初期發熱患者에 대한 防風解毒湯의 經時的 解熱效果

정우상,문상관,조기호,김영석,배형섭,이경섭 경희대학교 1997 慶熙醫學 Vol.13 No.4

괴화 추출물에 의한 모와 나일론직물의 염색성

배정숙,허만우 대한가정학회 2003 Family and Environment Research Vol.41 No.2

This study was discussed the dyeing of wool and nylon fabrics with Chinese Scholar Tree extract. The extracts of Chinese scholar tree was prepared in the condition of heating at 95±5C, for 1 hour and cooling to 40C. And then the extracts of color matter treate with vacuum concentration at 60±2℃, 30mmHg and dried with spray dryer. The dyeing of wool and nylon fabric in this experiment was also employed the mordant dyeing method such as pre-mordant, post-mordant and simultaneous mordant method. The mordanting agents used in this study were as followings ; aluminium potassium potassium sulfate, copper(Ⅱ) acetate monohydrate, chromium potassium sulfate·7H_2O, Tin(Ⅱ) chloride dinydrate, iron(Ⅱ)sulfate·7H_2O. For an evaluation of the dyeing property of the mordanting agents, the pre-mordant method, the repeat dyeing and the fastness of the light, dry cleaning, washing and rubbing measured respectively. From the results of the dye absorption, the optimum dyeing condition of the wool and nylon fabrics with Chinese Scholar Tree extract is at 80C dyeing temperature for 60 minutes. The optimum concentration of mordantion agent is Al, Cr, Sn 1%, Fe, Cu 2% solution. In general, the fastness property of the dyed wool and nylon fabrics had a comparatively high grade.

진상전류 추정에 의한 태양광 발전시스템의 최대출력제어

우정인,신동률,허태원,박지호,노인배 東亞大學校 大學院 1997 大學院論文集 Vol.22 No.-

Photovoltaic power may vary depending on the various solar cell has an optimal generating point to be able to get the maximum power tracking, in order to get the more power recovery on the switching control system. However the V-I characteristics of the solar array at the frequency have hysteresis, in such high frequency region the conventional controller based on no hysteresis can not be responsible for control of the photovoltaic power system. Therefore, in this paper we proposed a maximum power tracking technique to improve the operation in the region of high frequency[5KHz-30KHz] with added C-R differential circuit for zero cross switching. The distinguishing characteristics of this method is to be controlled by the estimated values of resistive current and sensed photovoltaic terminal voltage do not depend on the operating frequency. the experimental result of the power system is controlled by the proposed sampling.

DSP 인버터에 의한 편측식 선형 유도전동기의 비간섭제어

우정인,신동률,조용길,노인배,정영일 東亞大學校 附設 情報通信硏究所 1998 情報通信硏究所論文誌 Vol.6 No.1

We proposed the speed control of the inverter-fed SLIM(Single-sided Linear Induction Motor) for conveyance system by the decoupled thrust control with DSP board. The voltage equations of SLIM are expressed on the suitable α-β axis by the proposed equivalent circuits, which can analyze the characteristics of the thrust and the normal force and so on. These control methods, which are the slip angular frequency control and the decoupling control for the thrust and normal force by analyzing these parameters can be successfully driven without interfering of each axis. These results exemplified the linear drive of SLIM with the reference value.

초임계유체에 용해된 염료의 폴리에스터 섬유에 대한 염착

민정명,박민우,전정호,최백선,배효광 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.2

반유통형의 초임계유체 염색장치를 사용하여 333.2K, 373.2K, 413.2K의 일정온도와 150bar-300bar의 압력에서 이산화탄소에 분산염료를 용해하여 폴리에스터 직물을 염색하고 염색시간에 따른 염착량을 측정하였다. 같은 방법으로 HFC-134a를 사용하여 383.2K와 413.2K의 일정온도와 50bar-160bar의 압력에서 염료를 용해하여 염색을 실시하고 염색시간에 대한 염착량을 측정하였다. 염착랑에 대한 초임계유체의 온도와 압력의 영향이 검토되었다. 이산화탄소와 HFC-134a의 초임계 용매를 비교하기 위하여 두 용매에 대한 염료의 용해도와 평형염착량의 관계를 검토하였다. 동일한 온도에서 HFC-134a를 초임계유체로 사용할 때보다 이산화탄소를 사용하는 것이 큰 평형염착량을 나타내었다. HFC-134a에 대한 염료의 용해도는 이산화탄소보다 훨씬 크지만 직물을 염색하는 초임계용매는 이산화탄소가 더 유리하였다. The uptake of disperse dye into polyester fiber in supercritical carbon dioxide was measured in the pressure range between 150 bar and 300 bar at each temperature of 333.3K, 373.2K and 413.2K, and the uptake in supercritical HFC-134a was measured in the pressure range between 50 bar and 160 bar at each temperature of 383.2K, 413.2K, using a flow-type apparatus with a cylindrical dyeing vessel. The effect of dye uptake in supercritical fluids on temperature and pressure was investigated. The dye uptake at constant pressure was much increased with temperature than it did with the pressure at constant temperature. The equilibrium uptakes of disperse dye in supercritical carbon dioxide were compared with those in the supercritical HFC-134a. The equilibrium uptakes in the supercritical carbon dioxide were much great than those in the HFC-134a at the same temperature. The supercritical carbon dioxide is better supercritical media than the HFC-134a, even though dye in the supercritical HFC-134a is much solved than in the supercritical carbon dioxide.

적외선 열화상 카메라를 이용한 고속가공에서의 열 발생 특성

김흥배,이우영,최성주,유중학 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

The term 'High Speed Machining' has been used for many years to describe end milling with small diameter tools at high rotational speeds, typically 10,000 - 100,000 rpm. The process was applied in the aerospace industry for the machining of light alloys, notably aluminium. In recent year, however, the mold and die industry has begun to use the technology for the production of components, including those manufactured from hardened tool steels. With increasing cutting speed used in modern machining operation, the thermal aspects of cutting become more and more important. It not only directly influences in rate of tool wear, but also will affect machining precision recognized as thermal expansion and the roughness of the surface finish. Hence, one needs to accurately evaluate the rate of cutting heat generation and temperature distributions on the machining surface. To overcome the heat generation, we used to cutting fluid. Cutting fluid play a roles in metal cutting process. Mechanically coupled effectiveness of cutting fluids affect to friction coefficient at tool-work-piece interface and cutting temperature and chip control, surface finish, tool wear and form accuracy. Through this study, we examined the behavior of heat generation in high-speed machining and the cooling performance of various cooling methods.

레진 계열 근관봉함재 Adseal의 세포독성에 관한 연구

김희정,백승호,이우철,박한수,배광식 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.6

The properties of ideal root canal sealers include the ability of sealing the total root canal system and no toxic effects to periradicular tissues. Cytotoxicity test using cell culture is a common screening method for evaluation of the biocompatibility of root canal sealers. The purpose of this study was to investigate the cytotoxic effect of newly developed resin-based sealer (Adseal 1, 2, and 3) comparing with those commercial resin-based sealers (AH26 and AH Plus), ZOE-based sealers (Tubliseal EWT, Pulp Canal Sealer EWT) and calcium hydroxide based sealer (Sealapex). An indirect contact test of cytotoxicity by agar diffusion was performed according to the international standard ISO 10993-5. L929 fibroblast cells were incubated at 37℃ in humidified 5% CO₂-containing air atmosphere. The freshly mixed test materials were inserted into glass rings of internal diameter 5 ㎜ and height 5 ㎜ placed on the agar. After the 24 hrs incubation period, the decolorization zones around the test materials were assessed using an inverted microscope with a calibrated screen. A Decolorization Index was determined for each specimen. Adseal 1, 2, and 3 did not exert any cytotoxic effects, whereas AH26, AH Plus, Tubliseal EWT, Pulp Canal Sealer EWT, and Sealapex produced mild cytotoxicity.

정전 열 접합을 이용한 Multi-Substrate Bonding

이덕중,주병권,최우범,한정인,조경익,이광배,장진,오명환 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

We performed silicon-to-glass bonding using silicon direct bonding followed by anodic bonding(SDAB). Initial bonding between glass and silicon was caused by the hydrophilic surfaces of silicon and glass ensemble using silicon direct bonding(SDB) method. We found that the bonded specimen using SDAB process had higher strength than one using anodic bonding process only. We performed multiple layer bonding by SDAB, which is glass- silicon -glass as sandwich structure. In the silicon wafer, the (1mm x 2mm x 500μm)-sized cavity was formed by the anisotropic etching of the silicon substrate in EPW(Ethylendiamin-Pyrocatechol-Water). And, the cavity was sealed with glass wafers by SDAB method.

흰쥐 뇌세서의 Cholecystokinin mRNA 함유신경세포의 분포

김우태,배명애,이호섭,박매자,배용철,홍해숙,조희중,주강 慶北大學校 醫科大學 1994 慶北醫大誌 Vol.35 No.4

목적 : 뇌에서 Cholecystokinin(CCK)-8 함유신경세포의 분포에 대해서는 면역조직화학적기법을 이용하여 행한 연구가 많으나 CCK mRNA함유신경세포의 분포에 대한 연구는 아직 단편적이므로 본 연구에서는 이들 신경세포의 분포를 정확히 밝히고져 하였다. 대상 및 방법 : 흰쥐 뇌에서 ^35S가 표지된 oligonucleotide를 이용한 in situ hybridization기법으로 관찰하였다. 결과 및 결론 : 종뇌; 후구의 전후핵, 신피질, 이상엽, 후내야, 외측, 기저 및 피질 편도핵, 해마체, 그리고 선조체에서 CCK mRNA함유신경세포가 관찰되었다. 간뇌; CCK mRNA함유신경세포가 시상의 경우 전내측시상핵, 전복측시상핵, 외측시상핵, 내측시상핵, nucleus reunions, nucleus rhomboideus, 그리고 내측슬상핵에서 관찰되었으며 시상하부의 경우는 시삭상핵, 실방핵, 등내측시상하부핵, 그리고 유두상핵에서 관찰되었다. 중뇌; 흑질의 밀집부, 복측피개야, nucleus linea rostralis, 중심회색질, Edinger-Westphal nucleus, 그리고 하구에서 CCK mRNA 함유신경세포가 관찰되었다. 교 및 연수; CCK mRNA 함유신경세포들이 lateral parabrachial nucleus 삼차신경척수로고유핵, 거대그물구성체핵, 연수그물구성체, 그리고 삼차신경척수로핵에서 관찰되었다. 이상의 결과를 지금까 보고된 CCK-8함유신경세포의 분포에 대한 면역조직화학적 연구결과와 비교 하였을 때 대부분의 부위에서 CCK-8 및 CCK mRNA 함유신경세포의 분포가 유사하였으나 시상의 경우 CCK-8 함유신경세포는 검출되지 않은 반면 매우 많은 수의 CCK mRNA 함유신경세포가 존재함을 알 수 있었고 대뇌 피질의 경우 CCK mRNA 함유신경세포수가 CCK-8 함유신경세포보다 월등히 더 많았다. 반면, 등측봉선핵 및 고속핵에서는 CCK-8 함유신경세포가 다수 존재함이 보고되어 있으나 본 연구의 경우 CCK mRNA 함유신경세포를 관찰할 수 없었다. In order to investigate the distribution of cholecystokinin(CCK) mRNA containing neurons in the rat brain, brains were extirpated rapidly, frozen sectioned and processed for in situ hybridization technique with ^35S labeled oligonucleotide probe. The results obtained were as follows Telencephalon; CCK mRNA containing neurons were found in the anterior olfactory nucleus, neo-cortex, piriform cortex, entsorhinal cortex, lateral, basal and cortical amygdaloid nucleus, hippocampus and corpus striatum. Diencephalon; In the anterior medial thalamic nucleus, anterior ventral thalamic nucleus, lateral thalamic nucleus, medial thalamic nucleus, nucleus reuniens, nucleus rhomboideus, and medial geniculate nucleus, CCK mRNA containing neurons were found. In the hypothalamus, CCK mRNA containing neurons were located in the supraoptic nucleus, paraventricular nucleus, dorsomedial nucleus and supramammillary nucleus. Midbrain; CCK mRNA containing neurons were found in the substantia nigra pars compacta, ventral tegmental area, nucleus linea rostralis, substantia gricea centralis, Edinger-Westphal nucleus and inferior colliculus. Pons and Medulla oblongata; CCK mRNA containing neurons were found in the lateral parabrachial nucleus, nueteus originalis nervi trigemini, nucleus reticularis gigantocellularis, nucleus reticularis medullae oblongatae, nucleus tractus spinalis nervi trigemini.

Efavirenz, indinavir, lopinavir, ritonavir의 LC-MS/MS를 이용한 동시 정량법

채정우,배경진,백인환,서정원,이병요,이은주,남진경,강원구,권광일 충남대학교 약학대학 의약품개발연구소 2009 藥學論文集 Vol.24 No.-

Efavirenz indinavir and kaleta (co-formulation of lopinavir and ritonavir) are important antiretroviral drugs which have been proved to be human immunodeficiency virus (HIV) protease inhibitors and reduced the morbidity and mortality associated with HIV-1 infection. A brief and fast high performance liquid chromatography coupled with electrospray mass spectrometry (LC-MS/MS, API 4000) method for the determination of 4 anti-retroviral agents (efavirenz, lopinavir, indinavir, ritonavir) in human plasma was developed and validated. A simple protein precipitation method was used on 100μl of human plasma. And internal standard solution (10 ng/ml methaqualone) 1ml and reconstitution solution (MeOH) 1ml were added. After vortexing for 30 s and centrifuging at 13,200rpm for 10min, 2μl of supernatant was injected into the column (XTerra MS C_(18) column, 2.1mm × 50mm 3.5㎛ particle size). The mobile phase consisted of MeOH and 0.1% formic acid in water (80:20 , v/v). The chromatogram was run for 1.5 min at a flow rate of 300μl/min. A triple quadrupole mass spectrometer was operated in a positive ion mode (lopinavir, indinavir, ritonavir) and negative mode (efavirenz), simultaneously and multiple reaction monitoring (MRM) was used for drug quantification. The precursor-to-product ion transitions of m/z 316→69 (efavirenz) and 629→447 (lopinavir) and 614→421 (indinavir) and 721→296 (ritonavir)were used to measure and quantify the analyte. The limit of quantitation (LOQ) was 50 ng/ml (efavirenz, indinavir, ritonavir) and 100 ng/ml (lopinavir). The weighted (l/y²) calibration curve was linear over human plasma range 50∼5000ng/ml (efavirenz), 100∼20000ng/ml (lopinavir), 50∼10000ng/ml (indinavir), 50∼2000ng/ml (ritonavir), correlation coefficient(r²) of 4 antiretroviral agents were higher than 0.998. Accuracies and intra-run precisions ranged within 86.60 and 113.29%, 1.06 and 11.16% for all 4 drugs analysed. This analytical method used to determine these drugs was fast and easy to perform, with minimal sample preparation, and without compromising precision and accuracy. The developed method was successful to determine antiretroviral agents in human plasma, and proved suitable for clinical pharmacokinetic study.