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      • KCI등재

        연주환의 현미감정연구

        이유진,정지현,박종희 한국생약학회 2007 생약학회지 Vol.38 No.1

        Ju Hwan (蓮珠丸) is a Chinese patent medicine which has been used for improvement of blood circulation and thrombolysis in Korea. It consists of 28 kinds of powdered crude drugs. For the identification of individual ingredients in such powdery mixtures, microscopic method may advantageously be used, as it requires only small amount of specimens. And also it is considered a technique of choice since it takes only minimum time and requires a simple process. In this paper, the effectiveness of this method is exemplified by the identification of the ingredients in Yeon Ju Hwan, which contains 28 powdered crude drug ingredients.Key wordsYeon Ju Hwan, powder crude drug, Chinese patent medicine, microscopic identification분말생약의 감정연구에 관해서 일본의 木島,1-3) 下村,4-7) 영국의 Jackson and Snowdon,8) 중국의 Lau9) 및 우리나라의 朴10-17) 이 현미경을 이용하여 감정 발표하였다. 이와 같이 현미경을 이용하여 분말생약을 감정하는 방법은 미량의 시료를 사용하여 짧은 시간에 간편한 조작으로 여러 종류의 생약을 확인할 수 있는 특징 및 장점이 있다. 또한 함유된 생약들의 특징적인 부위, 조직학적 형태 및 요소들을 관찰함으로서 사용된 생약들의 구성요소들을 명확하게 확인 규명할 수 있다.우리나라의 경우 많은 종류의 분말 및 환제 생약들이 시중에서 수입 및 유통, 제조, 판매되고 있지만, 이것들의 감정확인법이 확립되어 있지 않은 점에 착안하여 현재 시중에서 많이 이용되고 있는 분말 및 환제 생약의 감정법을 확립할 목적으로 이번에 혈액순환, 혈전용해제로 사용되고 있는 연주환 (蓮株丸)을 시료로 하였다.

      • SCOPUSKCI등재

        생약복합제제(삼황사심탕(三黃瀉心湯), 황련해독탕(黃連解毒湯))가 흰쥐의 실험적 고지혈증에 미치는 영향

        한성준,정명현,Han, Sung-Jun,Chung, Myung-Hyun 한국생약학회 1996 생약학회지 Vol.27 No.4

        This study was attempted to investigate the effect of Composite Preparation (Sam Whang Sasim-Tang: SWST, Whang Ryun Haedok-Tang: WRHT) on the activities of GOT and GPT, the content of total lipids, triglyceride, total cholesterol. Phospholipid and ${\beta}-lipoprotein$ in the serum, and the change ratio of body and liver weight in the experimentally induced hyperlipemic rats, making use of the extract 150, 200, 300 and 500 mg/kg p.o. Significant test was performed by comparision with the values of corresponding experimentally hyperlipemic rats. The activities of S-GPT was significantly decreased in all dose of SWST and WRHT respectively. The activities of S-GPT was significantly decreased in dose of SWST 500 mg/kg and in all dose of WRHT respectively. The content of total lipids, triglyceride, total cholesterol and phospholipids were significantly decreased in all dose of two the extract. The rate of decrease on total lipids and triglyceride were remarkable in dose of SWST 300, 500 mg/kg and WRHT 200, 500 mg/kg, and then the content of total cholesterol was more remarkable in dose SWST 300, 500 mg/kg, and WRHT 150, 300 mg/kg, and the content of phospholipids was more remarkable in dose of the extract 150, 200 and 300 mg/kg. The content of ${\beta}-lipoprotein$ was significantly decreased in dose of WRHT 150, 200 and in all dose of SWST. Increase ratio of the body and liver weight were significantly decreased in dose of two the extract 300, 500 mg/kg respectively.

      • SCOPUSKCI등재

        Angelica속 생약의 정유 성분에 대한 연구 ( II ). -고본의 정유 성분-

        김현수,지형준,Kim, Hyun-Soo,Chi, Hyung-Joon 한국생약학회 1989 생약학회지 Vol.20 No.1

        In continuation of our studies on essential oils of Angelica genus(Umbelliferae), We report on the components of essential oils obtained from the root of Angelica tenuissima Nakai(藁子). Oils were obtained from the dried roots by steam distillation and fractionated by column chromatography. Each isolate or fraction was identified by GC, GC-MS and spectral analysis. Essential oils of the root of A. tenuissima(Gaoben) were found to contain $\alpha-pinene,\;camphene,\;\beta-pinene,\;myrcene,\;\alpha-phellandrene,\;\Delta-3-carene,\;p-cymene,\;limonene,\;\gamma-terpinene,\;terpinolene,\;4-vinylguauacol,\;\gamma-elemene$, one aromatic compound, three unidentified sesquiterpene alcohols, butylidenephthalide, senkyunolide and Z-ligustilide which was the most abundant compound comprising 75% of the whole oil. Also butylphthalide and hydroxybutylidenephalide were tentatively identified.

      • SCOPUSKCI등재

        이뇨성(利尿性) 생약(生藥)의 약리학적(藥理學的) 연구(硏究)

        안영란,김학성,박정섭,Ahn, Young-Ran,Kim, Hack-Seang,Park, Jung-Sup 한국생약학회 1978 생약학회지 Vol.9 No.2

        Several kinds of medicinal plants are used as diuretics in folk medicines and oriental drugs. The diuretic action of water extracts of the ten kinds of crude drugs, such as Pachyma hoelen $R_{UMPHIUS}$ Zea mays L., Akebia quinata $D_{ECAISNE}$, Alisma orientale Juzepezuk, Atractylodes koreana $N_{AKAI}$, phytolacca americana L., Achyranthes japo-nica $N_{AKAI}$, Juncus decipiens $N_{AKAI}$, Prunella asiatica $N_{AKAI}$ and Artemisia capillaris $T_{HUNBERG}$ was examined in mouse and compared with aminophylline as a control the following results were obtained. The urine volume was found to be remarkably increased by the Pachyma hoelen RUMPHIUS, Phytolacca americana L., Prunella asiatica $N_{AKAI}$ and Artemisia capillaris $T_{HUNBERG}$, moderately increased by the Akebia quinata $D_{ECAISNE}$, Achyranthes japonica $N_{AKAI}$ and Juncus decipiens $N_{AKAI}$, and slightly increased by Zea mays $L_{ENNE}$, Alisma orientale $J_{UZFPEZUK}$ and Atractylodes koreana $N_{AKAI}$.

      • SCOPUSKCI등재

        Candida albicans에 대한 생약의 항진균성에 관한 연구(I)

        유승조,서정식,Yoo, Seung-Cho,Suh, Jung-Sik 한국생약학회 1974 생약학회지 Vol.5 No.3

        Some crude drugs in ancient literatures have been used as traditional therapeutic agent of leucorrhea mainly caused by Trichomonas vaginalis and Candida albicans. Sixty six kinds of crude drugs in ancient literatures and ten constituents were selected as sample drugs. Trichomycin standard was tested to compare with the above drugs. To determine the anti-fungal effect of these drugs on Candida albicans Yu 1200, a test organism, screening test was conducted. Antifungal activities of crude drug water extracts were observed by means of two test methods : firstly through the agar slant method and secondly the counting chamber method which was used for acknowledged drug agents upon the result of the agar slant method. And in order to improve the fungicidal effect, the organisms were stained with 0.02% methylene blue solution. The results of the above test indicated that Fritillariae Rhizoma has antifungal action in the concentration of 310mcg/ml, Coptidis Rhizoma in 620mcg/ml, Meliae Cortex, Scutellariae Radix both in 5,000mcg/ml. Baicalin, catechol among the pure isolated constituents inhibited in the range of 50mcg/ml. This score was based on 50% inhibition in comparison with amounts of control organisms. Rhei Rhizoma, Mori Radicis Cortex, Linderae Radix, and Amomi globosi Fructus showed the antifungal effect moderately in 5,000mcg/ml, and baicalein and pectolinarin in 50mcg/ml in the limit of between 35% and 50% antifungal activity. Staining with 0.02% methylene blue showed that any of the crude drug extracts was unable to stain the cells, but trichomycin in 0.86unit/ml able to stain 12% of the cells. This result means that crude drugs probably do not have fungicidal but fungistatic action.

      • SCOPUSKCI등재

        민간약 괭이밥의 생약학적 연구

        김정묘,박종희,Kim, Jeong-Myo,Park, Jong-Hee 한국생약학회 2001 생약학회지 Vol.32 No.3

        Korean folk medicine 'Koaeng I Bab' has been used to cure hemorrhoid, boil and dermatopathy and as an antidote. The botanical origin of the crude drug has not been studied pharmacognostically. To clarify the botanical origin of 'Koaeng I Bab', the morphological and anatomical characteristics of the leaves of Oxalis species growing in Korea, i.e. O. acetosella, O. acetosella var. purpurascens, O. corniculata, O. obtriangulata were studied. As the result, the botanical origin of 'Koaeng I Bab' has been proved to be O. corniculata and O. acetosella var. purpurascens.

      • SCOPUSKCI등재

        한국산(韓國産) 수유나무의 Triglyceride 조성(組成)에 관(關)한 연구(硏究) (III)

        정보섭,고영수,Chung, Bo-Sup,Ko, Young-Su 한국생약학회 1979 생약학회지 Vol.10 No.1

        The Korean Euodia daniellii $H_{EMSLEY}$ seed oil of triglyceride composition were analysed by thinchrography. Responses of sterol, triglyceride, sterol ester and acetate on a thin layer chromatographic apparatus, which was equipped with a flame ionization detector were determined. It was found that thinchrography is very superior and convenient means for the estimation of seed oil triglyceride compositions. The triglyceride compositions were tripalmitin 7.3%, tristearin 1.8%, triolein 21.1%, trilinolein 32.9%, trilinolenin 33.4% and unknown 3.5% in the case of Euodia daniellii seed oil in Korea.

      • SCOPUSKCI등재

        한국산(韓國産) 식물(植物)의 보유(補遺) (I)

        육창수,김창민,정현배,Yook, Chang-Soo,Kim, Chang-Min,Chung, Hyon-Pea 한국생약학회 1979 생약학회지 Vol.10 No.2

        한국산 미기록 1종(種)과 신귀화식물(新歸化植物) 1종(種)을 기재(記載)하고 이들의 한국명(新稱)을 공기(供記)한다. Two kinds of unreported species of Korea, Apium leptophyllum (Pers.) F. Muell (Umbelliferae) and Polygonatum miserum $S_{ATAKE}$, (Liliaceae) are found by authors in Kwangnung area.

      • SCOPUSKCI등재

        강간제(强肝劑)로 사용된 생약(生藥)의 조사(調査) 연구(硏究) (III)

        장일무,윤혜숙,Chang, Il-Moo,YunChoi, Hye-Sook 한국생약학회 1979 생약학회지 Vol.10 No.2

        Total fourty-four medicinal plants described in old literatures to be hepatotonic were evaluated their potential hepatotonic activities against an animal model of hepatitis. Tweenty-seven plants extracts appeared to be significant hepatotonic activities, whereas twelve plants extracts exhibited rather some toxicity. And five plants extracts showed no significant hapatotonic activities and toxicity.

      • SCOPUSKCI등재

        생약 추출물에 의한 superoxide와 hydroxyl 라디칼 소거능 검색 방법의 개선

        이호섭,강대길,Lee, Ho-Sub,Kang, Dae-Gill 한국생약학회 2001 생약학회지 Vol.32 No.3

        The present study was designed for the improvement of routine measurement of superoxide and hydroxyl radical scavenging activities utilized by a microplate reader. Superoxide radical scavenging activity by the ascorbic acid, which is a well-known superoxide scavenger, was determined in a dose-dependent manner. Hydroxyl radical scavenging activity by the thiourea, which is a well-known hydroxyl radical scavenger, was also well detected in a dose-dependent manner. Our results suggest that the use of microplate reader to assay the superoxide and hydroxyl radical scavenging activities improves the accuracy of data and enables the use of much smaller amounts of samples and/or reagents, with much simpler experimental procedure. Therefore, These methods appear to be suitable for screening of superoxide and hydroxyl radical scavenging activities in both the plant medicinal extracts and the isolated compounds.

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