Vegetable or Pulse Granuloma in the Nasal Cavity

여남경,엄대운,임현우,송용진 대한이비인후과학회 2014 Clinical and Experimental Otorhinolaryngology Vol.7 No.4

Vegetable granuloma or pulse granuloma results from the implantation of food particles of vegetable origin. Pulse granulo- mas have mainly been reported in association with lung aspirations, the oral cavity with a history of oral procedures and less frequently in gastrointestinal tracks. We report a 31-year-old woman who presented with right nasal obstruction and was found to have a firm mass in the right nasal cavity. Paranasal sinus computerized tomography scans identified a calci- fied ring lesion in her right nasal cavity. Endoscopic sinus surgery was performed, and pathology examination revealed a lesion consistent with a pulse granuloma that contains starch granules with cellulose envelopes appearing as hyaline rings surrounded by inflammation cells and concentrically arranged delicate connective tissue. Pulse granuloma is a well de- scribed entity with distinct histopathology. However, pulse granulomas are rare, and especially extraoral pulse granulomas are extremely rare. We found that pulse granuloma can be occurred in the nasal cavity through regurgitation.

비부비동에 발생한 선양낭성암종의 임상적 특징

여남경,정유삼,장용주,이봉재 대한비과학회 2008 Journal of rhinology Vol.15 No.1

Background and Objectives:Adenoid cystic carcinoma is occasionally found, second to the squamous cell carcinoma, in the sinonasal tracts. The purpose of this study is to find out the clinical features, treatment outcome, and prognostic factors of adenoid cystic carcinoma in the sinonasal tracts. Materials and Methods:Between September 1993 and December 2005, 16 cases of adenoid cystic carcinoma of the sinonasal tracts (6 males, 10 females, ages ranging between 35-70 years;a mean age of 49 years) were selected. We reviewed medical records of the patients to examine their clinical presentations, treatment options, and their outcomes. Result:The most common site of affliction was the nasal cavity (37.5%) followed by the maxillary sinus (31.3%). Patients displayed various symptoms such as nasal obstruction, facial pain, and epistaxis. Nine out of 16 patients (56%) were diagnosed to be in stage IV (AJCC staging system). Histopathological examination revealed cribriform type (13 patients:81%) and solid type (3 patients:19%). In 3 patients, perineural invasion was observed. Surgery with or without postoperative radiation therapy (RT) was applied for 8 patients (stage I, II, III, IV), RT only for 7 patients (stage III, IV), and RT and chemotherapy for 1 patient (stage IV). Total recurrence rate was 43.8% (7 out of 16 patients) and the recurrence rate of the patients followed up over 5 years was 62.5% (5 out of 8 patients). Conclusion: Adenoid cystic carcinoma of the sinonasal tract develops more frequently among women and is usually discovered in the advanced stage. Surgery and postoperative RT are the main stay of the treatment. Background and Objectives:Adenoid cystic carcinoma is occasionally found, second to the squamous cell carcinoma, in the sinonasal tracts. The purpose of this study is to find out the clinical features, treatment outcome, and prognostic factors of adenoid cystic carcinoma in the sinonasal tracts. Materials and Methods:Between September 1993 and December 2005, 16 cases of adenoid cystic carcinoma of the sinonasal tracts (6 males, 10 females, ages ranging between 35-70 years;a mean age of 49 years) were selected. We reviewed medical records of the patients to examine their clinical presentations, treatment options, and their outcomes. Result:The most common site of affliction was the nasal cavity (37.5%) followed by the maxillary sinus (31.3%). Patients displayed various symptoms such as nasal obstruction, facial pain, and epistaxis. Nine out of 16 patients (56%) were diagnosed to be in stage IV (AJCC staging system). Histopathological examination revealed cribriform type (13 patients:81%) and solid type (3 patients:19%). In 3 patients, perineural invasion was observed. Surgery with or without postoperative radiation therapy (RT) was applied for 8 patients (stage I, II, III, IV), RT only for 7 patients (stage III, IV), and RT and chemotherapy for 1 patient (stage IV). Total recurrence rate was 43.8% (7 out of 16 patients) and the recurrence rate of the patients followed up over 5 years was 62.5% (5 out of 8 patients). Conclusion: Adenoid cystic carcinoma of the sinonasal tract develops more frequently among women and is usually discovered in the advanced stage. Surgery and postoperative RT are the main stay of the treatment.

후두에 발생한 신경 내분비암종 3예

여남경,최승호,김상윤,남순열,Yeo, Nam-Kyung,Choi, Seung-Ho,Kim, Sang-Yoon,Nam, Soon-Yuhl 대한후두음성언어의학회 2005 대한후두음성언어의학회지 Vol.16 No.1

Although primary neuroendocrine carcinomas(NEC) are uncommon tumors of the larynx, they represent the most common nonepidermoid malignancy of this organ. Whereas typical carcinoid tumors and small-cell carcinomas occur very rarely in the larynx, the majority of laryngeal NEC belong to a broad intermediate group between these two extremes of NEC. Through many case studies, a major protion of clinicopathologic characteristics of laryngeal NEC have been revealed; however, the gistogenesis of laryngeal NEC is still unknown. The only well-documented normal neuroendocrine structures of the larynx are paraganglions, but the incidence of laryngeal paragangliomas are much lower than that of NEC. Here, we report on three cases of NEC affecting the larynx and the results of searching for neuroendocriene cells in non-neoplastic larynx tissue.

농양을 형성한 결핵성 경부 림프절염의 치료

여남경,노종열,최승호,김상윤,남순열 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.5

Background and Objectives:Tuberculous cervical lymphadenitis is not an uncommon inflamatory disorder in Korea. It often does not respond to the antituberculous medication, but grows up gradually making the cervical abscess. Authors aimed to find out Subjects and Method:From Jan. 2001 through Dec. 2005, 52 cases of the tuberculous cervical abscess (16 males, 36 females:age range 18- 63 years, mean 30.4 years) were diagnosed and managed at the Department of Otolaryngology, Asan Medical Center. We reviewed medical records of patients to find out their presentations, diagnostic considerations, therapeutic options, and outcomes. Patients were folowed up for sixteen Results:There was no diference in the duration of antituberculous chemotherapy accor-ding to the surgical methods. However, in the cases of mass excision (91.7%), cure rate (remnant mass size <5 mm) was higher, compared to incision and drainage (80.0%). Compared to excision (3/15, 25%, 39 days), incision and drainage needed more days for dressing for healing (4/5, 80%, 90 days). :Therefore, we recommend, if possible, complete excision as a therapeutic modality in cases of tuberculous cervical abscess. (Korean J Otolaryngol 2007 ;50 :426-30)

희렴 추출물의 Heme Oxygenase-1 발현을 통한 생쥐 해마 유래 HT22 세포 보호효과

임남경,이동성,김윤철,여선정,정길생,장원영,김기영,고영상,김영리,현진원,강희경,맹영희,현창림 한국생약학회 2012 생약학회지 Vol.43 No.4

Siegesbeckia Herba is known to have anti-oxidant, anti-inflammatory, anti-allergic and anti-tumor. The objective of this study is to explore the neuroprotective effect of Siegesbeckia Herba against glutamate-induced oxidative stress in mouse hippocampal HT22 cells. Siegesbeckia Herba 70% ethanol extract and solvent fractions have the potent neroprotective effects on glutamate-induced nerotoxicity by induced the expression of heme oxygenase (HO)-1 in the mouse hippocampal HT22 cells. Especially, ethyl acetate fraction showed higher protective effect. In HT22 cell, Siegesbeckia Herba ethyl acetate fraction makes the nuclear accumulation of Nrf2. Further, we found that treatment with c-JUN N-terminal kinase (JNK) inhibitor (SP600125)reduced Siegesbeckia Herba ethyl acetate fraction induced HO-1 expression and Siegesbeckia Herba ethyl acetate fraction also increased JNK phosphorylation. In conclusion, the ethyl acetate fraction of 70% ethanol extract of Siegesbeckia Herba significantly protect glutamate-induced oxidative damage by induction of HO-1 via Nrf2 and JNK pathway in mouse hippocampal HT22. Taken together these finding suggest that Siegesbeckia Herba ethyl acetate fraction good source for taking active compounds and may be a potential therapeutic for brain disorder by targeting the oxidative stress of neuronal cell.

Morphologic Analysis of Crista Galli Using Computed Tomography

김종준,여남경,조재형,최재원,임현우,송용진,최수정 대한비과학회 2012 Journal of rhinology Vol.19 No.2

Objective : We often observe the variation of Crista galli (CG) which lies in the midline above the cribriform plate on computed tomography (CT) scans. We investigated the variations in CG and the factors which affect its pneumatization. Materials and Methods : We analyzed the CT images of 818 chronic rhinosinusitis patients between July 2003 and July 2011. We investigated height, position relative to the cribriform plate, degree of pneumatization,and cell origin for the pneumatization in CG. We analyzed the relationship between several factors (age, sex, and position of CG) and pneumatization of CG. Results : The average height of CG was 17.98 mm. In 13.9% of subjects, the base of CG did not extend below the level of the cribriform plate. In 84.2%, CG extended less than 50% of its height below the cribriform plate. In 1.8%, CG extended more than 50% of its height below the cribriform plate. Pneumatization of CG was found in 12.2%. Except one, every pneumatization was connected with the frontal sinus. The rate of pneumatization was significantly different depending on age. Conclusion : Our study demonstrated that CG showed various morphology and pneumatizaiton. The pneumatization of CG was mainly originated from frontal sinus and related to aging.

돌발성 난청 환자에서 촬영한 자기 공명 영상의 진단적 유용성

안중호,이정현,여남경,배기훈,윤태현,이광선,정종우 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.1

Objectives:To evaluate the diagnostic value of magnetic resonance imaging (MRI) of patients with sudden sensorineural hearing loss (SSNHL) and to analyze the various clinical aspects and treatments of the patients with abnormal MRI findings. Subjects and Method:We retrospectively reviewed medical and radiological records of patients with SSNHL over 5-year period. All consecutive patients took gadolinium-enhanced MRI including whole brain and all MRIs were evaluated by experienced independent investigators. Results:Twelve patients (8.0%) had obvious etiologies of SSNHL, which consisted of 5 cases of vestibular schwannoma, 3 cases of tumors of cerebellopontine angle, 3 cases of pontine infarction, and 1 case of inflammatory granuloma of internal auditory canal. One patient (0.7%) had possible etiologies of SSNHL, which was labyrinthitis ossificans. Conclusion:Gadolinium-enhanced magnetic resonance imaging (MRI) including whole brain seems to be an essential examination in patients with SSNHL and we recommend its application. (Korean J Otolaryngol 2006;49:7-12)

비강에 발생한 상피모양 혈관내피종 1예

김응호,윤민호,여남경 대한이비인후과학회 2016 대한이비인후과학회지 두경부외과학 Vol.59 No.3

Epithelioid hemangioendothelioma (EHE), a rare vascular tumor that is both clinically and histologically an intermediate between angiosarcoma and hemangioma, was first described by Sharon Weiss and Franz Enzinger. It is characterized by proliferation of a distinct type of endothelial cells, which exhibit epithelioid morphology. It typically occurs in the 20-40 age range with no sex predilection, although the overall age range involved is much broader. This indolent tumor is potentially recurrent, but it rarely metastasizes. There are very few cases of EHE of nasal cavity described in the English literature. We describe here a case of EHE on the left middle turbinate of a 17-year-old male who presented with history of intermittent epistaxis. Korean J Otorhinolaryngol-Head Neck Surg 2016;59(3):242-5

Neuroendocrine Tumor Grade 2 of the Nasal Cavity: Case Report and Review of Literature

신민준,박승진,여남경 대한이비인후과학회 부산,울산,경남 지부회 2020 임상이비인후과 Vol.31 No.2

Neuroendocrine tumors (NETs) of the sinonasal tract are rare in occurrence. According to the 2017 World Health Organization classification of the primary head and neck neuroendocrine carcinomas, they can be classified as follows: well-differentiated, moderately differentiated, and poorly differentiated types. Among these, welldifferentiated and moderately differentiated neuroendocrine carcinomas of the sinonasal tract are extremely rare. Based on a recent proposal, well-differentiated and moderately differentiated neuroendocrine carcinomas are also called neuroendocrine tumor grade 1 and 2, respectively. Because of its rarity and the lack of studies, treatment guidelines for NETs of the sinonasal tract have not been established yet. We report a case of NET grade 2 of the nasal cavity in a 46-year-old man treated by endoscopic sinus surgery. To the best of our knowledge, this is the first case report on an NET grade 2 of the nasal cavity in South Korea.

방선균증과 동반된 비부비동 및 비인두 Natural Killer/T 세포 림프종 1예

김준섭,안태훈,여남경 대한이비인후과학회 2022 대한이비인후과학회지 두경부외과학 Vol.65 No.11

Actinomycosis is a rare anaerobic, gram-positive bacterial infection caused by Actinomyces. As an infection site for the disease, the cervicofacial area is common but the nasal cavity andthe nasopharynx are rare. Actinomycosis causes chronic purulent granulomatous infection andis characterized by extensive infiltration, necrosis, and bone destruction on CT. Extranodalnatural killer/T cell (NK/T cell) lymphoma, nasal type is more common in East Asia thanelsewhere, comprising up to 7%-10% of all non-Hodgkin’s lymphoma. Early nasal symptomsare nonspecific and similar to chronic rhinosinusitis, such as nasal obstruction and nasalbleeding. With disease progression, inflammation and necrosis of the mucosa increase. Weexperienced a case of extranodal NK/T cell lymphoma in a 60-year-old female, who was diagnosedwith opportunistic infection of actinomycosis. We report this case with a review ofliterature.