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윤대위,이창희,Yun, Dae Wi,Lee, Chang Hui Korean Chemical Society 2000 Bulletin of the Korean Chemical Society Vol.21 No.6
The '3+1'type condensation of 16-thiatripyrromethane with $N-alkyl-24-bis[(\alpha+hydroxy-\alpha-phenyl)methyl]pvrole$, in the presence of acid catalyst afforded core-modified, N-confused porphyrins bearing alkyl groups at the rim nitrogen. The proton NMR spectra indicate that the bulkiness of the N-alkyl substituents is somewhat relatedwith the tiltedness of the inverted pyrrole ring. The changes in chemical shift of inner methine protons depending on the N-alkyl group and protonation site is discussed.
윤대위,신철 대한수면연구학회 2009 Journal of sleep medicine Vol.6 No.1
Although obstructive sleep apnea (OSA) is a major public health problem, the pathogenesis of OSA is not fully understood. According to recent studies, development of OSA generally depends on the followings : (1) upper airway anatomy, (2) the ability of upper airway dilator muscle to respond to stimulation, (3) loop gain, (4) arousal threshold. These factors determine upper airway patency and ventilatory control stability. Thus, abnormalities in these systems lead to a narrowed, more collapsible pharyngeal airway and ventilator control instability, which lead in turn to development of OSA. OSA is a heterogeneous disorder which can develop as the result of a variety of physiologic characteristics, and may differently respond to therapeutic approaches based on the predominant abnormality. Therefore, the treatment of OSA must be individualized to the cause of the development of OSA.
특집 - 폐쇄성 수면 무호흡증 : 폐쇄성 수면 무호흡증의 역학과 병인
윤대위 ( Dae Wui Yoon ),김진관 ( Jin Kwan Kim ),신철 ( Chol Shin ) 대한내과학회 2015 대한내과학회지 Vol.89 No.1
Obstructive sleep apnea (OSA) is one of common sleep disorders in western countries, affecting 4% of males and 2% of females. It is characterized by repeated obstruction of the upper airway during sleep, leading to intermittent hypoxemia, sympathetic activation, and sleep fragmentation. OSA is an independent risk factor for a range of medical problems, including cardiovascular disease, diabetes, depression, and cognitive dysfunctions. The etiology of OSA is complex and incompletely understood, but recent studies have shown that the development of OSA depends on the structure of the airway anatomy, the responsiveness of the upper airway dilator muscle to stimulation, and the stability of the respiratory control system. This review details the epidemiological and experimental evidence surrounding the associations between OSA and chronic diseases. Recent findings on the etiology of OSA will also be discussed. (Korean J Med 2015;89:6-12)
균혈증의 조기 발견을 위한 Procalcitonin/Albumin Ratio와 Blood Urea Nitrogen/Albumin Ratio의 임상적 유용성
표상신,윤대위,김현정,채현석,이혜경 대한임상미생물학회 2023 Annals of clinical microbiology Vol.26 No.4
Background: Early prediction of bacteremia is important because sepsis may develop ifbacteremia is not treated in time. We aimed to determine whether blood tests are clinicallyuseful in predicting gram-negative versus gram-positive bacteremia. Methods: We retrospectively analyzed the medical records of 16,569 patients who underwentblood culture testing among those who visited St. Mary’s Hospital of Uijeongbu, CatholicUniversity from January 1, 2018 to December 31, 2018. After excluding 15,580 patients withinsufficient data for analysis, the total study population was 989. Results: In the multivariable logistic regression analysis for gram-negative bacteremia, afteradjusting for major variables, procalcitonin (odds ratio [OR] 1.02, P < 0.001), high-sensitivityC-reactive protein (OR 1.03, P = 0.010), and albumin (OR 0.55, P = 0.010) were significant. Inthe same model, lactic acid (OR 1.08, P = 0.010), blood urea nitrogen (BUN) (OR 1.02, P =0.010), and albumin (OR 0.50, P = 0.005) were significant for gram-positive bacteremia. We constructed blood indicators by combining blood tests that were significant inmultivariable logistic regression analysis. Comparing the area under the curve (AUC) of thereceiver operating characteristic curve, the AUC of the procalcitonin/albumin ratio in gramnegativebacteremia was significantly higher than that of procalcitonin (0.846 vs. 0.837, P =0.005), and the AUC of the BUN/albumin ratio in gram-positive bacteremia was significantlyhigher than that of BUN (0.709 vs. 0.679, P = 0.007). Conclusion: The procalcitonin/albumin ratio is expected to be helpful in the early predictionof gram-negative bacteremia, whereas the BUN/albumin ratio in the early prediction of grampositivebacteremia.
Association of Sasang Constitutional Type with Bone Mineral Density, Osteopenia, and Osteoporosis
이승구,윤대위,김종렬,김진관,이혜련,이성희,애보트 로버트,신철,Lee, Seung Ku,Yoon, Dae Wui,Kim, Jong Yeol,Kim, Jin Kwan,Yi, Hyeryeon,Lee, Sunghee,Abbott, Robert D.,Shin, Chol The Society Of Sasang Constitutional Medicine 2020 사상체질의학회지 Vol.32 No.3
Object Although Taeeum and Soyang constitutional types have bigger body shapes and higher body mass index values than those with the Soeum, the relationship between the Sasang constitutional type and bone mass density is controversial and the association of osteopenia and osteoporosis remains unknown. Therefore, we investigated the relationship between bone mineral density, osteopenia, and osteoporosis according to Sasang constitutional type. Methods A total of 2,508 participants were included in this study. Among the study participants, 1,396 had Taeeum type, 276 had Soeum type, and 836 had Soyang type, respectively. The relationships to bone mass density, osteopenia, and osteoporosis in those with Sasang constitutional type were estimated using logistic and linear regression models. Results Bone mass density was significantly higher in the order of Taeeum, Soyang, and Soeum group (p < 0.01). Soeum group in comparison with Taeeum or Soyang group was significantly associated with a high odds ratio for osteopenia and osteoporosis except in the hip and femoral neck in the comparison of Taeeum and Soeum group (p < 0.01). Moreover, the bone mass density of Soeum group decreased more rapidly as the age increased when compared with Taeeum and Soyang group. Conclusions Our findings may contribute to the early prevention and management of high-risk individuals with poor bone mass density, osteopenia, and osteoporosis using Sasang constitution medicine.
Effects of Transglutaminase 2 Inhibition on Ventilator-Induced Lung Injury
서인범,윤대위,오원옥,이은주,민경훈,허규영,이승헌,이승룡,이상엽,신철,심재정,인광호,강경호,김제형 대한의학회 2014 Journal of Korean medical science Vol.29 No.4
This study was performed to examine the role of transglutaminase 2 (TG2) in ventilatorinducedlung injury (VILI). C57BL/6 mice were divided into six experimental groups: 1)control group; 2) lipopolysaccharide (LPS) group; 3) lung protective ventilation (LPV)group; 4) VILI group; 5) VILI with cystamine, a TG2 inhibitor, pretreatment (Cyst+VILI)group; and 6) LPV with cystamine pretreatment (Cyst+LPV) group. Acute lung injury (ALI)score, TG2 activity and gene expression, inflammatory cytokines, and nuclear factor-κB(NF-κB) activity were measured. TG2 activity and gene expression were significantlyincreased in the VILI group (P < 0.05). Cystamine pretreatment significantly decreased TG2activity and gene expression in the Cyst+VILI group (P < 0.05). Inflammatory cytokineswere higher in the VILI group than in the LPS and LPV groups (P < 0.05), and significantlylower in the Cyst+VILI group than the VILI group (P < 0.05). NF-κB activity was increasedin the VILI group compared with the LPS and LPV groups (P < 0.05), and significantlydecreased in the Cyst+VILI group compared to the VILI group (P = 0.029). The ALI score ofthe Cyst+VILI group was lower than the VILI group, but the difference was not statisticallysignificant (P = 0.105). These results suggest potential roles of TG2 in the pathogenesis ofVILI.
Proteomic analysis of plasma proteines from patients with Obstructive sleep apnea
Lee, SeungGwan,Lee, ChangKyou,Yoon, DaeWe,Sung, EuenMe,Kim, JinKwan,Shin, Chol,Lee, SungHo 高麗大學校 倂設 保健大學 保健科學硏究所 2003 保健科學論集 Vol.29 No.2
Obstructive Sleep Apnea(OSA) is characterized by episode of complete or partial pharyngeal obstruction during sleep and deeply related to cardiovascular disease and cerebrovascular disease. Many studies show that Hypoxia, Hypertension, and the production of superoxide produced by elevated homocysteine concentration may damage to vascular endothelium. In this study we performed proteomic-based approach to characterize the plasma protein associated with wound healing mechanism. First, overnight polysomnographic study was carried out in sleep laboratory, using standard recording techniques. Five cases of OSA patients and 5 normal controls were analyzed by two dimensional gel electrophoresis (pH 3-10NL, 8-18% gradient). Protein spots were cut from 2-D gels stained by Coomasie blue, and were identified by using matrix-assisted laser desorption ionization mass spectrometry(MALDI-MS). The results were compared with those of paired normal controls. Comparative analysis of the respective spot patterns in 2DE shows that Vitronectin which plays an important role in repairing wounded vessel was increased. Following protein was also increased in OSA patients : lg alpha-1 chain C region