설재 사용업체의 문제점은 원청업체의 가설재에 대한 하도급업체로의 비용전가와 가설재 반입 및 사용시 형식적인 품질검사로 나타났다. 그에 대한 개선방안으로는 가설재에 대한 비용을 설계이전 단계에서부터 계획에 포함, 전 공정에 대한 품질검사 절차의 모델화, 그리고 현재 유통되고 있는 기존의 불량 가설재에 대한 자발적인 폐기의 유도를 들 수 있다. This study aims to find the cause of temporary work accidents and suggests a improvement plan for the prevention of accidents in temporary works. For this purpose, the following research methods were used: statistical analysis of construction accidents, questionnaire survey, and a case study. As conclusions, causes of temporary work accidents were showed and a improvement plan for the prevention of the accidents in temporary works was suggested for the 2 groups: (1) temporary material manufacturers, lease and sales companies, (2) construction companies which use those temporary materials
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