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Purpose: Mutations in BRCA genes are the main cause of hereditarybreast cancer in Korea. The aim of this study was to investigatethe characteristics of breast cancers involving BRCA1(BRCA1 group) and BRCA2 (BRCA2 group) mutations. Methods:We retrospectively reviewed the medical records of patients withBRCA1 (BRCA1 group) or BRCA2 (BRCA2 group) mutation positivebreast cancer from multiple centers and compared the datato that of the Korean Breast Cancer Society registry (registrygroup). Results: The patients of the BRCA1 group were diagnosedat a younger age (median age, 37 years) and had tumorsof higher histological (61.3% with histological grade 3) and nuclear(37.5% with nuclear grade 3) grade than those of the registrygroup. In addition, the frequency of ductal carcinoma in situin the BRCA1 group was lower (3.7%) than in the registry group,and the BRCA1 group were more likely to be triple-negativebreast cancer (61.3%). Patients in the BRCA2 group were alsoyounger at diagnosis (mean age, 41 years) and were more likelyto have involvement of the axillary node than the registry group(45.5% vs. 33.5%, p=0.002). The BRCA1 and BRCA2 groupsdid not show a correlation between tumor size and axillary nodeinvolvement. Conclusion: We report the characteristics of BRCAmutation positive breast cancer patients in the Korean populationthrough multicenter data and nation-wide breast cancerregistry study. However, BRCA-mutated breast cancers appearhighly complex, and further research on their molecular basis isneeded in Korea.
Purpose: This experimental study verified the effect of adipose-tissue-derived stem cells (ASCs) on the healing of ischemic colonic anastomoses in rats. Methods: ASCs were isolated from the subcutaneous fat tissue of rats and identified as mesenchymal stem cells by identification of different potentials. An animal model of colonic ischemic anastomosis was induced by modifying Nagahata’s method. Sixty male Sprague-Dawley rats (10-week-old, 370 ± 50 g) were divided into two groups (n = 30 each): a control group in which the anastomosis was sutured in a single layer with 6-0 polypropylene without any treatment and an ASCtreated group (ASC group) in which the anastomosis was sutured as in the control group, but then ASCs were locally transplanted into the bowel wall around the anastomosis. The rats were sacrificed on postoperative day 7. Healing of the anastomoses was assessed by measuring loss of body weight, wound infection, anastomotic leakage, mortality, adhesion formation,ileus, anastomotic stricture, anastomotic bursting pressure, histopathological features, and microvascular density. Results: No differences in wound infection, anastomotic leakage, or mortality between the two groups were observed. The ASC group had significantly more favorable anastomotic healing, including less body weight lost, less ileus, and fewer ulcers and strictures, than the control group. ASCs augmented bursting pressure and collagen deposition. The histopathological features were significantly more favorable in the ASC group, and microvascular density was significantly higher than it was in the control group. Conclusion: Locally-transplanted ASCs enhanced healing of ischemic colonic anastomoses by increasing angiogenesis. ASCs could be a novel strategy for accelerating healing of colonic ischemic risk anastomoses.