관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

30% Minocycline 국소 약물송달제제의 생체내, 외방출역학, 세포독성 및 세포활성도 측정

최현순,이상철,김강주,장원규,정서영,정종평 대한구강생물학회 1992 International Journal of Oral Biology Vol.16 No.1

Present study was performed to examine in vitro and in vivo release kinetics, cell cytotoxicity and cellular growth survival of local 30% Minocycline delivery. The purpose of this study was to determine the possibility of clinical use of 30% Minocycline load polycaprolactone film(Mino-Strip). The size of Mino-strip is 6.5㎜×2.5㎜×0.3㎜, Mwt: 5.7㎎). In vitro releasing test, each film showed a large initial burst effect within first one and two hours and more than 84% of Minocycline was releasing test, each film showed a large burst effect within first two and three hours. A steady state kinetics was observed for 8 days both in vivo and in vitro releasing test. In cytotoxicity test, there was no significant cytotoxic effect in Mino-strip to human gingival fibroblast. In cellular growth survival test, there was no significant cellular growth survival effect in Mino-strip to human gingival fibroblast.

전기 화상 환자의 수술 전 평가,고압손상과 저압손상 비교

황정원,이정기,전영태,강종만,오용석,노규정,김현철 대한정맥마취학회 2004 정맥마취 Vol.8 No.1

NLOS Signal Effect Cancellation Algorithm for TDOA Localization in Wireless Sensor Network

Kang, Chul-Gyu,Lee, Hyun-Jae,Oh, Chang-Heon The Korea Institute of Information and Commucation 2010 Journal of information and communication convergen Vol.8 No.2

In this paper, the iteration localization algorithm that NLOS signal is iteratively removed to get the exact location in the wireless sensor network is proposed. To evaluate the performance of the proposed algorithm, TDOA location estimation method is used, and readers are located on every 150m intervals with rectangular shape in $300m{\times}300m$ searching field. In that searching field, the error distance is analyzed according to increasing the number of iteration, sub-blink and the estimated sensor node locations which are located in the iteration range. From simulation results, the error distance is diminished according to increasing the number of the sub-blink and iteration with the proposed location estimation algorithm in NLOS environment. Therefore, to get more accurate location information in wireless sensor network in NLOS environments, the proposed location estimation algorithm removing NLOS signal effects through iteration scheme is suitable.

Designing of Dynamic Sensor Networks based on Meter-range Swarming Flight Type Air Nodes

Kang, Chul-Gyu,Kim, Dae-Hwan The Korea Institute of Information and Commucation 2011 Journal of information and communication convergen Vol.9 No.6

Dynamic sensor network(DSN) technology which is based on swarming flight type air node offers analyzed and acquired information on target data gathered by air nodes in rotation flight or 3 dimension array flight. Efficient operation of dynamic sensor network based on air node is possible when problems of processing time, data transmission reliability, power consumption and intermittent connectivity are solved. Delay tolerant network (DTN) can be a desirable alternative to solve those problems. DTN using store-and-forward message switching technology is a solution to intermittent network connectivity, long and variable delay time, asymmetric data rates, and high error rates. However, all processes are performed at the bundle layer, so high power consumption, long processing time, and repeated reliability technique occur. DSN based on swarming flight type air node need to adopt store-and-forward message switching technique of DTN, the cancelation scheme of repeated reliability technique, fast processing time with simplified layer composition.

Characterization of Alkaline Serine Proteases Secreted from the Coryneform Bacterium TU-19

Kang, Sun-Chul,Park, Sang-Gyu,Choi, Myong-Chul The Korean Society for Microbiology and Biotechnol 1998 Journal of microbiology and biotechnology Vol.8 No.6

Extracellular serine proteases were isolated from a soil bacterium, alkalophilic coryneform bacterium TU-19, which have been grown in a liquid medium optimized at 3$0^{\circ}C$ and pH 10.0. Three different sizes, 120 kDa (protease I), 80 kDa (protease II), and 45 kDa (protease III), of serine pro teases were purified using Sephadex G-150 and QAE-Sephadex chromatography (Kang et al. 1995. Agric. Chem Biotech. 38: 534-540). SDS-PAGE showed that the 120 kDa protease was degraded into the 80 kDa protease in 20 mM Tris-HCI (pH 8.0) buffer solution. This degradation was enhanced in the presence of 0.5 M NaCl and 5 mM EDTA, but was inhibited in the presence of 5 mM $CaCl_2$. These results indicated that the $Ca^{2+}$ ion seems to stabilize the 120 kDa protease like other proteases derived from Bacillus species. The $NH_2$-terminal amino acid sequences of the 10 residues of both proteases were completely identical: Met-Asn-Thr-Gln-Asn-Ser-Phe-Leu-Ile-Lys. In contrast to this, the 80 kDa protease has 1.5 times higher specific activity than the 120 kDa protease does (Kang et al. 1995. Agric. Chern. Biotech. 38: 534-540). Therefore the C-terminal of the 120 kDa protease seems to be autolyzed to the 80 kDa protease but this autolysis did not decrease the protease activity. Optimum pH and temperature of both 80 kDa and 120 kDa proteases were pH 10.5 and $45^{\circ}C$, respectively, and pH and thermal stability were almost identical. Several divalent ions except the $Fe^{2+}$ ion showed similar effects on activities of both proteases, which are similarly resistant to three different detergents.

Morphological Traits and Cytogenetic Analysis of Intergeneric Hybrid between Neofinetia falcata and Sedirea japonicum

Chul Gu Been,Dong Gyu Kim,Sun Bin Kang,Jin Ki Kim,Byeong Jeong Lee,Hyun Yeol Shin,Kang Kwun Kim,Ki-Byung Lim 한국화훼산업육성협회 2014 화훼연구 Vol.22 No.4

The currently cultivated varieties of moth orchid flowers have weak or no fragrance and the plant requires high temperatures for cultivation. In order to develop a new variety of orchid that is psychrophilic and fragrant, intergeneric cross between wild wind orchids and moth orchids was performed. In 2009, To obtain intergeneric hybrids from Sedirea japonicum and Neofinetia falcata with moth orchids, artificial crosses with a total of 160 combinations were performed. Most of the cross combinations failed due to crossincompatibility after intergeneric crosses, with no pod formation, premature pod dropping after pod formation, and pod formation that did not produce seeds. From among these, the crosses that formed normal seeds and germinated to produce viable plants included Doritis pulcherrima × S. japonicum, N. falcata × D. pulcherrima, and N. falcata × P. equestris. From the hybrid specimens obtained through these crosses, 2 superior lines (819-3B and K9256) were selected based on their floral morphology, number of flowers, hardiness, and fragrance. Comparative analyses of the morphological and chromosomal traits were performed between the selected hybrid specimens and their parents. The flower and inflorescence characteristics of the selected hybrids exhibited intermediary traits of both the parents; however, more traits from the moth orchids were inherited. For pollinia traits, both 819-3B and K9256 specimens exhibited intermediate forms of their parents in terms of their shape and size. In the case of 819-3B specimen, a high degree of trait similarity with that of D. pulcherrima was observed; whereas, K9256 specimen showed lobes similar to that of P. equestris. The ploidy of moth orchid, S. japonicum, and N. falcata used for crosses was diploid, as determined by microscopic examination and ploidy analysis. The microscopic examination of chromosomes from the intergeneric hybrid pollens revealed mutation of the chromosome count among different specimens as well as irregular chromosome separation. For the production of next-generation progeny using the obtained hybrids, back-cross was performed; however, most of the progeny obtained were sterile and, among the 12 back-crosses, pod formation was noted in S. japonicum × 819-3B and 819-3B × S. japonicum crosses only.

Intrahepatic Splenosis Mimicking Liver Metastasis in a Patient with Gastric Cancer

Kang, Kyu-Chul,Cho, Gyu-Seok,Chung, Gui-Ae,Kang, Gil-Ho,Kim, Yong-Jin,Lee, Moon-Soo,Kim, Hee-Kyung,Park, Seong-Jin The Korean Gastric Cancer Association 2011 Journal of gastric cancer Vol.11 No.1

A 54 year old man was referred to our hospital with gastric cancer. The patient had a history of splenectomy and a left nephrectomy as a result of a traffic accident 15 years earlier. The endoscopic findings were advanced gastric cancer at the lower body of the stomach. Abdominal ultrasonography (USG) and magnetic resonance imaging demonstrated a metastatic nodule in the S2 segment of the liver. Eventually, the clinical stage was determined to be cT2cN1cM1 and a radical distal gastrectomy, lateral segmentectomy of the liver were performed. The histopathology findings confirmed the diagnosis of intrahepatic splenosis, omental splenosis. Hepatic splenosis is not rare in patients with a history of splenic trauma or splenectomy. Nevertheless, this is the first report describing a patient with gastric cancer and intrahepatic splenosis that was misinterpreted as a liver metastatic nodule. Intra-operative USG guided fine needle aspiration should be considered to avoid unnecessary liver resections in patients with a suspicious hepatic metastasis.

항공 통신 기술 분야 : 비행형 에어노드의 데이터 전송 신뢰성 향상을 위한 연접 단일 안테나 다이버시티 시스템

강철규 ( Chul Gyu Kang ),김대환 ( Dae Hwan Kim ) 한국항행학회 2011 韓國航行學會論文誌 Vol.15 No.6

본 논문에서는 비정형 궤도를 따라 이동하며 통신하는 비행체들 간의 데이터 전송 신뢰성을 보장하기 위해 컨볼루션 코드를 연접한 연접 단일 안테나 다이버시티 시스템을 제안하고 이 시스템의 성능을 분석하였다. 제안한 시스템은 단일 안테나를 사용하면서도 다이버시티 이득을 얻을 수 있고 컨볼루션 코드를 연접하였기 때문에 부호화 이득 또한 동시에 얻을 수 있다. 제안한 시스템의 비트 오율 성능(BER: bit error rate)을 시뮬레이션하여 컨볼루션 코드와 비교한 결과 BER 에서 약 9.5dB 우수하였고, 최대 다이버시티 이득을 갖는 시공간 블록코드와 비교한 결과 BER 에서 약 14dB 우수함을 확인 하였다. 마지막으로 부호화 이득과 다이버시티 이득을 동시에 갖는 시공간 트렐리스 코드와 그 성능을 비교하였을 때 의 BER에서 약 4dB 우수하였다. 따라서 비정형 궤도를 따라 이동하며 통신하는 비행형 에어노드간의 신뢰성 있는 통신을 위해서는 연접 단일 안테나 다이버시티 시스템의 적용이 필요하다. In this paper, we propose a concatenated single antenna diversity system to assure the data transmission reliability between flight type air nodes which move according to their atypical orbit, then analyze its performance. The proposed system achieve a diversity gain using single antenna and a coding gain from convolutional code simultaneously. Simulation result about the bit error rate(BER) of the proposed system shows that its BER performance is about 9.5dB greater than convolutional code at 10-4 and about 14dB greater than space time block code at 10-3 which has a full diversity gain. In addition, compared with space time trellis code with diversity gain and coding gain, the proposed system shows the better 4dB at a BER of 10-5, Therefore, it is necessary that concatenated single antenna diversity should be adopted to the reliable data transmission of flight type air nodes.