Clinical Practice Patterns of Radiotherapy in Patients with Hepatocellular Carcinoma: A Korean Radiation Oncology Group Study (KROG 14-07)

차혜정,박희철,유정일,김태현,남택근,윤상민,윤원섭,김준원,김미숙,장홍석,최영민,김진희,계철승,정인경,성진실 대한암학회 2017 Cancer Research and Treatment Vol.49 No.1

Purpose The aim of this study was to examine patterns of radiotherapy (RT) in Korean patients with hepatocellular carcinoma (HCC) according to the evolving guideline for HCC established by the Korean Liver Cancer Study Group-National Cancer Center (KLCSG-NCC). Materials and Methods We reviewed 765 patients with HCC who were treated with RT between January 2011 and December 2012 in 12 institutions. Results The median follow-up period was 13.3 months (range, 0.2 to 51.7 months). Compared with previous data between 2004 and 2005, the use of RT as a first treatment has increased (9.0% vs. 40.8%). Increased application of intensity-modulated RT resulted in an increase in radiation dose (fractional dose, 1.8 Gy vs. 2.5 Gy; biologically effective dose, 53.1 Gy10 vs. 56.3 Gy10). Median overall survival was 16.2 months, which is longer than that reported in previous data (12 months). In subgroup analysis, treatments were significantly different according to stage (p < 0.001). Stereotactic body RT was used in patients with early HCC, and most patients with advanced stage were treated with three-dimensional conformal RT. Conclusion Based on the evolving KLCSG-NCC practice guideline for HCC, clinical practice patterns of RT have changed. Although RT is still used mainly in advanced HCC, the number of patients with good performance status who were treated with RT as a first treatment has increased. This change in practice patterns could result in improvement in overall survival.

STRONG CONVERGENCE THEOREMS OF ITERATIVE ALGORITHMS FOR RELATIVELY NON-LIPSCHITZIAN MAPPINGS

차혜정,김태화 장전수학회 2017 Proceedings of the Jangjeon mathematical society Vol.20 No.2

In this paper, we rst review strong convergence theorems of iterative algorithms due to Matsushita and Takahashi [20] for relati- vely nonexpansive mappings and next extend their convergence results to the wider class of uniformly Lipschitzian mappings which are relati- vely asymptotically nonexpansive type. Finally we discuss some appli- cations relating to our main result.

재결성된 신년 봉사 모임

차혜정 샘터사 2019 월간 샘터 Vol.587 No.-

Patterns of care and treatment outcomes for primary thyroid lymphoma: a single institution study

차혜정,조재호,김준원,서창옥,김진석,정준원,이정심,금기창,이창걸 대한방사선종양학회 2013 Radiation Oncology Journal Vol.31 No.4

Purpose: The aim of this study was to analyze the patterns of care and treatment outcomes in patients with primary thyroid lymphoma (PTL) in a single institution. Materials and Methods: Medical records of 29 patients with PTL treated between April 1994 and February 2012 were retrospectively reviewed. Diagnosis was confirmed by biopsy (n = 17) or thyroidectomy (n = 12). Treatment modality and outcome were analyzed according to lymphoma grade. Results: The median follow-up was 43.2 months (range, 3.8 to 220.8 months). The median age at diagnosis was 57 years (range, 21 to 83 years) and 24 (82.8%) patients were female. Twenty-five (86.2%) patients had PTL with stage IEA and IIEA. There were 8 (27.6%) patients with mucosa-associated lymphoid tissue (MALT) lymphoma and the remaining patients had high-grade lymphoma. Patients were treated with surgery (n = 2), chemotherapy (n = 7), radiotherapy (n = 3) alone, or a combination of these methods (n = 17). Treatment modalities evolved over time and a combination of modalities was preferred, especially for the treatment of high-grade lymphoma in recent years. There was no death or relapse among MALT lymphoma patients. Among high-grade lymphoma patients, 5-year overall survival (OS) and 5-year progression-free survival (PFS) were 75.6% and 73.9%, respectively. Complete remission after initial treatment was the only significant prognostic factor for OS (p = 0.037) and PFS (p = 0.003). Conclusion: Patients with PTL showed a favorable outcome, especially with MALT lymphoma. Radiotherapy alone for MALT lymphoma and chemotherapy followed by radiotherapy for high-grade lymphoma can be effective treatment options for PTL

교사의 공감능력과 유아의 또래 유능성간의 관계에서 교사-유아관계의 매개효과 연구

차혜정,송승민 한국보육지원학회 2017 한국보육지원학회지 Vol.13 No.6

Objective: This study examined the relationships among teachers' empathy ability, children's peer competence and teacher-child relationships. Methods: 180 teachers and 360 children from 3 to 5 years old were included in the study. The research variables were measured by teachers’ self-report through questionnaires. The collected data were analyzed by t-test, one-way ANOVA, and three-step mediated regression analysis. Results: First, teachers' empathy ability and teacher-child relationship showed significant differences according to teacher variables (age, marital status, parental status). And children’s peer competence was significantly different according to gender. Second, intimacy which was a subfactor of teacher-child relationships showed a perfect mediating role in the association between teachers' empathy ability and peer competence. Conclusion/Implications: These results suggest the importance of teacher-child’s intimate relationships since it affects the child’s peer competence significantly. In this study, it was found that, in order to help foster the teacher's empathic ability and teacher-child relationships which have positive effects on the child's desirable peer formation, continuous teacher education and diverse studies are needed.

PowerPC 8349E를 적용한 무인기용 통합비행제어컴퓨터 설계

차혜정(Hye-jeong Cha),김재용(Jae-yong Kim),조인제(In-je Cho),이상율(Sang-yool Lee),정운석(Wun-suk Jeong) 한국정보과학회 2012 정보과학회지 Vol.30 No.9

TASC II 분류에 따른 최근 5년간 단일 병원에서 하지동맥 폐색성 질환의 치료방법의 변화

조원표,차혜정,공은미,전용선,조순구,김장용,홍기천,허윤석,이건영,김세중,조영업,안승익 대한혈관외과학회 2011 Vascular Specialist International Vol.27 No.1

Purpose: Endovascular treatment for peripheral arterial obstructive disease (PAOD) is replacing traditional arterial bypass in the western world. Yet there are few reports to evaluate the pattern of clinical practice pattern for PAOD in Korea. This study was conducted to evaluate the treatment pattern for PAOD between endovascular treatment and arterial bypass, and to compare their clinical characteristics. Methods: We conducted a retrospective study on the prospectively maintained database of patients who underwent endovascular treatment and arterial bypass for PAOD from March 2005 to December 2009 in Inha University Hospital. The aortoiliac lesions and femoropopliteal lesions were categorized by the Trans Atlantic Inter-Society Consensus (TASC) II classifications. Their treatments and clinical characteristics were compared between the former period (2005∼2007 y) and the latter period (2008∼2009 y). Results: Three hundred nine cases (178 patients) were treated for PAOD by either arterial bypass or endovascular treatment. The patients’ mean age was 69.1±11.3 year old. There was no difference in clinical characteristics between the two periods except for age. Endovascular treatments of both aortoiliac and femoropopliteal arterial lesions were increased in the latter period (P=0.023, P<0.001). Also, the endovascular treatments were increased in the TASC C and D aortoiliac and femoropopliteal lesions in the latter period (P=0.020, P<0.001). Conclusion: Endovascular treatment for PAOD is increasing in clinical practice and this shows feasibility in critically ill patient with TASC C and D lesions, although arterial bypass is still important.

ARINC653 기반의 무인기 통합비행제어컴퓨터 개발

김태형,정운석,차혜정,조인제 한국항공우주학회 2012 한국항공우주학회 학술발표회 논문집 Vol.2012 No.11

최근의 항공전자 개발 추세는 탑재 전자 장비 수를 줄여 무게와 비용을 줄이는 방향으로 발전하고 있다. 이를 위해서는 소프트웨어의 능력과 효율을 극대화하는 기반기술이 매우 중요하다. 프로세서의 성능향상과 ARINC653 OS 같은 Partition 기반의 RTOS 기술 발전은 이를 가능하게 해준다. 비행제어컴퓨터의 주된 기능은 비행체 조종면을 비행법칙에 따라 조종하는 것이며, 통합비행제어컴퓨터는 항법모듈을 내부에 통합시킨 단일 장비로서 비행연산, 다중화, ARINC653 및 자체 고장진단기능을 지원한다. 기존 비행제어컴퓨터가 비행체 자세제어라는 단일 기능을 주로 수행한 반면에, 통합비행제어컴퓨터는 ARINC653 OS 기반 위에 비행제어, 임무제어, 지상통신 등 복수 기능을 동시에 수행한다. 또한, 내부 탑재 항법모듈로부터 수신한 GPS/INS/AIR DATA 자료를 비행제어/임무제어/지상통신 OFP들이 서로 공유한다. 본 논문은 ARINC653 OS를 실행하기 위한 통합비행제어컴퓨터 설계 및 개발에 관련된 내용을 기술한다. Latest avionics development trend is evolving in the direction of reducing the weight and the cost of electronic equipment mounted. It is very important to them in order to maximize the capacity of the software. The main feature of the flight control computer is steering aircraft control surfaces in accordance with the laws of flight. Generally, flight control computer performs a single function such as attitude control, on the other hand, ARINC653 OS-based integrated flight control computer perform flight control, mission control, ground communication control at the same time. This paper explains on the design and development of ARINC653 OS-based integrated flight control computer.

Bladder filling variations during concurrent chemotherapy and pelvic radiotherapy in rectal cancer patients: early experience of bladder volume assessment using ultrasound scanner

장지석,윤홍인,차혜정,정윤선,조예나,금기창,금웅섭 대한방사선종양학회 2013 Radiation Oncology Journal Vol.31 No.1

Purpose: To describe the early experience of analyzing variations and time trends in bladder volume of the rectal cancer patients who received bladder ultrasound scan. Materials and Methods: We identified 20 consecutive rectal cancer patients who received whole pelvic radiotherapy (RT) and bladder ultrasound scan between February and April 2012. Before simulation and during the entire course of treatment, patients were scanned with portable automated ultrasonic bladder scanner, 5 times consecutively, and the median value was reported. Then a radiation oncologist contoured the bladder inner wall shown on simulation computed tomography (CT) and calculated its volume. Results: Before simulation, the median bladder volume measured using simulation CT and bladder ultrasound scan was 427 mL (range, 74 to 1,172 mL) and 417 mL (range, 147 to 1,245 mL), respectively. There was strong linear correlation (R = 0.93, p < 0.001) between the two results. During the course of treatment, there were wide variations in the bladder volume and every time, measurements were below the baseline with statistical significance (12/16). At 6 weeks after RT, the median volume was reduced by 59.3% to 175 mL. Compared to the baseline, bladder volume was reduced by 38% or 161 mL on average every week for 6 weeks. Conclusion: To our knowledge, this study is the first to prove that there are bladder volume variations and a reduction in bladder volume in rectal cancer patients. Moreover, our results will serve as the basis for implementation of bladder training to patients receiving RT with full bladder.

Which Patients with Left Breast Cancer Should be Candidates for Heart-Sparing Radiotherapy?

조원경,박원,최두호,차혜정,남석진,김석원,이정언,유종한,임영혁,안진석,박연희,김지연 한국유방암학회 2018 Journal of breast cancer Vol.21 No.2

Purpose: This study aimed to identify risk factors that have significant interaction with radiation exposure to the heart, and thus to determine candidates for heart-sparing radiotherapy (RT) among women with left breast cancer. Methods: We identified 4,333 patients who received adjuvant RT following breast-conserving surgery for ductal carcinoma in situ or invasive breast cancer from 1996 to 2010. Incidence rates of cardiovascular disease were compared between left-sided and right-sided RT, and stratified by age and risk factors such as body mass index (BMI), smoking, hyperlipidemia, hypertension, diabetes, administration of anthracycline, and trastuzumab. Results: In all patients, the cumulative incidence of cardiovascular disease was greater in patients treated with left-sided RT than in those treated with right-sided RT, but the difference was not significant (p=0.428). Smoking (hazard ratio [HR], 5.991; 95% confidence interval [CI], 2.109–17.022; p=0.002) and hyperlipidemia (HR, 5.567; 95% CI, 3.235–9.580; p<0.001) were the most powerful risk factors for cardiovascular disease. There was no significant factor that further increased the risk of cardiovascular disease after left breast RT compared to right breast RT. Conclusion: Although hyperlipidemia and smoking are risk factors for cardiovascular disease, they have not been proven to increase the risk of RT-related cardiovascular disease in Korean women.