In Vitro Allergen Challenge Upregulates the Expression of Local Vascular Endothelial Adhesion Molecules in the Nasal Mucosa of Allergic Rhinitics

이봉재,김재호,이인철 대한비과학회 1995 Journal of rhinology Vol.2 No.2

Background : The increases of inflammatory cells in the nasal lavages and the mucosal tissues hours after antigen challenge in the allergic rhinitics propose the possibility of the corresponding increase of vascular endothelial adhesion molecules. The purpose the this study is to investigate the effect of allergen challenge on the expression of adhesion molecules and their temporal pattern of expression in the nasal mucosa of allergic rhinitis. Materials and Methods : The inferior turbinate mucosae were taken from 6 patients with perennial allergic rhinitis and cultured in the RPMI 1640 media with relevant antigen(D.farinae) for 0, 1, 2, 4, 6, 12, 24, and 48 hours. The proportion (%) of mucosal vessels expressing endothelial adhesion molecules such as ICAM-1, E-seletin, and VCAM-1 was obtained from the specimens immunostained with ABC-AP method. Results : The expression of E-selectin, with minimal at baseline, was significantly upregulated 1hour after culture with antigen, reached peak at 4 hour (38.3%), and then returned to baseline at 24 hour. The baseline expression of ICAM-1 was most prominent (48%). The incubation of allergic mucosa with antigen increased the ICAM-1 expression slowly until reaching to the peak level (77%) at 12 hour , and the level was maintained as long as 48 hours. Unlike E-selectin or VCAM-1, ICAM-1 was also expressed on the epithelial cells, especially in the basal cell layer. Conclusion : The expression of E-selectin showed a characterisctic of rapid induction and decline in the allergic nasal mucsoa. The prominent expression of ICAM-1 on the epithelial cells as well as on the vascular endothelial cells suggests the active role of ICAM-1 in the extravasation of inflammatory cells and also in the transepithelial migration into the nasal secretion.

술전 색전술 없이 제거한 하비갑개에서 발생한비인강외 혈관 섬유종 치험 1례

이호민,이정민,김재기,남정권 대한비과학회 2013 Journal of rhinology Vol.20 No.2

The angiofibroma is a highly vascular and histologically benign neoplasm that usually arises in the nasopharyx in adolescent male patients. It accounts for less than 0.5% of all head and neck neoplasm. Reports of primary extra-nasopharyngeal angiofibroma have appeared sporadically in the literature. The inferior turbinate is a very rare site of extra-nasopharyngeal angiofibroma, with only 5 cases reported in the medical literature. Also, the value of embolization in surgery for extra-nasopharyngeal angiofibroma is a controversial matter. We report a case of extra-nasopharyngeal angiofibroma arising from the inferior turbinate of a 37-year-old male. The tumor was completely removed through endonasal, endoscopic technique without pre-operative embolization. Histopathology confirmed it to be a case of angiofibroma. The patient is currently free of relapse 6 months after surgery. Endoscopic resection is a feasible and safe method for angiofibroma surgery. The current evidence does not support obligatory embolization in every case of endoscopic angiofibroma resection.

후비중격에서 발병한 반전성 유두종 1예

이동훈,임상철,이창준,조시영 대한비과학회 2012 Journal of rhinology Vol.19 No.1

Inverted papilloma is an uncommon benign nasal tumor which usually occurs on the lateral nasal wall. An inverted papilloma originating from the medial nasal cavity, especially the nasal septum, is considered very rare. A 47-year-old male was referred with a 1-month history of snoring. On endoscopic examination, a nasal mass was observed in the left posterior septum. The mass filled the left nasal cavity and extended choanae and nasopharynx. The histopathologic examination of the nasal mass showed inverted papilloma, which was completely removed by endoscopic surgery. Herein, the authors report a case of inverted papilloma originating from the posterior nasal septum as well as a review of literature.

알레르기 질환의 건강증진과 예방

구수권 대한비과학회 2008 Journal of rhinology Vol.15 No.2

The prevalence of allergic diseases have been increasing over the last few decades. These diseases have become a global public health problem and a burden to health care resources. Allergen exposure in the high risk group is one of the numerous factors contributing to the developing and worsening allergic diseases. Thus, prevention is a very important strategy in treating allergic diseases. This review focuses on environmental risk factors and possible preventive methods in combating allergic diseases. The prevalence of allergic diseases have been increasing over the last few decades. These diseases have become a global public health problem and a burden to health care resources. Allergen exposure in the high risk group is one of the numerous factors contributing to the developing and worsening allergic diseases. Thus, prevention is a very important strategy in treating allergic diseases. This review focuses on environmental risk factors and possible preventive methods in combating allergic diseases.

Two Cases of Angioleiomyoma in the Nasal Cavity

박일호,홍성문,신재민,이흥만 대한비과학회 2013 Journal of rhinology Vol.20 No.2

Leiomyoma is a benign tumor arising from smooth muscle cells. They are commonly found in the uterus, skin, and gastrointestinal tract. However, it is rare in the head and neck area. Especially, only 3% of leiomyomas in the head and neck area occur in the nasal cavity. Rhinologists need to know leiomyoma as a differential diagnosis of the tumors in the nasal cavity. Herein we present two cases of angioleiomyoma in the nasal cavity and review the literature.

비강에 발생한 골내 혈관종

고성민,최지은,정승규,김효열 대한비과학회 2020 Journal of rhinology Vol.27 No.1

Osseous hemangioma typically occurs in the vertebral column or skull bones. It it is extremely rare in the nasal bone. Only nine cases originating in the turbinate and maxillary bone have been reported in the English and Korean literature. Herein, we present the case of a 51-year-old women with a dorsum mass to share our experience with intraosseous hemangioma successfully removed and reconstructed by an endonasal approach.

당질스테로이드를 이용한 진균에 의한 비강상피세포의 활성화 억제

신승헌 대한비과학회 2006 Journal of rhinology Vol.13 No.1

Background and Objectives:Airway epithelial cells contribute to the pathogenesis of air disease by their interaction with inhalant pathogenic extracts. Airborne fungi interact with nasal epithelial cell and enhance the production of inflammatory cytokines. Glucocorticosteroids (GCs) have been used therapeutically for nasal polyps and allergic disease with potent anti-inflammatory effects. The purpose of this study was to investigate the inhibitory effect of GCs on fungi induced nasal epithelial cell activation. Materials and Methods:The epithelial cells of nasal polyps were obtained from patients and stimulated with Alternaria. To evaluate the anti-inflammatory effects of GCs, Alternaria was pretreated with GCs (triamcinolone, dexamethasone, and budesonide) and cultured with epithelial cells. Interleukin-8 (IL-8) and granulocyte-macrophage colony stimulating factor (GM-CSF) were measured to determine the activation of epithelial cells. Reverse transcriptase-polymerase chain reaction (RT-PCR) test for protease-activated receptors (PARs) mRNA expression in nasal epithelial cells were performed. Results:Alternaria enhanced the production of IL-8 and GM-CSF from nasal epithelial cells. GCs inhibited the activation of nasal epithelial cells, but the PAR2 and PAR3 mRNA expression were not suppressed by GCs. Conclusion:These data suggest that GCs inhibit the production of chemical mediators by Alternaria, but anti-inflammatory effect of GCs are not associated with PARs. 당질스테로이드·Alternaria·비강상피세포·Protease-activated receptor.

A Case of Intranasal Angiofibroma -The Expression of Argurophilic Nucleolar Organizer Regions-

조진학,우광희,정인교,조진생,박경유 대한비과학회 1994 Journal of rhinology Vol.1 No.2

The angiofibroma is an unusual destructive but essentially benign neoplasm, mostly seen in the nasopharynx of adolescent males. Its occurrence within the nasal cavity as a primary tumor is extremely rare. The aim of this study is to describe the clinicopathological features and discuss the origin of this tumor as finding out the analysis of Argyrophilic nucleolar organizer regions(AgNORs) of the fibroblasts and endothelial cells of this rare tumor. The result of the analysis of AgNORs of the two components indicated that the fundamental elements were both of fibroblast cells and the vascular endothelial cells.

상악골에서 발생한 법랑모세포종 1예

김효열,민진영,이원용 대한비과학회 2011 Journal of rhinology Vol.18 No.1

Ameloblastoma is a benign tumor originating from residues of the dental lamina. Ameloblastoma constitute approximately 1% of all tumors of the jaw, and the occurrence in the mandible is four times higher than that in the maxilla, suggesting that maxillary ameloblastoma is a rare histopathological entity. Although these tumors grow slowly and demonstrate a histologically benign appearance, ameloblastomas are notorious for local invasiveness and a high incidence of local recurrence. We experienced a case of ameloblastoma arising from the left maxilla in a 70-year-old male who complained of left nasal obstruction. The ameloblastoma was completely removed via the endoscopic endonasal approach combined with the Caldwell-Luc approach. At a 29-month follow-up, there was no evidence of recurrence.

흡연이 부비동 내시경 수술에 미치는 영향

이주상,장은석,김해영,김진영,맹진우,고일주 대한비과학회 2009 Journal of rhinology Vol.16 No.2

Background and Objectives:This study is designed to assess the effect of smoking on the outcome of endoscopic sinus surgery. Materials and Methods:A total of 66 patients who underwent endoscopic sinus surgery with the diagnosis of chronic sinusitis were evaluated. They were divided into 3 groups; non-smoking, quit-smoking and still-smoking groups. Preoperative and postoperative visual analogue scale (VAS), Sinonasal Outcome Test (SNOT), and endoscopic score for each group were obtained and compared. Results:There were statistically significant correlations between VAS, SNOT score and smoking. However, all patients showed a similar degree of improvement on the subjective symptoms regardless of smoking or nonsmoking. And, postoperative relief of subjective symptoms was not apparent after smoking cessation. In objective findings, postoperative endoscopic scores were 1.6 in non-smoking group, 1.8 in quit-smoking group and 2.7 in still-smoking group. Stillsmoking group had the worst endoscopic result, However, these differences did not reach a statistical significance. Conclusion: This study suggests that smoking had a negative effect on subjective symptoms but not in objective endoscopic findings. In addition, the cessation of smoking after sinus surgery may have no meaningful benefit on the outcome of surgery. Background and Objectives:This study is designed to assess the effect of smoking on the outcome of endoscopic sinus surgery. Materials and Methods:A total of 66 patients who underwent endoscopic sinus surgery with the diagnosis of chronic sinusitis were evaluated. They were divided into 3 groups; non-smoking, quit-smoking and still-smoking groups. Preoperative and postoperative visual analogue scale (VAS), Sinonasal Outcome Test (SNOT), and endoscopic score for each group were obtained and compared. Results:There were statistically significant correlations between VAS, SNOT score and smoking. However, all patients showed a similar degree of improvement on the subjective symptoms regardless of smoking or nonsmoking. And, postoperative relief of subjective symptoms was not apparent after smoking cessation. In objective findings, postoperative endoscopic scores were 1.6 in non-smoking group, 1.8 in quit-smoking group and 2.7 in still-smoking group. Stillsmoking group had the worst endoscopic result, However, these differences did not reach a statistical significance. Conclusion: This study suggests that smoking had a negative effect on subjective symptoms but not in objective endoscopic findings. In addition, the cessation of smoking after sinus surgery may have no meaningful benefit on the outcome of surgery.